-
1
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. 2002. The protein kinase complement of the human genome. Science 298:1912-34
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
2
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P, Hunter T. 2001. Oncogenic kinase signalling. Nature 411:355-65
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
3
-
-
0034614490
-
Signaling-2000 and beyond
-
Hunter T. 2000. Signaling-2000 and beyond. Cell 100:113-27
-
(2000)
Cell
, vol.100
, pp. 113-127
-
-
Hunter, T.1
-
4
-
-
0027258640
-
pp60src is an endogenous substrate for calpain in human blood platelets
-
Oda A, Druker BJ, Ariyoshi H, Smith M, Salzman EW. 1993. pp60src is an endogenous substrate for calpain in human blood platelets. J. Biol. Chem. 268:12603-8
-
(1993)
J. Biol. Chem
, vol.268
, pp. 12603-12608
-
-
Oda, A.1
Druker, B.J.2
Ariyoshi, H.3
Smith, M.4
Salzman, E.W.5
-
5
-
-
0033623796
-
pp60(cSrc) is a caspase-3 substrate and is essential for the transformed phenotype of A431 cells
-
Karni R, Levitzki A. 2000. pp60(cSrc) is a caspase-3 substrate and is essential for the transformed phenotype of A431 cells. Mol. Cell Biol. Res. Commun. 3:98-104
-
(2000)
Mol. Cell Biol. Res. Commun
, vol.3
, pp. 98-104
-
-
Karni, R.1
Levitzki, A.2
-
6
-
-
0032479435
-
Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide
-
Gervais FG, Thornberry NA, Ruffolo SC, Nicholson DW, Roy S. 1998. Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide. J. Biol. Chem. 273:17102-8
-
(1998)
J. Biol. Chem
, vol.273
, pp. 17102-17108
-
-
Gervais, F.G.1
Thornberry, N.A.2
Ruffolo, S.C.3
Nicholson, D.W.4
Roy, S.5
-
7
-
-
0035830903
-
Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases
-
Carragher NO, Fincham VJ, Riley D, Frame MC. 2001. Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases. J. Biol. Chem. 276:4270-75
-
(2001)
J. Biol. Chem
, vol.276
, pp. 4270-4275
-
-
Carragher, N.O.1
Fincham, V.J.2
Riley, D.3
Frame, M.C.4
-
8
-
-
0035266318
-
XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells
-
Asselin E, Mills GB, Tsang BK. 2001. XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. Cancer Res. 61:1862-68
-
(2001)
Cancer Res
, vol.61
, pp. 1862-1868
-
-
Asselin, E.1
Mills, G.B.2
Tsang, B.K.3
-
9
-
-
0035860798
-
The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis
-
Bachelder RE,Wendt MA, Fujita N, Tsuruo T, Mercurio AM. 2001. The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis. J. Biol. Chem. 276:34702-7
-
(2001)
J. Biol. Chem
, vol.276
, pp. 34702-34707
-
-
Bachelder, R.E.1
Wendt, M.A.2
Fujita, N.3
Tsuruo, T.4
Mercurio, A.M.5
-
10
-
-
2642559887
-
Targeting E3 ubiquitin ligases for cancer therapy
-
Sun Y. 2003. Targeting E3 ubiquitin ligases for cancer therapy. Cancer Biol. Ther. 2:623-29
-
(2003)
Cancer Biol. Ther
, vol.2
, pp. 623-629
-
-
Sun, Y.1
-
11
-
-
0034327504
-
Ubiquitin in chains
-
Pickart CM. 2000. Ubiquitin in chains. Trends Biochem. Sci. 25:544-48
-
(2000)
Trends Biochem. Sci
, vol.25
, pp. 544-548
-
-
Pickart, C.M.1
-
12
-
-
0033525589
-
A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly
-
Koegl M, Hoppe T, Schlenker S, Ulrich HD,Mayer TU, Jentsch S. 1999. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell 96:635-44
-
(1999)
Cell
, vol.96
, pp. 635-644
-
-
Koegl, M.1
Hoppe, T.2
Schlenker, S.3
Ulrich, H.D.4
Mayer, T.U.5
Jentsch, S.6
-
13
-
-
43049162227
-
Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex
-
Jin L,Williamson A, Banerjee S, Philipp I, Rape M. 2008. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Cell 133:653-65
-
(2008)
Cell
, vol.133
, pp. 653-665
-
-
Jin, L.1
Williamson, A.2
Banerjee, S.3
Philipp, I.4
Rape, M.5
-
14
-
-
0035913278
-
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
-
Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ. 2001.TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412:346-51
-
(2001)
Nature
, vol.412
, pp. 346-351
-
-
Wang, C.1
Deng, L.2
Hong, M.3
Akkaraju, G.R.4
Inoue, J.5
Chen, Z.J.6
-
15
-
-
0034644474
-
Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
-
Deng L, Wang C, Spencer E, Yang L, Braun A, et al. 2000. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103:351-61
-
(2000)
Cell
, vol.103
, pp. 351-361
-
-
Deng, L.1
Wang, C.2
Spencer, E.3
Yang, L.4
Braun, A.5
-
16
-
-
33847705665
-
Role of ubiquitin- and Ubl-binding proteins in cell signaling
-
Kirkin V, Dikic I. 2007. Role of ubiquitin- and Ubl-binding proteins in cell signaling. Curr. Opin. Cell Biol. 19:199-205
-
(2007)
Curr. Opin. Cell Biol
, vol.19
, pp. 199-205
-
-
Kirkin, V.1
Dikic, I.2
-
18
-
-
33750532531
-
Molecular mechanisms of coupled monoubiquitination
-
Woelk T, Oldrini B, Maspero E, Confalonieri S, Cavallaro E, et al. 2006. Molecular mechanisms of coupled monoubiquitination. Nat. Cell Biol. 8:1246-54
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 1246-1254
-
-
Woelk, T.1
Oldrini, B.2
Maspero, E.3
Confalonieri, S.4
Cavallaro, E.5
-
19
-
-
42449090346
-
Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains
-
Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR. 2008. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. Biochem. J. 411:249-60
-
(2008)
Biochem. J
, vol.411
, pp. 249-260
-
-
Al-Hakim, A.K.1
Zagorska, A.2
Chapman, L.3
Deak, M.4
Peggie, M.5
Alessi, D.R.6
-
20
-
-
1342300578
-
Integral UBL domain proteins: A family of proteasome interacting proteins
-
Hartmann-Petersen R, Gordon C. 2004. Integral UBL domain proteins: a family of proteasome interacting proteins. Semin. Cell Dev. Biol. 15:247-59
-
(2004)
Semin. Cell Dev. Biol
, vol.15
, pp. 247-259
-
-
Hartmann-Petersen, R.1
Gordon, C.2
-
21
-
-
34547188530
-
Involvement of the ubiquitinlike domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes
-
Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, et al. 2007. Involvement of the ubiquitinlike domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J. 26:3451-62
-
(2007)
EMBO J
, vol.26
, pp. 3451-3462
-
-
Ikeda, F.1
Hecker, C.M.2
Rozenknop, A.3
Nordmeier, R.D.4
Rogov, V.5
-
22
-
-
33746570157
-
Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs
-
Kuranaga E, Kanuka H, Tonoki A, Takemoto K, Tomioka T, et al. 2006. Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs. Cell 126:583-96
-
(2006)
Cell
, vol.126
, pp. 583-596
-
-
Kuranaga, E.1
Kanuka, H.2
Tonoki, A.3
Takemoto, K.4
Tomioka, T.5
-
23
-
-
0034738959
-
Activation-dependent degradation of protein kinase C eta
-
Kang BS, French OG, Sando JJ, Hahn CS. 2000. Activation-dependent degradation of protein kinase C eta. Oncogene 19:4263-72
-
(2000)
Oncogene
, vol.19
, pp. 4263-4272
-
-
Kang, B.S.1
French, O.G.2
Sando, J.J.3
Hahn, C.S.4
-
24
-
-
0030987327
-
Tumor promotion by depleting cells of protein kinase Cδ
-
Lu Z, Hornia A, Jiang Y-W, Zang Q, Ohno S, Foster DA. 1997. Tumor promotion by depleting cells of protein kinase Cδ. Mol. Cell Biol. 17:3418-28
-
(1997)
Mol. Cell Biol
, vol.17
, pp. 3418-3428
-
-
Lu, Z.1
Hornia, A.2
Jiang, Y.-W.3
Zang, Q.4
Ohno, S.5
Foster, D.A.6
-
25
-
-
0031907117
-
Activation of protein kinaseCtriggers its ubiquitination and degradation
-
Lu Z, Liu D, Hornia A, Devonish W, Pagano M, Foster DA. 1998. Activation of protein kinaseCtriggers its ubiquitination and degradation. Mol. Cell Biol. 18:839-45
-
(1998)
Mol. Cell Biol
, vol.18
, pp. 839-845
-
-
Lu, Z.1
Liu, D.2
Hornia, A.3
Devonish, W.4
Pagano, M.5
Foster, D.A.6
-
26
-
-
33750497452
-
Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex
-
Nakamura M, Tokunaga F, Sakata S, Iwai K. 2006. Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex. Biochem. Biophys. Res. Commun. 351:340-47
-
(2006)
Biochem. Biophys. Res. Commun
, vol.351
, pp. 340-347
-
-
Nakamura, M.1
Tokunaga, F.2
Sakata, S.3
Iwai, K.4
-
27
-
-
36349030360
-
Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase
-
Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton AC. 2007. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. J. Biol. Chem. 282:33776-87
-
(2007)
J. Biol. Chem
, vol.282
, pp. 33776-33787
-
-
Chen, D.1
Gould, C.2
Garza, R.3
Gao, T.4
Hampton, R.Y.5
Newton, A.C.6
-
28
-
-
0242721318
-
Caspase processing activates atypical protein kinaseCzeta by relieving autoinhibition and destabilizes the protein
-
Smith L,Wang Z, Smith JB. 2003. Caspase processing activates atypical protein kinaseCzeta by relieving autoinhibition and destabilizes the protein. Biochem. J. 375:663-71
-
(2003)
Biochem. J
, vol.375
, pp. 663-671
-
-
Smith, L.1
Wang, Z.2
Smith, J.B.3
-
29
-
-
0035941291
-
-
Okuda H, Saitoh K, Hirai S, Iwai K, Takaki Y, et al. 2001. The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C. J. Biol. Chem. 276:43611-17
-
Okuda H, Saitoh K, Hirai S, Iwai K, Takaki Y, et al. 2001. The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C. J. Biol. Chem. 276:43611-17
-
-
-
-
30
-
-
0037113182
-
Phosphorylation is required for PMA- and cellcycle-induced degradation of protein kinase C delta
-
Srivastava J, Procyk KJ, Iturrioz X, Parker PJ. 2002. Phosphorylation is required for PMA- and cellcycle-induced degradation of protein kinase C delta. Biochem. J. 368:349-55
-
(2002)
Biochem. J
, vol.368
, pp. 349-355
-
-
Srivastava, J.1
Procyk, K.J.2
Iturrioz, X.3
Parker, P.J.4
-
32
-
-
0036279167
-
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2
-
Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T. 2002. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol. Cell 9:945-56
-
(2002)
Mol. Cell
, vol.9
, pp. 945-956
-
-
Lu, Z.1
Xu, S.2
Joazeiro, C.3
Cobb, M.H.4
Hunter, T.5
-
33
-
-
32644468347
-
Ubiquitin chains in the ladder of MAPK signaling
-
Laine A, Ronai Z. 2005. Ubiquitin chains in the ladder of MAPK signaling. Sci. STKE 2005:re5
-
(2005)
Sci. STKE
, vol.2005
-
-
Laine, A.1
Ronai, Z.2
-
34
-
-
13444292166
-
Deltex regulates T-cell activation by targeted degradation of active MEKK1
-
Liu WH, Lai MZ. 2005. Deltex regulates T-cell activation by targeted degradation of active MEKK1. Mol. Cell Biol. 25:1367-78
-
(2005)
Mol. Cell Biol
, vol.25
, pp. 1367-1378
-
-
Liu, W.H.1
Lai, M.Z.2
-
35
-
-
17044414102
-
Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation
-
Yamashita M, Ying SX, Zhang GM, Li C, Cheng SY, et al. 2005. Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 121:101-13
-
(2005)
Cell
, vol.121
