메뉴 건너뛰기




Volumn 2, Issue 2, 2009, Pages 195-208

Pros and cons of methods used for the prediction of oral drug absorption

Author keywords

Absorption; Current methods; Oral administration; Prediction

Indexed keywords

NEW DRUG;

EID: 70149113223     PISSN: 17512433     EISSN: None     Source Type: Journal    
DOI: 10.1586/17512433.2.2.195     Document Type: Review
Times cited : (12)

References (180)
  • 2
    • 0037364162 scopus 로고    scopus 로고
    • ADMET in silico modeling: Towards prediction paradise?
    • Van de Waterbeemd H, Gifford E. ADMET in silico modeling: towards prediction paradise? Nat. Rev. Drug Discov. 2(3), 192-204 (2003).
    • (2003) Nat. Rev. Drug Discov , vol.2 , Issue.3 , pp. 192-204
    • Van de Waterbeemd, H.1    Gifford, E.2
  • 3
    • 0030886937 scopus 로고    scopus 로고
    • Managing the drug discovery/development interface
    • Kennedy T. Managing the drug discovery/development interface. Drug Disc. Today 2, 436-444 (1997).
    • (1997) Drug Disc. Today , vol.2 , pp. 436-444
    • Kennedy, T.1
  • 4
    • 0032844618 scopus 로고    scopus 로고
    • Setting bioequivalence requirements for drug development based on preclinical data: Optimizing oral drug delivery systems
    • Lipka E, Amidon GL. Setting bioequivalence requirements for drug development based on preclinical data: optimizing oral drug delivery systems. J. Control Release 62, 41-49 (1999).
    • (1999) J. Control Release , vol.62 , pp. 41-49
    • Lipka, E.1    Amidon, G.L.2
  • 5
    • 0028948839 scopus 로고
    • A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
    • Amidon GL, Lennernas H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 12, 413-420 (1995).
    • (1995) Pharm. Res , vol.12 , pp. 413-420
    • Amidon, G.L.1    Lennernas, H.2    Shah, V.P.3    Crison, J.R.4
  • 6
    • 0031413702 scopus 로고    scopus 로고
    • Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond
    • Artursson P, Borchardt RT. Intestinal drug absorption and metabolism in cell cultures: caco-2 and beyond. Pharm. Res. 14(12), 1655-1658 (1997).
    • (1997) Pharm. Res , vol.14 , Issue.12 , pp. 1655-1658
    • Artursson, P.1    Borchardt, R.T.2
  • 7
    • 0034948871 scopus 로고    scopus 로고
    • Biorelevant dissolution testing to predict the plasma profile of lipophilic drugs after oral administration
    • Nicolaides E, Symillides M, Dressman JB, Reppas C. Biorelevant dissolution testing to predict the plasma profile of lipophilic drugs after oral administration. Pharm. Res. 18(3), 380-388 (2001).
    • (2001) Pharm. Res , vol.18 , Issue.3 , pp. 380-388
    • Nicolaides, E.1    Symillides, M.2    Dressman, J.B.3    Reppas, C.4
  • 8
    • 33747116165 scopus 로고    scopus 로고
    • Computational models to predict aqueous drug solubility, permeability and intestinal absorption
    • Bergstrom CAS. Computational models to predict aqueous drug solubility, permeability and intestinal absorption. Expert Opin. Drug Metab. Toxicol. 1(4), 613-627 (2005).
    • (2005) Expert Opin. Drug Metab. Toxicol , vol.1 , Issue.4 , pp. 613-627
    • Bergstrom, C.A.S.1
  • 9
    • 0034729673 scopus 로고    scopus 로고
    • QSAR model for drug human oral bioavailability
    • Yoshida F, Topliss JG. QSAR model for drug human oral bioavailability. J. Med. Chem. 43(13), 2575-2585 (2000).
    • (2000) J. Med. Chem , vol.43 , Issue.13 , pp. 2575-2585
    • Yoshida, F.1    Topliss, J.G.2
  • 10
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski CA, Lombardo F, Dominy BW et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug. Deliv. Rev. 23(1-3), 3-25 (1997).
    • (1997) Adv. Drug. Deliv. Rev , vol.23 , Issue.1-3 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3
  • 11
    • 0034491130 scopus 로고    scopus 로고
    • Optimizing the science of drug development: Opportunities for better candidate selection and accelerated evaluation in humans
    • Lesko LJ, Rowland M, Peck CC, Blaschke TF. Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans. Pharm. Res. 17(11), 1335-1344 (2000).
    • (2000) Pharm. Res , vol.17 , Issue.11 , pp. 1335-1344
    • Lesko, L.J.1    Rowland, M.2    Peck, C.C.3    Blaschke, T.F.4
  • 12
    • 33748338819 scopus 로고    scopus 로고
    • From physicochemistry to absorption and distribution: Predictive mechanistic modeling and computational tools
    • Willmann S, Lippert J, Schmitt W. From physicochemistry to absorption and distribution: predictive mechanistic modeling and computational tools. Expert Opin. Drug Metab. Toxicol. 1(1), 159-168 (2005).
    • (2005) Expert Opin. Drug Metab. Toxicol , vol.1 , Issue.1 , pp. 159-168
    • Willmann, S.1    Lippert, J.2    Schmitt, W.3
  • 13
    • 20444465945 scopus 로고    scopus 로고
    • The impact of early ADME profiling on drug discovery and development strategy
    • Wang J, Urban L. The impact of early ADME profiling on drug discovery and development strategy. Drug Discov. 4, 73-86 (2004).
    • (2004) Drug Discov , vol.4 , pp. 73-86
    • Wang, J.1    Urban, L.2
  • 14
    • 3042781869 scopus 로고    scopus 로고
    • Lombardo F, Gifford E, Shalaeva M Y. In silico ADME prediction: data, models, facts, myths. Minirev. Med. Chem. 3 (8), 861-875 (2003).
    • Lombardo F, Gifford E, Shalaeva M Y. In silico ADME prediction: data, models, facts, myths. Minirev. Med. Chem. 3 (8), 861-875 (2003).
  • 15
    • 15244339914 scopus 로고    scopus 로고
    • In silico predictions of drug solubility and permeability: Two rate-limiting barriers to oral drug absorption
    • Bergström CAS. In silico predictions of drug solubility and permeability: two rate-limiting barriers to oral drug absorption. Basic Clin. Pharmacol. Toxicol. 96, 156-161 (2005).
    • (2005) Basic Clin. Pharmacol. Toxicol , vol.96 , pp. 156-161
    • Bergström, C.A.S.1
  • 17
    • 0033840471 scopus 로고    scopus 로고
    • Predicting human oral bioavailability of a compound: Development of a novel quantitative structure - bioavailability relationship
    • Andrews CW, Bennett L, Yu LX. Predicting human oral bioavailability of a compound: development of a novel quantitative structure - bioavailability relationship. Pharm. Res. 17 (6), 639-644 (2000).
    • (2000) Pharm. Res , vol.17 , Issue.6 , pp. 639-644
    • Andrews, C.W.1    Bennett, L.2    Yu, L.X.3
  • 21
    • 37249042636 scopus 로고    scopus 로고
    • ADME evaluation in drug discovery. 8. The prediction of human intestinal absorption by a support vector machine
    • Hou T, Wang J, Li Y. ADME evaluation in drug discovery. 8. The prediction of human intestinal absorption by a support vector machine. J. Chem. Inf. Model. 47(6), 2408-2415 (2007).
    • (2007) J. Chem. Inf. Model , vol.47 , Issue.6 , pp. 2408-2415
    • Hou, T.1    Wang, J.2    Li, Y.3
  • 22
    • 33846855555 scopus 로고    scopus 로고
    • ADME evaluation in drug discovery. 7. Prediction of oral absorption by correlation and classification
    • Hou T, Wang J, Zhang W, Xu X. ADME evaluation in drug discovery. 7. Prediction of oral absorption by correlation and classification. J. Chem. Inf. Model. 47(1), 208-218 (2007).
    • (2007) J. Chem. Inf. Model , vol.47 , Issue.1 , pp. 208-218
    • Hou, T.1    Wang, J.2    Zhang, W.3    Xu, X.4
  • 23
    • 34247245174 scopus 로고    scopus 로고
    • ADME evaluation in drug discovery. Can oral bioavailability in humans be effectively predicted by simple molecular property-based rules?
    • Hou T, Wang J, Zhang W, Xu X. ADME evaluation in drug discovery. Can oral bioavailability in humans be effectively predicted by simple molecular property-based rules? J. Chem. Inf. Model. 47(2), 460-463 (2007).
    • (2007) J. Chem. Inf. Model , vol.47 , Issue.2 , pp. 460-463
    • Hou, T.1    Wang, J.2    Zhang, W.3    Xu, X.4
  • 24
    • 0030444550 scopus 로고    scopus 로고
    • Guidance in the setting of drug particle size specifications to minimize variability in absorption
    • Johnson K, Swindell A. Guidance in the setting of drug particle size specifications to minimize variability in absorption. Pharm. Res. 13(12), 1795-1798 (1996).
    • (1996) Pharm. Res , vol.13 , Issue.12 , pp. 1795-1798
    • Johnson, K.1    Swindell, A.2
  • 25
    • 2942585051 scopus 로고    scopus 로고
    • In vitro testing of drug absorption for drug 'developability' assessment: Forming an interface between in vitro preclinical data and clinical outcome
    • Sun D, Yu LX, Hussain MA, Wall DA, Smith RL, Amidon GL. In vitro testing of drug absorption for drug 'developability' assessment: forming an interface between in vitro preclinical data and clinical outcome. Curr. Opin. Drug Discov. Dev. 7, 75-85 (2004).
    • (2004) Curr. Opin. Drug Discov. Dev , vol.7 , pp. 75-85
    • Sun, D.1    Yu, L.X.2    Hussain, M.A.3    Wall, D.A.4    Smith, R.L.5    Amidon, G.L.6
  • 26
    • 56049112383 scopus 로고    scopus 로고
    • Applications of physiologically based absorption models in drug discovery and development
    • Parrott N, Lave T. Applications of physiologically based absorption models in drug discovery and development. Mol. Pharm. 5(5), 760-775 (2008).
