International union of basic and clinical pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family

Pharmacological Reviews

Volumn 61, Issue 2, 2009, Pages 119-161

  Ye, Richard D ^a   Boulay, François ^b,c,d   Ji, Ming Wang ^e   Dahlgren, Claes ^f   Gerard, Craig ^g   Parmentier, Marc ^h   Serhan, Charles N ⁱ   Murphy, Philip M ^j  

^a UNIVERSITY OF ILLINOIS   (United States)

^b CEA GRENOBLE   (France)

^c CNRS   (France)

^d UNIV GRENOBLE ALPES   (France)

^e NATIONAL CANCER INSTITUTE   (United States)

^f UNIVERSITY OF GOTHENBURG   (Sweden)

^g BOSTON CHILDREN S HOSPITAL   (United States)

^h UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

ⁱ BRIGHAM AND WOMEN S HOSPITAL   (United States)

^j NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; BETA ARRESTIN; CYCLOSPORIN H; FORMYLPEPTIDE RECEPTOR LIKE 1; LIPOCORTIN 1; PEPTIDE LIBRARY; PROTEIN KINASE C;

BINDING AFFINITY; CELL DISRUPTION; DEGRANULATION; DESENSITIZATION; DNA POLYMORPHISM; GENE CLUSTER; GENE EXPRESSION; GENE IDENTIFICATION; GENE SEQUENCE; HELICOBACTER PYLORI; MYCOBACTERIUM AVIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGOCYTE; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; REVIEW; STAPHYLOCOCCUS AUREUS; TISSUE DISTRIBUTION;

EID: 67649438808     PISSN: 00316997     EISSN: 15210081     Source Type: Journal    
DOI: 10.1124/pr.109.001578     Document Type: Review

References (401)

