-
1
-
-
0014738424
-
Factors affecting gastrointestinal absorption of drugs
-
Levine, R. R. Factors affecting gastrointestinal absorption of drugs. Am. J. Dig. Dis. 1970, 15, 171-88.
-
(1970)
Am. J. Dig. Dis.
, vol.15
, pp. 171-188
-
-
Levine, R.R.1
-
2
-
-
0017597779
-
Drug absorption in gastrointestinal disease with particular reference to malabsorption syndromes
-
Parsons, R. L. Drug absorption in gastrointestinal disease with particular reference to malabsorption syndromes. Clin. Pharmacokinet. 1977, 2, 45-60.
-
(1977)
Clin. Pharmacokinet.
, vol.2
, pp. 45-60
-
-
Parsons, R.L.1
-
3
-
-
0017876027
-
Effect of ionization on absorption of cephalosporins
-
DeYoung, J. L.; Tan, H. G.; Huber, H. E.; Zoglio, M. A. Effect of ionization on absorption of cephalosporins. J. Pharm. Sci. 1978, 67, 320-323.
-
(1978)
J. Pharm. Sci.
, vol.67
, pp. 320-323
-
-
DeYoung, J.L.1
Tan, H.G.2
Huber, H.E.3
Zoglio, M.A.4
-
4
-
-
0030614844
-
Physiochemical and physiological mechanisms for the effects of food on drug absorption: The role of lipids and pH
-
Charman, W. N.; Porter, C. J.; Mithani, S.; Dressman, J. B. Physiochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH. J. Pharm. Sci. 1997, 86, 269-282.
-
(1997)
J. Pharm. Sci.
, vol.86
, pp. 269-282
-
-
Charman, W.N.1
Porter, C.J.2
Mithani, S.3
Dressman, J.B.4
-
5
-
-
0017089322
-
Drugs, diseases and altered gastric emptying
-
Nimmo, W. S. Drugs, diseases and altered gastric emptying. Clin. Pharmacokinet. 1976, 1, 189-203.
-
(1976)
Clin. Pharmacokinet.
, vol.1
, pp. 189-203
-
-
Nimmo, W.S.1
-
6
-
-
0029838622
-
Effect of glucose and lipids on intestinal absorption of sorbitol: Role of gastric emptying
-
Beaugerie, L.; Lemann, M.; Jian, R.; Flourie, B.; Rain, J. D.; Rambaud, J. C. Effect of glucose and lipids on intestinal absorption of sorbitol: role of gastric emptying. Neurogastroenterol. Motil. 1996, 8, 235-239.
-
(1996)
Neurogastroenterol. Motil.
, vol.8
, pp. 235-239
-
-
Beaugerie, L.1
Lemann, M.2
Jian, R.3
Flourie, B.4
Rain, J.D.5
Rambaud, J.C.6
-
7
-
-
0033427120
-
An integrated model for determining causes of poor oral drug absorption
-
Yu, L. X. An Integrated Model for Determining Causes of Poor Oral Drug Absorption. Pharm. Res. 1999, 16, 1883-1887.
-
(1999)
Pharm. Res.
, vol.16
, pp. 1883-1887
-
-
Yu, L.X.1
-
8
-
-
0033775109
-
Effect of altered gastric emptying and gastrointestinal motility on metformin absorption
-
Marathe, P. H.; Wen, Y.; Norton, J.; Greene, D. S.; Barbhaiya, R. H.; Wilding, I. R. Effect of altered gastric emptying and gastrointestinal motility on metformin absorption. Br. J. Clin. Pharmacol. 2000, 50, 325-332.
-
(2000)
Br. J. Clin. Pharmacol.
, vol.50
, pp. 325-332
-
-
Marathe, P.H.1
Wen, Y.2
Norton, J.3
Greene, D.S.4
Barbhaiya, R.H.5
Wilding, I.R.6
-
9
-
-
0036481691
-
Gastrointestinal transit and drug absorption
-
Kimura, T.; Higaki, K. Gastrointestinal transit and drug absorption. Biol. Pharm. Bull. 2002, 25, 149-164.
