Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man

Biochemical Pharmacology

Volumn 64, Issue 11, 2002, Pages 1569-1578

  Goh, Lay Beng ^a   Spears, Kevin J ^a   Yao, Denggao ^a   Ayrton, Andy ^b   Morgan, Paul ^c   Roland Wolf, C ^a   Friedberg, Thomas ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Cell lines; Drug disposition; Expression profiling; Recombinant models

Indexed keywords

CARRIER PROTEIN; DRUG CARRIER; ESTRADIOL DERIVATIVE; ESTRADIOL GLUCURONIDE; ESTRONE SULFATE; ISOPROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VERAPAMIL; VINBLASTINE;

ANIMAL TISSUE; ARTICLE; CELL STRAIN; CELL TRANSPORT; CONTROLLED STUDY; DRUG DISPOSITION; DRUG TRANSPORT; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPECIES DIFFERENCE; TISSUE DISTRIBUTION;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; DNA, COMPLEMENTARY; DOGS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MALE; MODELS, BIOLOGICAL; ORGANIC ANION TRANSPORT POLYPEPTIDE C; P-GLYCOPROTEIN; PHARMACEUTICAL PREPARATIONS; PREDICTIVE VALUE OF TESTS; SWINE;

EID: 0036889665     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01355-2     Document Type: Article

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