Evaluation of a physiologically-based pharmacokinetic approach for simulating the first-time-in-animal study

Basic and Clinical Pharmacology and Toxicology

Volumn 96, Issue 3, 2005, Pages 254-256

  Germani, Massimiliano ^a   Crivori, Patrizia ^a   Rocchetti, Maurizio ^a   Burton, Philip S ^b   Wilson, Alan G E ^c   Smith, Mark E ^b   Poggesi, Italo ^a,d  

^a Pharmacokin Dynam and Metabolism   (Italy)

^b ADMETRx Inc   (United States)

^c PFIZER INC   (United States)

^d NERVIANO MEDICAL SCIENCES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DIAZEPAM; ETHENZAMIDE; NEW DRUG; PROPRANOLOL;

CONFERENCE PAPER; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG RESEARCH; LIPOPHILICITY; LIVER BLOOD FLOW; LIVER METABOLISM; MATHEMATICAL MODEL; MEAN RESIDENCE TIME; PARTITION COEFFICIENT; PHARMACOKINETICS; PHYSIOLOGY; PRIORITY JOURNAL; TISSUE BLOOD FLOW;

ANIMALS; BENZAMIDES; DIAZEPAM; MODELS, BIOLOGICAL; PHARMACOKINETICS; PROPRANOLOL; RATS;

ANIMALIA;

EID: 15244355849     PISSN: 17427835     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2005.pto960321.x     Document Type: Conference Paper

References (4)

1. Bernareggi, A. & M. Rowland: Physiological modelling of cyclosporine kinetics in rats and man. J. Pharmacokin. Biopharm. 1991, 19, 21-50.
2. Brown, R. P., M. D. Delp, S. L. Lindstedt, L. R. Rhomberg & R. P. Beliles: Physiological parameter values for physiologically based pharmacokinetic models. Toxicol. Industr. Health 1997, 13, 407-484.
3. Poulin, P. & F. P. Theil: A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery. J. Pharm. Sci. 2000, 89, 16-35.
4. Poulin, P. & F. P. Theil: Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition. J. Pharm. Sci. 2002, 91, 1358-1370.