, pp. 101-113
-
-
Yamashita, M.1
Ying, S.X.2
Zhang, G.M.3
Li, C.4
Cheng, S.Y.5
-
36
-
-
0036288581
-
Cell adhesion protects c-Raf-1 against ubiquitin-dependent degradation by the proteasome
-
Manenti S, Delmas C, Darbon JM. 2002. Cell adhesion protects c-Raf-1 against ubiquitin-dependent degradation by the proteasome. Biochem. Biophys. Res. Commun. 294:976-80
-
(2002)
Biochem. Biophys. Res. Commun
, vol.294
, pp. 976-980
-
-
Manenti, S.1
Delmas, C.2
Darbon, J.M.3
-
38
-
-
2542448112
-
ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathway
-
Kuo WL, Duke CJ, Abe MK, Kaplan EL, Gomes S, Rosner MR. 2004. ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathway. J. Biol. Chem. 279:23073-81
-
(2004)
J. Biol. Chem
, vol.279
, pp. 23073-23081
-
-
Kuo, W.L.1
Duke, C.J.2
Abe, M.K.3
Kaplan, E.L.4
Gomes, S.5
Rosner, M.R.6
-
39
-
-
0034923514
-
Regulation of G protein-initiated signal transduction in yeast: Paradigms and principles
-
Dohlman HG, Thorner JW. 2001. Regulation of G protein-initiated signal transduction in yeast: paradigms and principles. Annu. Rev. Biochem. 70:703-54
-
(2001)
Annu. Rev. Biochem
, vol.70
, pp. 703-754
-
-
Dohlman, H.G.1
Thorner, J.W.2
-
40
-
-
0037047096
-
Pheromone induction promotes Ste11 degradation through aMAPK feedback and ubiquitin-dependent mechanism
-
Esch RK, Errede B. 2002. Pheromone induction promotes Ste11 degradation through aMAPK feedback and ubiquitin-dependent mechanism. Proc. Natl. Acad. Sci. USA 99:9160-65
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 9160-9165
-
-
Esch, R.K.1
Errede, B.2
-
41
-
-
0037013202
-
Pheromone-dependent ubiquitination of the mitogen-activated protein kinase kinase Ste7
-
Wang Y, Dohlman HG. 2002. Pheromone-dependent ubiquitination of the mitogen-activated protein kinase kinase Ste7. J. Biol. Chem. 277:15766-72
-
(2002)
J. Biol. Chem
, vol.277
, pp. 15766-15772
-
-
Wang, Y.1
Dohlman, H.G.2
-
42
-
-
33745497728
-
Highwire restrains synaptic growth by attenuating a MAP kinase signal
-
Collins CA,Wairkar YP, Johnson SL, DiAntonio A. 2006. Highwire restrains synaptic growth by attenuating a MAP kinase signal. Neuron 51:57-69
-
(2006)
Neuron
, vol.51
, pp. 57-69
-
-
Collins, C.A.1
Wairkar, Y.P.2
Johnson, S.L.3
DiAntonio, A.4
-
43
-
-
0033536637
-
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
-
Joazeiro CA,Wing SS, Huang H, Leverson JD, Hunter T, Liu YC. 1999. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286:309-12
-
(1999)
Science
, vol.286
, pp. 309-312
-
-
Joazeiro, C.A.1
Wing, S.S.2
Huang, H.3
Leverson, J.D.4
Hunter, T.5
Liu, Y.C.6
-
44
-
-
0033529537
-
The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor
-
Waterman H, Levkowitz G, Alroy I, Yarden Y. 1999. The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor. J. Biol. Chem. 274:22151-54
-
(1999)
J. Biol. Chem
, vol.274
, pp. 22151-22154
-
-
Waterman, H.1
Levkowitz, G.2
Alroy, I.3
Yarden, Y.4
-
45
-
-
33748196233
-
The Cbl family proteins: Ring leaders in regulation of cell signaling
-
Swaminathan G,TsygankovAY. 2006. The Cbl family proteins: ring leaders in regulation of cell signaling. J. Cell Physiol. 209:21-43
-
(2006)
J. Cell Physiol
, vol.209
, pp. 21-43
-
-
Swaminathan, G.1
Tsygankov, A.Y.2
-
46
-
-
38849132555
-
Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation
-
Guenou H, Kaabeche K, Dufour C, Miraoui H, Marie PJ. 2006. Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation. Am. J. Pathol. 169:1303-11
-
(2006)
Am. J. Pathol
, vol.169
, pp. 1303-1311
-
-
Guenou, H.1
Kaabeche, K.2
Dufour, C.3
Miraoui, H.4
Marie, P.J.5
-
47
-
-
33646227897
-
Ubiquitin ligase Cbl-b downregulates bone formation through suppression of IGF-I signaling in osteoblasts during denervation
-
Suzue N, Nikawa T, Onishi Y, Yamada C, Hirasaka K, et al. 2006. Ubiquitin ligase Cbl-b downregulates bone formation through suppression of IGF-I signaling in osteoblasts during denervation. J. Bone Miner. Res. 21:722-34
-
(2006)
J. Bone Miner. Res
, vol.21
, pp. 722-734
-
-
Suzue, N.1
Nikawa, T.2
Onishi, Y.3
Yamada, C.4
Hirasaka, K.5
-
48
-
-
0142184484
-
Proteasome-dependent decrease in Akt by growth factors in vascular smooth muscle cells
-
Adachi M, Katsumura KR, Fujii K, Kobayashi S, Aoki H, Matsuzaki M. 2003. Proteasome-dependent decrease in Akt by growth factors in vascular smooth muscle cells. FEBS Lett. 554:77-80
-
(2003)
FEBS Lett
, vol.554
, pp. 77-80
-
-
Adachi, M.1
Katsumura, K.R.2
Fujii, K.3
Kobayashi, S.4
Aoki, H.5
Matsuzaki, M.6
-
49
-
-
3042572347
-
Degradation of PKB/Akt protein by inhibition of the VEGF receptor/mTOR pathway in endothelial cells
-
Riesterer O, Zingg D, Hummerjohann J, Bodis S, Pruschy M. 2004. Degradation of PKB/Akt protein by inhibition of the VEGF receptor/mTOR pathway in endothelial cells. Oncogene 23:4624-35
-
(2004)
Oncogene
, vol.23
, pp. 4624-4635
-
-
Riesterer, O.1
Zingg, D.2
Hummerjohann, J.3
Bodis, S.4
Pruschy, M.5
-
50
-
-
18844372276
-
Tumor necrosis factor-α decreases Akt protein levels in 3T3-L1 adipocytes via the caspase-dependent ubiquitination of Akt
-
Medina EA, Afsari RR, Ravid T, Castillo SS, Erickson KL, Goldkorn T. 2005. Tumor necrosis factor-α decreases Akt protein levels in 3T3-L1 adipocytes via the caspase-dependent ubiquitination of Akt. Endocrinology 146:2726-35
-
(2005)
Endocrinology
, vol.146
, pp. 2726-2735
-
-
Medina, E.A.1
Afsari, R.R.2
Ravid, T.3
Castillo, S.S.4
Erickson, K.L.5
Goldkorn, T.6
-
51
-
-
33746657223
-
Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity
-
Yan D, Guo L, Wang Y. 2006. Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity. J. Cell Biol. 174:415-24
-
(2006)
J. Cell Biol
, vol.174
, pp. 415-424
-
-
Yan, D.1
Guo, L.2
Wang, Y.3
-
52
-
-
51749095471
-
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression
-
Mao JH, Kim IJ,Wu D, Climent J, Kang HC, et al. 2008. FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science 321:1499-502
-
(2008)
Science
, vol.321
, pp. 1499-1502
-
-
Mao, J.H.1
Kim, I.J.2
Wu, D.3
Climent, J.4
Kang, H.C.5
-
53
-
-
36048999753
-
IAP antagonists induce autoubiquitination of c-IAPs, NF-κB activation, and TNFα-dependent apoptosis
-
Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, et al. 2007. IAP antagonists induce autoubiquitination of c-IAPs, NF-κB activation, and TNFα-dependent apoptosis. Cell 131:669-81
-
(2007)
Cell
, vol.131
, pp. 669-681
-
-
Varfolomeev, E.1
Blankenship, J.W.2
Wayson, S.M.3
Fedorova, A.V.4
Kayagaki, N.5
-
54
-
-
0029595282
-
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
-
Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV. 1995. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83:1243-52
-
(1995)
Cell
, vol.83
, pp. 1243-1252
-
-
Rothe, M.1
Pan, M.G.2
Henzel, W.J.3
Ayres, T.M.4
Goeddel, D.V.5
-
55
-
-
2942731516
-
Regulation of the NF-κB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation
-
Liao G, Zhang M, Harhaj EW, Sun SC. 2004. Regulation of the NF-κB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. J. Biol. Chem. 279:26243-50
-
(2004)
J. Biol. Chem
, vol.279
, pp. 26243-26250
-
-
Liao, G.1
Zhang, M.2
Harhaj, E.W.3
Sun, S.C.4
-
56
-
-
33750494135
-
Rescue of TRAF3-null mice by p100 NF-κB deficiency
-
He JQ, Zarnegar B, Oganesyan G, Saha SK, Yamazaki S, et al. 2006. Rescue of TRAF3-null mice by p100 NF-κB deficiency. J. Exp. Med. 203:2413-18
-
(2006)
J. Exp. Med
, vol.203
, pp. 2413-2418
-
-
He, J.Q.1
Zarnegar, B.2
Oganesyan, G.3
Saha, S.K.4
Yamazaki, S.5
-
57
-
-
33845226781
-
Ubiquitin-proteasome degradation of serum- and glucocorticoid-regulated kinase-1 (SGK-1) is mediated by the chaperonedependent E3 ligase CHIP
-
Belova L, Sharma S, Brickley DR, Nicolarsen JR, Patterson C, Conzen SD. 2006. Ubiquitin-proteasome degradation of serum- and glucocorticoid-regulated kinase-1 (SGK-1) is mediated by the chaperonedependent E3 ligase CHIP. Biochem. J. 400:235-44
-
(2006)
Biochem. J
, vol.400
, pp. 235-244
-
-
Belova, L.1
Sharma, S.2
Brickley, D.R.3
Nicolarsen, J.R.4
Patterson, C.5
Conzen, S.D.6
-
58
-
-
33745188921
-
A novel N-terminal hydrophobic motif mediates constitutive degradation of serum- and glucocorticoid-induced kinase-1 by the ubiquitin-proteasome pathway
-
Bogusz AM, Brickley DR, Pew T, Conzen SD. 2006. A novel N-terminal hydrophobic motif mediates constitutive degradation of serum- and glucocorticoid-induced kinase-1 by the ubiquitin-proteasome pathway. FEBS J. 273:2913-28
-
(2006)
FEBS J
, vol.273
, pp. 2913-2928
-
-
Bogusz, A.M.1
Brickley, D.R.2
Pew, T.3
Conzen, S.D.4
-
59
-
-
14244254080
-
Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation
-
Zhou R, Snyder PM. 2005. Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation. J. Biol. Chem. 280:4518-23
-
(2005)
J. Biol. Chem
, vol.280
, pp. 4518-4523
-
-
Zhou, R.1
Snyder, P.M.2
-
60
-
-
0033598173
-
Ubiquitin-dependent degradation of active Src
-
Hakak Y, Martin GS. 1999. Ubiquitin-dependent degradation of active Src. Curr. Biol. 9:1039-42
-
(1999)
Curr. Biol
, vol.9
, pp. 1039-1042
-
-
Hakak, Y.1
Martin, G.S.2
-
61
-
-
0033598775
-
Ubiquitin-mediated degradation of active Src tyrosine kinase
-
Harris KF, Shoji I, Cooper EM, Kumar S, Oda H, Howley PM. 1999. Ubiquitin-mediated degradation of active Src tyrosine kinase. Proc. Natl. Acad. Sci. USA 96:13738-43
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 13738-13743
-
-
Harris, K.F.1
Shoji, I.2
Cooper, E.M.3
Kumar, S.4
Oda, H.5
Howley, P.M.6
-
62
-
-
0035825121
-
3 integrin-mediated signaling, cell adhesion, and osteoclast motility
-
3 integrin-mediated signaling, cell adhesion, and osteoclast motility. J. Cell Biol. 152:181-95
-
(2001)
J. Cell Biol
, vol.152
, pp. 181-195
-
-
Sanjay, A.1
Houghton, A.2
Neff, L.3
DiDomenico, E.4
Bardelay, C.5
-
63
-
-
0036587680
-
The Cbl family of ubiquitin ligases: Critical negative regulators of tyrosine kinase signaling in the immune system
-
Rao N, Dodge I, Band H. 2002. The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. J. Leukoc. Biol. 71:753-63
-
(2002)
J. Leukoc. Biol
, vol.71
, pp. 753-763
-
-
Rao, N.1
Dodge, I.2
Band, H.3
-
64
-
-
6344262249
-
Differential regulation of the B cell receptor-mediated signaling by the E3 ubiquitin ligase Cbl
-
Shao Y, Yang C, Elly C, Liu Y-C. 2004. Differential regulation of the B cell receptor-mediated signaling by the E3 ubiquitin ligase Cbl. J. Biol. Chem. 279:43646-53
-
(2004)
J. Biol. Chem
, vol.279
, pp. 43646-43653
-
-
Shao, Y.1
Yang, C.2
Elly, C.3
Liu, Y.-C.4
-
65
-
-
27744485874
-
Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion
-
Thien CB, Blystad FD, Zhan Y, Lew AM, Voigt V, et al. 2005. Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion. EMBO J. 24:3807-19
-
(2005)
EMBO J
, vol.24
, pp. 3807-3819
-
-
Thien, C.B.1
Blystad, F.D.2
Zhan, Y.3
Lew, A.M.4
Voigt, V.5
-
66
-
-
0035856481
-
Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway
-
Echarri A, Pendergast AM. 2001. Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway. Curr. Biol. 11:1759-65
-
(2001)
Curr. Biol
, vol.11
, pp. 1759-1765
-
-
Echarri, A.1
Pendergast, A.M.2
-
67
-
-
0036371220
-
Abl: Mechanisms of regulation and activation
-
Smith JM, Mayer BJ. 2002. Abl: mechanisms of regulation and activation. Front. Biosci. 7:d31-42
-
(2002)
Front. Biosci
, vol.7
-
-
Smith, J.M.1
Mayer, B.J.2
-
68
-
-
0034634597
-
c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines
-
Brasher BB, Van Etten RA. 2000. c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines. J. Biol. Chem. 275:35631-37
-
(2000)
J. Biol. Chem
, vol.275
, pp. 35631-35637
-
-
Brasher, B.B.1
Van Etten, R.A.2
-
70
-
-
17844406439
-
Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress
-
Cao C, Li Y, Leng Y, Li P, Ma Q, Kufe D. 2005. Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress. Oncogene 24:2433-40
-
(2005)
Oncogene
, vol.24
, pp. 2433-2440
-
-
Cao, C.1
Li, Y.2
Leng, Y.3
Li, P.4
Ma, Q.5
Kufe, D.6
-
71
-
-
9644287858
-
Loss of syk kinase during IgE-mediated stimulation of human basophils
-
MacGlashan D Jr, Miura K. 2004. Loss of syk kinase during IgE-mediated stimulation of human basophils. J. Allergy Clin. Immunol. 114:1317-24
-
(2004)
J. Allergy Clin. Immunol
, vol.114
, pp. 1317-1324
-
-
MacGlashan Jr, D.1
Miura, K.2
-
72
-
-
0033756590
-
Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases
-
Winberg G, Matskova L, Chen F, Plant P, Rotin D, et al. 2000. Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases. Mol. Cell Biol. 20:8526-35
-
(2000)
Mol. Cell Biol
, vol.20
, pp. 8526-8535
-
-
Winberg, G.1
Matskova, L.2
Chen, F.3
Plant, P.4
Rotin, D.5
-
73
-
-
0141865509
-
Negative regulation of FAK signaling by SOCS proteins
-
Liu E, Cote JF, Vuori K. 2003. Negative regulation of FAK signaling by SOCS proteins. EMBO J. 22:5036-46
-
(2003)
EMBO J
, vol.22
, pp. 5036-5046
-
-
Liu, E.1
Cote, J.F.2
Vuori, K.3
-
74
-
-
34848915422
-
Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase
-
Sekine Y, Tsuji S, Ikeda O, Sugiyma K, Oritani K, et al. 2007. Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase. J. Immunol. 179:2397-407
-
(2007)
J. Immunol
, vol.179
, pp. 2397-2407
-
-
Sekine, Y.1
Tsuji, S.2
Ikeda, O.3
Sugiyma, K.4
Oritani, K.5
-
75
-
-
33644877639
-
-
Ungureanu D, Silvennoinen O. 2005. SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling. Sci. STKE 2005:pe49
-
Ungureanu D, Silvennoinen O. 2005. SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling. Sci. STKE 2005:pe49
-
-
-
-
76
-
-
0346101802
-
SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/ degradation downstream of the prolactin receptor
-
Ali S, Nouhi Z, Chughtai N, Ali S. 2003. SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/ degradation downstream of the prolactin receptor. J. Biol. Chem. 278:52021-31
-
(2003)
J. Biol. Chem
, vol.278
, pp. 52021-52031
-
-
Ali, S.1
Nouhi, Z.2
Chughtai, N.3
Ali, S.4
-
77
-
-
33646345376
-
Ubiquitin ligases: Cell-cycle control and cancer
-
Nakayama KI, Nakayama K. 2006. Ubiquitin ligases: cell-cycle control and cancer. Nat. Rev. Cancer 6:369-81
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 369-381
-
-
Nakayama, K.I.1
Nakayama, K.2
-
78
-
-
0035895604
-
Regulation of the G1 to S transition by the ubiquitin pathway
-
DeSalle LM, Pagano M. 2001. Regulation of the G1 to S transition by the ubiquitin pathway. FEBS Lett. 490:179-89
-
(2001)
FEBS Lett
, vol.490
, pp. 179-189
-
-
DeSalle, L.M.1
Pagano, M.2
-
79
-
-
34248566788
-
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins
-
Busino L, Bassermann F, Maiolica A, Lee C, Nolan PM, et al. 2007. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science 316:900-4
-
(2007)
Science
, vol.316
, pp. 900-904
-
-
Busino, L.1
Bassermann, F.2
Maiolica, A.3
Lee, C.4
Nolan, P.M.5
-
80
-
-
0036713310
-
The anaphase-promoting complex: It's not just for mitosis any more
-
Harper JW, Burton JL, Solomon MJ. 2002. The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev. 16:2179-206
-
(2002)
Genes Dev
, vol.16
, pp. 2179-2206
-
-
Harper, J.W.1
Burton, J.L.2
Solomon, M.J.3
-
81
-
-
0034816198
-
Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1
-
Nakayama KI, Hatakeyama S, Nakayama K. 2001. Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1. Biochem. Biophys. Res. Commun. 282:853-60
-
(2001)
Biochem. Biophys. Res. Commun
, vol.282
, pp. 853-860
-
-
Nakayama, K.I.1
Hatakeyama, S.2
Nakayama, K.3
-
82
-
-
0035123105
-
Ubiquitin-mediated proteolysis of vertebrate G1- and S-phase regulators
-
Yew PR. 2001. Ubiquitin-mediated proteolysis of vertebrate G1- and S-phase regulators. J. Cell Physiol. 187:1-10
-
(2001)
J. Cell Physiol
, vol.187
, pp. 1-10
-
-
Yew, P.R.1
-
83
-
-
0037022355
-
Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes
-
Liou YC, Ryo A, Huang HK, Lu PJ, Bronson R, et al. 2002. Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc. Natl. Acad. Sci. USA 99:1335-40
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 1335-1340
-
-
Liou, Y.C.1
Ryo, A.2
Huang, H.K.3
Lu, P.J.4
Bronson, R.5
-
84
-
-
33750460897
-
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCFFBX4-αB crystallin complex
-
Lin DI, Barbash O, Kumar KG,Weber JD, Harper JW, et al. 2006. Phosphorylation-dependent ubiquitination of cyclin D1 by the SCFFBX4-αB crystallin complex. Mol. Cell 24:355-66
-
(2006)
Mol. Cell
, vol.24
, pp. 355-366
-
-
Lin, D.I.1
Barbash, O.2
Kumar, K.G.3
Weber, J.D.4
Harper, J.W.5
-
85
-
-
45849131324
-
Mutations in Fbx4 inhibit dimerization of the SCFFbx4 ligase and contribute to cyclin D1 overexpression in human cancer
-
Barbash O, Zamfirova P, Lin DI, Chen X, Yang K, et al. 2008. Mutations in Fbx4 inhibit dimerization of the SCFFbx4 ligase and contribute to cyclin D1 overexpression in human cancer. Cancer Cell 14:68-78
-
(2008)
Cancer Cell
, vol.14
, pp. 68-78
-
-
Barbash, O.1
Zamfirova, P.2
Lin, D.I.3
Chen, X.4
Yang, K.5
-
86
-
-
38549086019
-
FBW7 ubiquitin ligase: A tumour suppressor at the crossroads of cell division, growth and differentiation
-
Welcker M, Clurman BE. 2008. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat. Rev. Cancer 8:83-93
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 83-93
-
-
Welcker, M.1
Clurman, B.E.2
-
88
-
-
0033568639
-
Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells
-
Singer JD, Gurian-West M, Clurman B, Roberts JM. 1999. Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 13:2375-87
-
(1999)
Genes Dev
, vol.13
, pp. 2375-2387
-
-
Singer, J.D.1
Gurian-West, M.2
Clurman, B.3
Roberts, J.M.4
-
89
-
-
0032851221
-
Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E
-
Dealy MJ, Nguyen KV, Lo J, Gstaiger M, Krek W, et al. 1999. Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E. Nat. Genet. 23:245-48
-
(1999)
Nat. Genet
, vol.23
, pp. 245-248
-
-
Dealy, M.J.1
Nguyen, K.V.2
Lo, J.3
Gstaiger, M.4
Krek, W.5
-
90
-
-
24044476837
-
Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway
-
Zhang YW, Otterness DM, Chiang GG, Xie W, Liu YC, et al. 2005. Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol. Cell 19:607-18
-
(2005)
Mol. Cell
, vol.19
, pp. 607-618
-
-
Zhang, Y.W.1
Otterness, D.M.2
Chiang, G.G.3
Xie, W.4
Liu, Y.C.5
-
91
-
-
36749061942
-
Structural organization of the anaphasepromoting complex bound to the mitotic activator Slp1
-
Ohi MD, Feoktistova A, Ren L, Yip C, Cheng Y, et al. 2007. Structural organization of the anaphasepromoting complex bound to the mitotic activator Slp1. Mol. Cell 28:871-85
-
(2007)
Mol. Cell
, vol.28
, pp. 871-885
-
-
Ohi, M.D.1
Feoktistova, A.2
Ren, L.3
Yip, C.4
Cheng, Y.5
-
92
-
-
33747589184
-
The anaphase promoting complex/cyclosome: A machine designed to destroy
-
Peters JM. 2006. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat. Rev. Mol. Cell Biol. 7:644-56
-
(2006)
Nat. Rev. Mol. Cell Biol
, vol.7
, pp. 644-656
-
-
Peters, J.M.1
-
93
-
-
34447097834
-
Sequential E2s drive polyubiquitin chain assembly on APC targets
-
Rodrigo-Brenni MC, Morgan DO. 2007. Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell 130:127-39
-
(2007)
Cell
, vol.130
, pp. 127-139
-
-
Rodrigo-Brenni, M.C.1
Morgan, D.O.2
-
94
-
-
0038243172
-
Control of meiotic and mitotic progression by the F box protein β-Trcp1 in vivo
-
Guardavaccaro D, Kudo Y, Boulaire J, Barchi M, Busino L, et al. 2003. Control of meiotic and mitotic progression by the F box protein β-Trcp1 in vivo. Dev. Cell 4:799-812
-
(2003)
Dev. Cell
, vol.4
, pp. 799-812
-
-
Guardavaccaro, D.1
Kudo, Y.2
Boulaire, J.3
Barchi, M.4
Busino, L.5
-
95
-
-
2542617641
-
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
-
Moshe Y, Boulaire J, Pagano M, Hershko A. 2004. Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. Proc. Natl. Acad. Sci. USA 101:7937-42
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 7937-7942
-
-
Moshe, Y.1
Boulaire, J.2
Pagano, M.3
Hershko, A.4
-
96
-
-
34547174700
-
APC/CCdc20 controls the ubiquitin-mediated degradation of p21 in prometaphase
-
Amador V, Ge S, Santamaría PG, Guardavaccaro D, Pagano M. 2007. APC/CCdc20 controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol. Cell 27:462-73
-
(2007)
Mol. Cell
, vol.27
, pp. 462-473
-
-
Amador, V.1
Ge, S.2
Santamaría, P.G.3
Guardavaccaro, D.4
Pagano, M.5
-
97
-
-
1642602695
-
The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex
-
Song MS, Song SJ, Ayad NG, Chang JS, Lee JH, et al. 2004. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat. Cell Biol. 6:129-37
-
(2004)
Nat. Cell Biol
, vol.6
, pp. 129-137
-
-
Song, M.S.1
Song, S.J.2
Ayad, N.G.3
Chang, J.S.4
Lee, J.H.5
-
98
-
-
0035795408
-
Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
-
