pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers

European Journal of Pharmaceutical Sciences

Volumn 25, Issue 2-3, 2005, Pages 211-220

  Neuhoff, Sibylle ^a,b   Ungell, Anna Lena ^b   Zamora, Ismael ^c,d   Artursson, Per ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c Lead Molecular Design   (Spain)

^d UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

Caco 2; Drug absorption; OATP B; Passive and active influx; pH Dependency; SLC21A9; SLCO2B1

Indexed keywords

AMINO ACID; INDOMETACIN; SALICYLIC ACID;

ACTIVE TRANSPORT; ARTICLE; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG TRANSPORT; GASTROINTESTINAL TRACT; HUMAN; HUMAN CELL; IN VIVO STUDY; PARTITION COEFFICIENT; PH; PHYSIOLOGY; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE;

BIOLOGICAL TRANSPORT, ACTIVE; CACO-2 CELLS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; HUMANS; HYDROGEN-ION CONCENTRATION; INDOMETHACIN; SALICYLIC ACID;

EID: 19444382806     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2005.02.009     Document Type: Article

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