ADMET in silico modelling: Towards prediction paradise?

Nature Reviews Drug Discovery

Volumn 2, Issue 3, 2003, Pages 192-204

  van de Waterbeemd, Han ^a   Gifford, Eric ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHISTAMINIC AGENT; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; DRUG;

BLOOD BRAIN BARRIER; COMBINATORIAL CHEMISTRY; COMPUTER MODEL; COMPUTER PROGRAM; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG PENETRATION; DRUG SCREENING; DRUG SOLUBILITY; LIPOPHILICITY; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; ANIMAL; BIOAVAILABILITY; BIOLOGICAL MODEL; COMPUTER SIMULATION; HUMAN; PHARMACOKINETICS; PHYSICAL CHEMISTRY; PROTEIN BINDING; TISSUE DISTRIBUTION;

ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD-BRAIN BARRIER; CHEMISTRY, PHYSICAL; COMPUTER SIMULATION; DRUG DESIGN; HUMANS; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SOFTWARE; TISSUE DISTRIBUTION;

EID: 0037364162     PISSN: 14741776     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrd1032     Document Type: Review

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