Cell phenotype-specific down-regulation of Smad3 involves decreased gene activation as well as protein degradation

Journal of Biological Chemistry

Volumn 282, Issue 21, 2007, Pages 15534-15540

  Poncelet, Anne Christine ^a,b   Schnaper, H William ^b   Tan, Ruoyun ^c   Liu, Youhua ^c   Runyan, Constance E ^b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

E-CADHERIN; ENDOGENOUS SMAD3; PROTEASOME MACHINERY; SMAD3 EXPRESSION; UBIQUITINATION;

DEGRADATION; ENZYME INHIBITION; FIBROBLASTS; GENE EXPRESSION; PROTEINS; RNA; SIGNAL TRANSDUCTION;

GENETIC ENGINEERING;

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ALPHA SMOOTH MUSCLE ACTIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; MESSENGER RNA; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN; UVOMORULIN; ACTIN; CADHERIN; SMAD2 PROTEIN, HUMAN; SMAD2 PROTEIN, MOUSE; SMAD3 PROTEIN, HUMAN; SMAD3 PROTEIN, MOUSE; SMAD4 PROTEIN, HUMAN; SMAD4 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; GENE ACTIVATION; GENE CONTROL; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KIDNEY FIBROSIS; MALE; MESANGIUM CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; RAT; SPRAGUE DAWLEY RAT; UPREGULATION; URETER OBSTRUCTION; WESTERN BLOTTING; ANIMAL; ANTIBODY SPECIFICITY; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; FIBROSIS; KIDNEY TUBULE; METABOLISM; MOUSE; PATHOLOGY; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TIME;

ACTINS; ANIMALS; CADHERINS; CELLS, CULTURED; DOWN-REGULATION; EPITHELIAL CELLS; FIBROSIS; HUMANS; KIDNEY TUBULES; MALE; MESANGIAL CELLS; MICE; ORGAN SPECIFICITY; PHENOTYPE; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN; UP-REGULATION;

EID: 34447522128     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M701991200     Document Type: Article

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