Geley S, Kramer E, Gieffers C, Gannon J, Peters JM, Hunt T. 2001. Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. J. Cell Biol. 153:137-48
-
(2001)
J. Cell Biol
, vol.153
, pp. 137-148
-
-
Geley, S.1
Kramer, E.2
Gieffers, C.3
Gannon, J.4
Peters, J.M.5
Hunt, T.6
-
99
-
-
33947310066
-
Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint
-
Burton JL, Solomon MJ. 2007. Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint. Genes Dev. 21:655-67
-
(2007)
Genes Dev
, vol.21
, pp. 655-667
-
-
Burton, J.L.1
Solomon, M.J.2
-
100
-
-
34250799719
-
Cdc20: AWD40 activator for a cell cycle degradation machine
-
Yu H. 2007. Cdc20: aWD40 activator for a cell cycle degradation machine. Mol. Cell 27:3-16
-
(2007)
Mol. Cell
, vol.27
, pp. 3-16
-
-
Yu, H.1
-
101
-
-
0032133145
-
Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1
-
Fang G, Yu H, Kirschner MW. 1998. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Mol. Cell 2:163-71
-
(1998)
Mol. Cell
, vol.2
, pp. 163-171
-
-
Fang, G.1
Yu, H.2
Kirschner, M.W.3
-
102
-
-
21244467405
-
Mutual inhibition of separase and Cdk1 by two-step complex formation
-
Gorr IH, Boos D, Stemmann O. 2005. Mutual inhibition of separase and Cdk1 by two-step complex formation. Mol. Cell 19:135-41
-
(2005)
Mol. Cell
, vol.19
, pp. 135-141
-
-
Gorr, I.H.1
Boos, D.2
Stemmann, O.3
-
103
-
-
0033567387
-
Whose end is destruction: Cell division and the anaphase-promoting complex
-
Zachariae W, Nasmyth K. 1999. Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev. 13:2039-58
-
(1999)
Genes Dev
, vol.13
, pp. 2039-2058
-
-
Zachariae, W.1
Nasmyth, K.2
-
104
-
-
34247635494
-
Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos
-
Li M, York JP, Zhang P. 2007. Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos. Mol. Cell Biol. 27:3481-88
-
(2007)
Mol. Cell Biol
, vol.27
, pp. 3481-3488
-
-
Li, M.1
York, J.P.2
Zhang, P.3
-
105
-
-
0035865138
-
Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis
-
Zur A, Brandeis M. 2001. Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis. EMBO J. 20:792-801
-
(2001)
EMBO J
, vol.20
, pp. 792-801
-
-
Zur, A.1
Brandeis, M.2
-
106
-
-
49849098630
-
Regulation of APC/C activators in mitosis and meiosis
-
Pesin JA, Orr-Weaver TL. 2008. Regulation of APC/C activators in mitosis and meiosis. Annu. Rev. Cell Dev. Biol. 24:475-99
-
(2008)
Annu. Rev. Cell Dev. Biol
, vol.24
, pp. 475-499
-
-
Pesin, J.A.1
Orr-Weaver, T.L.2
-
107
-
-
33847366732
-
Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis
-
Holt LJ, Hutti JE, Cantley LC, Morgan DO. 2007. Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. Mol. Cell 25:689-702
-
(2007)
Mol. Cell
, vol.25
, pp. 689-702
-
-
Holt, L.J.1
Hutti, J.E.2
Cantley, L.C.3
Morgan, D.O.4
-
108
-
-
10344247126
-
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry
-
Rape M, Kirschner MW. 2004. Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature 432:588-95
-
(2004)
Nature
, vol.432
, pp. 588-595
-
-
Rape, M.1
Kirschner, M.W.2
-
109
-
-
2342508503
-
Mammalian Cdh1/Fzr mediates its own degradation
-
Listovsky T, Oren YS, Yudkovsky Y, Mahbubani HM, Weiss AM, et al. 2004. Mammalian Cdh1/Fzr mediates its own degradation. EMBO J. 23:1619-26
-
(2004)
EMBO J
, vol.23
, pp. 1619-1626
-
-
Listovsky, T.1
Oren, Y.S.2
Yudkovsky, Y.3
Mahbubani, H.M.4
Weiss, A.M.5
-
110
-
-
25444517778
-
Involvement of the SCF complex in the control of Cdh1 degradation in S-phase
-
Benmaamar R, Pagano M. 2005. Involvement of the SCF complex in the control of Cdh1 degradation in S-phase. Cell Cycle 4:1230-32
-
(2005)
Cell Cycle
, vol.4
, pp. 1230-1232
-
-
Benmaamar, R.1
Pagano, M.2
-
111
-
-
0037126610
-
APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box
-
Hames RS, Wattam SL, Yamano H, Bacchieri R, Fry AM. 2001. APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box. EMBO J. 20:7117-27
-
(2001)
EMBO J
, vol.20
, pp. 7117-7127
-
-
Hames, R.S.1
Wattam, S.L.2
Yamano, H.3
Bacchieri, R.4
Fry, A.M.5
-
113
-
-
1642458099
-
Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells
-
Lindon C, Pines J. 2004. Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells. J. Cell Biol. 164:233-41
-
(2004)
J. Cell Biol
, vol.164
, pp. 233-241
-
-
Lindon, C.1
Pines, J.2
-
114
-
-
0032560029
-
The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae
-
Charles JF, Jaspersen SL,Tinker-Kulberg RL, Hwang L, Szidon A, Morgan DO. 1998. The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae. Curr. Biol. 8:497-507
-
(1998)
Curr. Biol
, vol.8
, pp. 497-507
-
-
Charles, J.F.1
Jaspersen, S.L.2
Tinker-Kulberg, R.L.3
Hwang, L.4
Szidon, A.5
Morgan, D.O.6
-
115
-
-
24944592549
-
Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20
-
Morrow CJ,Tighe A, Johnson VL, Scott MI, Ditchfield C,Taylor SS. 2005. Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20. J. Cell Sci. 118:3639-52
-
(2005)
J. Cell Sci
, vol.118
, pp. 3639-3652
-
-
Morrow, C.J.1
Tighe, A.2
Johnson, V.L.3
Scott, M.I.4
Ditchfield, C.5
Taylor, S.S.6
-
116
-
-
7744230752
-
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint
-
Tang Z, Shu H, Oncel D, Chen S, Yu H. 2004. Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. Mol. Cell 16:387-97
-
(2004)
Mol. Cell
, vol.16
, pp. 387-397
-
-
Tang, Z.1
Shu, H.2
Oncel, D.3
Chen, S.4
Yu, H.5
-
117
-
-
25444493567
-
Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1
-
Stewart S, Fang G. 2005. Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1. Cancer Res. 65:8730-35
-
(2005)
Cancer Res
, vol.65
, pp. 8730-8735
-
-
Stewart, S.1
Fang, G.2
-
118
-
-
33947545651
-
KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome
-
Qi W, Yu H. 2007. KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome. J. Biol. Chem. 282:3672-79
-
(2007)
J. Biol. Chem
, vol.282
, pp. 3672-3679
-
-
Qi, W.1
Yu, H.2
-
119
-
-
1642399624
-
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
-
Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG Jr. 2004. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 428:194-98
-
(2004)
Nature
, vol.428
, pp. 194-198
-
-
Wei, W.1
Ayad, N.G.2
Wan, Y.3
Zhang, G.J.4
Kirschner, M.W.5
Kaelin Jr., W.G.6
-
120
-
-
1642378661
-
Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase
-
Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M. 2004. Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature 428:190-93
-
(2004)
Nature
, vol.428
, pp. 190-193
-
-
Bashir, T.1
Dorrello, N.V.2
Amador, V.3
Guardavaccaro, D.4
Pagano, M.5
-
121
-
-
34147213257
-
Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor β-induced growth inhibition
-
Liu W, Wu G, Li W, Lobur D, Wan Y. 2007. Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor β-induced growth inhibition. Mol. Cell Biol. 27:2967-79
-
(2007)
Mol. Cell Biol
, vol.27
, pp. 2967-2979
-
-
Liu, W.1
Wu, G.2
Li, W.3
Lobur, D.4
Wan, Y.5
-
122
-
-
39449106065
-
Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase
-
Rodier G, Coulombe P,Tanguay PL, Boutonnet C, Meloche S. 2008. Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase. EMBO J. 27:679-91
-
(2008)
EMBO J
, vol.27
, pp. 679-691
-
-
Rodier, G.1
Coulombe, P.2
Tanguay, P.L.3
Boutonnet, C.4
Meloche, S.5
-
123
-
-
1842428734
-
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP
-
Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, et al. 2004. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP. Proc. Natl. Acad. Sci. USA 101:4419-24
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 4419-4424
-
-
Watanabe, N.1
Arai, H.2
Nishihara, Y.3
Taniguchi, M.4
Watanabe, N.5
-
124
-
-
0037418836
-
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC
-
Ayad NG, Rankin S, Murakami M, Jebanathirajah J, Gygi S, Kirschner MW. 2003. Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell 113:101-13
-
(2003)
Cell
, vol.113
, pp. 101-113
-
-
Ayad, N.G.1
Rankin, S.2
Murakami, M.3
Jebanathirajah, J.4
Gygi, S.5
Kirschner, M.W.6
-
125
-
-
23844525856
-
Cyclin-dependent kinase (CDK) phosphorylation destabilizes somaticWee1 via multiple pathways
-
Watanabe N, Arai H, Iwasaki J, Shiina M, Ogata K, et al. 2005. Cyclin-dependent kinase (CDK) phosphorylation destabilizes somaticWee1 via multiple pathways. Proc. Natl. Acad. Sci. USA 102:11663-68
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 11663-11668
-
-
Watanabe, N.1
Arai, H.2
Iwasaki, J.3
Shiina, M.4
Ogata, K.5
-
126
-
-
21844458914
-
Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeast
-
Asano S, Park JE, Sakchaisri K, Yu LR, Song S, et al. 2005. Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeast. EMBO J. 24:2194-204
-
(2005)
EMBO J
, vol.24
, pp. 2194-2204
-
-
Asano, S.1
Park, J.E.2
Sakchaisri, K.3
Yu, L.R.4
Song, S.5
-
127
-
-
33644852909
-
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain
-
Huang F, Kirkpatrick D, Jiang X, Gygi S, Sorkin A. 2006. Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol. Cell 21:737-48
-
(2006)
Mol. Cell
, vol.21
, pp. 737-748
-
-
Huang, F.1
Kirkpatrick, D.2
Jiang, X.3
Gygi, S.4
Sorkin, A.5
-
128
-
-
0029557613
-
The epidermal growth factor receptor is covalently linked to ubiquitin
-
Galcheva-Gargova Z, Theroux SJ, Davis RJ. 1995. The epidermal growth factor receptor is covalently linked to ubiquitin. Oncogene 11:2649-55
-
(1995)
Oncogene
, vol.11
, pp. 2649-2655
-
-
Galcheva-Gargova, Z.1
Theroux, S.J.2
Davis, R.J.3
-
129
-
-
0029124883
-
Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl
-
Yoon CH, Lee J, Jongeward GD, Sternberg PW. 1995. Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl. Science 269:1102-5
-
(1995)
Science
, vol.269
, pp. 1102-1105
-
-
Yoon, C.H.1
Lee, J.2
Jongeward, G.D.3
Sternberg, P.W.4
-
130
-
-
27444445613
-
c-Cbl and Cbl-b ubiquitin ligases: Substrate diversity and the negative regulation of signalling responses
-
Thien CB, Langdon WY. 2005. c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses. Biochem. J. 391:153-66
-
(2005)
Biochem. J
, vol.391
, pp. 153-166
-
-
Thien, C.B.1
Langdon, W.Y.2
-
131
-
-
3142618052
-
Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations
-
Kassenbrock CK, Anderson SM. 2004. Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations. J. Biol. Chem. 279:28017-27
-
(2004)
J. Biol. Chem
, vol.279
, pp. 28017-28027
-
-
Kassenbrock, C.K.1
Anderson, S.M.2
-
132
-
-
34848888401
-
Structural basis for UBAmediated dimerization of c-Cbl ubiquitin ligase
-
