Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway

Current Biology

Volumn 11, Issue 22, 2001, Pages 1759-1765

  Echarri, Asier ^a   Pendergast, Ann Marie ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CERCOPITHECUS;

EID: 0035856481     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00538-3     Document Type: Article

References (21)

1. Cycling, stressed-out and nervous: Cellular functions of c-Abl
2. From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility
3. Activation of the cytoplasmic c-Abl tyrosine kinase by reactive oxygen species
4. Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents
5. Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport
6. c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF
7. N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-Abl
8. Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential
9. Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor
10. Oncogenic activation of c-Abl by mutation within its last exon
11. Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway
12. Introduction of a loss-of-function point mutation from the SH3 region of the Caenorhabditis elegans sem-5 gene activates the transforming ability of c-abl in vivo and abolishes binding of proline-rich ligands in vitro
13. An intramolecular SH3-domain interaction regulates c-Abl activity
14. c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines
15. Ubiquitin-dependent degradation of active Src
16. Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
17. The ubiquitin system
18. The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation
19. Ubiquitin-mediated degradation of active Src tyrosine kinase
20. Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase
21. Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation