Ubiquitin-mediated proteolysis of vertebrate G1- and S-phase regulators

Journal of Cellular Physiology

Volumn 187, Issue 1, 2001, Pages 1-10

  Renee Yew, P ^a  

^a University of Texas Health Science Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 6; CYCLIN A; CYCLIN D; CYCLIN DEPENDENT KINASE; CYCLIN E; DNA; GEMININ; PROTEIN P19; PROTEIN P21; PROTEIN P27; PROTEIN P57; REGULATOR PROTEIN; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG;

CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; DNA REPLICATION; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATOR GENE; REVIEW; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

ANIMALS; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA REPLICATION; G1 PHASE; S PHASE; UBIQUITINS; YEASTS;

EUKARYOTA; VERTEBRATA;

EID: 0035123105     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4652(2001)9999:9999<1::AID-JCP1049>3.0.CO;2-O     Document Type: Review

References (137)

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10. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
11. Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21
12. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
13. The p21(Cip1) and p27(Kip1) CDK "inhibitors" are essential activators of cyclin D-dependent kinases in murine fibroblasts
14. Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation
15. Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle
16. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts
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19. Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E
20. Review: Nuclear structure and DNA replication
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31. Phosphorylation controls timing of Cdc6p destruction: A biochemical analysis
32. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p
33. Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex
34. Cell cycle regulation of DNA replication initiation proteins in mammalian cells
35. Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism
36. Transcriptional regulation of the p21(WAF1/CIP1) gene
37. Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286
38. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts
39. The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme
40. Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4
41. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
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44. Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast
45. The ubiquitin system
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47. The Saccharomyces cerevisiae ubiquitin-proteasome system
48. The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway
49. Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2
50. Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation
51. The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex
52. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
53. Role of E2F in cell cycle control and cancer
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55. Redundant cyclin overexpression and gene amplification in breast cancer cells
56. How the cyclin became a cyclin: Regulated proteolysis in the cell cycle
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58. Modes of regulation of ubiquitin-mediated protein degradation
59. Proteolysis and the G1-S transition: The SCF connection
60. Induction of G1 arrest and selective growth inhibition by lactacystin in human umbilical vein endothelial cells
61. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution
62. Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage
63. Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction
64. Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1
65. Detailed analysis of cell cycle kinetics upon proteasome inhibition
66. Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation
67. Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation
68. p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene
69. Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins
70. Geminin, an inhibitor of DNA replication, is degraded during mitosis
71. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
72. Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1)
73. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
74. Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome
75. Association with cullin partners protects ROC proteins from proteasome-dependent degradation
76. Human cyclin E, a nuclear protein essential for the G1-to-S phase transition
77. Cyclin A is required at two points in the human cell cycle
78. Combinatorial control in ubiquitin-dependent proteolysis: Don't Skp the F-box hypothesis
79. Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle
80. Subunits and substrates of the anaphase-promoting complex
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83. A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination
84. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
85. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
86. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
87. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts
88. Dynamics of proteasome distribution in living cells
89. Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer
90. The Cdc6 protein is ubiquitinated in vivo for proteolysis in Saccharomyces cerevisiae
91. The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae
92. Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34
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94. Multiple functions of p27(Kip1) and its alterations in tumor cells: A review
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96. Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination
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100. CDK inhibitors: Positive and negative regulators of G1-phase progression
101. In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal
102. Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing
103. Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells
104. Regulation of the cdk inhibitor p27 and its deregulation in cancer
105. Deregulated cyclin E induces chromosome instability
106. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis
107. p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells
108. Ubiquitin/proteasome-mediated degradation of p19INK4d determines its periodic expression during the cell cycle
109. Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors
110. Two distinct ubiquitin-proteolysis pathways in the fission yeast cell cycle
111. Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1
112. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
113. p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27
114. Proteolysis and the cell cycle: With this RING I do thee destroy
115. The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation
116. p57(Kip2) is degraded through the proteasome in osteoblasts stimulated to proliferation by transforming growth factor beta1
117. Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase
118. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
119. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
120. Role of proteasomes in T cell activation and proliferation
121. Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E
122. Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen
123. SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis
124. Culprits in the degradation of cyclin E apprehended
125. Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E
126. p21 is a universal inhibitor of cyclin kinases
127. p34Cdc28-mediated control of Cln3 cyclin degradation
128. Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2
129. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells
130. Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development
131. Ubiquitin-like proteins: New wines in new bottles
132. Proteolysis and DNA replication: The CDC34 requirement in the Xenopus egg cell cycle
133. Human CUL-associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins
134. p21-containing cyclin kinases exist in both active and inactive states
135. p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase
136. p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step
137. Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases