Evaluation of using dog as an animal model to study the fraction of oral dose absorbed of 43 drugs in humans

Pharmaceutical Research

Volumn 17, Issue 2, 2000, Pages 135-140

  Chiou, Win L ^a   Jeong, Hyun Y ^a   Chung, Sang M ^a   Wu, Ta C ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Dogs; Humans; Interspecies scale up; Oral absorption; Pharmacokinetics; Rats

Indexed keywords

ACARBOSE; ACICLOVIR; ATENOLOL; BENAZEPRIL; BISOPROLOL; CAMAZEPAM; CHLOROTHIAZIDE; CIMETIDINE; DOXAZOSIN; ENALAPRIL MALEATE; ETHINYLESTRADIOL; FAMOTIDINE; FENOTEROL; FLUINDOSTATIN; FOSINOPRIL; FUROSEMIDE; GRANISETRON; IOTALAMIC ACID; ISOXEPAC; KETANSERIN; METHYLDOPA; MEVINOLIN; MIGLITOL; NADOLOL; PARACETAMOL; RANITIDINE; SUMATRIPTAN; TAMSULOSIN; UNINDEXED DRUG; ZOPICLONE;

ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG TRANSPORT; HUMAN; HUMAN EXPERIMENT; INTESTINE TRANSIT TIME; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

ACARBOSE; ACIDS; ACYCLOVIR; ADMINISTRATION, ORAL; ALKALIES; ANIMALS; ANTIHYPERTENSIVE AGENTS; ANTIVIRAL AGENTS; CHLOROTHIAZIDE; DOGS; ENZYME INHIBITORS; FASTING; HUMANS; INTESTINAL ABSORPTION; PHARMACOKINETICS; RATS; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; SPECIES SPECIFICITY;

EID: 0034017007     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007552927404     Document Type: Article

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