Cbl associates with Pyk2 and Src to regulate Src kinase activity, αvβ3 integrin-mediated signaling, cell adhesion, and osteoclast motility

Journal of Cell Biology

Volumn 152, Issue 1, 2001, Pages 181-195

  Sanjay, Archana ^a   Houghton, Adam ^a   Neff, Lynn ^a   DiDomenico, Emilia ^a   Bardelay, Chantal ^b   Antoine, Evelyne ^b   Levy, Joan ^a   Gailit, James ^c   Bowtell, David ^d   Horne, William C ^a   Baron, Roland ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SANOFI   (France)

^c STONY BROOK UNIVERSITY   (United States)

^d PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

Cbl; Osteoclast; Pyk2; Src; Vitronectin receptor ( v 3)

Indexed keywords

BETA3 INTEGRIN; FOCAL ADHESION KINASE 2; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CELL ADHESION; CELL MOTILITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; MOUSE; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; PROTO ONCOGENE; SIGNAL TRANSDUCTION;

CALCIUM; CELL ADHESION; CELL LINE; CELL MOVEMENT; FOCAL ADHESION KINASE 2; HUMANS; MUTAGENESIS; OSTEOCLASTS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CBL; PROTO-ONCOGENE PROTEINS PP60(C-SRC); PSEUDOPODIA; RECEPTORS, VITRONECTIN; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA;

EID: 0035825121     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.152.1.181     Document Type: Article

References (55)

1. Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and association with CRK adaptor proteins
2. Leucine zipper-mediated homodimerization of the adaptor protein c-Cbl: A role in c-Cbl's tyrosine phosphorylation and its association with epidermal growth factor receptor
3. Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor α signaling cascade by transforming mutants of Cbl: Implications for Cbl's function and oncogenicity
4. The protooncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases
5. Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells
6. Transmembrane interactions at cell adhesion and invasion sites
7. Blocking monoclonal antibodies to αVβ3 integrin: A unique epitope of αVβ3 integrin is present on human osteoclasts
8. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
9. 3 integrin, and phosphorylated by Src kinase
10. The role of integrins in osteoclast function
11. Selective regulation of integrin-cytoskeleton interactions by the tyrosine kinase Src
12. Human fibroblasts bind directly to fibrinogen at RGD sites through integrin αVβ3
13. c-src in association with intracellular membranes
14. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
15. c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism
16. Cloning and characterization of cbl-b: A SH3 binding protein with homology to the c-cbl proto-oncogene
17. Cell migration: A physically integrated molecular process
18. 2+-induced regulation of ion channel and MAP kinase functions
19. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
20. The FAK-related kinase, Pyk2, is tyrosine phosphorylated in response to integrin stimulation in osteoclasts
21. Integrin-mediated signal transduction
22. Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts
23. Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis
24. Knockouts of Src-family kinases: Stiff bones, wimpy T cells, and bad memories
25. 292 negative regulatory phosphorylation site of ZAP-70
26. Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323
27. Tyrosine phosphorylation of the product of the c-cbl protooncogene is induced after integrin stimulation
28. Cell-substratum interaction of cultured avian osteoclasts is mediated by specific adhesion structures
29. Rous sarcoma virus-transformed fibroblasts and cells of monocytic origin display a peculiar dot-like organization of cytoskeletal proteins involved in microfilament-membrane interactions
30. 1 integrin signaling pathway involving Src-family kinases. Cbl and PI-3 kinase is required for macrophage spreading and migration
31. The Cbl protooncogene product: From an enigmatic oncogene to center stage of signal transduction
32. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice
33. Cell/substratum adhesions in RSV-transformed rat fibroblasts
34. A functional link between dynamin and the actin cytoskeleton at podosomes
35. cbl links c-Src and phosphatidylinositol 3′-kinase to the integrin signaling pathway
36. The product of the proto-oncogene c-cbl: A negative regulator of the Syk tyrosine kinase
37. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness
38. Physical and biochemical regulation of integrin release during rear detachment of migrating cells
39. Integrin function in osteoclasts
40. Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice
41. - cell migration
42. Impaired osteoclast function in Pyk2 knockout mice and cumulative effects in Pyk2/Src double knockout
43. Integrin-mediated calcium signaling and regulation of cell adhesion by intracellular calcium
44. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
45. Alpha-actinin-containing aggregates in transformed cells are highly dynamic structures
46. c-src, preferentially on ruffled border membranes
47. Tyrosine phosphorylation and translocation of the c-Cbl protein after activation of tyrosine kinase signaling pathways
48. c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption
49. Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes
50. Cellular functions regulated by Src family kinases
51. c-Cbl is transiently tyrosine-phosphorylated, ubiquitinated, and membrane-targeted following CSF-1 stimulation of macrophages
52. The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor
53. Crystal structures of c-Src reveal features of its autoinhibitory mechanism
54. Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7
55. Regulation of β1-integrin-mediated cell adhesion by the Cbl adaptor protein