Tumor promotion by depleting cells of protein kinase Cδ

Molecular and Cellular Biology

Volumn 17, Issue 6, 1997, Pages 3418-3428

  Lu, Zhimin ^a   Hornia, Armand ^a   Jiang, You Wei ^a,c   Zang, Qun ^a   Ohno, Shigeo ^b   Foster, David A ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHORBOL ESTER; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL MUTANT; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; FIBROBLAST; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; PROTO ONCOGENE; RAT; TUMOR PROMOTION;

ANIMALIA;

EID: 0030987327     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.17.6.3418     Document Type: Article

References (46)

1. Borner, C., M. Ueffing, S. Jaken, P. J. Parker, and I. B. Weinstein. 1995. Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. J. Biol. Chem. 270:78-86.
2. Chin, J. E., M. Dickens, J. M. Tavare, and R. A. Roth. 1993. Overexpression of protein kinase C isoenzymes α, βI, γ, and ε in cells overexpressing the insulin receptor. J. Biol. Chem. 268:6338-6347.
3. c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets. Mol. Cell. Biol. 13:1863-1871.
4. Couldwell, W. T., D. R. Hinton, S. He, T. C. Chen, I. Sebat, M. H. Weiss, and R. E. Law. 1994. Protein kinase C inhibitors induce apoptosis in human malignant glioma cells. FEBS Lett. 345:43-46.
5. Daub, H., F. U. Weiss, C. Wallasch, and A. Ullrich. 1996. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 379:557-560.
6. Decker, S. J. 1984. Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts. Mol. Cell. Biol. 4:1718-1724.
7. Decker, S. J. 1993. Transmembrane signaling by epidermal growth factor receptors lacking autophosphorylation sites. J. Biol. Chem. 268:9176-9179.
8. Ha gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C δ. J. Biol. Chem. 268:26079-26081.
9. Denning, M. F., A. A. Dlugosz, D. W. Threadgill, T. Magnuson, and S. H. Yuspa. 1996. Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C δ. J. Biol. Chem. 271:5325-5331.
10. Dingiovanni, J. 1992. Multistage carcinogenesis in mouse skin. Pharmacol. Ther. 54:63-128.
11. Downward, J., M. D. Waterfield, and P. J. Parker. 1985. Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity. J. Biol. Chem. 260:14538-14546.
12. Friedman, B., A. R. Frackelton, A. H. Ross, J. M. Connors, H. Fujiki, T. Sugimora, and M. R. Rosner. 1984. Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor. Proc. Natl. Acad. Sci. USA 81:3034-3038.
13. Gschwendt, M., H.-J. Muller, K. Kielbassa, R. Zang, W. Kittstein, G. Rincke, and F. Marks. 1994. Rottlerin, a novel protein kinase inhibitor. Biochem. Biophys. Res. Commun. 199:63-98.
14. Hennings, H., P. M. Blumberg, G. R. Pettit, C. L. Herald, R. Shores, and S. H. Yuspa. 1987. Bryostatin 1, an activator of protein kinase C. inhibits tumor promotion by phorbol esters in SENCAR mouse skin. Carcinogenesis 8:1343-1346.
15. Hill, T. D., N. M. Dean, L. J. Mordan, A. F. Lau, M. Y. Kanemitsu, and A. L. Boynton. 1990. PDGF-induced activation of phospholipase C is not required for induction of DNA synthesis. Science 248:1660-1663.
16. Hirai, S., Y. Izumi, K. Higa, K. Kaibuchi, K. Mizuno, S. Osada, K. Suzuki, and S. Ohno. 1994. Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKCδ. EMBO J. 13:2331-2340.
17. Jarvis, W. D., A. J. Turner, L. F. Porvik, R. S. Traylor, and S. Grant. 1994. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res. 54:1707-1714.
18. Jiang, H., J.-Q. Luo, T. Urano, Z. Lu, D. A. Foster, and L. Feig. 1995. Involvement of Ral GTPase in v-Src-induced phospholipase D activation. Nature 378:409-412.
19. Joseph, C. K., S. A. Qureshi, D. W. Wallace, and D. A. Foster. 1992. MARCKS protein is transcriptionally down-regulated in v-Src-transformed BALB/c 3T3 cells. J. Biol. Chem. 267:1327-1330.
20. Li, W., H. Miachak, J.-C. Yu, L.-M. Wang, J. F. Mushinski, M. A. Heidaran, and J. H. Pierce. 1994. Tyrosine phosphorylation of protein kinase C-δ in response to its activation. J. Biol. Chem. 269:2349-2352.
21. Li, W., J.-C. Yu, D.-Y. Shin, and J. H. Pierce. 1995. Characterization of a protein kinase C-δ (PKC δ) ATP-binding mutant. An inactive enzyme that competitively inhibits wild type PKC δ enzymatic activity. J. Biol. Chem. 270:8311-8318.
22. Liao, L., K. Ramsey, and S. Jaken. 1994. Protein kinase C isozymes in progressively transformed rat fibroblasts. Cell Growth Differ. 5:1185-1194.
23. Martiny-Baron, G., M. G. Kazanietz, H. Mischak, P. M. Blumberg, G. Kochs, H. Hug, D. Marme, and C. Schiachtele. 1993. Selective inhibition of protein kinase C isozymes by the indolocarbazole GO 6976. J. Biol. Chem. 268:9194-9197.
24. McCaffrey, P. G., B. Friedman, and M. R. Rosner. 1984. Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor. J. Biol. Chem. 259:12502-12507.
25. Mischak, H., J. Goodnight, W. Kolch, G. Martiny-Baron, C. Schaechtle, M. G. Kazanietz, P. M. Blumberg, J. H. Pierce, and J. F. Mushinski. 1993. Overexpression of protein kinase C-δ and -ε in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J. Biol. Chem. 268:6090-6096.
26. Mohammadi, M., C. A. Dionne, W. Li, N. Li, T. Spivak, A. M. Honneger, M. Jaye, and J. Schlessinger. 1992. Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Nature 358: 681-684.
27. Nishizuka, Y. 1995. Protein kinases 5: protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9:484-496.
28. Noh, D. Y., S. H. Shin, and S. G. Rhee. 1995. Phosphinositide-specific phospholipase C and mitogenic signaling. Biochim. Biophys. Acta 1242:99-113.
29. 2+ flux but not mitogenesis. Nature 358:678-681.
30. Peterson, J. E., T. Jelinek, M. Kaleko, K. Siddle, and M. J. Weber. 1994. C phosphorylation and activation of the IGF-I receptor in src-transformed cells. J. Biol. Chem. 269:27315-27321.
31. Qureshi, S. A., C. K. Joseph, M.-H. Rim, A. Maroney, and D. A. Foster. 1991. v-Src activates both protein kinase C-dependent and independent signaling pathways in murine fibroblasts. Oncogene 6:995-999.
32. Qureshi, S. A., C. K. Joseph, R. Gupta, M. Hendrickson, J. Song, J. Bruder, U. R. Rapp, and D. A. Foster. 1993. A dominant-negative Raf-1 mutant prevents v-Src-induced transformation. Biochem. Biophys. Res. Commun. 192:969-975.
33. Seedorf, K., M. Shearman, and A. Ullrich. 1995. Rapid and long term effects of protein kinase C on receptor tyrosine kinase phosphorylation and degradation. J. Biol. Chem. 270:18953-18960.
34. Singer, W. D., H. A. Brown, X. Jiang, and P. C. Sternweis. 1996. Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity. J. Biol. Chem. 271:4504-4510.
35. Song, J., L. M. Pfeffer and D. A. Foster. 1991. v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine. Mol. Cell. Biol. 11:4903-4908.
36. Song, J., and D. A. Foster. 1993. v-Src activates a phospholipase D activity that is distinguishable from phospholipase D activity activated by protein kinase C. Biochem. J. 294:711-717.
37. Spangler, R., C. K. Joseph, S. A. Qureshi, K. B. Berg, and D. A. Foster. 1989. Evidence that v-src and v-fps use protein kinase C-mediated pathway to induce expression of a transformation-related gene. Proc. Natl. Acad. Sci. USA 86:7017-7021.
38. Szallasi, Z., C. B. Smith, G. R. Pettit, and P. M. Blumberg. 1994. Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. J. Biol. Chem. 269:2118-2124.
39. Szallasi, Z., M. F. Denning, C. B. Smith, A. A. Dlugosz, S. H. Yuspa, G. R. Pettit, and P. M. Blumberg. 1994. Bryostatin 1 protects protein kinase C-δ from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation. Mol. Pharmacol. 46:840-850
40. Toullec, D., P. Pianetti, H. Coste, P. Bellevergue, T. Grand-Perret, M. Ajakane, V. Baudet, P. Boissin, E. Boursier, F. Loriolle, L. Duhamel, D. Charon, and J. Kirilovsky. 1991. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266:15771-15781.
41. Valius, M., C. Bazenet, and A. Kazlauskas. 1993. Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor β subunit and are required for binding of phospholipase Cγ and a 64-kilodalton protein, respectively. Mol. Cell. Biol. 13:133-143.
42. Wasilenko, W. J., D. M. Payne, D. L. Fitzgerald, and M. J. Weber. 1991. Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogene. Mol. Cell. Biol. 11:309-321.
43. Young, S., P. J. Parker, A. Ullrich, and S. Stabel. 1987. Down-regulation of protein kinase C is due to an increased rate of degradation. Biochem. J. 244:711-717.
44. Yuspa, S. H., and M. C. Poirier. 1988. Chemical carcinogenesis: from animal models to molecular models in one decade. Adv. Cancer Res. 50:25-70
45. Zang, Q., P. Frankel, and D. A. Foster. 1995. Selective activation of protein kinase C isoforms by v-Src. Cell Growth Differ. 6:1367-1373.
46. Zang, Q., Z. Lu, M. Curto, N. Barile, D. Shalloway, and D. A. Foster. Interaction between v-Src and protein kinase C δ in v-Src-transformed fibroblasts. J. Biol. Chem., in press.