-
(2002)
Biol. Pharm. Bull.
, vol.25
, pp. 149-164
-
-
Kimura, T.1
Higaki, K.2
-
10
-
-
0005932784
-
Gastrointestinal absorption - Physicochemical considerations
-
Lea and Febiger: Philadelphia
-
Gibaldi, M. Gastrointestinal absorption - Physicochemical considerations. In Biopharmaceutics and Clinical Pharmacokinetics; Lea and Febiger: Philadelphia, 1991; pp 40-60.
-
(1991)
Biopharmaceutics and Clinical Pharmacokinetics
, pp. 40-60
-
-
Gibaldi, M.1
-
11
-
-
0031742986
-
Link between drug absorption solubility and permeability measurements in caco-2 cells
-
Pade, V.; Stavchansky, S. Link between Drug Absorption Solubility and Permeability Measurements in Caco-2 Cells. J. Pharm. Sci. 1998, 87, 1604-1607.
-
(1998)
J. Pharm. Sci.
, vol.87
, pp. 1604-1607
-
-
Pade, V.1
Stavchansky, S.2
-
12
-
-
0001980501
-
Mechanisms of absorption of small molecules
-
Prescott, F. F., Nimmo, W. S., Eds.; John Wiley & Sons: New York
-
Leahy, D. E.; Lynch, J.; Taylor, D. C. Mechanisms of absorption of small molecules. In Novel Drug Delivery and Its Therapeutic Application; Prescott, F. F., Nimmo, W. S., Eds.; John Wiley & Sons: New York, 1989; pp 33-44.
-
(1989)
Novel Drug Delivery and Its Therapeutic Application
, pp. 33-44
-
-
Leahy, D.E.1
Lynch, J.2
Taylor, D.C.3
-
13
-
-
0032189375
-
Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight
-
Camenisch, G.; Alsenz, J.; van de Waterbeemd, H.; Folkers, G. Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight. Eur. J. Pharm. Sci. 1998, 6, 317-324.
-
(1998)
Eur. J. Pharm. Sci.
, vol.6
, pp. 317-324
-
-
Camenisch, G.1
Alsenz, J.2
Van De Waterbeemd, H.3
Folkers, G.4
-
14
-
-
0032190504
-
Shapes of membrane permeability-lipophilicity curves: Extension of theoretical models with an aqueous pore pathway
-
Camenisch, G.; Folkers, G.; van de Waterbeemd, H. Shapes of membrane permeability-lipophilicity curves: Extension of theoretical models with an aqueous pore pathway. Eur. J. Pharm. Sci. 1998, 6, 325-333.
-
(1998)
Eur. J. Pharm. Sci.
, vol.6
, pp. 325-333
-
-
Camenisch, G.1
Folkers, G.2
Van De Waterbeemd, H.3
-
15
-
-
0031026707
-
Simulation models to predict oral drug absorption from in vitro data
-
Grass, G. M. Simulation models to predict oral drug absorption from in vitro data. Adv. Drug. Delivery Rev. 1997, 23, 199-219.
-
(1997)
Adv. Drug. Delivery Rev.
, vol.23
, pp. 199-219
-
-
Grass, G.M.1
-
16
-
-
0033966128
-
A priori prediction of tissue: Plasma partition coefficients of drugs to facilitate the use of physiologically based pharmacokinetic models in drug discovery
-
Poulin, P.; Theil, F. P. A priori prediction of tissue: plasma partition coefficients of drugs to facilitate the use of physiologically based pharmacokinetic models in drug discovery. J. Pharm. Sci. 2000, 89, 16-35.
-
(2000)
J. Pharm. Sci.
, vol.89
, pp. 16-35
-
-
Poulin, P.1
Theil, F.P.2
-
17
-
-
0033999569
-
Development of predictive pharmacokinetic simulation models for drug discovery
-
Norris, D. A.; Leesman, G. D.; Sinko, P. J.; Grass, G. M. Development of predictive pharmacokinetic simulation models for drug discovery. J. Controlled Release 2000, 65, 55-62.