1. Abo A, Pick E, Hall A, Totty N, Teahan CG, and Segal AW (1991) Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1. Nature 353:668-670. (Pubitemid 21912587)
2. Agarwal S, Reynolds MA, Duckett LD, and Suzuki JB (1989) Altered free cytosolic calcium changes and neutrophil chemotaxis in patients with juvenile periodontitis. J Periodontal Res 24:149-154.
3. Ali H, Richardson RM, Haribabu B, and Snyderman R (1999) Chemoattractant receptor cross-desensitization. J Biol Chem 274:6027-6030. (Pubitemid 29111002)
4. Ali H, Richardson RM, Tomhave ED, Didsbury JR, and Snyderman R (1993) Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization. J Biol Chem 268:24247-24254. (Pubitemid 23335411)
5. Aliberti J, Hieny S, Reis e Sousa C, Serhan CN, and Sher A (2002a) Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity. Nat Immunol 3:76-82.
6. Aliberti J, Serhan C, and Sher A (2002b) Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection. J Exp Med 196:1253-1262. (Pubitemid 35304190)
7. Allen RA, Tolley JO, and Jesaitis AJ (1986) Preparation and properties of an improved photoaffinity ligand for the N-formyl peptide receptor. Biochim Biophys Acta 882:271-280. (Pubitemid 16044553)
8. Almkvist J, Dahlgren C, Leffler H, and Karlsson A (2004) Newcastle disease virus neuraminidase primes neutrophils for stimulation by galectin-3 and formyl-Met-Leu-Phe. Exp Cell Res 298:74-82. (Pubitemid 38887308)
9. Almkvist J, Fä ldt J, Dahlgren C, Leffler H, and Karlsson A (2001) Lipopolysaccharide-induced gelatinase granule mobilization primes neutrophils for activation by galectin-3 and formylmethionyl-Leu-Phe. Infect Immun 69:832-837.
10. Alvarez V, Coto E, Setién F, González-Roces S, and López-Larrea C (1996) Molecular evolution of the N-formyl peptide and C5a receptors in non-human primates. Immunogenetics 44:446-452. (Pubitemid 26336388)
11. Amatruda TT 3rd, Dragas-Graonic S, Holmes R, and Perez HD (1995) Signal transduction by the formyl peptide receptor. Studies using chimeric receptors and site-directed mutagenesis define a novel domain for interaction with G-proteins. J Biol Chem 270:28010-28013.
12. Amatruda TT 3rd, Steele DA, Slepak VZ, and Simon MI (1991) G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells. Proc Natl Acad Sci U S A 88:5587-5591.
13. Arcaro A and Wymann MP (1993) Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J 296:297-301.
14. Aruffo A and Seed B (1987) Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. Proc Natl Acad Sci U S A 84:8573-8577.
15. Aswanikumar S, Corcoran B, Schiffmann E, Day AR, Freer RJ, Showell HJ, and Becker EL (1977) Demonstration of a receptor on rabbit neutrophils for chemotactic peptides. Biochem Biophys Res Commun 74:810-817. (Pubitemid 8022277)
16. Babior BM, Lambeth JD, and Nauseef W (2002) The neutrophil NADPH oxidase. Arch Biochem Biophys 397:342-344. (Pubitemid 34852301)
17. Bae YS, Lee HY, Jo EJ, Kim JI, Kang HK, Ye RD, Kwak JY, and Ryu SH (2004) Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling. J Immunol 173:607-614. (Pubitemid 38797390)
18. 2 or lipoxin A4 in human neutrophils. Mol Pharmacol 64:721-730.
19. Baek SH, Seo JK, Chae CB, Suh PG, and Ryu SH (1996) Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries. J Biol Chem 271:8170-8175. (Pubitemid 26108645)
20. Bao L, Gerard NP, Eddy RL Jr, Shows TB, and Gerard C (1992) Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1,FPRH2) to chromosome 19. Genomics 13:437-440.
21. Baranova IN, Vishnyakova TG, Bocharov AV, Kurlander R, Chen Z, Kimelman ML, Remaley AT, Csako G, Thomas F, Eggerman TL, et al. (2005) Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases. J Biol Chem 280:8031-8040. (Pubitemid 40349701)
22. Becker EL, Forouhar FA, Grunnet ML, Boulay F, Tardif M, Bormann BJ, Sodja D, Ye RD, Woska JR Jr, and Murphy PM (1998) Broad immunocytochemical localization of the formylpeptide receptor in human organs, tissues, and cells. Cell Tissue Res 292:129-135. (Pubitemid 28143884)
23. Bellner L, Thorén F, Nygren E, Liljeqvist JA, Karlsson A, and Eriksson K (2005) A proinflammatory peptide from herpes simplex virus type 2 glycoprotein G affects neutrophil, monocyte, and NK cell functions. J Immunol 174:2235-2241. (Pubitemid 40223970)
24. Bennett JP, Hirth KP, Fuchs E, Sarvas M, and Warren GB (1980) The bacterial factors which stimulate neutrophils may be derived from procaryote signal peptides. FEBS Lett 116:57-61.
25. Bennett TA, Foutz TD, Gurevich VV, Sklar LA, and Prossnitz ER (2001) Partial phosphorylation of the N-formyl peptide receptor inhibits G protein association independent of arrestin binding. J Biol Chem 276:49195-49203. (Pubitemid 37370628)
26. Bentwood BJ and Henson PM (1980) The sequential release of granule constitutents from human neutrophils. J Immunol 124:855-862. (Pubitemid 10097825)
