3-hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing Rho GTPase-induced down-regulation of p27(Kip1)

Journal of Biological Chemistry

Volumn 274, Issue 31, 1999, Pages 21926-21931

  Laufs, Ulrich ^a   Marra, Diego ^a   Node, Koichi ^a   Liao, James K ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; PROTEIN P27; RAS PROTEIN; RHO FACTOR; SIMVASTATIN;

ARTICLE; CELL PROLIFERATION; CHOLESTEROL SYNTHESIS; DNA SYNTHESIS; DRUG MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR SMOOTH MUSCLE;

AORTA; CELL CYCLE PROTEINS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KINETICS; MEVALONIC ACID; MICROTUBULE-ASSOCIATED PROTEINS; MUSCLE, SMOOTH, VASCULAR; PLATELET-DERIVED GROWTH FACTOR; PROTEINS; RAS GTPASE-ACTIVATING PROTEINS; RHOA GTP-BINDING PROTEIN; SAPHENOUS VEIN; SIMVASTATIN; TUMOR SUPPRESSOR PROTEINS; TUNICA MEDIA;

EID: 0033618378     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.31.21926     Document Type: Article

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