Kozlov G, Peschard P, Zimmerman B, Lin T, Moldoveanu T, et al. 2007. Structural basis for UBAmediated dimerization of c-Cbl ubiquitin ligase. J. Biol. Chem. 282:27547-55
-
(2007)
J. Biol. Chem
, vol.282
, pp. 27547-27555
-
-
Kozlov, G.1
Peschard, P.2
Zimmerman, B.3
Lin, T.4
Moldoveanu, T.5
-
133
-
-
34547195241
-
Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b
-
Peschard P, Kozlov G, Lin T, Mirza IA, Berghuis AM, et al. 2007. Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b. Mol. Cell 27:474-85
-
(2007)
Mol. Cell
, vol.27
, pp. 474-485
-
-
Peschard, P.1
Kozlov, G.2
Lin, T.3
Mirza, I.A.4
Berghuis, A.M.5
-
134
-
-
0037018146
-
Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies
-
Longva KE, Blystad FD, Stang E, Larsen AM, Johannessen LE, Madshus IH. 2002. Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies. J. Cell Biol. 156:843-54
-
(2002)
J. Cell Biol
, vol.156
, pp. 843-854
-
-
Longva, K.E.1
Blystad, F.D.2
Stang, E.3
Larsen, A.M.4
Johannessen, L.E.5
Madshus, I.H.6
-
135
-
-
17544365654
-
Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins
-
Fukazawa T, Miyake S, Band V, Band H. 1996. Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins. J. Biol. Chem. 271:14554-59
-
(1996)
J. Biol. Chem
, vol.271
, pp. 14554-14559
-
-
Fukazawa, T.1
Miyake, S.2
Band, V.3
Band, H.4
-
136
-
-
0034607805
-
Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation
-
Stang E, Johannessen LE, Knardal SL, Madshus IH. 2000. Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation. J. Biol. Chem. 275:13940-47
-
(2000)
J. Biol. Chem
, vol.275
, pp. 13940-13947
-
-
Stang, E.1
Johannessen, L.E.2
Knardal, S.L.3
Madshus, I.H.4
-
137
-
-
0034949705
-
c-Cbl ubiquitinates theEGFreceptor at the plasma membrane and remains receptor associated throughout the endocytic route
-
de Melker AA,Van Der Horst G, Calafat J, Jansen H, Borst J. 2001. c-Cbl ubiquitinates theEGFreceptor at the plasma membrane and remains receptor associated throughout the endocytic route. J. Cell Sci. 114:2167-78
-
(2001)
J. Cell Sci
, vol.114
, pp. 2167-2178
-
-
de Melker, A.A.1
Van Der Horst, G.2
Calafat, J.3
Jansen, H.4
Borst, J.5
-
138
-
-
54249151578
-
Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation
-
Umebayashi K, Stenmark H, Yoshimori T. 2008. Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation. Mol. Biol. Cell 19:3454-62
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 3454-3462
-
-
Umebayashi, K.1
Stenmark, H.2
Yoshimori, T.3
-
139
-
-
0032217156
-
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
-
Levkowitz G,Waterman H, Zamir E, Kam Z, Oved S, et al. 1998. c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev. 12:3663-74
-
(1998)
Genes Dev
, vol.12
, pp. 3663-3674
-
-
Levkowitz, G.1
Waterman, H.2
Zamir, E.3
Kam, Z.4
Oved, S.5
-
140
-
-
0033392493
-
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
-
Levkowitz G,Waterman H, Ettenberg SA, Katz M, Tsygankov AY, et al. 1999. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol. Cell 4:1029-40
-
(1999)
Mol. Cell
, vol.4
, pp. 1029-1040
-
-
Levkowitz, G.1
Waterman, H.2
Ettenberg, S.A.3
Katz, M.4
Tsygankov, A.Y.5
-
141
-
-
33845685698
-
p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration
-
Frey MR, Dise RS, Edelblum KL, Polk DB. 2006. p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration. EMBO J. 25:5683-92
-
(2006)
EMBO J
, vol.25
, pp. 5683-5692
-
-
Frey, M.R.1
Dise, R.S.2
Edelblum, K.L.3
Polk, D.B.4
-
142
-
-
0034163550
-
Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas
-
Frederick L, Wang XY, Eley G, James CD. 2000. Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res. 60:1383-87
-
(2000)
Cancer Res
, vol.60
, pp. 1383-1387
-
-
Frederick, L.1
Wang, X.Y.2
Eley, G.3
James, C.D.4
-
143
-
-
33750209646
-
EGFRvIII undergoes activationdependent downregulation mediated by the Cbl proteins
-
Davies GC, Ryan PE, Rahman L, Zajac-Kaye M, Lipkowitz S. 2006. EGFRvIII undergoes activationdependent downregulation mediated by the Cbl proteins. Oncogene 25:6497-509
-
(2006)
Oncogene
, vol.25
, pp. 6497-6509
-
-
Davies, G.C.1
Ryan, P.E.2
Rahman, L.3
Zajac-Kaye, M.4
Lipkowitz, S.5
-
144
-
-
1842591231
-
Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases
-
Marmor MD, Yarden Y. 2004. Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases. Oncogene 23:2057-70
-
(2004)
Oncogene
, vol.23
, pp. 2057-2070
-
-
Marmor, M.D.1
Yarden, Y.2
-
145
-
-
0042206678
-
Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis
-
Duan L, Miura Y, Dimri M, Majumder B, Dodge IL, et al. 2003. Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis. J. Biol. Chem. 278:28950-60
-
(2003)
J. Biol. Chem
, vol.278
, pp. 28950-28960
-
-
Duan, L.1
Miura, Y.2
Dimri, M.3
Majumder, B.4
Dodge, I.L.5
-
146
-
-
0025359062
-
Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body
-
Felder S, Miller K, Moehren G, Ullrich A, Schlessinger J, Hopkins CR. 1990. Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body. Cell 61:623-34
-
(1990)
Cell
, vol.61
, pp. 623-634
-
-
Felder, S.1
Miller, K.2
Moehren, G.3
Ullrich, A.4
Schlessinger, J.5
Hopkins, C.R.6
-
147
-
-
33746797288
-
Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases
-
Oved S, Mosesson Y, Zwang Y, Santonico E, Shtiegman K, et al. 2006. Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases. J. Biol. Chem. 281:21640-51
-
(2006)
J. Biol. Chem
, vol.281
, pp. 21640-21651
-
-
Oved, S.1
Mosesson, Y.2
Zwang, Y.3
Santonico, E.4
Shtiegman, K.5
-
148
-
-
37649013040
-
Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation
-
Thiel KW, Carpenter G. 2007. Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation. Proc. Natl. Acad. Sci. USA 104:19238-43
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 19238-19243
-
-
Thiel, K.W.1
Carpenter, G.2
-
149
-
-
0034714277
-
Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome
-
Bao J, Alroy I, Waterman H, Schejter ED, Brodie C, et al. 2000. Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome. J. Biol. Chem. 275:26178-86
-
(2000)
J. Biol. Chem
, vol.275
, pp. 26178-26186
-
-
Bao, J.1
Alroy, I.2
Waterman, H.3
Schejter, E.D.4
Brodie, C.5
-
150
-
-
0033796072
-
Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain
-
Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, et al. 2000. Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain. Mol. Cell Biol. 20:7735-50
-
(2000)
Mol. Cell Biol
, vol.20
, pp. 7735-7750
-
-
Fiorentino, L.1
Pertica, C.2
Fiorini, M.3
Talora, C.4
Crescenzi, M.5
-
151
-
-
33947148666
-
Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation
-
Shen F, Lin Q, Gu Y, Childress C, Yang W. 2007. Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation. Mol. Biol. Cell 18:732-42
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 732-742
-
-
Shen, F.1
Lin, Q.2
Gu, Y.3
Childress, C.4
Yang, W.5
-
152
-
-
0035920225
-
Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex
-
Ettenberg SA, Magnifico A, Cuello M, Nau MM, Rubinstein YR, et al. 2001. Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex. J. Biol. Chem. 276:27677-84
-
(2001)
J. Biol. Chem
, vol.276
, pp. 27677-27684
-
-
Ettenberg, S.A.1
Magnifico, A.2
Cuello, M.3
Nau, M.M.4
Rubinstein, Y.R.5
-
153
-
-
0034859108
-
Internalization of the epidermal growth factor receptor: Role in signalling
-
Sorkin A. 2001. Internalization of the epidermal growth factor receptor: role in signalling. Biochem. Soc. Trans. 29:480-84
-
(2001)
Biochem. Soc. Trans
, vol.29
, pp. 480-484
-
-
Sorkin, A.1
-
154
-
-
34250873547
-
Compartmentalization of signalingcompetent epidermal growth factor receptors in endosomes
-
Balbis A, Parmar A, Wang Y, Baquiran G, Posner BI. 2007. Compartmentalization of signalingcompetent epidermal growth factor receptors in endosomes. Endocrinology 148:2944-54
-
(2007)
Endocrinology
, vol.148
, pp. 2944-2954
-
-
Balbis, A.1
Parmar, A.2
Wang, Y.3
Baquiran, G.4
Posner, B.I.5
-
155
-
-
0242290342
-
WWdomain HECT E3s target Cbl RING finger E3s for proteasomal degradation
-
Magnifico A, Ettenberg S, Yang C, Mariano J, Tiwari S, et al. 2003.WWdomain HECT E3s target Cbl RING finger E3s for proteasomal degradation. J. Biol. Chem. 278:43169-77
-
(2003)
J. Biol. Chem
, vol.278
, pp. 43169-43177
-
-
Magnifico, A.1
Ettenberg, S.2
Yang, C.3
Mariano, J.4
Tiwari, S.5
-
156
-
-
0035316576
-
Cbl: Many adaptations to regulate protein tyrosine kinases
-
Thien CB, Langdon WY. 2001. Cbl: many adaptations to regulate protein tyrosine kinases. Nat. Rev. Mol. Cell Biol. 2:294-307
-
(2001)
Nat. Rev. Mol. Cell Biol
, vol.2
, pp. 294-307
-
-
Thien, C.B.1
Langdon, W.Y.2
-
157
-
-
0036911112
-
c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation
-
Naramura M, Jang IK, Kole H, Huang F, Haines D, Gu H. 2002. c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation. Nat. Immunol. 3:1192-99
-
(2002)
Nat. Immunol
, vol.3
, pp. 1192-1199
-
-
Naramura, M.1
Jang, I.K.2
Kole, H.3
Huang, F.4
Haines, D.5
Gu, H.6
-
158
-
-
0035106341
-
RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation
-
Thien CB, Walker F, Langdon WY. 2001. RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation. Mol. Cell 7:355-65
-
(2001)
Mol. Cell
, vol.7
, pp. 355-365
-
-
Thien, C.B.1
Walker, F.2
Langdon, W.Y.3
-
159
-
-
0034682718
-
Structure of a c-Cbl-UbcH7 complex:RINGdomain function in ubiquitin-protein ligases
-
Zheng N,Wang P, Jeffrey PD, Pavletich NP. 2000. Structure of a c-Cbl-UbcH7 complex:RINGdomain function in ubiquitin-protein ligases. Cell 102:533-39
-
(2000)
Cell
, vol.102
, pp. 533-539
-
-
Zheng, N.1
Wang, P.2
Jeffrey, P.D.3
Pavletich, N.P.4
-
160
-
-
33646877450
-
Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule βPix
-
Schmidt MH, Husnjak K, Szymkiewicz I, Haglund K, Dikic I. 2006. Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule βPix. Oncogene 25:3071-78
-
(2006)
Oncogene
, vol.25
, pp. 3071-3078
-
-
Schmidt, M.H.1
Husnjak, K.2
Szymkiewicz, I.3
Haglund, K.4
Dikic, I.5
-
161
-
-
54849372300
-
Endocytosis and intracellular trafficking of ErbBs
-
Sorkin A, Goh LK. 2008. Endocytosis and intracellular trafficking of ErbBs. Exp. Cell Res. 314:3093-106
-
(2008)
Exp. Cell Res
, vol.314
, pp. 3093-3106
-
-
Sorkin, A.1
Goh, L.K.2
-
162
-
-
14544306526
-
Clathrin-independent endocytosis of ubiquitinated cargos
-
Sigismund S,Woelk T, Puri C, Maspero E, Tacchetti C, et al. 2005. Clathrin-independent endocytosis of ubiquitinated cargos. Proc. Natl. Acad. Sci. USA 102:2760-65
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 2760-2765
-
-
Sigismund, S.1
Woelk, T.2
Puri, C.3
Maspero, E.4
Tacchetti, C.5
-
163
-
-
3342970389
-
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits
-
Stang E, Blystad FD, Kazazic M, Bertelsen V, Brodahl T, et al. 2004. Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits. Mol. Biol. Cell 15:3591-604
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 3591-3604
-
-
Stang, E.1
Blystad, F.D.2
Kazazic, M.3
Bertelsen, V.4
Brodahl, T.5
-
164
-
-
36248989248
-
The Nedd4-like family of E3 ubiquitin ligases and cancer
-
Chen C, Matesic LE. 2007. The Nedd4-like family of E3 ubiquitin ligases and cancer. Cancer Metastasis Rev. 26:587-604
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 587-604
-
-
Chen, C.1
Matesic, L.E.2
-
165
-
-
8744255464
-
c-Cbl directs EGF receptors into an endocytic pathway that involves the ubiquitin-interacting motif of Eps15
-
de Melker AA, van der Horst G, Borst J. 2004. c-Cbl directs EGF receptors into an endocytic pathway that involves the ubiquitin-interacting motif of Eps15. J. Cell Sci. 117:5001-12
-
(2004)
J. Cell Sci
, vol.117
, pp. 5001-5012
-
-
de Melker, A.A.1
van der Horst, G.2
Borst, J.3
-
166
-
-
33746594215
-
A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling
-
Fallon L, Belanger CM, Corera AT, Kontogiannea M, Regan-Klapisz E, et al. 2006. A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling. Nat. Cell Biol. 8:834-42
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 834-842
-
-
Fallon, L.1
Belanger, C.M.2
Corera, A.T.3
Kontogiannea, M.4
Regan-Klapisz, E.5
-
167
-
-
33645148675
-
Regulation of ubiquitin-binding proteins by monoubiquitination
-
Hoeller D, Crosetto N, Blagoev B, Raiborg C, Tikkanen R, et al. 2006. Regulation of ubiquitin-binding proteins by monoubiquitination. Nat. Cell Biol. 8:163-69
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 163-169
-
-
Hoeller, D.1
Crosetto, N.2
Blagoev, B.3
Raiborg, C.4
Tikkanen, R.5
-
168
-
-
0037187597
-
A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins
-
Polo S, Sigismund S, Faretta M, Guidi M, Capua MR, et al. 2002. A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature 416:451-55
-
(2002)
Nature
, vol.416
, pp. 451-455
-
-
Polo, S.1
Sigismund, S.2
Faretta, M.3
Guidi, M.4
Capua, M.R.5
-
169
-
-
48549088895
-
Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation
-
Sigismund S, Argenzio E, Tosoni D, Cavallaro E, Polo S, Di Fiore PP. 2008. Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation. Dev. Cell 15:209-19
-
(2008)
Dev. Cell
, vol.15
, pp. 209-219
-
-
Sigismund, S.1
Argenzio, E.2
Tosoni, D.3
Cavallaro, E.4
Polo, S.5
Di Fiore, P.P.6
-
171
-
-
0029979181
-
Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes
-
Futter CE, Pearse A, Hewlett LJ, Hopkins CR. 1996. Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes. J. Cell Biol. 132:1011-23
-
(1996)
J. Cell Biol
, vol.132
, pp. 1011-1023
-
-
Futter, C.E.1
Pearse, A.2
Hewlett, L.J.3
Hopkins, C.R.4
-
172
-
-
0035162703
-
Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking
-
Burke P, Schooler K, Wiley HS. 2001. Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. Mol. Biol. Cell 12:1897-910
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 1897-1910
-
-
Burke, P.1
Schooler, K.2
Wiley, H.S.3
-
173
-
-
0036500994
-
Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum
-
Haj FG, Verveer PJ, Squire A, Neel BG, Bastiaens PI. 2002. Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum. Science 295:1708-11
-
(2002)
Science
, vol.295
, pp. 1708-1711
-
-
Haj, F.G.1
Verveer, P.J.2
Squire, A.3
Neel, B.G.4
Bastiaens, P.I.5
-
174
-
-
0041816011
-
Ligand-induced lysosomal epidermal growth factor receptor (EGFR) degradation is preceded by proteasome-dependent EGFR deubiquitination
-
Alwan HA, van Zoelen EJ, van Leeuwen JE. 2003. Ligand-induced lysosomal epidermal growth factor receptor (EGFR) degradation is preceded by proteasome-dependent EGFR deubiquitination. J. Biol. Chem. 278:35781-90
-
(2003)
J. Biol. Chem
, vol.278
, pp. 35781-35790
-
-
Alwan, H.A.1
van Zoelen, E.J.2
van Leeuwen, J.E.3
-
175
-
-
34748860356
-
Epidermal growth factor receptor degradation: An alternative view of oncogenic pathways
-
Kirisits A, Pils D, Krainer M. 2007. Epidermal growth factor receptor degradation: an alternative view of oncogenic pathways. Int. J. Biochem. Cell Biol. 39:2173-82
-
(2007)
Int. J. Biochem. Cell Biol
, vol.39
, pp. 2173-2182
-
-
Kirisits, A.1
Pils, D.2
Krainer, M.3
-
176
-
-
34247236217
-
Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking
-
Kim BY, Olzmann JA, Barsh GS, Chin LS, Li L. 2007. Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking. Mol. Biol. Cell 18:1129-42
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 1129-1142
-
-
Kim, B.Y.1
Olzmann, J.A.2
Barsh, G.S.3
Chin, L.S.4
Li, L.5
-
177
-
-
0036696804
-
Escrt-III: An endosome-associated heterooligomeric protein complex required for mvb sorting
-
Babst M, Katzmann DJ, Estepa-Sabal EJ, Meerloo T, Emr SD. 2002. Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev. Cell 3:271-82
-
(2002)
Dev. Cell
, vol.3
, pp. 271-282
-
-
Babst, M.1
Katzmann, D.J.2
Estepa-Sabal, E.J.3
Meerloo, T.4
Emr, S.D.5
-
178
-
-
14844299757
-
Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling
-
Kario E, Marmor MD, Adamsky K, Citri A, Amit I, et al. 2005. Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. J. Biol. Chem. 280:7038-48
-
(2005)
J. Biol. Chem
, vol.280
, pp. 7038-7048
-
-
Kario, E.1
Marmor, M.D.2
Adamsky, K.3
Citri, A.4
Amit, I.5
-
179
-
-
0347093486
-
-
Hrs mediates downregulation of multiple signalling receptors in
-
Jekely G, Rorth P. 2003. Hrs mediates downregulation of multiple signalling receptors in Drosophila. EMBO Rep. 4:1163-68
-
(2003)
Drosophila. EMBO Rep
, vol.4
, pp. 1163-1168
-
-
Jekely, G.1
Rorth, P.2
-
180
-
-
0034234854
-
Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2
-
Klapper LN, Waterman H, Sela M, Yarden Y. 2000. Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2. Cancer Res. 60:3384-88
-
(2000)
Cancer Res
, vol.60
, pp. 3384-3388
-
-
Klapper, L.N.1
Waterman, H.2
Sela, M.3
Yarden, Y.4
-
181
-
-
0036789884
-
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu
-
Xu W, Marcu M, Yuan X, Mimnaugh E, Patterson C, Neckers L. 2002. Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu. Proc. Natl. Acad. Sci. USA 99:12847-52
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 12847-12852
-
-
Xu, W.1
Marcu, M.2
Yuan, X.3
Mimnaugh, E.4
Patterson, C.5
Neckers, L.6
-
182
-
-
0033816632
-
Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression
-
Oster SK, Marhin WW, Asker C, Facchini LM, Dion PA, et al. 2000. Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression. Mol. Cell Biol. 20:6768-78
-
(2000)
Mol. Cell Biol
, vol.20
, pp. 6768-6778
-
-
Oster, S.K.1
Marhin, W.W.2
Asker, C.3
Facchini, L.M.4
Dion, P.A.5
-
183
-
-
0026664626
-
Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor
-
Mori S, Heldin CH, Claesson-Welsh L. 1992. Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor. J. Biol. Chem. 267:6429-34
-
(1992)
J. Biol. Chem
, vol.267
, pp. 6429-6434
-
-
Mori, S.1
Heldin, C.H.2
Claesson-Welsh, L.3
-
184
-
-
0027402689
-
Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling
-
Mori S, Heldin CH, Claesson-Welsh L. 1993. Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling. J. Biol. Chem. 268:577-83
-
(1993)
J. Biol. Chem
, vol.268
, pp. 577-583
-
-
Mori, S.1
Heldin, C.H.2
Claesson-Welsh, L.3
-
185
-
-
35748960228
-
Binding of Cbl to a phospholipaseCγ1-docking site on platelet-derived growth factor receptor β provides a dual mechanism of negative regulation
-
Reddi AL,Ying G, Duan L, Chen G, DimriM,et al. 2007. Binding of Cbl to a phospholipaseCγ1-docking site on platelet-derived growth factor receptor β provides a dual mechanism of negative regulation. J. Biol. Chem. 282:29336-47
-
(2007)
J. Biol. Chem
, vol.282
, pp. 29336-29347
-
-
Reddi, A.L.1
Ying, G.2
Duan, L.3
Chen, G.4
Dimri, M.5
-
186
-
-
13544272718
-
TGF-β, c-Cbl, and PDGFR-α the in mammary stroma
-
Crowley MR, Bowtell D, Serra R. 2005. TGF-β, c-Cbl, and PDGFR-α the in mammary stroma. Dev. Biol. 279:58-72
-
(2005)
Dev. Biol
, vol.279
, pp. 58-72
-
-
Crowley, M.R.1
Bowtell, D.2
Serra, R.3
-
187
-
-
0038105017
-
CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl
-
Cormont M, Meton I, Mari M, Monzo P, Keslair F, et al. 2003. CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl. Traffic 4:97-112
-
(2003)
Traffic
, vol.4
, pp. 97-112
-
-
Cormont, M.1
Meton, I.2
Mari, M.3
Monzo, P.4
Keslair, F.5
-
188
-
-
33845999302
-
Alix facilitates the interaction between c-Cbl and platelet-derived growth factor β-receptor and thereby modulates receptor downregulation
-
Lennartsson J, Wardega P, Engström U, Hellman U, Heldin CH. 2006. Alix facilitates the interaction between c-Cbl and platelet-derived growth factor β-receptor and thereby modulates receptor downregulation. J. Biol. Chem. 281:39152-58
-
(2006)
J. Biol. Chem
, vol.281
, pp. 39152-39158
-
-
Lennartsson, J.1
Wardega, P.2
Engström, U.3
Hellman, U.4
Heldin, C.H.5
-
189
-
-
33749390318
-
Direct binding of Cbl toTyr568 andTyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation
-
Masson K, Heiss E, Band H, Ronnstrand L. 2006. Direct binding of Cbl toTyr568 andTyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation. Biochem. J. 399:59-67
-
(2006)
Biochem. J
, vol.399
, pp. 59-67
-
-
Masson, K.1
Heiss, E.2
Band, H.3
Ronnstrand, L.4
-
190
-
-
11144244315
-
Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl)
-
Zeng S, Xu Z, Lipkowitz S, Longley JB. 2005. Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl). Blood 105:226-32
-
(2005)
Blood
, vol.105
, pp. 226-232
-
-
Zeng, S.1
Xu, Z.2
Lipkowitz, S.3
Longley, J.B.4
-
191
-
-
0033169024
-
The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation
-
Lee PS,Wang Y, Dominguez MG, Yeung YG, Murphy MA, et al. 1999. The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. EMBO J. 18:3616-28
-
(1999)
EMBO J
, vol.18
, pp. 3616-3628
-
-
Lee, P.S.1
Wang, Y.2
Dominguez, M.G.3
Yeung, Y.G.4