27. Betten A, Bylund J, Christophe T, Cristophe T, Boulay F, Romero A, Hellstrand K, and Dahlgren C (2001) A proinflammatory peptide from Helicobacter pylori activates monocytes to induce lymphocyte dysfunction and apoptosis. J Clin Invest 108:1221-1228. (Pubitemid 32995381)
28. Björkman L, Karlsson J, Karlsson A, Rabiet MJ, Boulay F, Fu H, Bylund J, and Dahlgren C (2008) Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like-1. J Leukoc Biol 83:245-253. (Pubitemid 351225604)
29. Bokoch GM and Gilman AG (1984) Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. Cell 39:301-308. (Pubitemid 15191213)
30. Bokoch GM, Katada T, Northup JK, Ui M, and Gilman AG (1984) Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. J Biol Chem 259:3560-3567. (Pubitemid 14170085)
31. Bommakanti RK, Bokoch GM, Tolley JO, Schreiber RE, Siemsen DW, Klotz KN, and Jesaitis AJ (1992) Reconstitution of a physical complex between the N-formyl chemotactic peptide receptor and G protein. Inhibition by pertussis toxin-catalyzed ADP ribosylation. J Biol Chem 267:7576-7581.
32. Bommakanti RK, Dratz EA, Siemsen DW, and Jesaitis AJ (1994) Characterization of complex formation between Gi2 and octyl glucoside solubilized neutrophil N-formyl peptide chemoattractant receptor by sedimentation velocity. Biochim Biophys Acta 1209:69-76. (Pubitemid 24351990)
33. Bommakanti RK, Dratz EA, Siemsen DW, and Jesaitis AJ (1995) Extensive contact between Gi2 and N-formyl peptide receptor of human neutrophils: mapping of binding sites using receptor-mimetic peptides. Biochemistry 34:6720-6728.
34. Bommakanti RK, Klotz KN, Dratz EA, and Jesaitis AJ (1993) A carboxyl-terminal tail peptide of neutrophil chemotactic receptor disrupts its physical complex with G protein. J Leukoc Biol 54:572-577. (Pubitemid 24024228)
35. Bonnans C, Gras D, Chavis C, Mainprice B, Vachier I, Godard P, and Chanez P (2007) Synthesis and anti-inflammatory effect of lipoxins in human airway epithelial cells. Biomed Pharmacother 61:261-267. (Pubitemid 46891725)
36. Borregaard N, Lollike K, Kjeldsen L, Sengeløv H, Bastholm L, Nielsen MH, and Bainton DF (1993) Human neutrophil granules and secretory vesicles. Eur J Haematol 51:187-198. (Pubitemid 24014145)
37. Boulay F, Tardif M, Brouchon L, and Vignais P (1990a) The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors. Biochemistry 29:11123-11133.
38. Boulay F, Tardif M, Brouchon L, and Vignais P (1990b) Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA. Biochem Biophys Res Commun 168:1103-1109. (Pubitemid 20175994)
39. Boulven I, Levasseur S, Marois S, Paré G, Rollet-Labelle E, and Naccache PH (2006) Class IA phosphatidylinositide 3-kinases, rather than p110 gamma, regulate formylmethionyl-leucyl-phenylalanine-stimulated chemotaxis and superoxide production in differentiated neutrophil-like PLB-985 cells. J Immunol 176:7621-7627. (Pubitemid 43849062)
40. Boxer LA, Yoder M, Bonsib S, Schmidt M, Ho P, Jersild R, and Baehner RL (1979) Effects of a chemotactic factor, N-formylmethionyl peptide, on adherence, superoxide anion generation, phagocytosis, and microtubule assembly of human polymorphonuclear leukocytes. J Lab Clin Med 93:506-514. (Pubitemid 10165621)
41. Brazil TJ, Rossi AG, Haslett C, McGorum B, Dixon PM, and Chilvers ER (1998) Priming induces functional coupling of N-formyl-methionyl-leucyl- phenylalanine receptors in equine neutrophils. J Leukoc Biol 63:380-388. (Pubitemid 28106853)
42. Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, and Yokomizo T (2003) International Union of Pharmacology. XXXVII. Nomenclature for leukotriene and lipoxin receptors. Pharmacol Rev 55:195-227. (Pubitemid 36268403)
43. Brown GE, Stewart MQ, Bissonnette SA, Elia AE, Wilker E, and Yaffe MB (2004) Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase. J Biol Chem 279:27059-27068. (Pubitemid 38812542)
44. Burg M, Raffetseder U, Grove M, Klos A, Köhl J, and Bautsch W (1995) G alpha-16 complements the signal transduction cascade of chemotactic receptors for complement factor C5a (C5a-R) and N-formylated peptides (fMLF-R) in Xenopus laevis oocytes: G alpha-16 couples to chemotactic receptors in Xenopus oocytes. FEBS Lett 377:426-428. (Pubitemid 3013751)
45. Bü rli RW, Xu H, Zou X, Muller K, Golden J, Frohn M, Adlam M, Plant MH, Wong M, McElvain M, et al. (2006) Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg Med Chem Lett 16:3713-3718.
46. Bylund J, Karlsson A, Boulay F, and Dahlgren C (2002) Lipopolysaccharide-induced granule mobilization and priming of the neutrophil response to Helicobacter pylori peptide Hp(2-20), which activates formyl peptide receptor-like 1. Infect Immun 70:2908-2914. (Pubitemid 34564148)
47. Cai H, Song C, Endoh I, Goyette J, Jessup W, Freedman SB, McNeil HP, and Geczy CL (2007) Serum amyloid A induces monocyte tissue factor. J Immunol 178:1852-1860. (Pubitemid 46154658)