    • (2008) Mol. Pharm , vol.5 , Issue.5 , pp. 760-775
    • Parrott, N.1    Lave, T.2
  • 28
    • 70149094268 scopus 로고    scopus 로고
    • Note for guidance on the investigation of bioavailability and bioequivalence
    • EMEA, Committee for Proprietary Medicinal Products, London, UK
    • EMEA. Note for guidance on the investigation of bioavailability and bioequivalence. European Agency for Evaluation of Medicinal Products, Committee for Proprietary Medicinal Products, London, UK (2001).
    • (2001) European Agency for Evaluation of Medicinal Products
  • 29
    • 0027473738 scopus 로고
    • Estimating the fraction dose absorbed from suspensions of poorly soluble compounds in humans - a mathematical-model
    • Oh DM, Curl RL, Amidon GL. Estimating the fraction dose absorbed from suspensions of poorly soluble compounds in humans - a mathematical-model. Pharm. Res. 10(2), 264-270 (1993).
    • (1993) Pharm. Res , vol.10 , Issue.2 , pp. 264-270
    • Oh, D.M.1    Curl, R.L.2    Amidon, G.L.3
  • 30
    • 0343527392 scopus 로고    scopus 로고
    • Modern bioavailability, bioequivalence and biopharmaceutics classification system: New scientific approaches to international regulatory standards
    • Lobenberg R, Amidon GL. Modern bioavailability, bioequivalence and biopharmaceutics classification system: new scientific approaches to international regulatory standards. Eur. J. Pharm. Biopharm. 50, 3-12 (2000).
    • (2000) Eur. J. Pharm. Biopharm , vol.50 , pp. 3-12
    • Lobenberg, R.1    Amidon, G.L.2
  • 31
    • 14744272833 scopus 로고    scopus 로고
    • The use of biopharmaceutic classification of drugs in drug discovery and development: Current status and future extension. In drug bioavailability, estimation of solubility, permeability, absorption and bioavailability
    • Lennernäs H, Abrahamsson B. The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension. In drug bioavailability, estimation of solubility, permeability, absorption and bioavailability. J. Pharm. Pharmacol. 57, 273-285 (2005).
    • (2005) J. Pharm. Pharmacol , vol.57 , pp. 273-285
    • Lennernäs, H.1    Abrahamsson, B.2
  • 32
    • 2642530433 scopus 로고    scopus 로고
    • Summary workshop report: Biopharmaceutics Classification System - implementation challenges and extension opportunities
    • Polli JE, Yu LX, Cook JA et al. Summary workshop report: Biopharmaceutics Classification System - implementation challenges and extension opportunities. J. Pharm. Sci. 93, 1375-1381 (2004).
    • (2004) J. Pharm. Sci , vol.93 , pp. 1375-1381
    • Polli, J.E.1    Yu, L.X.2    Cook, J.A.3
  • 33
    • 0035997323 scopus 로고    scopus 로고
    • Biopharmaceutics Classification System: The scientific basis for biowaiver extensions
    • Yu LX, Amidon GL, Polli JE. et al. Biopharmaceutics Classification System: the scientific basis for biowaiver extensions. Pharm. Res. 19, 921-925 (2002).
    • (2002) Pharm. Res , vol.19 , pp. 921-925
    • Yu, L.X.1    Amidon, G.L.2    Polli, J.E.3
  • 34
    • 34447336490 scopus 로고    scopus 로고
    • Application and experience in the EU of BCS in the review of new generics
    • Barends, DM. Application and experience in the EU of BCS in the review of new generics. J. Pharm. Pharmacol. 57(Suppl.), 117 (2005).
    • (2005) J. Pharm. Pharmacol , vol.57 , Issue.SUPPL. , pp. 117
    • Barends, D.M.1
  • 35
    • 17644380257 scopus 로고    scopus 로고
    • Predicting drug disposition via application of BCS: Transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system
    • Wu CY, Benet LZ. Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm. Res. 22(1), 11-23 (2005).
    • (2005) Pharm. Res , vol.22 , Issue.1 , pp. 11-23
    • Wu, C.Y.1    Benet, L.Z.2
  • 36
    • 0348107338 scopus 로고    scopus 로고
    • Quantitative biopharmaceutics classification system: The central role of dose/solubility ratio
    • Rinaki E, Valsami G, Macheras P. Quantitative biopharmaceutics classification system: the central role of dose/solubility ratio. Pharm. Res. 20, 1917-1925 (2003).
    • (2003) Pharm. Res , vol.20 , pp. 1917-1925
    • Rinaki, E.1    Valsami, G.2    Macheras, P.3
  • 37
    • 34447329572 scopus 로고    scopus 로고
    • Evaluation and suggested improvements of the Biopharmaceutics Classification System (BCS)
    • Fagerholm U. Evaluation and suggested improvements of the Biopharmaceutics Classification System (BCS). J. Pharm. Pharmacol. 59, 751-757 (2007).
    • (2007) J. Pharm. Pharmacol , vol.59 , pp. 751-757
    • Fagerholm, U.1
  • 38
    • 51249095402 scopus 로고    scopus 로고
    • Use of the Biopharmaceutical Classification System in early drug development
    • Ku MS. Use of the Biopharmaceutical Classification System in early drug development. AAPS J. 10(1), 208-212 (2008).
    • (2008) AAPS J , vol.10 , Issue.1 , pp. 208-212
    • Ku, M.S.1
  • 39
    • 28644439792 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of the cyclooxygenase inhibiting nitric oxide donator (CINOD). AZD3582
    • Fagerholm U, Björnsson MA. Clinical pharmacokinetics of the cyclooxygenase inhibiting nitric oxide donator (CINOD). AZD3582. J. Pharm. Pharmacol. 57(12), 1539-1554 (2005).
    • (2005) J. Pharm. Pharmacol , vol.57 , Issue.12 , pp. 1539-1554
    • Fagerholm, U.1    Björnsson, M.A.2
  • 40
    • 1242337282 scopus 로고    scopus 로고
    • The "high solubility" definition of the current FDA Guidance on Biopharmaceutical Classification System may be too strict for acidic drugs
    • Yazdanian M, Briggs K, Jankovsky C, Hawi A. The "high solubility" definition of the current FDA Guidance on Biopharmaceutical Classification System may be too strict for acidic drugs. Pharm. Res. 21, 293-299 (2004).
    • (2004) Pharm. Res , vol.21 , pp. 293-299
    • Yazdanian, M.1    Briggs, K.2    Jankovsky, C.3    Hawi, A.4
  • 41
    • 52949112291 scopus 로고    scopus 로고
    • FDA and drug companies alike want ADME-tox testing performed earlier and earlier in a drug's life cycle
    • Canavan N. FDA and drug companies alike want ADME-tox testing performed earlier and earlier in a drug's life cycle. Drug Discov. Dev. 10, 34-36 (2007).
    • (2007) Drug Discov. Dev , vol.10 , pp. 34-36
    • Canavan, N.1
  • 42
    • 48949117177 scopus 로고    scopus 로고
    • Structure - ADME relationship: Still a long way to go?
    • Hou TJ, Wang JM. Structure - ADME relationship: still a long way to go? Expert Opin. Drug Metab. Toxicol. 4, 759-771 (2008).
    • (2008) Expert Opin. Drug Metab. Toxicol , vol.4 , pp. 759-771
    • Hou, T.J.1    Wang, J.M.2
  • 43
    • 33748545599 scopus 로고    scopus 로고
    • Recent advances in computational prediction of drug absorption and permeability in drug discovery
    • Hou T, Wang J, Zhang W, Wang W, Xu X. Recent advances in computational prediction of drug absorption and permeability in drug discovery. Curr. Med. Chem. 13(22), 2653-2667 (2006).
    • (2006) Curr. Med. Chem , vol.13 , Issue.22 , pp. 2653-2667
    • Hou, T.1    Wang, J.2    Zhang, W.3    Wang, W.4    Xu, X.5
  • 44
    • 0029840951 scopus 로고    scopus 로고
    • QSAR analysis of membrane permeability to organic compounds
    • Ren S, Das A, Lien EJ. QSAR analysis of membrane permeability to organic compounds. J. Drug Target. 4, 104-107 (1996).
    • (1996) J. Drug Target , vol.4 , pp. 104-107
    • Ren, S.1    Das, A.2    Lien, E.J.3
  • 45
    • 0023923405 scopus 로고
    • Intestinal absorption kinetics of various model drugs, in relation to partition coefficients
    • Nook T, Doelker E, Buri P. Intestinal absorption kinetics of various model drugs, in relation to partition coefficients. Int. J. Pharm. 43, 119-129 (1988).
    • (1988) Int. J. Pharm , vol.43 , pp. 119-129
    • Nook, T.1    Doelker, E.2    Buri, P.3
  • 48
    • 0031946994 scopus 로고    scopus 로고
    • Membrane transport of drugs in different regions of the intestinal tract of the rat
    • Ungell AL, Nylander S, Bergstrand S, Sjöberg Å, Lennernäs H. Membrane transport of drugs in different regions of the intestinal tract of the rat. J. Pharm. Sci. 87, 360-366 (1998).
    • (1998) J. Pharm. Sci , vol.87 , pp. 360-366
    • Ungell, A.L.1    Nylander, S.2    Bergstrand, S.3    Sjöberg, A.4    Lennernäs, H.5
  • 49
    • 0035286778 scopus 로고    scopus 로고
    • Caco-2 monolayers in experimental and theoretical predictions of drug transport
    • Artursson P, Palm K, Luthman K. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv. Drug Del. Rev. 46, 27-43 (2001).
    • (2001) Adv. Drug Del. Rev , vol.46 , pp. 27-43
    • Artursson, P.1    Palm, K.2    Luthman, K.3
  • 50
    • 0030914681 scopus 로고    scopus 로고
    • Polar molecular surface properties predict the intestinal absorption of drugs in humans
    • Palm K, Stenberg P, Luthman K, Artursson P. Polar molecular surface properties predict the intestinal absorption of drugs in humans. Pharm. Res. 14, 568-571 (1997).
    • (1997) Pharm. Res , vol.14 , pp. 568-571
    • Palm, K.1    Stenberg, P.2    Luthman, K.3    Artursson, P.4
  • 51
    • 3242778534 scopus 로고    scopus 로고
    • A physiological model for the estimation of the fraction dose absorbed in humans
    • Willmann S, Schmitt W, Keldenich J, Lippert J, Dressman JB. A physiological model for the estimation of the fraction dose absorbed in humans. J. Med. Chem. 47, 4022-4031 (2004).