-
(2000)
J. Controlled Release
, vol.65
, pp. 55-62
-
-
Norris, D.A.1
Leesman, G.D.2
Sinko, P.J.3
Grass, G.M.4
-
18
-
-
0035478779
-
Predicting the impact of physiological and biochemical processes on oral drug bioavailability
-
Agoram, B.; Woltosz, W. S.; Bolger, M. B. Predicting the impact of physiological and biochemical processes on oral drug bioavailability. Adv. Drug Delivery Rev. 2001, 50, 41-67.
-
(2001)
Adv. Drug Delivery Rev.
, vol.50
, pp. 41-67
-
-
Agoram, B.1
Woltosz, W.S.2
Bolger, M.B.3
-
19
-
-
0036365420
-
Prediction of human pharmacokinetics based on preclinical in vitro and in vivo data
-
Lave, T.; Luttringer, O.; Zuegge, J.; Schneider, G.; Coassolo, P.; Theil, F. P. Prediction of human pharmacokinetics based on preclinical in vitro and in vivo data. Ernst Schering Res. Found. Workshop 2002, 37, 81-104.
-
(2002)
Ernst Schering Res. Found. Workshop
, vol.37
, pp. 81-104
-
-
Lave, T.1
Luttringer, O.2
Zuegge, J.3
Schneider, G.4
Coassolo, P.5
Theil, F.P.6
-
20
-
-
0344084044
-
A physiological model for simulating gastro-intestinal flow and drug absorption in rats
-
Willmann, S.; Schmitt, W.; Keldenich, J.; Dressman, J. B. A physiological model for simulating gastro-intestinal flow and drug absorption in rats. Pharm. Res. 2003, 20, 1766-1771.
-
(2003)
Pharm. Res.
, vol.20
, pp. 1766-1771
-
-
Willmann, S.1
Schmitt, W.2
Keldenich, J.3
Dressman, J.B.4
-
22
-
-
0025030536
-
Upper gastrointestinal (GI) pH in young, healthy men and women
-
Dressman, J. B.; Berardi, R. R.; Dermentzoglou, L. C.; Russell, T. L.; Schmaltz, S. P.; Barnett, J. L.; Jarvenpaa, K. M. Upper gastrointestinal (GI) pH in young, healthy men and women. Pharm. Res. 1990, 7, 756-761.
-
(1990)
Pharm. Res.
, vol.7
, pp. 756-761
-
-
Dressman, J.B.1
Berardi, R.R.2
Dermentzoglou, L.C.3
Russell, T.L.4
Schmaltz, S.P.5
Barnett, J.L.6
Jarvenpaa, K.M.7
-
23
-
-
33845222050
-
Change of pH requirements for simulated intestinal fluid
-
Gray, V. A.; Dressman, J. B. Change of pH requirements for simulated intestinal fluid. Pharmacopeial Forum 1996, 22, 1943-1945.
-
(1996)
Pharmacopeial Forum
, vol.22
, pp. 1943-1945
-
-
Gray, V.A.1
Dressman, J.B.2
-
24
-
-
0020540487
-
Regulation of the gastric emptying of glucose
-
Brener, W.; Hendrix, T. R.; McHugh, P. R. Regulation of the gastric emptying of glucose. Gastroenterology 1983, 85, 76-82.
-
(1983)
Gastroenterology
, vol.85
, pp. 76-82
-
-
Brener, W.1
Hendrix, T.R.2
McHugh, P.R.3
-
25
-
-
0025687509
-
Inhibition of gastric emptying by acids depends on pH, titratable acidity, and length of intestine exposed to acid
-
Lin, H. C.; Doty, J. E.; Reedy, T. J.; Meyer, J. H. Inhibition of gastric emptying by acids depends on pH, titratable acidity, and length of intestine exposed to acid. Am. J. Physiol. 1990, 259, 1025-1030.
-
(1990)
Am. J. Physiol.
, vol.259
, pp. 1025-1030
-
-
Lin, H.C.1
Doty, J.E.2
Reedy, T.J.3
Meyer, J.H.4
-
26
-
-
0022538998
-
Transit of pharmaceutical dosage forms through the small intestine
-
Davis, S. S.; Hardy, J. G.; Fara, J. W. Transit of pharmaceutical dosage forms through the small intestine. Gut 1986, 27, 886-892.
-
(1986)
Gut
, vol.27
, pp. 886-892
-
-
Davis, S.S.1
Hardy, J.G.2
Fara, J.W.3
-
27
-
-
0021682974
-
Intestinal transit of solid and liquid components of a meal in health
-
Malagelada, J. R.; Robertson, J. S.; Brown, M. L.; Remington, M.; Duenes, J. A.; Thomforde, G. M.; Carryer, P. W. Intestinal transit of solid and liquid components of a meal in health. Gastroenterology 1984, 87, 1255-1263.
-
(1984)
Gastroenterology
, vol.87
, pp. 1255-1263
-
-
Malagelada, J.R.1
Robertson, J.S.2
Brown, M.L.3
Remington, M.4
Duenes, J.A.5
Thomforde, G.M.6
Carryer, P.W.7
-
28
-
-
0016705882
-
Absorption and secretion by the colon
-
Cummings, J. H. Absorption and secretion by the colon. Gut 1975, 16, 323-329.
-
(1975)
Gut
, vol.16
, pp. 323-329
-
-
Cummings, J.H.1
-
29
-
-
0028033502
-
Targeting drugs to the colon: Delivery systems for oral administration
-
Ashford, M.; Fell, J. T. Targeting drugs to the colon: delivery systems for oral administration. J. Drug. Target. 1994, 2, 241-257.
-
(1994)
J. Drug. Target.
, vol.2
, pp. 241-257
-
-
Ashford, M.1
Fell, J.T.2
-
30
-
-
0028832474
-
Approaches and opportunities in colon-specific drug delivery
-
Rubinstein, A. Approaches and opportunities in colon-specific drug delivery. Crit. Rev. Ther. Drug. Carrier Syst. 1995, 12, 101-149.
-
(1995)
Crit. Rev. Ther. Drug. Carrier Syst.
, vol.12
, pp. 101-149
-
-
Rubinstein, A.1
-
31
-
-
0032711289
-
A pharmacokinetic model for multiple sites discontinuous gastrointestinal absorption
-
Plusquellec, Y.; Efthymiopoulos, C.; Duthil, P.; Houin, G. A pharmacokinetic model for multiple sites discontinuous gastrointestinal absorption. Med. Eng. Phys. 1999, 21, 525-532.
-
(1999)
Med. Eng. Phys.
, vol.21
, pp. 525-532
-
-
Plusquellec, Y.1
Efthymiopoulos, C.2
Duthil, P.3
Houin, G.4
-
32
-
-
0032888376
-
A compartmental absorption and transit model for estimating oral drug absorption
-
Yu, L. X.; Amidon, G. L. A compartmental absorption and transit model for estimating oral drug absorption. Int. J. Pharm. 1999, 186, 119-125.
-
(1999)
Int. J. Pharm.
, vol.186
, pp. 119-125
-
-
Yu, L.X.1
Amidon, G.L.2
-
33
-
-
0017454732
-
Shift of pH-absorption curves
-
Winne, D. Shift of pH-Absorption Curves. J. Pharmacokin. Biopharm. 1977, 5, 53-94.
-
(1977)
J. Pharmacokin. Biopharm.
, vol.5
, pp. 53-94
-
-
Winne, D.1
-
34
-
-
0030914681
-
Polar molecular surface properties predict the intestinal absorption of drugs in humans
-
Palm, K.; Stenberg, P.; Luthman, K.; Artursson P. Polar molecular surface properties predict the intestinal absorption of drugs in humans. Pharm. Res. 1997, 14, 568-571.
-
(1997)
Pharm. Res.