48. Cai L, de Beer MC, de Beer FC, and van der Westhuyzen DR (2005) Serum amyloid A is a ligand for scavenger receptor class B type I and inhibits high density lipoprotein binding and selective lipid uptake. J Biol Chem 280:2954-2961. (Pubitemid 40189405)
49. Campbell JJ, Foxman EF, and Butcher EC (1997) Chemoattractant receptor cross talk as a regulatory mechanism in leukocyte adhesion and migration. Eur J Immunol 27:2571-2578. (Pubitemid 27453846)
50. Camps M, Carozzi A, Schnabel P, Scheer A, Parker PJ, and Gierschik P (1992a) Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits. Nature 360:684-686. (Pubitemid 23007685)
51. Camps M, Hou C, Sidiropoulos D, Stock JB, Jakobs KH, and Gierschik P (1992b) Stimulation of phospholipase C by guanine-nucleotide-binding protein beta gamma subunits. Eur J Biochem 206:821-831.
52. Carp H (1982) Mitochondrial N-formylmethionyl proteins as chemoattractants for neutrophils. J Exp Med 155:264-275. (Pubitemid 12209828)
53. Cassatella MA, Bazzoni F, Ceska M, Ferro I, Baggiolini M, and Berton G (1992) IL-8 production by human polymorphonuclear leukocytes. The chemoattractant formylmethionyl-leucyl-phenylalanine induces the gene expression and release of IL-8 through a pertussis toxin-sensitive pathway. J Immunol 148:3216-3220.
54. Chen J, Bernstein HS, Chen M, Wang L, Ishii M, Turck CW, and Coughlin SR (1995) Tethered ligand library for discovery of peptide agonists. J Biol Chem 270:23398-23401.
55. Chen K, Iribarren P, Hu J, Chen J, Gong W, Cho EH, Lockett S, Dunlop NM, and Wang JM (2006) Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide. J Biol Chem 281:3651-3659. (Pubitemid 43845983)
56. Chen Q, Powell DW, Rane MJ, Singh S, Butt W, Klein JB, and McLeish KR (2003) Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils. J Immunol 170:5302-5308. (Pubitemid 36554765)
57. Chen Q, Wade D, Kurosaka K, Wang ZY, Oppenheim JJ, and Yang D (2004) Temporin A and related frog antimicrobial peptides use formyl peptide receptor-like 1 as a receptor to chemoattract phagocytes. J Immunol 173:2652-2659. (Pubitemid 39063125)
58. Chen X, Mellon RD, Yang L, Dong H, Oppenheim JJ, and Howard OM (2002) Regulatory effects of deoxycholic acid, a component of the anti-inflammatory traditional Chinese medicine Niuhuang, on human leukocyte response to chemoattractants. Biochem Pharmacol 63:533-541. (Pubitemid 34169733)
59. Chen X, Yang D, Shen W, Dong HF, Wang JM, Oppenheim JJ, and Howard MZ (2000) Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors. Inflamm Res 49:744-755. (Pubitemid 32097093)
60. Cheng N, He R, Tian J, Dinauer MC, and Ye RD (2007) A critical role of protein kinase C delta activation loop phosphorylation in formyl-methionyl- leucylphenylalanine-induced phosphorylation of p47(phox) and rapid activation of nicotinamide adenine dinucleotide phosphate oxidase. J Immunol 179:7720-7728.
61. Cheng N, He R, Tian J, Ye PP, and Ye RD (2008) Cutting edge: TLR2 is a functional receptor for acute-phase serum amyloid A. J Immunol 181:22-26.
62. Chiang N, Fierro IM, Gronert K, and Serhan CN (2000) Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation. J Exp Med 191:1197-1208. (Pubitemid 30207682)
63. Chiang N, Serhan CN, Dahlén SE, Drazen JM, Hay DW, Rovati GE, Shimizu T, Yokomizo T, and Brink C (2006) The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. Pharmacol Rev 58:463-487. (Pubitemid 44394909)
64. Christenson K, Björkman L, Tängemo C, and Bylund J (2008) Serum amyloid A inhibits apoptosis of human neutrophils via a P2X7-sensitive pathway independent of formyl peptide receptor-like 1. J Leukoc Biol 83:139-148.
65. 2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J Biol Chem 276:21585-21593.
66. Christophe T, Karlsson A, Rabiet MJ, Boulay F, and Dahlgren C (2002) Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. Scand J Immunol 56:470-476. (Pubitemid 35373683)
67. Clark RA, Page RC, and Wilde G (1977) Defective neutrophil chemotaxis in juvenile periodontitis. Infect Immun 18:694-700. (Pubitemid 8247686)
68. Colgan SP, Serhan CN, Parkos CA, Delp-Archer C, and Madara JL (1993) Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers. J Clin Invest 92:75-82. (Pubitemid 23208982)
69. Colotta F, Re F, Polentarutti N, Sozzani S, and Mantovani A (1992) Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood 80:2012-2020.
70. Condliffe AM, Davidson K, Anderson KE, Ellson CD, Crabbe T, Okkenhaug K, Vanhaesebroeck B, Turner M, Webb L, Wymann MP, et al. (2005) Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106:1432-1440. (Pubitemid 41129612)
71. Cui Y, Le Y, Yazawa H, Gong W, and Wang JM (2002) Potential role of the formyl peptide receptor-like 1 (FPRL1) in inflammatory aspects of Alzheimer's disease. J Leukoc Biol 72:628-635. (Pubitemid 36277832)