    • (2004) J. Med. Chem , vol.47 , pp. 4022-4031
    • Willmann, S.1    Schmitt, W.2    Keldenich, J.3    Lippert, J.4    Dressman, J.B.5
  • 52
    • 0036891365 scopus 로고    scopus 로고
    • ADME evaluation. A computer model for the prediction of intestinal absorption in humans
    • Klopman G, Stefan LR, Saiakhov RD. ADME evaluation. A computer model for the prediction of intestinal absorption in humans. Eur. J. Pharm. Sci. 17, 253-263 (2002).
    • (2002) Eur. J. Pharm. Sci , vol.17 , pp. 253-263
    • Klopman, G.1    Stefan, L.R.2    Saiakhov, R.D.3
  • 54
    • 0141611171 scopus 로고    scopus 로고
    • Predicting passive transport in silico - history, hype, hope
    • Clark DE, Grootenhuis PDJ. Predicting passive transport in silico - history, hype, hope. Curr. Top. Med. Chem. 3, 1193-1203 (2003).
    • (2003) Curr. Top. Med. Chem , vol.3 , pp. 1193-1203
    • Clark, D.E.1    Grootenhuis, P.D.J.2
  • 55
    • 0032795192 scopus 로고    scopus 로고
    • Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. Prediction of intestinal absorption
    • Clark DE. Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. Prediction of intestinal absorption. J. Pharm. Sci. 88, 807-814 (1999).
    • (1999) J. Pharm. Sci , vol.88 , pp. 807-814
    • Clark, D.E.1
  • 56
    • 53849085797 scopus 로고    scopus 로고
    • In vitro studies are sometimes better than conventional human pharmacokinetic in vivo studies in assessing bioequivalence of immediate-release solid oral dosage forms
    • Polli J. In vitro studies are sometimes better than conventional human pharmacokinetic in vivo studies in assessing bioequivalence of immediate-release solid oral dosage forms. AAPS J. 10(2), 289-299 (2008).
    • (2008) AAPS J , vol.10 , Issue.2 , pp. 289-299
    • Polli, J.1
  • 57
    • 0031925268 scopus 로고    scopus 로고
    • Human intestinal permeability
    • Lennernäs H. Human intestinal permeability. J. Pharm. Sci. 87(4), 403-410 (1998).
    • (1998) J. Pharm. Sci , vol.87 , Issue.4 , pp. 403-410
    • Lennernäs, H.1
  • 58
    • 0035524138 scopus 로고    scopus 로고
    • Assessing the absorption of new Pharmaceuticals
    • Hidalgo IJ. Assessing the absorption of new Pharmaceuticals. Curr. Top. Med. Chem. 1(5), 385-401 (2001).
    • (2001) Curr. Top. Med. Chem , vol.1 , Issue.5 , pp. 385-401
    • Hidalgo, I.J.1
  • 59
    • 0041882163 scopus 로고    scopus 로고
    • in vitro system for prediction of oral absorption of relatively water-soluble drugs and ester prodrugs
    • He X. Sugawara M. Kobayashi M. Takekuma Y. Miyazaki K. An in vitro system for prediction of oral absorption of relatively water-soluble drugs and ester prodrugs. Int. J. Pharm. 263, 35-44 (2003).
    • (2003) Int. J. Pharm , vol.263 , pp. 35-44
    • He, X.1    Sugawara, M.2    Kobayashi, M.3    Takekuma, Y.4    An, M.K.5
  • 60
    • 0025783111 scopus 로고
    • + coupled transport of orally active cephalosporins lacking and α-amino group across brush-border membrane vesicles from rat small intestine
    • + coupled transport of orally active cephalosporins lacking and α-amino group across brush-border membrane vesicles from rat small intestine. J. Pharm. Pharmacol. 43, 433-435 (1991).
    • (1991) J. Pharm. Pharmacol , vol.43 , pp. 433-435
    • Sugawara, M.1    Iseki, K.2    Miyazaki, K.3
  • 61
    • 0037336533 scopus 로고    scopus 로고
    • Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers
    • Tavelin S, Taipalensuu J, Söderberg L, Morrison R, Chong S, Artursson P. Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers. Pharm. Res, 20, 397-405 (2003).
    • (2003) Pharm. Res , vol.20 , pp. 397-405
    • Tavelin, S.1    Taipalensuu, J.2    Söderberg, L.3    Morrison, R.4    Chong, S.5    Artursson, P.6
  • 62
    • 0025358551 scopus 로고
    • Transport of bile acids in a human intestinal epithelial cell line, Caco-2
    • Hidalgo IJ, Borchardt RT. Transport of bile acids in a human intestinal epithelial cell line, Caco-2. Biochim. Biophys. Acta 1035, 97-103 (1990).
    • (1990) Biochim. Biophys. Acta , vol.1035 , pp. 97-103
    • Hidalgo, I.J.1    Borchardt, R.T.2
  • 63
    • 0029991481 scopus 로고    scopus 로고
    • Immobilized-artificial-membrane chromatography: Measurements of membrane partition coefficient and predicting drug membrane permeability
    • Ong S, Liu H, Pidgeon C. Immobilized-artificial-membrane chromatography: measurements of membrane partition coefficient and predicting drug membrane permeability. J. Chromatogr. A 728(1-2), 113-128 (1996).
    • (1996) J. Chromatogr. A , vol.728 , Issue.1-2 , pp. 113-128
    • Ong, S.1    Liu, H.2    Pidgeon, C.3
  • 64
    • 14644398632 scopus 로고    scopus 로고
    • Cell culture-based models for intestinal permeability: A critique
    • Balimane PV, Chong S. Cell culture-based models for intestinal permeability: a critique. Drug Discov. Today 10, 335-343 (2005).
    • (2005) Drug Discov. Today , vol.10 , pp. 335-343
    • Balimane, P.V.1    Chong, S.2
  • 65
    • 0032568397 scopus 로고    scopus 로고
    • Physicochemical high throughput screening: Parallel artificial membrane permeability assay in the description of passive absorption processes
    • Kansy M, Senner F, Gubernator K. Physicochemical high throughput screening: parallel artificial membrane permeability assay in the description of passive absorption processes. J. Med. Chem. 41, 1007-1010 (1998).
    • (1998) J. Med. Chem , vol.41 , pp. 1007-1010
    • Kansy, M.1    Senner, F.2    Gubernator, K.3
  • 66
    • 31344451056 scopus 로고    scopus 로고
    • Development and evaluation of an in vitro method for prediction of human drug absorption. II. Demonstration of the method suitability
    • Corti G, Maestrelli F, Cirri M, Zerrouk N, Mura P. Development and evaluation of an in vitro method for prediction of human drug absorption. II. Demonstration of the method suitability. Eur. J. Pharm. Sci. 27, 354-362 (2006).
    • (2006) Eur. J. Pharm. Sci , vol.27 , pp. 354-362
    • Corti, G.1    Maestrelli, F.2    Cirri, M.3    Zerrouk, N.4    Mura, P.5
  • 67
    • 3242728351 scopus 로고    scopus 로고
    • Molecular properties of WHO essential drugs and provisional biopharmaceutical classification
    • Kasim NA, Whitehouse M, Ramachandran C et al. Molecular properties of WHO essential drugs and provisional biopharmaceutical classification. Mol. Pharm. 1(1), 85-96 (2004).
    • (2004) Mol. Pharm , vol.1 , Issue.1 , pp. 85-96
    • Kasim, N.A.1    Whitehouse, M.2    Ramachandran, C.3
  • 68
    • 33746903600 scopus 로고    scopus 로고
    • Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model?
    • Cao X, Gibbs ST, Fang L et al. Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model? Pharm. Res. 23, 1675-1686 (2006).
    • (2006) Pharm. Res , vol.23 , pp. 1675-1686
    • Cao, X.1    Gibbs, S.T.2    Fang, L.3
  • 69
    • 0031014265 scopus 로고    scopus 로고
    • In vitro models for selection of development candidates. Permeability studies to define mechanisms of absorption enhancement
    • LeCluyse EL, Sutton SC. In vitro models for selection of development candidates. Permeability studies to define mechanisms of absorption enhancement. Adv. Drug Deliv. 23, 163-183 (1997).
    • (1997) Adv. Drug Deliv , vol.23 , pp. 163-183
    • LeCluyse, E.L.1    Sutton, S.C.2
  • 70
    • 0029055473 scopus 로고
    • Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
    • Kararli TT. Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharm. Drug Dispos. 16, 351-380 (1995).
    • (1995) Biopharm. Drug Dispos , vol.16 , pp. 351-380
    • Kararli, T.T.1
  • 71
    • 33747090656 scopus 로고    scopus 로고
    • Variability in mRNA expression of ABC- and SCL-transporters in human intestinal cells: Comparison between human segments and Caco-2 cells
    • Seithel A, Karlsson J, Hilgendorf C, Björquist A, Ungell AL. Variability in mRNA expression of ABC- and SCL-transporters in human intestinal cells: comparison between human segments and Caco-2 cells. Eur. J. Pharm. Sci. 28, 291-299 (2006).
    • (2006) Eur. J. Pharm. Sci , vol.28 , pp. 291-299
    • Seithel, A.1    Karlsson, J.2    Hilgendorf, C.3    Björquist, A.4    Ungell, A.L.5
  • 72
    • 19444382806 scopus 로고    scopus 로고
    • pH dependent passive and active transport of acidic drugs across Caco-2 monolayers
    • Neuhoff S, Ungell AL, Zamora I, Artursson P. pH dependent passive and active transport of acidic drugs across Caco-2 monolayers. Eur. J. Pharm. Res. 25, 211-220 (2005).
    • (2005) Eur. J. Pharm. Res , vol.25 , pp. 211-220
    • Neuhoff, S.1    Ungell, A.L.2    Zamora, I.3    Artursson, P.4
  • 73
    • 0043127396 scopus 로고    scopus 로고
    • pH dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: Implications for drug - drug interactions
    • Neuhoff S, Ungell AL, Zamora I, Artursson P. pH dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug - drug interactions. Pharm. Res. 20, 1141-1148 (2003).
    • (2003) Pharm. Res , vol.20 , pp. 1141-1148
    • Neuhoff, S.1    Ungell, A.L.2    Zamora, I.3    Artursson, P.4
  • 74
    • 33750181267 scopus 로고    scopus 로고
    • Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2
    • Englund G, Rorsman F, Rönnblom A et al. Regional levels of drug transporters along the human intestinal tract: co-expression of ABC and SLC transporters and comparison with Caco-2, Eur. J. Pharm. Sci. 29, 269-277 (2006).
    • (2006) Eur. J. Pharm. Sci , vol.29 , pp. 269-277
    • Englund, G.1    Rorsman, F.2    Rönnblom, A.3
  • 75
    • 1842557505 scopus 로고    scopus 로고
    • Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers
    • Ingels F, Beck B, Oth M et al. Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers. Int. J. Pharm. 274(1-2), 221-232 (2004).
    • (2004) Int. J. Pharm , vol.274 , Issue.1-2 , pp. 221-232
    • Ingels, F.1    Beck, B.2    Oth, M.3
  • 76
    • 0030023536 scopus 로고    scopus 로고
    • Comparison between active and passive drug transport in human intestinal epithelial (Caco-2). cells in vitro and human jejunum in vivo
    • Lennernäs H, Palm K, Fagerholm U, Artursson P. Comparison between active and passive drug transport in human intestinal epithelial (Caco-2). cells in vitro and human jejunum in vivo. Int. J. Pharm. 127, 103-107 (1996).
    • (1996) Int. J. Pharm , vol.127 , pp. 103-107
    • Lennernäs, H.1    Palm, K.2    Fagerholm, U.3    Artursson, P.4
  • 77
    • 0031781430 scopus 로고    scopus 로고
    • Correlating partitioning and Caco-2 cell permeability of structurally diverse small molecular weight compounds
    • Yazdanian M, Glynn SL, Wright JL, Hawi A. Correlating partitioning and Caco-2 cell permeability of structurally diverse small molecular weight compounds. Pharm. Res. 15, 1490-1494 (1998).
    • (1998) Pharm. Res , vol.15 , pp. 1490-1494
    • Yazdanian, M.1    Glynn, S.L.2    Wright, J.L.3    Hawi, A.4
  • 78
    • 0037204540 scopus 로고    scopus 로고
    • Physiologically-based pharmacokinetic simulation modeling
    • Grass GM, Sinko PJ. Physiologically-based pharmacokinetic simulation modeling. Adv. Drug Del. Rev. 54, 433-451 (2002).
    • (2002) Adv. Drug Del. Rev , vol.54 , pp. 433-451
    • Grass, G.M.1    Sinko, P.J.2
  • 79
    • 0036803219 scopus 로고    scopus 로고
    • Prediction of intestinal absorption: Comparative assessment of GastroPlus™ and IDEA™
    • Parrott N, Lavé T. Prediction of intestinal absorption: comparative assessment of GastroPlus™ and IDEA™. Eur. J. Pharm. Sci. 17, 51-61 (2002).
    • (2002) Eur. J. Pharm. Sci , vol.17 , pp. 51-61
    • Parrott, N.1    Lavé, T.2
  • 80
    • 0346216088 scopus 로고    scopus 로고
    • Development of a 7-day, 96-well Caco-2 permeability assaywith high-throughput direct UV compound analysis
    • Alsenz J, Haenel E. Development of a 7-day, 96-well Caco-2 permeability assaywith high-throughput direct UV compound analysis. Pharm. Res. 20(12), 1961-1969 (2003).
    • (2003) Pharm. Res , vol.20 , Issue.12 , pp. 1961-1969
    • Alsenz, J.1    Haenel, E.2
  • 81
    • 0021490671 scopus 로고
    • Epithelial properties of human colonic carcinoma cell line Caco-2: Electrical parameters
    • Grasset E, Pinto M, Dussaulx E, Zwebaum A, Desjeux JF. Epithelial properties of human colonic carcinoma cell line Caco-2: electrical parameters. Am. J. Physiol. 247, C260-C267 (1984).
    • (1984) Am. J. Physiol , vol.247
    • Grasset, E.1    Pinto, M.2    Dussaulx, E.3    Zwebaum, A.4    Desjeux, J.F.5
  • 82
    • 0028275005 scopus 로고
    • D-cycloserine uses an active transport mechanism in the human intestinal cell line Caco-2
    • Ranaldi G, Islam K, Sambuy Y. D-cycloserine uses an active transport mechanism in the human intestinal cell line Caco-2. Antimicrob. Agents Chemother. 38, 1239-1245 (1994).
    • (1994) Antimicrob. Agents Chemother , vol.38 , pp. 1239-1245
    • Ranaldi, G.1    Islam, K.2    Sambuy, Y.3
  • 83
    • 0027988025 scopus 로고
    • Comparison of the transport characteristics of D- and L-methionine in a human intestinal epithelial model (Caco-2). and in a perfused rat intestinal model
    • Zheng L, Chen J, Zhu Y, Yang H, Elmquist W, Hu M. Comparison of the transport characteristics of D- and L-methionine in a human intestinal epithelial model (Caco-2). and in a perfused rat intestinal model. Pharm. Res. 11, 1771-1776 (1994).
    • (1994) Pharm. Res , vol.11 , pp. 1771-1776
    • Zheng, L.1    Chen, J.2    Zhu, Y.3    Yang, H.4    Elmquist, W.5    Hu, M.6
  • 84
    • 33646640645 scopus 로고    scopus 로고
    • Current industrial practices of assessing permeability and p-glycoprotein interaction
    • Balimane PV, Han Y, Chong S. Current industrial practices of assessing permeability and p-glycoprotein interaction. AAPS J. 8(1), E1-E13 (2006).
    • (2006) AAPS J , vol.8 , Issue.1
    • Balimane, P.V.1    Han, Y.2    Chong, S.3
  • 85
    • 0037335192 scopus 로고    scopus 로고
    • An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: Characterization of transport routes
    • Tavelin S, Taipalensuu J, Hallböök F, Vellonen KS, Moore V, Artursson P. An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: characterization of transport routes. Pharm. Res. 20, 373-381 (2003).
    • (2003) Pharm. Res , vol.20 , pp. 373-381
    • Tavelin, S.1    Taipalensuu, J.2    Hallböök, F.3    Vellonen, K.S.4    Moore, V.5    Artursson, P.6
  • 86
    • 34447337731 scopus 로고    scopus 로고
    • Prediction of human pharmacokinetics - gastrointestinal absorption
    • Fagerholm U. Prediction of human pharmacokinetics - gastrointestinal absorption. J. Pharm. Pharmacol. 59, 905-916 (2007).
    • (2007) J. Pharm. Pharmacol , vol.59 , pp. 905-916
    • Fagerholm, U.1
  • 87
    • 0030839044 scopus 로고    scopus 로고
    • Regional intestinal permeability in rats of compounds with different physicochemical properties and transport mechanisms
    • Fagerholm U, Lindahl A, Lennernäs H. Regional intestinal permeability in rats of compounds with different physicochemical properties and transport mechanisms. J. Pharm. Pharmacol. 49, 687-690 (1997).
    • (1997) J. Pharm. Pharmacol , vol.49 , pp. 687-690
    • Fagerholm, U.1    Lindahl, A.2    Lennernäs, H.3
  • 88
    • 70149095436 scopus 로고    scopus 로고
    • USP 24. The United States Pharmacopeia, United States Pharmacopeial Convention, Inc. Rockville, MD, USA (2000).
    • USP 24. The United States Pharmacopeia, United States Pharmacopeial Convention, Inc. Rockville, MD, USA (2000).
  • 89
    • 1842450785 scopus 로고    scopus 로고
    • A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions
    • Blanquet S, Zeijdner E, Beyssac E et al. A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions. Pharm. Res. 21(4), 585-591 (2004).
    • (2004) Pharm. Res , vol.21 , Issue.4 , pp. 585-591
    • Blanquet, S.1    Zeijdner, E.2    Beyssac, E.3
  • 90
    • 52949135236 scopus 로고    scopus 로고
    • Irregular absorption profiles observed from diclofenac extended release tablets can be predicted using a dissolution test apparatus that mimics in vivo physical stresses
    • Garbacz G, Wedemeyer RS, Nagel S et al. Irregular absorption profiles observed from diclofenac extended release tablets can be predicted using a dissolution test apparatus that mimics in vivo physical stresses. Eur. J. Pharm. Biopharm. 70(2), 421-428 (2008).
    • (2008) Eur. J. Pharm. Biopharm , vol.70 , Issue.2 , pp. 421-428
    • Garbacz, G.1    Wedemeyer, R.S.2    Nagel, S.3
  • 91
    • 33745416604 scopus 로고    scopus 로고
    • Oral absorption of poorly water-soluble drugs: Computer simulation of fraction absorbed in humans from a miniscale dissolution test
    • Takano R, Sugano K, Higashida A et al. Oral absorption of poorly water-soluble drugs: computer simulation of fraction absorbed in humans from a miniscale dissolution test. Pharm. Res. 23(6), 1144-1156 (2006).
    • (2006) Pharm. Res , vol.23 , Issue.6 , pp. 1144-1156
    • Takano, R.1    Sugano, K.2    Higashida, A.3
  • 92
    • 0031750861 scopus 로고    scopus 로고
    • Evaluation of various dissolution media for predicting in vivo performance of class I and II drugs
    • Galia E, Nicolaides E, Hoerter D, Loebenberg R, Reppas C, Dressman JB. Evaluation of various dissolution media for predicting in vivo performance of class I and II drugs. Pharm. Res. 15, 698-705 (1998).
    • (1998) Pharm. Res , vol.15 , pp. 698-705
    • Galia, E.1    Nicolaides, E.2    Hoerter, D.3    Loebenberg, R.4    Reppas, C.5    Dressman, J.B.6
  • 93
    • 0033452575 scopus 로고    scopus 로고
    • Forecasting the in vivo performance of for low solubility drugs from their in vitro dissolution data
    • Nicolaides E, Galia E, Efthymiopoulos C, Dressman JB, Reppas C. Forecasting the in vivo performance of for low solubility drugs from their in vitro dissolution data. Pharm. Res. 16 (12), 1876-1882 (1999).
