Recent advances in computational prediction of drug absorption and permeability in drug discovery

Current Medicinal Chemistry

Volumn 13, Issue 22, 2006, Pages 2653-2667

  Hou, Tingjun ^a   Wang, Junmei ^b   Zhang, Wei ^c   Wang, Wei ^a   Xu, Xiaojie ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PEKING UNIVERSITY   (China)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

ADME; Blood brain partitioning (BBB); Caco 2 monolayer; Drug adsorption; LogBB; Permeability; QSAR

Indexed keywords

BESTATIN; BETA LACTAM ANTIBIOTIC; CALCIUM CARBONATE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR;

ARTIFICIAL NEURAL NETWORK; BINDING AFFINITY; BLOOD BRAIN BARRIER; COMPUTER ANALYSIS; COMPUTER PROGRAM; CORRELATION ANALYSIS; DRUG ABSORPTION; DRUG ADSORPTION; DRUG DESIGN; DRUG PENETRATION; DRUG RESEARCH; DRUG SCREENING; DRUG SELECTIVITY; GENETIC ALGORITHM; HUMAN; INTESTINE ABSORPTION; LIPOPHILICITY; MULTIPLE LINEAR REGRESSION ANALYSIS; PHYSICAL CHEMISTRY; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; THEORETICAL MODEL; VIRTUAL REALITY;

COMPUTER SIMULATION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; INTESTINAL ABSORPTION; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS;

EID: 33748545599     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986706778201558     Document Type: Review

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