72. Czapiga M, Gao JL, Kirk A, and Lekstrom-Himes J (2005) Human platelets exhibit chemotaxis using functional N-formyl peptide receptors. Exp Hematol 33:73-84. (Pubitemid 40127646)
73. Damian M, Mary S, Martin A, Pin JP, and Banères JL (2008) G protein activation by the leukotriene B4 receptor dimer. Evidence for an absence of trans-activation. J Biol Chem 283:21084-21092.
74. D'Andrea AD, Lodish HF, and Wong GG (1989) Expression cloning of the murine erythropoietin receptor. Cell 57:277-285. (Pubitemid 19112366)
75. Dang PM, Fontayne A, Hakim J, El Benna J, and Périanin A (2001) Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst. J Immunol 166:1206-1213. (Pubitemid 32060281)
76. De Lean A, Stadel JM, and Lefkowitz RJ (1980) A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor. J Biol Chem 255:7108-7117. (Pubitemid 11232874)
77. de Paulis A, Montuori N, Prevete N, Fiorentino I, Rossi FW, Visconte V, Rossi G, Marone G, and Ragno P (2004a) Urokinase induces basophil chemotaxis through a urokinase receptor epitope that is an endogenous ligand for formyl peptide receptor-like 1 and -like 2. J Immunol 173:5739-5748. (Pubitemid 39392163)
78. de Paulis A, Prevete N, Fiorentino I, Walls AF, Curto M, Petraroli A, Castaldo V, Ceppa P, Fiocca R, and Marone G (2004b) Basophils infiltrate human gastric mucosa at sites of Helicobacter pylori infection, and exhibit chemotaxis in response to H. pylori-derived peptide Hp(2-20). J Immunol 172:7734-7743. (Pubitemid 38747641)
79. DeLeo FR and Quinn MT (1996) Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins. J Leukoc Biol 60:677-691. (Pubitemid 27041655)
80. DeLeo FR, Renee J, McCormick S, Nakamura M, Apicella M, Weiss JP, and Nauseef WM (1998) Neutrophils exposed to bacterial lipopolysaccharide upregulate NADPH oxidase assembly. J Clin Invest 101:455-463. (Pubitemid 28067343)
81. Deng X, Ueda H, Su SB, Gong W, Dunlop NM, Gao JL, Murphy PM, and Wang JM (1999) A synthetic peptide derived from human immunodeficiency virus type 1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R. Blood 94:1165-1173. (Pubitemid 29380396)
82. Derian CK, Solomon HF, Higgins JD 3rd, Beblavy MJ, Santulli RJ, Bridger GJ, Pike MC, Kroon DJ, and Fischman AJ (1996) Selective inhibition of N-formylpeptide-induced neutrophil activation by carbamate-modified peptide analogues. Biochemistry 35:1265-1269.
83. Devchand PR, Arita M, Hong S, Bannenberg G, Moussignac RL, Gronert K, and Serhan CN (2003) Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host defense. Faseb J 17:652-659. (Pubitemid 37221150)
84. Dewas C, Dang PM, Gougerot-Pocidalo MA, and El-Benna J (2003) TNF-alpha induces phosphorylation of p47(phox) in human neutrophils: partial phosphorylation of p47phox is a common event of priming of human neutrophils by TNF-alpha and granulocyte-macrophage colony-stimulating factor. J Immunol 171:4392-4398. (Pubitemid 37238718)
85. Dewas C, Fay M, Gougerot-Pocidalo MA, and El-Benna J (2000) The mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl-methionyl-leucyl-phenylalanine-induced p47phox phosphorylation in human neutrophils. J Immunol 165:5238-5244. (Pubitemid 30809456)
86. Didsbury JR, Uhing RJ, Tomhave E, Gerard C, Gerard N, and Snyderman R (1991) Receptor class desensitization of leukocyte chemoattractant receptors. Proc Natl Acad Sci U S A 88:11564-11568. (Pubitemid 21916082)
87. Didsbury JR, Uhing RJ, Tomhave E, Gerard C, Gerard N, and Snyderman R (1992) Functional high efficiency expression of cloned leukocyte chemoattractant receptor cDNAs. FEBS Lett 297:275-279.
88. Dixon RA, Kobilka BK, Strader DJ, Benovic JL, Dohlman HG, Frielle T, Bolanowski MA, Bennett CD, Rands E, Diehl RE, et al. (1986) Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature 321:75-79. (Pubitemid 16080889)
89. Dohlman HG, Thorner J, Caron MG, and Lefkowitz RJ (1991) Model systems for the study of seven-transmembrane-segment receptors. Annu Rev Biochem 60:653-688.
90. Dolmatch B and Niedel J (1983) Formyl peptide chemotactic receptor. Evidence for an active proteolytic fragment. J Biol Chem 258:7570-7577.
91. Donabedian H and Gallin JI (1981) Deactivation of human neutrophil chemotaxis by chemoattractants: effect on receptors for the chemotactic factor f-Met-Leu-Phe. J Immunol 127:839-844. (Pubitemid 11051113)
92. Dong X, Mo Z, Bokoch G, Guo C, Li Z, and Wu D (2005) P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils. Curr Biol 15:1874-1879. (Pubitemid 41501524)
93. Dormann D, Weijer G, Parent CA, Devreotes PN, and Weijer CJ (2002) Visualizing PI3 kinase-mediated cell-cell signaling during Dictyostelium development. Curr Biol 12:1178-1188. (Pubitemid 34801165)
94. Dutil EM, Toker A, and Newton AC (1998) Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1). Curr Biol 8:1366-1375. (Pubitemid 29020145)