Murphy, M.A.5
-
192
-
-
0037034167
-
C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus
-
Wilhelmsen K, Burkhalter S, van der Geer P. 2002. C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus. Oncogene 21:1079-89
-
(2002)
Oncogene
, vol.21
, pp. 1079-1089
-
-
Wilhelmsen, K.1
Burkhalter, S.2
van der Geer, P.3
-
193
-
-
0028860225
-
Oncogenic activation of v-kit involves deletion of a putative tyrosine-substrate interaction site
-
Herbst R, Munemitsu S, Ullrich A. 1995. Oncogenic activation of v-kit involves deletion of a putative tyrosine-substrate interaction site. Oncogene 10:369-79
-
(1995)
Oncogene
, vol.10
, pp. 369-379
-
-
Herbst, R.1
Munemitsu, S.2
Ullrich, A.3
-
194
-
-
0025190309
-
FMS mutations in myelodysplastic, leukemic, and normal subjects
-
Ridge SA, Worwood M, Oscier D, Jacobs A, Padua RA. 1990. FMS mutations in myelodysplastic, leukemic, and normal subjects. Proc. Natl. Acad. Sci. USA 87:1377-80
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 1377-1380
-
-
Ridge, S.A.1
Worwood, M.2
Oscier, D.3
Jacobs, A.4
Padua, R.A.5
-
195
-
-
0038386452
-
Escape from Cbl-mediated downregulation: A recurrent theme for oncogenic deregulation of receptor tyrosine kinases
-
Peschard P, Park M. 2003. Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases. Cancer Cell 3:519-23
-
(2003)
Cancer Cell
, vol.3
, pp. 519-523
-
-
Peschard, P.1
Park, M.2
-
196
-
-
0035081241
-
-
Ornitz DM, Itoh N. 2001. Fibroblast growth factors. Genome Biol. 2:reviews3005
-
Ornitz DM, Itoh N. 2001. Fibroblast growth factors. Genome Biol. 2:reviews3005
-
-
-
-
197
-
-
0028356454
-
Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766
-
Sorokin A, Mohammadi M, Huang J, Schlessinger J. 1994. Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766. J. Biol. Chem. 269:17056-61
-
(1994)
J. Biol. Chem
, vol.269
, pp. 17056-17061
-
-
Sorokin, A.1
Mohammadi, M.2
Huang, J.3
Schlessinger, J.4
-
198
-
-
0030706168
-
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
-
Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, et al. 1997. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell 89:693-702
-
(1997)
Cell
, vol.89
, pp. 693-702
-
-
Kouhara, H.1
Hadari, Y.R.2
Spivak-Kroizman, T.3
Schilling, J.4
Bar-Sagi, D.5
-
199
-
-
0031835659
-
Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
-
Hadari YR, Kouhara H, Lax I, Schlessinger J. 1998. Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation. Mol. Cell Biol. 18:3966-73
-
(1998)
Mol. Cell Biol
, vol.18
, pp. 3966-3973
-
-
Hadari, Y.R.1
Kouhara, H.2
Lax, I.3
Schlessinger, J.4
-
200
-
-
0033974109
-
FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors
-
Ong SH, Guy GR, Hadari YR, Laks S, Gotoh N, et al. 2000. FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. Mol. Cell Biol. 20:979-89
-
(2000)
Mol. Cell Biol
, vol.20
, pp. 979-989
-
-
Ong, S.H.1
Guy, G.R.2
Hadari, Y.R.3
Laks, S.4
Gotoh, N.5
-
201
-
-
0037076329
-
FRS2́ attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl
-
Wong A, Lamothe B, Lee A, Schlessinger J, Lax I, Li A. 2002. FRS2́ attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl. Proc. Natl. Acad. Sci. USA 99:6684-89
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 6684-6689
-
-
Wong, A.1
Lamothe, B.2
Lee, A.3
Schlessinger, J.4
Lax, I.5
Li, A.6
-
202
-
-
0345743700
-
Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia
-
Cho JY, Guo C,Torello M, Lunstrum GP, Iwata T, et al. 2004. Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia. Proc. Natl. Acad. Sci. USA 101:609-14
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 609-614
-
-
Cho, J.Y.1
Guo, C.2
Torello, M.3
Lunstrum, G.P.4
Iwata, T.5
-
203
-
-
33847292778
-
From Tpr-Met to Met, tumorigenesis and tubes
-
Peschard P, Park M. 2007. From Tpr-Met to Met, tumorigenesis and tubes. Oncogene 26:1276-85
-
(2007)
Oncogene
, vol.26
, pp. 1276-1285
-
-
Peschard, P.1
Park, M.2
-
204
-
-
0037695000
-
Endosomal dynamics of Met determine signaling output
-
Hammond DE, Carter S, McCullough J, Urbe S, Vande Woude G, Clague MJ. 2003. Endosomal dynamics of Met determine signaling output. Mol. Biol. Cell 14:1346-54
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 1346-1354
-
-
Hammond, D.E.1
Carter, S.2
McCullough, J.3
Urbe, S.4
Vande Woude, G.5
Clague, M.J.6
-
205
-
-
11144227936
-
The met receptor degradation pathway: Requirement for Lys48-linked polyubiquitin independent of proteasome activity
-
Carter S, Urbe S, Clague MJ. 2004. The met receptor degradation pathway: requirement for Lys48-linked polyubiquitin independent of proteasome activity. J. Biol. Chem. 279:52835-39
-
(2004)
J. Biol. Chem
, vol.279
, pp. 52835-52839
-
-
Carter, S.1
Urbe, S.2
Clague, M.J.3
-
206
-
-
31544462584
-
Somatic mutations lead to an oncogenic deletion of met in lung cancer
-
Kong-Beltran M, Seshagiri S, Zha J, Zhu W, Bhawe K, et al. 2006. Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res. 66:283-89
-
(2006)
Cancer Res
, vol.66
, pp. 283-289
-
-
Kong-Beltran, M.1
Seshagiri, S.2
Zha, J.3
Zhu, W.4
Bhawe, K.5
-
207
-
-
27144512084
-
Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation
-
Abella JV, Peschard P, Naujokas MA, Lin T, Saucier C, et al. 2005. Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. Mol. Cell Biol. 25:9632-45
-
(2005)
Mol. Cell Biol
, vol.25
, pp. 9632-9645
-
-
Abella, J.V.1
Peschard, P.2
Naujokas, M.A.3
Lin, T.4
Saucier, C.5
-
208
-
-
33847181657
-
LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy
-
Shattuck DL, Miller JK, Laederich M, Funes M, Petersen H, et al. 2007. LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy. Mol. Cell Biol. 27:1934-46
-
(2007)
Mol. Cell Biol
, vol.27
, pp. 1934-1946
-
-
Shattuck, D.L.1
Miller, J.K.2
Laederich, M.3
Funes, M.4
Petersen, H.5
-
209
-
-
33750869288
-
A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion
-
Takeuchi T, Adachi Y, Sonobe H, Furihata M, Ohtsuki Y. 2006. A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion. Oncogene 25:7059-69
-
(2006)
Oncogene
, vol.25
, pp. 7059-7069
-
-
Takeuchi, T.1
Adachi, Y.2
Sonobe, H.3
Furihata, M.4
Ohtsuki, Y.5
-
210
-
-
0037534097
-
c-Cbl is a critical modulator of the Ron tyrosine kinase receptor
-
Penengo L, Rubin C, Yarden Y, Gaudino G. 2003. c-Cbl is a critical modulator of the Ron tyrosine kinase receptor. Oncogene 22:3669-79
-
(2003)
Oncogene
, vol.22
, pp. 3669-3679
-
-
Penengo, L.1
Rubin, C.2
Yarden, Y.3
Gaudino, G.4
-
211
-
-
33746819784
-
Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling
-
Germano S, Barberis D, Santoro MM, Penengo L, Citri A, et al. 2006. Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling. J. Biol. Chem. 281:21710-19
-
(2006)
J. Biol. Chem
, vol.281
, pp. 21710-21719
-
-
Germano, S.1
Barberis, D.2
Santoro, M.M.3
Penengo, L.4
Citri, A.5
-
213
-
-
0037816235
-
Mdm2-dependent ubiquitination and degradation of the insulinlike growth factor 1 receptor
-
Girnita L, Girnita A, Larsson O. 2003. Mdm2-dependent ubiquitination and degradation of the insulinlike growth factor 1 receptor. Proc. Natl. Acad. Sci. USA 100:8247-52
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8247-8252
-
-
Girnita, L.1
Girnita, A.2
Larsson, O.3
-
214
-
-
40449095393
-
Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: Potential mechanistic involvement of Mdm2 and β-arrestin1
-
Vasilcanu R, Vasilcanu D, Rosengren L, Natalishvili N, Sehat B, et al. 2008. Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and β-arrestin1. Oncogene 27:1629-38
-
(2008)
Oncogene
, vol.27
, pp. 1629-1638
-
-
Vasilcanu, R.1
Vasilcanu, D.2
Rosengren, L.3
Natalishvili, N.4
Sehat, B.5
-
215
-
-
0242413155
-
Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle: Implications on decreased myocardial protection in diabetic cardiomyopathy
-
Shan YX, Yang TL, Mestril R,Wang PH. 2003. Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle: implications on decreased myocardial protection in diabetic cardiomyopathy. J. Biol. Chem. 278:45492-98
-
(2003)
J. Biol. Chem
, vol.278
, pp. 45492-45498
-
-
Shan, Y.X.1
Yang, T.L.2
Mestril, R.3
Wang, P.H.4
-
216
-
-
33845998883
-
Regulation of IGF-I receptor signaling in diabetic cardiac muscle: Dysregulation of cytosolic and mitochondria HSP60
-
Lai HC, Liu TJ, Ting CT, Yang JY, Huang L, et al. 2007. Regulation of IGF-I receptor signaling in diabetic cardiac muscle: dysregulation of cytosolic and mitochondria HSP60. Am. J. Physiol. Endocrinol. Metab. 292:E292-97
-
(2007)
Am. J. Physiol. Endocrinol. Metab
, vol.292
-
-
Lai, H.C.1
Liu, T.J.2
Ting, C.T.3
Yang, J.Y.4
Huang, L.5
-
217
-
-
33847716712
-
Negative regulation of TGF-beta receptor/Smad signal transduction
-
Itoh S, ten Dijke P. 2007. Negative regulation of TGF-beta receptor/Smad signal transduction. Curr. Opin. Cell Biol. 19:176-84
-
(2007)
Curr. Opin. Cell Biol
, vol.19
, pp. 176-184
-
-
Itoh, S.1
ten Dijke, P.2
-
218
-
-
41349120730
-
Transforming growth factor-β signaling and ubiquitinators in cancer
-
Glasgow E, Mishra L. 2008. Transforming growth factor-β signaling and ubiquitinators in cancer. Endocrinol. Relat. Cancer 15:59-72
-
(2008)
Endocrinol. Relat. Cancer
, vol.15
, pp. 59-72
-
-
Glasgow, E.1
Mishra, L.2
-
219
-
-
0036670339
-
Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-β receptor activity
-
Inman GJ, Nicolas FJ, Hill CS. 2002. Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-β receptor activity. Mol. Cell 10:283-94
-
(2002)
Mol. Cell
, vol.10
, pp. 283-294
-
-
Inman, G.J.1
Nicolas, F.J.2
Hill, C.S.3
-
220
-
-
2342488852
-
New insights into TGF-β-Smad signalling
-
ten Dijke P, Hill CS. 2004. New insights into TGF-β-Smad signalling. Trends Biochem. Sci. 29:265-73
-
(2004)
Trends Biochem. Sci
, vol.29
, pp. 265-273
-
-
ten Dijke, P.1
Hill, C.S.2
-
221
-
-
44649163272
-
The type I TGF-β receptor is covalently modified and regulated by sumoylation
-
Kang JS, Saunier EF, Akhurst RJ, Derynck R. 2008. The type I TGF-β receptor is covalently modified and regulated by sumoylation. Nat. Cell Biol. 10:654-64
-
(2008)
Nat. Cell Biol
, vol.10
, pp. 654-664
-
-
Kang, J.S.1
Saunier, E.F.2
Akhurst, R.J.3
Derynck, R.4
-
222
-
-
0032483418
-
Differential requirement for type I and type II transforming growth factor β receptor kinase activity in ligand-mediated receptor endocytosis
-
Anders RA, Dore JJ Jr, Arline SL, Garamszegi N, Leof EB. 1998. Differential requirement for type I and type II transforming growth factor β receptor kinase activity in ligand-mediated receptor endocytosis. J. Biol. Chem. 273:23118-25
-
(1998)
J. Biol. Chem
, vol.273
, pp. 23118-23125
-
-
Anders, R.A.1
Dore Jr, J.J.2
Arline, S.L.3
Garamszegi, N.4
Leof, E.B.5
-
223
-
-
20944435641
-
Transcriptional induction of Smurf2 ubiquitin ligase by TGF-β
-
Ohashi N, Yamamoto T, Uchida C, Togawa A, Fukasawa H, et al. 2005. Transcriptional induction of Smurf2 ubiquitin ligase by TGF-β. FEBS Lett. 579:2557-63
-
(2005)
FEBS Lett
, vol.579
, pp. 2557-2563
-
-
Ohashi, N.1
Yamamoto, T.2
Uchida, C.3
Togawa, A.4
Fukasawa, H.5
-
224
-
-
0038363366
-
Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-β signaling by Smad7
-
Tajima Y, Goto K, Yoshida M, Shinomiya K, Sekimoto T, et al. 2003. Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-β signaling by Smad7. J. Biol. Chem. 278:10716-21
-
(2003)
J. Biol. Chem
, vol.278
, pp. 10716-10721
-
-
Tajima, Y.1
Goto, K.2
Yoshida, M.3
Shinomiya, K.4
Sekimoto, T.5
-
225
-
-
34548238145
-
Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation
-
Levy L, Howell M, Das D, Harkin S, Episkopou V, Hill CS. 2007. Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Mol. Cell Biol. 27:6068-83
-
(2007)
Mol. Cell Biol
, vol.27
, pp. 6068-6083
-
-
Levy, L.1
Howell, M.2
Das, D.3
Harkin, S.4
Episkopou, V.5
Hill, C.S.6
-
226
-
-
34547108879
-
Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-β signaling
-
Nagano Y, Mavrakis KJ, Lee KL, Fujii T, Koinuma D, et al. 2007. Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-β signaling. J. Biol. Chem. 282:20492-501
-
(2007)
J. Biol. Chem
, vol.282
, pp. 20492-20501
-
-
Nagano, Y.1
Mavrakis, K.J.2
Lee, K.L.3
Fujii, T.4
Koinuma, D.5
-
227
-
-
33947280935
-
Arkadia enhances Nodal/TGF-β signaling by coupling Phospho-Smad2/3 activity and turnover
-
Mavrakis KJ, Andrew RL, Lee KL, Petropoulou C, Dixon JE, et al. 2007. Arkadia enhances Nodal/TGF-β signaling by coupling Phospho-Smad2/3 activity and turnover. PLoS Biol. 5:e67
-
(2007)
PLoS Biol
, vol.5
-
-
Mavrakis, K.J.1
Andrew, R.L.2
Lee, K.L.3
Petropoulou, C.4
Dixon, J.E.5
-
228
-
-
0042858169
-
Differential ubiquitination defines the functional status of the tumor suppressor Smad4
-
Moren A, Hellman U, Inada Y, Imamura T, Heldin CH, Moustakas A. 2003. Differential ubiquitination defines the functional status of the tumor suppressor Smad4. J. Biol. Chem. 278:33571-82
-
(2003)
J. Biol. Chem
, vol.278
, pp. 33571-33582
-
-
Moren, A.1
Hellman, U.2
Inada, Y.3
Imamura, T.4
Heldin, C.H.5
Moustakas, A.6
-
229
-
-
0041731797
-
SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4
-
Lin X, Liang M, Liang YY, Brunicardi FC, Feng XH. 2003. SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4. J. Biol. Chem. 278:31043-48
-
(2003)
J. Biol. Chem
, vol.278
, pp. 31043-31048
-
-
Lin, X.1
Liang, M.2
Liang, Y.Y.3
Brunicardi, F.C.4
Feng, X.H.5
-
230
-
-
0042867243
-
Sumoylation of Smad4, the common Smad mediator of transforming growth factor-β family signaling
-
Lee PS, Chang C, Liu D, Derynck R. 2003. Sumoylation of Smad4, the common Smad mediator of transforming growth factor-β family signaling. J. Biol. Chem. 278:27853-63
-
(2003)
J. Biol. Chem
, vol.278
, pp. 27853-27863
-
-
Lee, P.S.1
Chang, C.2
Liu, D.3
Derynck, R.4
-
231
-
-
0141557542
-
Regulation of transforming growth factor-β signaling by protein inhibitor of activated STAT, PIASy through Smad3
-
Imoto S, Sugiyama K, Muromoto R, Sato N, Yamamoto T, Matsuda T. 2003. Regulation of transforming growth factor-β signaling by protein inhibitor of activated STAT, PIASy through Smad3. J. Biol. Chem. 278:34253-58
-
(2003)
J. Biol. Chem
, vol.278
, pp. 34253-34258
-
-
Imoto, S.1
Sugiyama, K.2
Muromoto, R.3
Sato, N.4
Yamamoto, T.5
Matsuda, T.6
-
232
-
-
34447522128
-
Cell phenotype-specific down-regulation of Smad3 involves decreased gene activation as well as protein degradation
-
Poncelet AC, Schnaper HW, Tan R, Liu Y, Runyan CE. 2007. Cell phenotype-specific down-regulation of Smad3 involves decreased gene activation as well as protein degradation. J. Biol. Chem. 282:15534-40
-
(2007)
J. Biol. Chem
, vol.282
, pp. 15534-15540
-
-
Poncelet, A.C.1
Schnaper, H.W.2
Tan, R.3
Liu, Y.4
Runyan, C.E.5
-
233
-
-
0141629679
-
Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases
-
Penela P, Ribas C, Mayor F Jr. 2003. Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal 15:973-81
-
(2003)
Cell Signal
, vol.15
, pp. 973-981
-
-
Penela, P.1
Ribas, C.2
Mayor Jr., F.3
-
234
-
-
0042707658
-
MAPK-dependent degradation of G protein-coupled receptor kinase 2
-
Elorza A, Penela P, Sarnago S, Mayor F Jr. 2003. MAPK-dependent degradation of G protein-coupled receptor kinase 2. J. Biol. Chem. 278:29164-73
-
(2003)
J. Biol. Chem
, vol.278
, pp. 29164-29173
-
-
Elorza, A.1
Penela, P.2
Sarnago, S.3
Mayor Jr., F.4
-
235
-
-
33750208522
-
Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2
-
Salcedo A, Mayor F Jr, Penela P. 2006. Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. EMBO J. 25:4752-62
-
(2006)
EMBO J
, vol.25
, pp. 4752-4762
-
-
Salcedo, A.1
Mayor Jr, F.2
Penela, P.3
-
236
-
-
12144266330
-
Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation
-
5:1165-70
-
Citri A,GanJ, Mosesson Y,Vereb G, Szollosi J,Yarden Y. 2004. Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation. EMBO Rep. 5:1165-70
-
(2004)
EMBO Rep
-
-
Citri, A.1
Gan, J.2
Mosesson, Y.3
Vereb, G.4
Szollosi, J.5
Yarden, Y.6
-
237
-
-
33744931946
-
Hsp90 recognizes a common surface on client kinases
-
Citri A, Harari D, Shohat G, Ramakrishnan P, Gan J, et al. 2006. Hsp90 recognizes a common surface on client kinases. J. Biol. Chem. 281:14361-69
-
(2006)
J. Biol. Chem
, vol.281
, pp. 14361-14369
-
-
Citri, A.1
Harari, D.2
Shohat, G.3
Ramakrishnan, P.4
Gan, J.5
-
238
-
-
15544372341
-
Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex
-
Xu W, Yuan X, Xiang Z, Mimnaugh E, Marcu M, Neckers L. 2005. Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex. Nat. Struct. Mol. Biol. 12:120-26
-
(2005)
Nat. Struct. Mol. Biol
, vol.12
, pp. 120-126
-
-
Xu, W.1
Yuan, X.2
Xiang, Z.3
Mimnaugh, E.4
Marcu, M.5
Neckers, L.6
-
239
-
-
9644280977
-
Cooperation of molecular chaperones with the ubiquitin/proteasome system
-
Esser C, Alberti S, Hohfeld J. 2004. Cooperation of molecular chaperones with the ubiquitin/proteasome system. Biochim. Biophys. Acta 1695:171-88
-
(2004)
Biochim. Biophys. Acta
, vol.1695
, pp. 171-188
-
-
Esser, C.1
Alberti, S.2
Hohfeld, J.3
-
240
-
-
85047695528
-
Hsp-90-associated oncoproteins: Multiple targets of geldanamycin and its analogs
-
Blagosklonny MV. 2002. Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs. Leukemia 16:455-62
-
(2002)
Leukemia
, vol.16
, pp. 455-462
-
-
Blagosklonny, M.V.1
-
241
-
-
0037107454
-
Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes
-
Lange BM, Rebollo E, Herold A, Gonzalez C. 2002. Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes. EMBO J. 21:5364-74
-
(2002)
EMBO J
, vol.21
, pp. 5364-5374
-
-
Lange, B.M.1
Rebollo, E.2
Herold, A.3
Gonzalez, C.4
-
242
-
-
0036500652
-
C/EBPalpha triggers proteasomedependent degradation of cdk4 during growth arrest
-
Wang H, Goode T, Iakova P, Albrecht JH, Timchenko NA. 2002. C/EBPalpha triggers proteasomedependent degradation of cdk4 during growth arrest. EMBO J. 21:930-41
-
(2002)
EMBO J
, vol.21
, pp. 930-941
-
-
Wang, H.1
Goode, T.2
Iakova, P.3
Albrecht, J.H.4
Timchenko, N.A.5
-
243
-
-
0037195907
-
Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome
-
Alberti S, Demand J, Esser C, Emmerich N, Schild H, Hohfeld J. 2002. Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome. J. Biol. Chem. 277:45920-27
-
(2002)
J. Biol. Chem
, vol.277
, pp. 45920-45927
-
-
Alberti, S.1
Demand, J.2
Esser, C.3
Emmerich, N.4
Schild, H.5
Hohfeld, J.6
-
244
-
-
0035899897
-
Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling
-
Demand J, Alberti S, Patterson C, Hohfeld J. 2001. Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling. Curr. Biol. 11:1569-77
-
(2001)
Curr. Biol
, vol.11
, pp. 1569-1577
-
-
Demand, J.1
Alberti, S.2
Patterson, C.3
Hohfeld, J.4
-
245
-
-
0034745354
-
Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth
-
Song J, Takeda M, Morimoto RI. 2001. Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nat. Cell Biol. 3:276-82
-
(2001)
Nat. Cell Biol
, vol.3
, pp. 276-282
-
-
Song, J.1
Takeda, M.2
Morimoto, R.I.3
-
246
-
-
0029937303
-
Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1
-
Wang HG, Takayama S, Rapp UR, Reed JC. 1996. Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc. Natl. Acad. Sci. USA 93:7063-68
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 7063-7068
-
-
Wang, H.G.1
Takayama, S.2
Rapp, U.R.3
Reed, J.C.4
-
247
-
-
21744438271
-
C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis
-
Hwang JR, Zhang C, Patterson C. 2005. C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis. Cell Stress Chaperones 10:147-56
-
(2005)
Cell Stress Chaperones
, vol.10
, pp. 147-156
-
-
Hwang, J.R.1
Zhang, C.2
Patterson, C.3
-
248
-
-
33845975299
-
Down-regulation of the mixed-lineage dual leucine zipper-bearing kinase by heat shock protein 70 and its cochaperone CHIP
-
Daviau A, Proulx R, Robitaille K, Di Fruscio M, Tanguay RM, et al. 2006. Down-regulation of the mixed-lineage dual leucine zipper-bearing kinase by heat shock protein 70 and its cochaperone CHIP. J. Biol. Chem. 281:31467-77
-
(2006)
J. Biol. Chem
, vol.281
, pp. 31467-31477
-
-
Daviau, A.1
Proulx, R.2
Robitaille, K.3
Di Fruscio, M.4
Tanguay, R.M.5
-
249
-
-
36749010218
-
The age of crosstalk: Phosphorylation, ubiquitination, and beyond
-
Hunter T. 2007. The age of crosstalk: phosphorylation, ubiquitination, and beyond. Mol. Cell 28:730-38
-
(2007)
Mol. Cell
, vol.28
, pp. 730-738
-
-
Hunter, T.1
-
250
-
-
0032523919
-
Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway
-
Dai Z, Quackenbush RC, Courtney KD, Grove M, Cortez D, et al. 1998. Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. Genes Dev. 12:1415-24
-
(1998)
Genes Dev
, vol.12
, pp. 1415-1424
-
-
Dai, Z.1
Quackenbush, R.C.2
Courtney, K.D.3
Grove, M.4
Cortez, D.5
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