Irregular absorption profiles observed from diclofenac extended release tablets can be predicted using a dissolution test apparatus that mimics in vivo physical stresses

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 70, Issue 2, 2008, Pages 421-428

  Garbacz, Grzegorz ^a   Wedemeyer, Ralph Steven ^a   Nagel, Stefan ^a   Giessmann, Thomas ^a   Mönnikes, Hubert ^b   Wilson, Clive G ^c   Siegmund, Werner ^a   Weitschies, Werner ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Biorelevant dissolution test; Diclofenac; Dose dumping; Extended release tablets

Indexed keywords

DICLOFENAC; DICLOFENAC RATIOPHARM; UNCLASSIFIED DRUG;

ADULT; APPARATUS; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG SOLUBILITY; EXTENDED RELEASE FORMULATION; FEMALE; GASTROINTESTINAL TRANSIT; HUMAN; HUMAN EXPERIMENT; INTERMETHOD COMPARISON; INTESTINE ABSORPTION; INTESTINE PRESSURE; INTESTINE WALL; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PHYSICAL STRESS; PLASMA CONCENTRATION-TIME CURVE; PREDICTION; RANDOMIZED CONTROLLED TRIAL; SHEAR STRESS; SIMULATION; TABLET FORMULATION; TIME TO MAXIMUM PLASMA CONCENTRATION; VOLUNTEER;

ABSORPTION; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DELAYED-ACTION PREPARATIONS; DICLOFENAC; FEMALE; HUMANS; MALE; SOLUBILITY; TABLETS;

EID: 52949135236     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.05.029     Document Type: Article

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