Prediction of the disposition of midazolam in surgical patients by a physiologically based pharmacokinetic model

Journal of Pharmaceutical Sciences

Volumn 90, Issue 9, 2001, Pages 1226-1241

  Björkman, Sven ^a   Wada, D Russell ^b   Berling, Britt Marie ^a   Benoni, Göran ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b PHARSIGHT CORPORATION   (United States)

Author keywords

Midazolam; Pharmacokinetics; Physiological models; Tissue distribution

Indexed keywords

MIDAZOLAM;

ADIPOSE TISSUE; ADULT; AGED; ARTICLE; BODY COMPOSITION; COMPARTMENT MODEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG HALF LIFE; DRUG TISSUE LEVEL; FEMALE; HEMODILUTION; HUMAN; INDIVIDUALIZATION; LEAN BODY WEIGHT; LIVER BLOOD FLOW; MALE; MATHEMATICAL MODEL; ORTHOPEDIC SURGERY; PARTITION COEFFICIENT; PREDICTION; SEDATION; STEADY STATE; SURGICAL PATIENT; TISSUE DISTRIBUTION;

EID: 0034820636     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.1076     Document Type: Article

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