In vitro models for selection of development candidates. Permeability studies to define mechanisms of absorption enhancement

Advanced Drug Delivery Reviews

Volumn 23, Issue 1-3, 1997, Pages 163-183

  LeCluyse, Edward L ^a   Sutton, Steven C ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b PFIZER INC   (United States)

Author keywords

absorption promoter; asorption enhancers; paracellular transport; permeability enhancer; tight junctions; transcellular transport

Indexed keywords

ABSORPTION; AMINO ACIDS; CELLS; DRUG PRODUCTS; PHYSIOLOGICAL MODELS; PHYSIOLOGY; SURFACE ACTIVE AGENTS;

ABSORPTION ENHANCERS; ABSORPTION PROMOTER; PARACELLULAR TRANSPORT; PERMEABILITY ENHANCER; TIGHT JUNCTIONS; TRANSCELLULAR TRANSPORT;

CONTROLLED DRUG DELIVERY;

ACYLCARNITINE; ADENOSINE TRIPHOSPHATE; ANIONIC SURFACTANT; BILE SALT; CALCIUM; CALCIUM CHELATING AGENT; CATIONIC SURFACTANT; CHITOSAN; CHOLIC ACID; CYCLIC AMP; DECANOATE SODIUM; DIETHYLAMINOETHYLDEXTRAN; DOCUSATE SODIUM; DODECYL SULFATE SODIUM; GLYCOCHOLIC ACID; LYSOPHOSPHATIDYLCHOLINE; MEDIUM CHAIN ACYLGLYCEROL; MEDIUM CHAIN FATTY ACID; NONIONIC SURFACTANT; PALMITOYLLYSOLECITHIN; PENETRATION ENHANCING AGENT; PHOSPHOLIPID; POLYSORBATE 80; TAUROCHOLIC ACID; TRITON X 100; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANATOMY; DRUG ABSORPTION; DRUG FORMULATION; DRUG MECHANISM; DRUG TRANSPORT; HUMAN; INTESTINE ABSORPTION; INTESTINE EPITHELIUM; MICELLE; MODEL; NONHUMAN; PERMEABILITY BARRIER; PHYSIOLOGY; PRIORITY JOURNAL; REVIEW; TIGHT JUNCTION;

EID: 0031014265     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(96)00434-6     Document Type: Review

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