    • (1999) Pharm. Res , vol.16 , Issue.12 , pp. 1876-1882
    • Nicolaides, E.1    Galia, E.2    Efthymiopoulos, C.3    Dressman, J.B.4    Reppas, C.5
  • 94
    • 0034080127 scopus 로고    scopus 로고
    • Dissolution testing as a prognostic tool for oral drug absorption: Dissolution behavior of glibenclamide
    • Löbenberg R, Krämer J, Shah VP, Amidon GL, Dressman JB. Dissolution testing as a prognostic tool for oral drug absorption: dissolution behavior of glibenclamide. Pharm. Res. 17(4), 439-444 (2000).
    • (2000) Pharm. Res , vol.17 , Issue.4 , pp. 439-444
    • Löbenberg, R.1    Krämer, J.2    Shah, V.P.3    Amidon, G.L.4    Dressman, J.B.5
  • 95
    • 0037371606 scopus 로고    scopus 로고
    • Separation and characterization of the colloidal phases produced on digestion of common formulation lipids and assessment of their impact on the apparent solubility of selected poorly water-soluble drugs
    • Kossena GA, Boyd BJ, Porter CJ, Charman WN. Separation and characterization of the colloidal phases produced on digestion of common formulation lipids and assessment of their impact on the apparent solubility of selected poorly water-soluble drugs. J. Pharm. Sci. 92(3), 634-648 (2003).
    • (2003) J. Pharm. Sci , vol.92 , Issue.3 , pp. 634-648
    • Kossena, G.A.1    Boyd, B.J.2    Porter, C.J.3    Charman, W.N.4
  • 96
    • 32244434196 scopus 로고    scopus 로고
    • Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies
    • Kalantzi L, Goumas K, Kalioras V, Abrahamsson B, Dressman JB, Reppas C. Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies. Pharm. Res, 23(1), 165-176 (2006).
    • (2006) Pharm. Res , vol.23 , Issue.1 , pp. 165-176
    • Kalantzi, L.1    Goumas, K.2    Kalioras, V.3    Abrahamsson, B.4    Dressman, J.B.5    Reppas, C.6
  • 97
    • 44749087279 scopus 로고    scopus 로고
    • Dissolution media simulating conditions in the proximal human gastrointestinal tract: An update
    • Jantratid E, Janssen N, Reppas C, Dressman JB. Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update. Pham. Res. 25(7), 1663-1676 (2008).
    • (2008) Pham. Res , vol.25 , Issue.7 , pp. 1663-1676
    • Jantratid, E.1    Janssen, N.2    Reppas, C.3    Dressman, J.B.4
  • 98
    • 0033805179 scopus 로고    scopus 로고
    • In vitro - in vivo correlations for lipophilic, poorly water-soluble drugs
    • Dressman JB, Reppas C. In vitro - in vivo correlations for lipophilic, poorly water-soluble drugs. Eur. J. Pharm. Sci. 11, S73-S80 (2000).
    • (2000) Eur. J. Pharm. Sci , vol.11
    • Dressman, J.B.1    Reppas, C.2
  • 99
    • 0031913402 scopus 로고    scopus 로고
    • Dissolution testing as a prognostic tool for oral drug absorption: Immediate release dosage forms
    • Dressman J, Amidon G, Reppas C, Shah V. Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms. Pharm. Res. 15, 11-22 (1998).
    • (1998) Pharm. Res , vol.15 , pp. 11-22
    • Dressman, J.1    Amidon, G.2    Reppas, C.3    Shah, V.4
  • 100
    • 21544447265 scopus 로고    scopus 로고
    • Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds
    • Vertzoni M, Dressman J, Butler J, Hempenstall J, Reppas C. Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds. Eur. J. Pharm. Biopharm. 60(3), 413-417 (2005).
    • (2005) Eur. J. Pharm. Biopharm , vol.60 , Issue.3 , pp. 413-417
    • Vertzoni, M.1    Dressman, J.2    Butler, J.3    Hempenstall, J.4    Reppas, C.5
  • 101
    • 0036195307 scopus 로고    scopus 로고
    • Forecasting the oral absorption behavior of poorly soluble weak bases using solubility and dissolution studies in biorelevant media
    • Kostewicz ES, Brauns U, Becker R, Dressman JB. Forecasting the oral absorption behavior of poorly soluble weak bases using solubility and dissolution studies in biorelevant media. Pharm. Res. 19(3), 345-349 (2002).
    • (2002) Pharm. Res , vol.19 , Issue.3 , pp. 345-349
    • Kostewicz, E.S.1    Brauns, U.2    Becker, R.3    Dressman, J.B.4
  • 102
    • 14144250013 scopus 로고    scopus 로고
    • In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media
    • Sunesen VH, Pedersen BL, Kristensen HG, Mullertz A. In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media. Eur. J. Pharm. Sci. 24(4), 305-313 (2005).
    • (2005) Eur. J. Pharm. Sci , vol.24 , Issue.4 , pp. 305-313
    • Sunesen, V.H.1    Pedersen, B.L.2    Kristensen, H.G.3    Mullertz, A.4
  • 103
    • 24644431507 scopus 로고    scopus 로고
    • Canine versus in vitro data for predicting input profiles of L-sulpiride after oral administration
    • Fotaki N, Symillides M, Reppas C. Canine versus in vitro data for predicting input profiles of L-sulpiride after oral administration. Eur. J. Pharm. Sci. 26, 324-333 (2005).
    • (2005) Eur. J. Pharm. Sci , vol.26 , pp. 324-333
    • Fotaki, N.1    Symillides, M.2    Reppas, C.3
  • 104
    • 11144225143 scopus 로고    scopus 로고
    • In vitro versus canine data for predicting input profiles of isosorbide-5-mononitrate from oral extended release products on a confidence interval basis
    • Fotaki N, Symillides M, Reppas C. In vitro versus canine data for predicting input profiles of isosorbide-5-mononitrate from oral extended release products on a confidence interval basis. Eur. J. Pharm. Sci. 24(1), 115-122 (2005).
    • (2005) Eur. J. Pharm. Sci , vol.24 , Issue.1 , pp. 115-122
    • Fotaki, N.1    Symillides, M.2    Reppas, C.3
  • 105
    • 33747759752 scopus 로고    scopus 로고
    • Biorelevant dissolution media as a predictive tool for glyburide a class II drug
    • Wei H, Löbenberg R. Biorelevant dissolution media as a predictive tool for glyburide a class II drug. Eur. J. Pharm. Sci. 29, 45-52 (2006).
    • (2006) Eur. J. Pharm. Sci , vol.29 , pp. 45-52
    • Wei, H.1    Löbenberg, R.2
  • 106
    • 24644465873 scopus 로고    scopus 로고
    • RIVM report, anatomical and physiological differences between various species used in studies on the pharmacokinetics and toxicology of xenobiotics, a review of literature
    • Report no. 623860010. National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    • De Zwart LL, Rompelberg CJM, Sips AJAM, Welink J, Van Engelen JGM. RIVM report, anatomical and physiological differences between various species used in studies on the pharmacokinetics and toxicology of xenobiotics, a review of literature. Report no. 623860010. National Institute for Public Health and the Environment, Bilthoven, The Netherlands (1999).
    • (1999)
    • De Zwart, L.L.1    Rompelberg, C.J.M.2    Sips, A.J.A.M.3    Welink, J.4    Van Engelen, J.G.M.5
  • 107
    • 2942521757 scopus 로고    scopus 로고
    • Companion animal physiology and dosage form performance
    • Sutton SC. Companion animal physiology and dosage form performance. Adv. Drug Deliv. Rev. 56, 1383-1398 (2004).
    • (2004) Adv. Drug Deliv. Rev , vol.56 , pp. 1383-1398
    • Sutton, S.C.1
  • 108
    • 0036296060 scopus 로고    scopus 로고
    • Comparison of oral absorption and bioavailablity of drugs between monkey and human
    • Chiou WL, Buehler PW. Comparison of oral absorption and bioavailablity of drugs between monkey and human. Pharm. Res. 19(6), 868-874 (2002).
    • (2002) Pharm. Res , vol.19 , Issue.6 , pp. 868-874
    • Chiou, W.L.1    Buehler, P.W.2
  • 109
    • 0031786518 scopus 로고    scopus 로고
    • Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats
    • Chiou WL, Barve A. Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats. Pharm. Res. 15(11), 1792-1795 (1998).
    • (1998) Pharm. Res , vol.15 , Issue.11 , pp. 1792-1795
    • Chiou, W.L.1    Barve, A.2
  • 110
    • 0027275566 scopus 로고
    • Commentary: Physiological parameters in laboratory animals and humans
    • Davies B, Morris T. Commentary: physiological parameters in laboratory animals and humans. Pharm. Res. 10(7), 1093-1095 (1993).
    • (1993) Pharm. Res , vol.10 , Issue.7 , pp. 1093-1095
    • Davies, B.1    Morris, T.2
  • 111
    • 0029855969 scopus 로고    scopus 로고
    • Comparison between permeability coefficients in rat and human jejunum
    • Fagerholm U, Johansson M, Lennernäs H. Comparison between permeability coefficients in rat and human jejunum. Pharm. Res. 13, 1336-1342 (1996).
    • (1996) Pharm. Res , vol.13 , pp. 1336-1342
    • Fagerholm, U.1    Johansson, M.2    Lennernäs, H.3
  • 112
    • 0037343896 scopus 로고    scopus 로고
    • Evaluation of rat intestinal absorption data and correlation with human intestinal absorption
    • Zhao YH, Abraham MH, Le J et al. Evaluation of rat intestinal absorption data and correlation with human intestinal absorption. Eur. J. Med. Chem. 38, 233-243 (2003).
    • (2003) Eur. J. Med. Chem , vol.38 , pp. 233-243
    • Zhao, Y.H.1    Abraham2    MH, L.J.3
  • 113
    • 0032428485 scopus 로고    scopus 로고
    • Applications and limitations of interspecies scaling and in vitro extrapolation in pharmacokinetics
    • Lin JH. Applications and limitations of interspecies scaling and in vitro extrapolation in pharmacokinetics. Drug Metab. Dispos. 26, 1202-1212 (1998).
    • (1998) Drug Metab. Dispos , vol.26 , pp. 1202-1212
    • Lin, J.H.1
  • 114
    • 1542436531 scopus 로고    scopus 로고
    • Suitability of the cynomolgus monkey as an animal model for drug absorption studies of oral dosage forms from the viewpoint of gastrointestinal physiology
    • Ikegami K, Tagawa K, Narisawa S, Osawa T. Suitability of the cynomolgus monkey as an animal model for drug absorption studies of oral dosage forms from the viewpoint of gastrointestinal physiology. Biol. Pharm. Bull. 26(10), 1442-1447 (2003).
    • (2003) Biol. Pharm. Bull , vol.26 , Issue.10 , pp. 1442-1447
    • Ikegami, K.1    Tagawa, K.2    Narisawa, S.3    Osawa, T.4
  • 115
    • 34250004062 scopus 로고    scopus 로고
    • Development and validation of a physiology-based model for the prediction of oral absorption in monkeys
    • Willmann S, Edginton AN, Dressman JB. Development and validation of a physiology-based model for the prediction of oral absorption in monkeys. Pharm. Res. 24(7), 1275-1282 (2007).
    • (2007) Pharm. Res , vol.24 , Issue.7 , pp. 1275-1282
    • Willmann, S.1    Edginton, A.N.2    Dressman, J.B.3
  • 116
    • 34547209778 scopus 로고    scopus 로고
    • Asymmetric intestinal first-pass metabolism causes minimal oral bioavailability of midazolam in cynomolgus monkey
    • Nishimura T, Amano N, Kubo Y et al. Asymmetric intestinal first-pass metabolism causes minimal oral bioavailability of midazolam in cynomolgus monkey. Drug Metab. Dispos. 35(8), 1275-1284 (2007).
    • (2007) Drug Metab. Dispos , vol.35 , Issue.8 , pp. 1275-1284
    • Nishimura, T.1    Amano, N.2    Kubo, Y.3
  • 117
    • 0037242105 scopus 로고    scopus 로고
    • Characteristics of the gastric pH profiles of unfed and fed cynomolgus monkeys as pharmaceutical product development subjects
    • Kondo H, Shinoda T, Nakashima H, Watanabe T, Yokohama S. Characteristics of the gastric pH profiles of unfed and fed cynomolgus monkeys as pharmaceutical product development subjects. Biopharm. Drug Dispos. 24, 45-51 (2003).
    • (2003) Biopharm. Drug Dispos , vol.24 , pp. 45-51
    • Kondo, H.1    Shinoda, T.2    Nakashima, H.3    Watanabe, T.4    Yokohama, S.5
  • 118
    • 0001608810 scopus 로고
    • Animal models for oral drug absorption
    • Welling P, Tse FL Eds, Dekker, NY, USA
    • Dressman JB, Yamada K. Animal models for oral drug absorption. In: Pharmaceutical Bioequivalence. Welling P, Tse FL (Eds). Dekker, NY, USA 235-266 (1991).
    • (1991) Pharmaceutical Bioequivalence , pp. 235-266
    • Dressman, J.B.1    Yamada, K.2
  • 119
    • 0032945581 scopus 로고    scopus 로고
    • Paracellular glucose transport plays a minor role in the unanesthetized dog
    • Lane JS, Whang EE, Rigberg DA et al. Paracellular glucose transport plays a minor role in the unanesthetized dog. Am. J. Physiol. 276(3), G789-G794 (1999).
    • (1999) Am. J. Physiol , vol.276 , Issue.3
    • Lane, J.S.1    Whang, E.E.2    Rigberg, D.A.3
  • 120
    • 0031958251 scopus 로고    scopus 로고
    • Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides
    • He YL, Murby S, Warhurst G et al. Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides. J. Pharm. Sci. 87(5), 626-633 (1998).
    • (1998) J. Pharm. Sci , vol.87 , Issue.5 , pp. 626-633
    • He, Y.L.1    Murby, S.2    Warhurst, G.3
  • 121
    • 0034017007 scopus 로고    scopus 로고
    • Evaluation of using dog as an animal model to study the fraction of oral dose absorbed of 43 drugs in humans
    • Chiou WL, Jeong HY, Chung SM, Wu TC. Evaluation of using dog as an animal model to study the fraction of oral dose absorbed of 43 drugs in humans. Pharm. Res. 17(2), 135-140 (2000).
    • (2000) Pharm. Res , vol.17 , Issue.2 , pp. 135-140
    • Chiou, W.L.1    Jeong, H.Y.2    Chung, S.M.3    Wu, T.C.4
  • 122
    • 0022966980 scopus 로고
    • Comparison of canine and human gastrointestinal physiology
    • Dressman JB. Comparison of canine and human gastrointestinal physiology. Pharm. Res. 3(3), 123-131 (1986).
    • (1986) Pharm. Res , vol.3 , Issue.3 , pp. 123-131
    • Dressman, J.B.1
  • 123
    • 33745377516 scopus 로고    scopus 로고
    • Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents
    • Kalantzi L, Persson E, Polentarutti B et al. Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents. Pharm. Res. 23(6), 1373-1381 (2006).
    • (2006) Pharm. Res , vol.23 , Issue.6 , pp. 1373-1381
    • Kalantzi, L.1    Persson, E.2    Polentarutti, B.3
  • 124
    • 0035040782 scopus 로고    scopus 로고
    • Pharmacokinetics of celecoxib after oral administration in dogs and humans: Effect of food and site of absorption
    • Paulson SK, Vaughn MB, Jessen SM et al. Pharmacokinetics of celecoxib after oral administration in dogs and humans: effect of food and site of absorption. J. Pharmacol. Exp. Ther. 297(2), 638-645 (2001).
    • (2001) J. Pharmacol. Exp. Ther , vol.297 , Issue.2 , pp. 638-645
    • Paulson, S.K.1    Vaughn, M.B.2    Jessen, S.M.3
  • 125
    • 0034762181 scopus 로고    scopus 로고
    • A conscious dog model for assessing the absorption, enterocyte-based metabolism, and intestinal lymphatic transport of halofantrine
    • Khoo SM, Edwards GA, Porter CJH, Charman WN. A conscious dog model for assessing the absorption, enterocyte-based metabolism, and intestinal lymphatic transport of halofantrine. J. Pharm. Sci. 90(10), 1599-1607 (2001).
    • (2001) J. Pharm. Sci , vol.90 , Issue.10 , pp. 1599-1607
    • Khoo, S.M.1    Edwards, G.A.2    Porter, C.J.H.3    Charman, W.N.4
  • 127
    • 0029830929 scopus 로고    scopus 로고
    • Development and validation of a pig model for colon-specific drug delivery
    • Gardner N, Haresign W, Spiller R et al. Development and validation of a pig model for colon-specific drug delivery. J. Pharm. Pharmacol. 48(7), 689-693 (1996).
    • (1996) J. Pharm. Pharmacol , vol.48 , Issue.7 , pp. 689-693
    • Gardner, N.1    Haresign, W.2    Spiller, R.3
  • 128
    • 29244445764 scopus 로고    scopus 로고
    • The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids
    • Persson EM, Gustafsson AS, Carlsson AS et al. The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids. Pharm. Res. 22(12), 2141-2151 (2005).
    • (2005) Pharm. Res , vol.22 , Issue.12 , pp. 2141-2151
    • Persson, E.M.1    Gustafsson, A.S.2    Carlsson, A.S.3
  • 129
    • 0032888376 scopus 로고    scopus 로고
    • A compartmental absorption and transit model for estimating oral drug absorption
    • Yu LX, Amidon GL. A compartmental absorption and transit model for estimating oral drug absorption. Int. J. Pharm. 186(2), 119-125 (1999).
    • (1999) Int. J. Pharm , vol.186 , Issue.2 , pp. 119-125
    • Yu, L.X.1    Amidon, G.L.2
  • 130
    • 0035478779 scopus 로고    scopus 로고
    • Predicting the impact of physiological and biochemical processes on oral drug bioavailability
    • Agoram B, Woltosz WS, Bolger MB. Predicting the impact of physiological and biochemical processes on oral drug bioavailability. Adv. Drug Deliv. Rev. 50(Suppl. 1), S41-S67 (2001).
    • (2001) Adv. Drug Deliv. Rev , vol.50 , Issue.SUPPL. 1
    • Agoram, B.1    Woltosz, W.S.2    Bolger, M.B.3
  • 131
    • 0344084044 scopus 로고    scopus 로고
    • A physiologic model for simulating gastrointestinal flow and drug absorption in rats
    • Willmann S, Schmitt W, Keldenich J, Dressman JB. A physiologic model for simulating gastrointestinal flow and drug absorption in rats. Pharm. Res. 20(11), 1766-1771 (2003).
    • (2003) Pharm. Res , vol.20 , Issue.11 , pp. 1766-1771
    • Willmann, S.1    Schmitt, W.2    Keldenich, J.3    Dressman, J.B.4
  • 132
    • 0032766163 scopus 로고    scopus 로고
    • General solution for diffusion controlled dissolution of spherical particles. 1. Theory
    • Wang JZ, Flanagan DR. General solution for diffusion controlled dissolution of spherical particles. 1. Theory. J. Pharm. Sci. 88(7), 731-738 (1999).
    • (1999) J. Pharm. Sci , vol.88 , Issue.7 , pp. 731-738
    • Wang, J.Z.1    Flanagan, D.R.2
  • 133
    • 0001151974 scopus 로고
    • A multi compartmental dynamic computer-controlled model simulating the stomach and small intestine
    • Minekus M, Marteau P, Havenaar R, Huis in't Veld JHJ. A multi compartmental dynamic computer-controlled model simulating the stomach and small intestine. ATLA 23, 197-209 (1995).
    • (1995) ATLA , vol.23 , pp. 197-209
    • Minekus, M.1    Marteau, P.2    Havenaar, R.3    Huis in't Veld, J.H.J.4
  • 134
    • 57149095631 scopus 로고    scopus 로고
    • Drug absorption modeling as a tool to define the strategy in clinical formulation development
    • Kuentz M. Drug absorption modeling as a tool to define the strategy in clinical formulation development. AAPS J. 10(3), 473-479 (2008).
    • (2008) AAPS J , vol.10 , Issue.3 , pp. 473-479
    • Kuentz, M.1
  • 135
    • 33845467297 scopus 로고    scopus 로고
    • Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modeling
    • Jones HM, Parrott N, Ohlenbusch G, Lave T. Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modeling. Clin. Pharmacokinet. 45(12), 1213-1226 (2006).