, vol.14
, pp. 568-571
-
-
Palm, K.1
Stenberg, P.2
Luthman, K.3
Artursson, P.4
-
35
-
-
0032112107
-
Prediction of human intestinal absorption of drug compounds from molecular structure
-
Wessel, M. D.; Jurs, P. C.; Tolan, J. W.; Muskal, S. M. Prediction of human intestinal absorption of drug compounds from molecular structure. J. Chem. Inf. Comput. Sci. 1998, 38, 726-735.
-
(1998)
J. Chem. Inf. Comput. Sci.
, vol.38
, pp. 726-735
-
-
Wessel, M.D.1
Jurs, P.C.2
Tolan, J.W.3
Muskal, S.M.4
-
36
-
-
0032568397
-
Physicochemical high throughput screening: Parallel artificial membrane permeation assay in the description of passive absorption processes
-
Kansy, M.; Senner, F.; Gubernator, K. Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes. J. Med. Chem. 1998, 41, 1007-1010.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 1007-1010
-
-
Kansy, M.1
Senner, F.2
Gubernator, K.3
-
37
-
-
0033013540
-
Drug liposome partitioning as a tool for the prediction of human passive intestinal absorption
-
Balon, K.; Riebesehl, B. U.; Muller, B. W. Drug liposome partitioning as a tool for the prediction of human passive intestinal absorption. Pharm. Res. 1999, 16, 882-888.
-
(1999)
Pharm. Res.
, vol.16
, pp. 882-888
-
-
Balon, K.1
Riebesehl, B.U.2
Muller, B.W.3
-
40
-
-
0031741846
-
Physical chemical properties of oral drug candidates in the discovery and exploratory development settings
-
Curatolo, W. Physical chemical properties of oral drug candidates in the discovery and exploratory development settings. Pharm. Sci. Technol. Today 1998, 1, 387-393.
-
(1998)
Pharm. Sci. Technol. Today
, vol.1
, pp. 387-393
-
-
Curatolo, W.1
-
41
-
-
0024593744
-
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
-
Hidalgo, I. J.; Raub, T. J.; Borchardt, R. T. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 1989, 96, 736-749.
-
(1989)
Gastroenterology
, vol.96
, pp. 736-749
-
-
Hidalgo, I.J.1
Raub, T.J.2
Borchardt, R.T.3
-
42
-
-
0025132942
-
Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa
-
Hilgers, A. R.; Conradi, R. A.; Burton, P. S. Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa. Pharm. Res. 1990, 7, 902-910.
-
(1990)
Pharm. Res.
, vol.7
, pp. 902-910
-
-
Hilgers, A.R.1
Conradi, R.A.2
Burton, P.S.3
-
43
-
-
0034687231
-
Prediction of drug absorption using multivariate statistics
-
Egan, W. J.; Merz, K. M.; Baldwin, J. J. Prediction of drug absorption using multivariate statistics. J. Med. Chem. 2000, 43, 3867-3877.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3867-3877
-
-
Egan, W.J.1
Merz, K.M.2
Baldwin, J.J.3
-
44
-
-
0035286778
-
Caco-2 monolayers in experimental and theoretical predictions of drug transport
-
Artursson, P.; Palm, K.; Luthman, K. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv. Drug Deliv. Rev. 2001, 46, 27-43.
-
(2001)
Adv. Drug Deliv. Rev.
, vol.46
, pp. 27-43
-
-
Artursson, P.1
Palm, K.2
Luthman, K.3
-
45
-
-
0035035820
-
Solid-supported lipid membranes as a tool for determination of membrane affinity: High-throughput screening of a physicochemical parameter
-
Loidl-Stahlhofen, A.; Eckert, A.; Hartmann, T.; Schottner, M. Solid-supported lipid membranes as a tool for determination of membrane affinity: high-throughput screening of a physicochemical parameter. J. Pharm. Sci. 2001, 90, 599-606.