95. Edwards BS, Bologa C, Young SM, Balakin KV, Prossnitz ER, Savchuck NP, Sklar LA, and Oprea TI (2005) Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists. Mol Pharmacol 68:1301-1310. (Pubitemid 41539986)
96. El Benna J, Han J, Park JW, Schmid E, Ulevitch RJ, and Babior BM (1996) Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK. Arch Biochem Biophys 334:395-400. (Pubitemid 26347324)
97. El Kebir D, József L, Khreiss T, Pan W, Petasis NA, Serhan CN, and Filep JG (2007) Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils: a novel mechanism for resolution of inflammation. J Immunol 179:616-622. (Pubitemid 46986579)
98. Elagoz A, Henderson D, Babu PS, Salter S, Grahames C, Bowers L, Roy MO, Laplante P, Grazzini E, Ahmad S, et al. (2004) A truncated form of CKbeta8-1 is a potent agonist for human formyl peptide-receptor-like 1 receptor. Br J Pharmacol 141:37-46. (Pubitemid 38241161)
99. Ernst S, Lange C, Wilbers A, Goebeler V, Gerke V, and Rescher U (2004a) An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family. J Immunol 172:7669-7676. (Pubitemid 38747633)
100. Ernst S, Zobiack N, Boecker K, Gerke V, and Rescher U (2004b) Agonist-induced trafficking of the low-affinity formyl peptide receptor FPRL1. Cell Mol Life Sci 61:1684-1692. (Pubitemid 38967190)
101. Finney DA and Sklar LA (1983) Ligand/receptor internalization: a kinetic, flow cytometric analysis of the internalization of N-formyl peptides by human neutrophils. Cytometry 4:54-60.
102. Fiore S, Maddox JF, Perez HD, and Serhan CN (1994) Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. J Exp Med 180:253-260. (Pubitemid 24181074)
103. Fiore S, Romano M, Reardon EM, and Serhan CN (1993) Induction of functional lipoxin A4 receptors in HL-60 cells. Blood 81:3395-3403. (Pubitemid 23172926)
104. Fiore S, Ryeom SW, Weller PF, and Serhan CN (1992) Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils. J Biol Chem 267:16168-16176.
105. Fletcher MP and Gallin JI (1983) Human neutrophils contain an intracellular pool of putative receptors for the chemoattractant N-formyl-methionyl-leucyl-phenylalanine. Blood 62:792-799.
106. Foxman EF, Campbell JJ, and Butcher EC (1997) Multistep navigation and the combinatorial control of leukocyte chemotaxis. J Cell Biol 139:1349-1360. (Pubitemid 27523220)
107. Foxman EF, Kunkel EJ, and Butcher EC (1999) Integrating conflicting chemotactic signals. The role of memory in leukocyte navigation. J Cell Biol 147:577-588. (Pubitemid 29523463)
108. Freer RJ, Day AR, Muthukumaraswamy N, Pinon D, Wu A, Showell HJ, and Becker EL (1982) Formyl peptide chemoattractants: a model of the receptor on rabbit neutrophils. Biochemistry 21:257-263.
109. Freer RJ, Day AR, Radding JA, Schiffmann E, Aswanikumar S, Showell HJ, and Becker EL (1980) Further studies on the structural requirements for synthetic peptide chemoattractants. Biochemistry 19:2404-2410.
110. Fu H, Björkman L, Janmey P, Karlsson A, Karlsson J, Movitz C, and Dahlgren C (2004a) The two neutrophil members of the formylpeptide receptor family activate the NADPH-oxidase through signals that differ in sensitivity to a gelsolin derived phosphoinositide-binding peptide. BMC Cell Biol 5:50. (Pubitemid 41357603)
111. Fu H, Bylund J, Karlsson A, Pellmé S, and Dahlgren C (2004b) The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8. Immunology 112:201-210. (Pubitemid 38703566)
112. Fu H, Dahlgren C, and Bylund J (2003) Subinhibitory concentrations of the deformylase inhibitor actinonin increase bacterial release of neutrophil-activating peptides: a new approach to antimicrobial chemotherapy. Antimicrob Agents Chemother 47:2545-2550. (Pubitemid 36919457)
113. Funamoto S, Meili R, Lee S, Parry L, and Firtel RA (2002) Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109:611-623. (Pubitemid 34628724)
114. Furlan F, Orlando S, Laudanna C, Resnati M, Basso V, Blasi F, and Mondino A (2004) The soluble D2D3(88-274) fragment of the urokinase receptor inhibits monocyte chemotaxis and integrin-dependent cell adhesion. J Cell Sci 117:2909-2916. (Pubitemid 39117666)
115. Gao JL, Becker EL, Freer RJ, Muthukumaraswamy N, and Murphy PM (1994) A high potency nonformylated peptide agonist for the phagocyte N-formylpeptide chemotactic receptor. J Exp Med 180:2191-2197. (Pubitemid 24983542)
116. Gao JL, Chen H, Filie JD, Kozak CA, and Murphy PM (1998) Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse. Genomics 51:270-276. (Pubitemid 28395033)
117. Gao JL, Guillabert A, Hu J, Le Y, Urizar E, Seligman E, Fang KJ, Yuan X, Imbault V, Communi D, et al. (2007) F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor. J Immunol 178:1450-1456. (Pubitemid 46154616)
118. Gao JL, Lee EJ, and Murphy PM (1999) Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor. J Exp Med 189:657-662. (Pubitemid 29193366)
119. Gao JL and Murphy PM (1993) Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains. J Biol Chem 268:25395-25401. (Pubitemid 23358142)
