Inhaled Nitric Oxide in Premature Infants with the Respiratory Distress Syndrome

New England Journal of Medicine

Volumn 349, Issue 22, 2003, Pages 2099-2107

  Schreiber, Michael D ^a   Gin Mestan, Karen ^a   Marks, Jeremy D ^a   Huo, Dezheng ^a   Lee, Grace ^a   Srisuparp, Pimol ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; PLACEBO;

ARTICLE; ARTIFICIAL VENTILATION; BRAIN HEMORRHAGE; CHILD DEATH; CHRONIC LUNG DISEASE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; GESTATION PERIOD; HIGH FREQUENCY VENTILATION; HUMAN; INCIDENCE; INFANT; LEUKOMALACIA; MAJOR CLINICAL STUDY; MALE; OSCILLATION; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY DISTRESS SYNDROME; SIDE EFFECT; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; BIRTH WEIGHT; BRONCHOPULMONARY DYSPLASIA; CHRONIC DISEASE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INCIDENCE; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, PREMATURE; INTRACRANIAL HEMORRHAGES; LEUKOMALACIA, PERIVENTRICULAR; LUNG DISEASES; MALE; NITRIC OXIDE; OXYGEN INHALATION THERAPY; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, NEWBORN;

EID: 0344943241     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMoa031154     Document Type: Article

References (42)

1. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001;163:1723-9.
2. Giacoia GP, Venkataraman PS, West-Wilson KI, Faulkner MJ. Follow-up of school-age children with bronchopulmonary dysplasia. J Pediatr 1997;130:400-8.
3. Groothuis JR, Gutierrez KM, Lauer BA. Respiratory syncytial virus infection in children with bronchopulmonary dysplasia. Pediatrics 1988;82:199-203.
4. Schmidt B, Asztalos EV, Roberts PS, et al. Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms. JAMA 2003;289:1124-9.
5. Kinsella JP, Parker TA, Galan H, Sheridan BC, Halbower AC, Abman SH. Effects of inhaled nitric oxide on pulmonary edema and lung neutrophil accumulation in severe experimental hyaline membrane disease. Pediatr Res 1997;41:457-63.
6. Roberts JD Jr, Chiche JD, Weimann J, Steudel W, Zapol WM, Bloch KD. Nitric oxide inhalation decreases pulmonary artery remodeling in the injured lungs of rat pups. Circ Res 2000;87:140-5.
7. Clark RH, Kueser TJ, Walker MW, et al. Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. N Engl J Med 2000;342:469-74.
8. Lemons JA, Bauer CR, Oh W, et al. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1995 through December 1996. Pediatrics 2001;107:164. abstract.
9. Shennan AT, Dunn MS, Ohlsson A, Lennox K, Hoskins EM. Abnormal pulmonary outcomes in premature infants: prediction from oxygen requirement in the neonatal period. Pediatrics 1988;82:527-32.
10. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978;92:529-34.
11. Skullerud K, Westre B. Frequency and prognostic significance of germinal matrix hemorrhage, periventricular leukomalacia, and pontosubicular necrosis in preterm neonates. Acta Neuropathol (Berl) 1986;70:257-61.
12. Snedecor GW, Cochran WG. Statistical methods. 7th ed. Ames: Iowa State University Press, 1980.
13. McCullagh P, Nelder JA. Generalized linear models. 2nd ed. London: Chapman & Hall, 1989.
14. Gaston B, Drazen JM, Loscalzo J, Stamler JS. The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med 1994;149:538-51.
15. Young SL, Evans K, Eu JP. Nitric oxide modulates branching morphogenesis in fetal rat lung explants. Am J Physiol Lung Cell Mol Physiol 2002;282:L379-L385.
16. Kawai N, Bloch DB, Filippov G, et al. Constitutive endothelial nitric oxide synthase gene expression is regulated during lung development. Am J Physiol 1995;268: L589-L595.
17. Barnes PJ. Nitric oxide and airway disease. Ann Med 1995;27:389-93.
18. Afshar S, Gibson LL, Yuhanna IS, et al. Pulmonary NO synthase expression is attenuated in a fetal baboon model of chronic lung disease. Am J Physiol Lung Cell Mol Physiol 2003;284:L749-L758.
19. MacRitchie AN, Albertine KH, Sun J, et al. Reduced endothelial nitric oxide synthase in lungs of chronically ventilated preterm lambs. Am J Physiol Lung Cell Mol Physiol 2001;281:L1011-L1020.
20. Issa A, Lappalainen U, Kleinman M, Bry K, Hallman M. Inhaled nitric oxide decreases hyperoxia-induced surfactant abnormality in preterm rabbits. Pediatr Res 1999;45:247-54.
21. Speer CP, Ruess D, Harms K, Herting E, Gefeller O. Neutrophil elastase and acute pulmonary damage in neonates with severe respiratory distress syndrome. Pediatrics 1993;91:794-9.
22. Terada LS, Mahr NN, Jacobson ED. Nitric oxide decreases lung injury after intestinal ischemia. J Appl Physiol 1996;81:2456-60.
23. Kourembanas S, McQuillan LP, Leung GK, Faller DV. Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J Clin Invest 1993;92:99-104.
24. Thomae KR, Nakayama DK, Billiar TR, Simmons RL, Pitt BR, Davies P. The effect of nitric oxide on fetal pulmonary artery smooth muscle growth. J Surg Res 1995;59:337-43.
25. Srisuparp P, Marks JD, Khoshnood B, Schreiber MD. Predictive power of initial severity of pulmonary disease for subsequent development of bronchopulmonary dysplasia. Biol Neonate 2003;84:31-6.
26. Takashima S, Mito T, Ando Y. Pathogenesis of periventricular white matter hemorrhages in preterm infants. Brain Dev 1986;8:25-30.
27. Radomski MW, Palmer RM, Moncada S. The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Commun 1987;148:1482-9.
28. Idem. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet 1987;2:1057-8.
29. Lackmann GM, Hesse L, Tollner U. Reduced iron-associated antioxidants in premature newborns suffering intracerebral hemorrhage. Free Radic Biol Med 1996;20:407-9.
30. Hogman M, Frostell C, Arnberg H, Hedenstierna G. Bleeding time prolongation and NO inhalation. Lancet 1993;341:1664-5.
31. George TN, Johnson KJ, Bates JN, Segar JL. The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates. J Pediatr 1998;132:731-4.
32. Cheung PY, Salas E, Etches PC, Phillipos E, Schulz R, Radomski MW. Inhaled nitric oxide and inhibition of platelet aggregation in critically ill neonates. Lancet 1998;351:1181-2.
33. Meurs KP, Rhine WD, Asselin JM, Durand DJ. Response of premature infants with severe respiratory failure to inhaled nitric oxide. Pediatr Pulmonol 1997;24:319-23.
34. The Franco-Belgium Collaborative NO Trial Group. Early compared with delayed inhaled nitric oxide in moderately hypoxaemic neonates with respiratory failure: a randomised controlled trial. Lancet 1999;354:1066-71. [Erratum, Lancet 1999;354:1826.]
35. The Franco-Belgium Collaborative NO Trial Group. Early compared with delayed inhaled nitric oxide in moderately hypoxaemic neonates with respiratory failure: a randomised controlled trial. Lancet 1999;354:1066-71. [Erratum, Lancet 1999;354:1826.]
36. Skimming JW, Bender KA, Hutchison AA, Drummond WH. Nitric oxide inhalation in infants with respiratory distress syndrome. J Pediatr 1997;130:225-30.
37. Kinsella JP, Walsh WF, Bose CL, et al. Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial. Lancet 1999;354:1061-5.
38. The Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Engl J Med 1997;336:597-604. [Erratum, N Engl J Med 1997;337:434.]
39. The Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Engl J Med 1997;336:597-604. [Erratum, N Engl J Med 1997;337:434.]
40. Koberts JD Jr, Fineman JR, Morin FC III, et al. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. N Engl J Med 1997;336:605-10.
41. Aikio O, Vuopala K, Pokela ML, Andersson S, Hallman M. Nitrotyrosine and NO synthases in infants with respiratory failure: influence of inhaled NO. Pediatr Pulmonol 2003;35:8-16.
42. Hallman M, Bry K, Turbow R, Waffam F, Lappalainen U. Pulmonary toxicity associated with nitric oxide in term infants with severe respiratory failure. J Pediatr 1998;132:827-9.