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 599-606
-
-
Loidl-Stahlhofen, A.1
Eckert, A.2
Hartmann, T.3
Schottner, M.4
-
46
-
-
0035666579
-
Multilamellar liposomes and solid-supported lipid membranes (TRANSIL): Screening of lipid-water partitioning toward a high-throughput scale
-
Loidl-Stahlhofen, A.; Hartmann, T.; Schottner, M.; Rohring, C.; Brodowsky, H.; Schmitt, J.; Keldenich, J. Multilamellar liposomes and solid-supported lipid membranes (TRANSIL): screening of lipid-water partitioning toward a high-throughput scale. Pharm. Res. 2001, 18, 1782-1788.
-
(2001)
Pharm. Res.
, vol.18
, pp. 1782-1788
-
-
Loidl-Stahlhofen, A.1
Hartmann, T.2
Schottner, M.3
Rohring, C.4
Brodowsky, H.5
Schmitt, J.6
Keldenich, J.7
-
47
-
-
0030581089
-
The intestinal peptide carrier: A potential transport system for small peptide derived drugs
-
Walter, E.; Kissel, T.; Amidon, G. L. The intestinal peptide carrier: A potential transport system for small peptide derived drugs. Adv. Drug Delivery Rev. 1996, 20, 33-58.
-
(1996)
Adv. Drug Delivery Rev.
, vol.20
, pp. 33-58
-
-
Walter, E.1
Kissel, T.2
Amidon, G.L.3
-
48
-
-
0032889057
-
Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein
-
van Asperen, J.; van Tellingen, O.; Tijssen, F.; Schinkel, A. H.; Beijnen, J. H. Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein. Br. J. Cancer 1999, 79, 108-113.
-
(1999)
Br. J. Cancer
, vol.79
, pp. 108-113
-
-
Van Asperen, J.1
Van Tellingen, O.2
Tijssen, F.3
Schinkel, A.H.4
Beijnen, J.H.5
-
49
-
-
0032589932
-
Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2
-
Collett, A.; Higgs, N. B.; Sims, E.; Rowland, M.; Warhurst, G. Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2. J. Pharmacol. Exp. Ther. 1999, 288, 171-178.
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.288
, pp. 171-178
-
-
Collett, A.1
Higgs, N.B.2
Sims, E.3
Rowland, M.4
Warhurst, G.5
-
50
-
-
0033636283
-
Mechanisms of transport and structure-permeability relationship of sulfasalazine and its analogs in Caco-2 cell monolayers
-
Liang, E.; Proudfoot, J.; Yazdanian, M. Mechanisms of transport and structure-permeability relationship of sulfasalazine and its analogs in Caco-2 cell monolayers. Pharm. Res. 2000, 17, 1168-1174.
-
(2000)
Pharm. Res.
, vol.17
, pp. 1168-1174
-
-
Liang, E.1
Proudfoot, J.2
Yazdanian, M.3
-
52
-
-
0015453518
-
Linearization of dissolution rate curves by the Inert monolithic device with a central hole for constant drug release Weibull distribution
-
Langenbucher, F. Linearization of dissolution rate curves by the Inert monolithic device with a central hole for constant drug release Weibull distribution. J. Pharm. Pharmacol. 1972, 24, 979-981.
-
(1972)
J. Pharm. Pharmacol.
, vol.24
, pp. 979-981
-
-
Langenbucher, F.1
-
53
-
-
3242747026
-
-
http://www.lionbioscience.com/solutions/products/idea.
-
-
-
-
54
-
-
3242784387
-
-
http://www.simulations-plus.com/products/gastro_plus.html.
-
-
-
-
55
-
-
0036803219
-
Prediction of intestinal absorption: Comparative assessment of GASTROPLUS and IDEA
-
Parrott, N.; Lave, T. Prediction of intestinal absorption: comparative assessment of GASTROPLUS and IDEA. Eur. J. Pharm. Sci. 2002, 17, 51-61.
-
(2002)
Eur. J. Pharm. Sci.
, vol.17
, pp. 51-61
-
-
Parrott, N.1
Lave, T.2
|