120. Gargiulo L, Longanesi-Cattani I, Bifulco K, Franco P, Raiola R, Campiglia P, Grieco P, Peluso G, Stoppelli MP, and Carriero MV (2005) Cross-talk between fMLP and vitronectin receptors triggered by urokinase receptor-derived SRSRY peptide. J Biol Chem 280:25225-25232. (Pubitemid 40934616)
121. Gavins FN, Yona S, Kamal AM, Flower RJ, and Perretti M (2003) Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms. Blood 101:4140-4147. (Pubitemid 36857897)
122. Gewirtz AT, Neish AS, and Madara JL (2002) Mechanisms of active intestinal inflammation and potential down-regulation via lipoxins. Adv Exp Med Biol 507:229-236. (Pubitemid 37330186)
123. Gierschik P, Sidiropoulos D, and Jakobs KH (1989) Two distinct Gi-proteins mediate formyl peptide receptor signal transduction in human leukemia (HL-60) cells. J Biol Chem 264:21470-21473. (Pubitemid 20028703)
124. Gilbert TL, Bennett TA, Maestas DC, Cimino DF, and Prossnitz ER (2001) Internalization of the human N-formyl peptide and C5a chemoattractant receptors occurs via clathrin-independent mechanisms. Biochemistry 40:3467-3475. (Pubitemid 32242803)
125. Godson C, Mitchell S, Harvey K, Petasis NA, Hogg N, and Brady HR (2000) Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages. J Immunol 164:1663-1667. (Pubitemid 30108713)
126. Goh J, Baird AW, O'Keane C, Watson RW, Cottell D, Bernasconi G, Petasis NA, Godson C, Brady HR, and MacMathuna P (2001) Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophilenterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo. J Immunol 167:2772-2780. (Pubitemid 32768909)
127. Goodman OB Jr, Krupnick JG, Santini F, Gurevich VV, Penn RB, Gagnon AW, Keen JH, and Benovic JL (1996) Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Nature 383:447-450. (Pubitemid 26330835)
128. Gripentrog JM, Jesaitis AJ, and Miettinen HM (2000) A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activation and chemotaxis. Biochem J 352:399-407. (Pubitemid 32011433)
129. Gripentrog JM and Miettinen HM (2008) Formyl peptide receptor-mediated ERK1/2 activation occurs through G(i) and is not dependent on beta-arrestin1/2. Cell Signal 20:424-431.
130. Gripentrog JM, Mills JS, Saari GJ, and Miettinen HM (2008) Variable responses of formyl peptide receptor haplotypes toward bacterial peptides. Immunogenetics 60:83-93.
131. Grumbach Y, Quynh NV, Chiron R, and Urbach V (2009) LXA4 stimulates ZO-1 expression and transepithelial electrical resistance in human airway epithelial (16HBE14o-) cells. Am J Physiol Lung Cell Mol Physiol 296:L101-108.
132. Guichard C, Pedruzzi E, Dewas C, Fay M, Pouzet C, Bens M, Vandewalle A, Ogier-Denis E, Gougerot-Pocidalo MA, and Elbim C (2005) Interleukin-8-induced
133. Gulden PH, Fischer P 3rd, Sherman NE, Wang W, Engelhard VH, Shabanowitz J, Hunt DF, and Pamer EG (1996) A Listeria monocytogenes pentapeptide is presented to cytolytic T lymphocytes by the H2-M3 MHC class Ib molecule. Immunity 5:73-79.
134. Gunji T, Onouchi Y, Nagasawa T, Katagiri S, Watanabe H, Kobayashi H, Arakawa S, Noguchi K, Hata A, Izumi Y, et al. (2007) Functional polymorphisms of the FPR1 gene and aggressive periodontitis in Japanese. Biochem Biophys Res Commun 364:7-13. (Pubitemid 47603181)
135. Gwinn MR, Sharma A, and De Nardin E (1999) Single nucleotide polymorphisms of the N-formyl peptide receptor in localized juvenile periodontitis. J Periodontol 70:1194-1201.
136. Haas PJ, de Haas CJ, Kleibeuker W, Poppelier MJ, van Kessel KP, Kruijtzer JA, Liskamp RM, and van Strijp JA (2004) N-terminal residues of the chemotaxis inhibitory protein of Staphylococcus aureus are essential for blocking formylated peptide receptor but not C5a receptor. J Immunol 173:5704-5711. (Pubitemid 39392159)
137. Hachicha M, Pouliot M, Petasis NA, and Serhan CN (1999) Lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1alpha-initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis. J Exp Med 189:1923-1930. (Pubitemid 29295890)
138. Han M, Gurevich VV, Vishnivetskiy SA, Sigler PB, and Schubert C (2001) Crystal structure of beta-arrestin at 1.9 A: possible mechanism of receptor binding and membrane translocation. Structure 9:869-880. (Pubitemid 32913504)
139. Harada M, Habata Y, Hosoya M, Nishi K, Fujii R, Kobayashi M, and Hinuma S (2004) N-Formylated humanin activates both formyl peptide receptor-like 1 and 2. Biochem Biophys Res Commun 324:255-261. (Pubitemid 39311487)
140. HARRIS H (1954) Role of chemotaxis in inflammation. Physiol Rev 34:529-562.
141. Hartt JK, Barish G, Murphy PM, and Gao JL (1999) N-formylpeptides induce two distinct concentration optima for mouse neutrophil chemotaxis by differential interaction with two N-formylpeptide receptor (FPR) subtypes. Molecular characterization of FPR2, a second mouse neutrophil FPR. J Exp Med 190:741-747. (Pubitemid 29428656)