    • (2006) Clin. Pharmacokinet , vol.45 , Issue.12 , pp. 1213-1226
    • Jones, H.M.1    Parrott, N.2    Ohlenbusch, G.3    Lave, T.4
  • 136
    • 33746893861 scopus 로고    scopus 로고
    • In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect
    • Tubic M, Wagner D, Spahn-Langguth H, Bolger M, Langguth P. In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect. Pharm. Res. 23(8), 1712-1720 (2006).
    • (2006) Pharm. Res , vol.23 , Issue.8 , pp. 1712-1720
    • Tubic, M.1    Wagner, D.2    Spahn-Langguth, H.3    Bolger, M.4    Langguth, P.5
  • 137
    • 41049104351 scopus 로고    scopus 로고
    • Early identification of drug-induced impairment of gastric emptying through physiologically based pharmacokinetic (PBPK) simulation of plasma concentration - time profiles in rat
    • Peters SA, Hultin L. Early identification of drug-induced impairment of gastric emptying through physiologically based pharmacokinetic (PBPK) simulation of plasma concentration - time profiles in rat. J. Pharmacokinet. Pharmacodyn. 35(1), 1-30 (2008).
    • (2008) J. Pharmacokinet. Pharmacodyn , vol.35 , Issue.1 , pp. 1-30
    • Peters, S.A.1    Hultin, L.2
  • 138
    • 40549096396 scopus 로고    scopus 로고
    • Identification of intestinal loss of a drug through physiologically based pharmacokinetic simulation of plasma concentration - time profiles
    • Peters SA. Identification of intestinal loss of a drug through physiologically based pharmacokinetic simulation of plasma concentration - time profiles. Clin. Pharmacokinet. 47(4), 245-259 (2008).
    • (2008) Clin. Pharmacokinet , vol.47 , Issue.4 , pp. 245-259
    • Peters, S.A.1
  • 139
    • 0033730756 scopus 로고    scopus 로고
    • Pharmacokinetics/ pharmacodynamics in drug development: An industrial perspective
    • Chaikin P, Rhodes GR, Bruno R, Rohatagi S, Natarajan C. Pharmacokinetics/ pharmacodynamics in drug development: an industrial perspective. J. Clin. Pharmacol. 40, 1428-1438 (2000).
    • (2000) J. Clin. Pharmacol , vol.40 , pp. 1428-1438
    • Chaikin, P.1    Rhodes, G.R.2    Bruno, R.3    Rohatagi, S.4    Natarajan, C.5
  • 140
    • 0033810574 scopus 로고    scopus 로고
    • Pharmacometrics modeling and simulation tools to improve decision making in clinical drug development
    • Gieschke R, Steimer JL. Pharmacometrics modeling and simulation tools to improve decision making in clinical drug development. Eur. J. Drug Metab. Pharmacokinet. 25(1), 49-58 (2000).
    • (2000) Eur. J. Drug Metab. Pharmacokinet , vol.25 , Issue.1 , pp. 49-58
    • Gieschke, R.1    Steimer, J.L.2
  • 141
    • 0141762330 scopus 로고    scopus 로고
    • Biomarkers, validation and pharmacokinetic - pharmacodynamic modeling
    • Colburn WA, Lee JW. Biomarkers, validation and pharmacokinetic - pharmacodynamic modeling. Clin. Pharmacokinet. 42, 997-1022 (2003).
    • (2003) Clin. Pharmacokinet , vol.42 , pp. 997-1022
    • Colburn, W.A.1    Lee, J.W.2
  • 142
    • 52649130373 scopus 로고    scopus 로고
    • Whole body physiologically-based pharmacokinetic models: Their use in clinical drug development
    • Edginton AN, Theil F, Schmitt W, Willmann S. Whole body physiologically-based pharmacokinetic models: their use in clinical drug development. Expert Opin. Drug Metab. Toxicol 4(9), 1143-1152 (2008).
    • (2008) Expert Opin. Drug Metab. Toxicol , vol.4 , Issue.9 , pp. 1143-1152
    • Edginton, A.N.1    Theil, F.2    Schmitt, W.3    Willmann, S.4
  • 143
    • 34447330544 scopus 로고    scopus 로고
    • Whole-body physiologically based pharmacokinetic models
    • Nestorov I. Whole-body physiologically based pharmacokinetic models. Expert Opin. Drug Metab. Toxicol. 3(2), 235-249 (2007).
    • (2007) Expert Opin. Drug Metab. Toxicol , vol.3 , Issue.2 , pp. 235-249
    • Nestorov, I.1
  • 144
    • 0034902212 scopus 로고    scopus 로고
    • Application of in silico approaches to predicting drug - drug interactions
    • Ekins S, Wrighton S. Application of in silico approaches to predicting drug - drug interactions. J. Pharmacol. Toxicol. Methods 45, 65-69 (2001).
    • (2001) J. Pharmacol. Toxicol. Methods , vol.45 , pp. 65-69
    • Ekins, S.1    Wrighton, S.2
  • 145
    • 15244355849 scopus 로고    scopus 로고
    • Evaluation of a physiologically-based pharmacokinetic approach for simulating the first-time-in-animal study
    • Germani M, Crivori P, Rocchetti M et al. Evaluation of a physiologically-based pharmacokinetic approach for simulating the first-time-in-animal study. Basic Clin. Pharmacol. Toxicol. 96(3), 254-256 (2005).
    • (2005) Basic Clin. Pharmacol. Toxicol , vol.96 , Issue.3 , pp. 254-256
    • Germani, M.1    Crivori, P.2    Rocchetti, M.3
  • 146
    • 0034820636 scopus 로고    scopus 로고
    • Prediction of the disposition of midazolam in surgical patients by a physiologically based pharmacokinetic model
    • Bjorkman S, Wada DR, Berling BM, et al. Prediction of the disposition of midazolam in surgical patients by a physiologically based pharmacokinetic model. J. Pharm. Sci. 90(9), 1226-1241 (2001).
    • (2001) J. Pharm. Sci , vol.90 , Issue.9 , pp. 1226-1241
    • Bjorkman, S.1    Wada, D.R.2    Berling, B.M.3
  • 147
    • 0036852418 scopus 로고    scopus 로고
    • In vitro tests for predicting drug - drug interactions: The need for validated procedure
    • Kremers P. In vitro tests for predicting drug - drug interactions: the need for validated procedure. Pharmacol. Toxicol. 91, 209-217(2002).
    • (2002) Pharmacol. Toxicol , vol.91 , pp. 209-217
    • Kremers, P.1
  • 148
    • 34248680469 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetics in drug development and regulatory science: A workshop report
    • Rowland M, Balant L, Peck C. Physiologically based pharmacokinetics in drug development and regulatory science: a workshop report. AAPS J. 6(1), 56-67 (2004).
    • (2004) AAPS J , vol.6 , Issue.1 , pp. 56-67
    • Rowland, M.1    Balant, L.2    Peck, C.3
  • 149
    • 0002041834 scopus 로고    scopus 로고
    • Multivariate pharmaceutical profiling for drug discovery
    • Kerns EH, Di L. Multivariate pharmaceutical profiling for drug discovery. Curr. Top. Med. Chem. 2, 87-98 (2002).
    • (2002) Curr. Top. Med. Chem , vol.2 , pp. 87-98
    • Kerns, E.H.1    Di, L.2
  • 150
    • 16644369555 scopus 로고    scopus 로고
    • In silico approaches for predicting ADME properties of drugs
    • Yamashita F, Hashida M. In silico approaches for predicting ADME properties of drugs. Drug Metab. Pharmacokinet. 19(5), 327-338 (2004).
    • (2004) Drug Metab. Pharmacokinet , vol.19 , Issue.5 , pp. 327-338
    • Yamashita, F.1    Hashida, M.2
  • 151
    • 35548954739 scopus 로고    scopus 로고
    • Improving early drug discovery through ADME modeling: An overview
    • Wishart DS. Improving early drug discovery through ADME modeling: an overview. Drugs RD 8(6), 349-362 (2007).
    • (2007) Drugs RD , vol.8 , Issue.6 , pp. 349-362
    • Wishart, D.S.1
  • 152
    • 2942525302 scopus 로고    scopus 로고
    • Applications of high-throughput ADME in drug discovery
    • Kassel DB. Applications of high-throughput ADME in drug discovery. Curr. Opin. Chem. Biol. 8(3), 339-345 (2004).
    • (2004) Curr. Opin. Chem. Biol , vol.8 , Issue.3 , pp. 339-345
    • Kassel, D.B.1
  • 153
    • 28844477024 scopus 로고    scopus 로고
    • Development and application of physiologically based pharmacokinetic-modeling tools to support drug discovery
    • Lüpfert C, Reichel A. Development and application of physiologically based pharmacokinetic-modeling tools to support drug discovery. Chem. Biodivers. 2(11), 1462-1486 (2005).
    • (2005) Chem. Biodivers , vol.2 , Issue.11 , pp. 1462-1486
    • Lüpfert, C.1    Reichel, A.2
  • 154
    • 13244293389 scopus 로고    scopus 로고
    • Simulation models for drug disposition and drug interactions
    • Dickins M, Van de Waterbeemd H. Simulation models for drug disposition and drug interactions. DDT: Biosilico 2(1), 38-45 (2004).
    • (2004) DDT: Biosilico , vol.2 , Issue.1 , pp. 38-45
    • Dickins, M.1    Van de Waterbeemd, H.2
  • 155
    • 0036606241 scopus 로고    scopus 로고
    • Predicting ADME properties in silico: Methods and models
    • Butina D, Segall MD, Frankcombe K. Predicting ADME properties in silico: methods and models. Drug Discov. Today 7(Suppl. 11), S83-S88 (2002).
    • (2002) Drug Discov. Today , vol.7 , Issue.SUPPL. 11
    • Butina, D.1    Segall, M.D.2    Frankcombe, K.3
  • 156
  • 157
    • 35648980041 scopus 로고    scopus 로고
    • Future directions for drug transporter modelling
    • Ekins S, Ecker GF, Chiba P, Swaan PW. Future directions for drug transporter modelling. Xenobiotica 37(10-11), 1152-1170 (2007).
    • (2007) Xenobiotica , vol.37 , Issue.10-11 , pp. 1152-1170
    • Ekins, S.1    Ecker, G.F.2    Chiba, P.3    Swaan, P.W.4
  • 158
    • 0036889665 scopus 로고    scopus 로고
    • Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man
    • Goh LB, Spears KJ, Yao D et al. Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man. Biochem. Pharmacol. 64, 1569-1578 (2002).
