Activation of protein kinase C triggers its ubiquitination and degradation

Molecular and Cellular Biology

Volumn 18, Issue 2, 1998, Pages 839-845

  Lu, Zhimin ^a   Liu, David ^b   Hornia, Armand ^a   Devonish, Wayne ^a   Pagano, Michele ^b   Foster, David A ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEINASE; UBIQUITIN;

ANIMAL CELL; ARTICLE; CANCER PREVENTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; FIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS REGULATION; RAT; TRANSCRIPTION REGULATION;

EID: 0031907117     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.2.839     Document Type: Article

References (19)

1. Avantaggiati, M. L., M. Carbone, A. Graessmann, Y. Nakatani, B. Howard, and A. S. Levine. 1996. The SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional co-activator, p300. EMBO J. 15:2236-2248.
2. Ha gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C δ. J. Biol. Chem. 268:26079-26081.
3. Dingiovanni, J. 1992. Multistage carcinogenesis in mouse skin. Pharmacol. Ther. 54:63-128.
4. Gschwendt, M., H.-J. Muller, K. Kielbassa, R. Zang, W. Kittstein, G. Rincke, and F. Marks. 1994. Rottlerin, a novel protein kinase inhibitor. Biochem. Biophys. Res. Commun. 199:63-98.
5. Johnston, R. N., J. Feder, A. B. Hill, S. W. Sherwood, and R. T. Schimke. 1986. Transient inhibition of DNA synthesis results in increased dihydrofolate reductase synthesis and subsequent increased DNA content per cell. Mol. Cell. Biol. 6:3373-3381.
6. Lee, H. W., L. Smith, G. R. Pettit, A. Vinitsky, and J. B. Smith. 1996. Ubiquitination of protein kinase C-α and degradation by the proteasome. J. Biol. Chem. 271:20973-20976.
7. Lu, Z., A. Hornia, Y.-W. Jiang, Q. Zang, and D. A. Foster. 1997 Tumor-promotion by depleting cells of protein kinase C δ. Mol. Cell Biol. 17:3418-3428.
8. Martiny-Baron, G., M. G. Kazanietz, H. Mischak, P. M. Blumberg, G. Kochs, H. Hug, D. Marme, and C. Schlachtele. 1993. Selective inhibition of protein kinase C isozymes by the indolocarbazole G0 6976. J. Biol. Chem. 268:9194-9197.
9. Nishizuka, Y. 1995. Protein kinases 5: protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9:484-496.
10. Pagano, M., S. W. Tam, A. M. Theodoras, P. Beer-Romero, G. Del Sal, V. Chau, P. R. Yew, G. F. Draetta, and M. Rolfe. 1995 Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269:682-685.
11. Palombella, V., O. Rando, A. Goldberg, and T. Maniatis. 1994. The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and activation of NF-κB. Cell 78:773-785.
12. Rock, K. L., C. Gramm, L. Rothstein, K. Clark, R. Stein, L. Dick, D. Hwang, and A. L. Goldberg. 1994. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761-771.
13. Rolfe, M., M. I. Chiu, and M. Pagano. 1997. The ubiquitin-mediated proteolitic pathway as a therapeutic area. J. Mol. Med. 75:5-17.
14. Suzuki, A., O. Kozawa, and K. Kato. 1996. Protein kinase C activation inhibits stress-induced synthesis of heat shock protein 27 in osteoblast-like cells: function of arachidonic acid. J. Cell. Biochem. 62:69-75.
15. Ueda, Y., S. Hirai, S. Osada, A. Suzuku, K. Mizuno, and S. Ohno. 1996. Protein kinase C δ activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J. Biol. Chem. 271:23512-23519.
16. Young, S., P. J. Parker, A. Ulrich, and S. Stabel. 1987. Down-regulation of protein kinase C is due to an increased rate of degradation. Biochem. J. 244:711-717.
17. Yupsa, S. H., M. C. Poirier. 1988. Chemical carcinogenesis: from animal models to molecular models in one decade. Adv. Cancer. Res. 50:25-70.
18. Zang, Q., P. Frankel, and D. A. Foster. 1995. Selective activation of protein kinase C isoforms by v-Src. Cell Growth Differ. 6:1367-1373.
19. Zang, Q., Z. Lu, M. Curto, N. Barile, D. Shalloway, and D. A. Foster. 1997. Interaction between v-Src and protein kinase C δ in v-Src-transformed fibroblasts. J. Biol. Chem. 272:13275-13280.