Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex

Nature Structural and Molecular Biology

Volumn 12, Issue 2, 2005, Pages 120-126

  Xu, Wanping ^a   Yuan, Xitong ^a   Xiang, Zhexin ^b   Mimnaugh, Edward ^a   Marcu, Monica ^a   Neckers, Len ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; CYCLOHEXIMIDE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; MUTANT PROTEIN; PHOSPHOTRANSFERASE; BENZOQUINONE DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR; MACROCYCLIC LACTAM; MULTIPROTEIN COMPLEX; QUINONE DERIVATIVE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG SENSITIVITY; ELECTRIC POTENTIAL; HUMAN; HUMAN CELL; HYDROPHOBICITY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SURFACE PROPERTY; ANIMAL; CELL STRAIN COS1; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ELECTRICITY; GENETICS; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

ANIMALIA;

ANIMALS; BENZOQUINONES; CELL LINE, TUMOR; COS CELLS; ELECTROSTATICS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYDROPHOBICITY; LACTAMS, MACROCYCLIC; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; QUINONES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2;

EID: 15544372341     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb885     Document Type: Article

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