    • (2002) Biochem. Pharmacol , vol.64 , pp. 1569-1578
    • Goh, L.B.1    Spears, K.J.2    Yao, D.3
  • 159
    • 0034821939 scopus 로고    scopus 로고
    • The role of transport proteins in drug absorption, distribution and excretion
    • Ayrton A, Morgan P. The role of transport proteins in drug absorption, distribution and excretion. Xenobiotica 31, 469-497 (2001).
    • (2001) Xenobiotica , vol.31 , pp. 469-497
    • Ayrton, A.1    Morgan, P.2
  • 161
    • 33645809139 scopus 로고    scopus 로고
    • The human intestinal cytochrome P450 'pie'
    • Paine MF, Hart HL, Ludington SS et al. The human intestinal cytochrome P450 'pie'. Drug Metab. Dispos. 34(5), 880-886 (2006).
    • (2006) Drug Metab. Dispos , vol.34 , Issue.5 , pp. 880-886
    • Paine, M.F.1    Hart, H.L.2    Ludington, S.S.3
  • 162
    • 35348895572 scopus 로고    scopus 로고
    • Prediction of intestinal first-pass drug metabolism
    • Yang J, Jamei M, Yeo KR et al. Prediction of intestinal first-pass drug metabolism. Curr. Drug Metab. 8(7), 676-684 (2007).
    • (2007) Curr. Drug Metab , vol.8 , Issue.7 , pp. 676-684
    • Yang, J.1    Jamei, M.2    Yeo, K.R.3
  • 163
    • 0031797635 scopus 로고    scopus 로고
    • Effect of age on pharmacokinetics and pharmacodynamics in man
    • Klotz U. Effect of age on pharmacokinetics and pharmacodynamics in man. Int. J. Clin. Pharmacol. Ther. 36(11), 581-585 (1998).
    • (1998) Int. J. Clin. Pharmacol. Ther , vol.36 , Issue.11 , pp. 581-585
    • Klotz, U.1
  • 164
    • 0024835315 scopus 로고
    • Clinical pharmacokinetics in infants and children: A reappraisal
    • Kearns GL, Reed MD. Clinical pharmacokinetics in infants and children: a reappraisal. Clin. Pharmacokinet. 17(Suppl, 1), 29-67 (1989).
    • (1989) Clin. Pharmacokinet , vol.17 , Issue.SUPPL.and 1 , pp. 29-67
    • Kearns, G.L.1    Reed, M.D.2
  • 165
    • 0037370813 scopus 로고    scopus 로고
    • Pharmacokinetic strategies in deciphering atypical drug absorption profiles
    • Zhou H. Pharmacokinetic strategies in deciphering atypical drug absorption profiles. J. Clin. Pharmacol. 43, 211-227 (2003).
    • (2003) J. Clin. Pharmacol , vol.43 , pp. 211-227
    • Zhou, H.1
  • 167
    • 34848816783 scopus 로고    scopus 로고
    • Investigating the utility of momentum-space descriptors for predicting blood - brain barrier penetration
    • Al-Fahemi JH, Cooper DL, Allan NL. Investigating the utility of momentum-space descriptors for predicting blood - brain barrier penetration. J. Mol. Graph. Model. 26(3), 607-612 (2007).
    • (2007) J. Mol. Graph. Model , vol.26 , Issue.3 , pp. 607-612
    • Al-Fahemi, J.H.1    Cooper, D.L.2    Allan, N.L.3
  • 168
    • 18244374478 scopus 로고    scopus 로고
    • 3D QSAR investigation of the blood- brain barrier penetration of chemical compounds
    • Lessigiarska I, Pajeva I, Cronin MT, Worth AP. 3D QSAR investigation of the blood- brain barrier penetration of chemical compounds. SAR QSAR Environ. Res. 16(1-2), 79-91 (2005).
    • (2005) SAR QSAR Environ. Res , vol.16 , Issue.1-2 , pp. 79-91
    • Lessigiarska, I.1    Pajeva, I.2    Cronin, M.T.3    Worth, A.P.4
  • 169
    • 85088718939 scopus 로고    scopus 로고
    • ADME evaluation in drug discovery. 3. Modeling blood - brain barrier partitioning using simple molecular descriptors
    • Hou TJ, Xu XJ. ADME evaluation in drug discovery. 3. Modeling blood - brain barrier partitioning using simple molecular descriptors. J. Chem. Inf. Comput. Sci. 4(2), 766-770 (2004).
    • (2004) J. Chem. Inf. Comput. Sci , vol.4 , Issue.2 , pp. 766-770
    • Hou, T.J.1    Xu, X.J.2
  • 170
    • 34248561199 scopus 로고    scopus 로고
    • The role of nuclear receptors in pharmacokinetic drug - drug interactions in oncology
    • Harmsen S, Meijerman I, Beijnen JH, Schellens JH. The role of nuclear receptors in pharmacokinetic drug - drug interactions in oncology. Cancer Treat. Rev. 33(4), 369-380 (2007).
    • (2007) Cancer Treat. Rev , vol.33 , Issue.4 , pp. 369-380
    • Harmsen, S.1    Meijerman, I.2    Beijnen, J.H.3    Schellens, J.H.4
  • 171
    • 34547702167 scopus 로고    scopus 로고
    • Development of reliable aqueous solubility models and their application in druglike analysis
    • Wang J, Krudy G, Hou T, Zhang W, Holland G, Xu X. Development of reliable aqueous solubility models and their application in druglike analysis. J. Chem. Inf. Model. 47(4), 1395-1404 (2007).
    • (2007) J. Chem. Inf. Model , vol.47 , Issue.4 , pp. 1395-1404
    • Wang, J.1    Krudy, G.2    Hou, T.3    Zhang, W.4    Holland, G.5    Xu, X.6
  • 172
    • 1542741028 scopus 로고    scopus 로고
    • ADME evaluation in drug discovery. 4. Prediction of aqueous solubility based on atom contribution approach
    • Hou TJ, Xia K, Zhang W, Xu XJ. ADME evaluation in drug discovery. 4. Prediction of aqueous solubility based on atom contribution approach. J. Chem. Inf. Comput. Sci. 44(1), 266-275 (2004).
    • (2004) J. Chem. Inf. Comput. Sci , vol.44 , Issue.1 , pp. 266-275
    • Hou, T.J.1    Xia, K.2    Zhang, W.3    Xu, X.J.4
  • 173
    • 52949113498 scopus 로고    scopus 로고
    • PK/DB: Database for pharmacokinetic properties and predictive in silico ADME models
    • Moda T, Torres LG, Carrara AE, Andricopulo AD. PK/DB: database for pharmacokinetic properties and predictive in silico ADME models, Bioinformatics 24(19), 2270-2271 (2008).
    • (2008) Bioinformatics , vol.24 , Issue.19 , pp. 2270-2271
    • Moda, T.1    Torres, L.G.2    Carrara, A.E.3    Andricopulo, A.D.4
  • 174
    • 70149101516 scopus 로고    scopus 로고
    • Understanding the effect of API properties on bioavailability through absorption modelling
    • Kesisoglou F, Wu Y. Understanding the effect of API properties on bioavailability through absorption modelling. AAPS J. (2009).
    • (2009) AAPS J
    • Kesisoglou, F.1    Wu, Y.2
  • 175
    • 51649104303 scopus 로고    scopus 로고
    • Towards quantitative prediction of oral drug absorption
    • Dressman JB, Thelen K, Jantratid E. Towards quantitative prediction of oral drug absorption. Clin. Pharmacokinet. 47(10), 655-667 (2008).
    • (2008) Clin. Pharmacokinet , vol.47 , Issue.10 , pp. 655-667
    • Dressman, J.B.1    Thelen, K.2    Jantratid, E.3
  • 176
    • 48549102969 scopus 로고    scopus 로고
    • Theoretical dissolution model of poly-disperse drug particles in biorelevant media
    • Okazaki A, Mano T, Sugano K. Theoretical dissolution model of poly-disperse drug particles in biorelevant media. J. Pharm. Sci. 97, 1843-1852 (2008).
    • (2008) J. Pharm. Sci , vol.97 , pp. 1843-1852
    • Okazaki, A.1    Mano, T.2    Sugano, K.3
  • 177
    • 35648955151 scopus 로고    scopus 로고
    • Challenges and opportunities with modeling and simulation in drug discovery and drug development
    • Lavé T, Parrott N, Grimm HP, Fleury A, Reddy M. Challenges and opportunities with modeling and simulation in drug discovery and drug development. Xenobiotica 37(10-11), 1295-1310 (2007).
    • (2007) Xenobiotica , vol.37 , Issue.10-11 , pp. 1295-1310
    • Lavé, T.1    Parrott, N.2    Grimm, H.P.3    Fleury, A.4    Reddy, M.5
  • 178
    • 0036242411 scopus 로고    scopus 로고
    • Evolutionary computational methods to predict oral bioavailability QSPRs
    • Bains W, Gilbert R, Sviridenko L et al. Evolutionary computational methods to predict oral bioavailability QSPRs. Curr. Opin. Drug Disc. Dev. 5, 44-51 (2002).
    • (2002) Curr. Opin. Drug Disc. Dev , vol.5 , pp. 44-51
    • Bains, W.1    Gilbert, R.2    Sviridenko, L.3
  • 179
    • 33745104130 scopus 로고    scopus 로고
    • The impact of systems biology and biosimulation on drug discovery and development
    • Michelson S. The impact of systems biology and biosimulation on drug discovery and development. Mol. Biosyst. 2(6-7), 288-291 (2006).
    • (2006) Mol. Biosyst , vol.2 , Issue.6-7 , pp. 288-291
    • Michelson, S.1
  • 180
    • 31144456067 scopus 로고    scopus 로고
    • Application of predictive biosimulation within pharmaceutical clinical development: Examples of significance for translational medicine and clinical trial design
    • Kansal AR, Trimmer J. Application of predictive biosimulation within pharmaceutical clinical development: examples of significance for translational medicine and clinical trial design. Syst. Biol. (Stevenage) 152(4), 214-220 (2005).
    • (2005) Syst. Biol. (Stevenage) , vol.152 , Issue.4 , pp. 214-220
    • Kansal, A.R.1    Trimmer, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.