142. Hartt JK, Liang T, Sahagun-Ruiz A, Wang JM, Gao JL, and Murphy PM (2000) The HIV-1 cell entry inhibitor T-20 potently chemoattracts neutrophils by specifically activating the N-formylpeptide receptor. Biochem Biophys Res Commun 272:699-704. (Pubitemid 30420702)
143. Hashimoto Y, Niikura T, Ito Y, Sudo H, Hata M, Arakawa E, Abe Y, Kita Y, and Nishimoto I (2001) Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults. J Neurosci 21:9235-9245. (Pubitemid 33096867)
144. Hayhoe RP, Kamal AM, Solito E, Flower RJ, Cooper D, and Perretti M (2006) Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement. Blood 107:2123-2130. (Pubitemid 43289398)
145. He R, Browning DD, and Ye RD (2001) Differential roles of the NPXXY motif in formyl peptide receptor signaling. J Immunol 166:4099-4105. (Pubitemid 32224941)
146. He R, Nanamori M, Sang H, Yin H, Dinauer MC, and Ye RD (2004) Reconstitution of chemotactic peptide-induced nicotinamide adenine dinucleotide phosphate (reduced) oxidase activation in transgenic COS-phox cells. J Immunol 173:7462-7470. (Pubitemid 39628186)
147. He R, Sang H, and Ye RD (2003) Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R. Blood 101:1572-1581. (Pubitemid 36182537)
148. Hecht I, Rong J, Sampaio AL, Hermesh C, Rutledge C, Shemesh R, Toporik A, Beiman M, Dassa L, Niv H, et al. (2009) A novel peptide agonist of formyl-peptide receptor-like 1 (ALX) displays anti-inflammatory and cardioprotective effects. J Pharmacol Exp Ther 328:426-434.
149. Heit B, Robbins SM, Downey CM, Guan Z, Colarusso P, Miller BJ, Jirik FR, and Kubes P (2008) PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils. Nat Immunol 9:743-752. (Pubitemid 351859157)
150. Heit B, Tavener S, Raharjo E, and Kubes P (2002) An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients. J Cell Biol 159:91-102. (Pubitemid 35191521)
151. α subunits. J Biol Chem 268:14367-14375.
152. Higgins JD 3rd, Bridger GJ, Derian CK, Beblavy MJ, Hernandez PE, Gaul FE, Abrams MJ, Pike MC, and Solomon HF (1996) N-terminus urea-substituted chemotactic peptides: new potent agonists and antagonists toward the neutrophil fMLF receptor. J Med Chem 39:1013-1015.
153. Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, Sozzani S, Mantovani A, Altruda F, and Wymann MP (2000) Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 287:1049-1053. (Pubitemid 30094362)
154. Hsu MH, Chiang SC, Ye RD, and Prossnitz ER (1997) Phosphorylation of the N-formyl peptide receptor is required for receptor internalization but not chemotaxis. J Biol Chem 272:29426-29429. (Pubitemid 27508023)
155. Hu JY, Le Y, Gong W, Dunlop NM, Gao JL, Murphy PM, and Wang JM (2001) Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1. J Leukoc Biol 70:155-161. (Pubitemid 32613676)
156. Huet E, Boulay F, Barral S, and Rabiet MJ (2007) The role of beta-arrestins in the formyl peptide receptor-like 1 internalization and signaling. Cell Signal 19:1939-1948. (Pubitemid 47090179)
157. Hughes BJ, Hollers JC, Crockett-Torabi E, and Smith CW (1992) Recruitment of CD11b/CD18 to the neutrophil surface and adherence-dependent cell locomotion. J Clin Invest 90:1687-1696.
158. Jesaitis AJ, Naemura JR, Sklar LA, Cochrane CG, and Painter RG (1984) Rapid modulation of N-formyl chemotactic peptide receptors on the surface of human granulocytes: formation of high-affinity ligand-receptor complexes in transient association with cytoskeleton. J Cell Biol 98:1378-1387. (Pubitemid 14128922)
159. Jesaitis AJ, Tolley JO, Painter RG, Sklar LA, and Cochrane CG (1985) Membrane-cytoskeleton interactions and the regulation of chemotactic peptide-induced activation of human granulocytes: the effects of dihydrocytochalasin B. J Cell Biochem 27:241-253. (Pubitemid 15108323)
160. Jiang H, Kuang Y, Wu Y, Xie W, Simon MI, and Wu D (1997) Roles of phospholipase C beta2 in chemoattractant-elicited responses. Proc Natl Acad Sci U S A 94:7971-7975. (Pubitemid 27343759)
161. Jones BE, Miettinen HM, Jesaitis AJ, and Mills JS (2003) Mutations of F110 and C126 of the formyl peptide receptor interfere with G-protein coupling and chemotaxis. J Periodontol 74:475-484. (Pubitemid 36553385)
162. József L, Zouki C, Petasis NA, Serhan CN, and Filep JG (2002) Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes. Proc Natl Acad Sci U S A 99:13266-13271.
163. Kamal AM, Hayhoe RP, Paramasivam A, Cooper D, Flower RJ, Solito E, and Perretti M (2006) Antiflammin-2 activates the human formyl-peptide receptor like 1. ScientificWorldJournal 6:1375-1384. (Pubitemid 44715631)
164. Kanai F, Liu H, Field SJ, Akbary H, Matsuo T, Brown GE, Cantley LC, and Yaffe MB (2001) The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat Cell Biol 3:675-678. (Pubitemid 32624424)
165. Kang HK, Lee HY, Kim MK, Park KS, Park YM, Kwak JY, and Bae YS (2005) The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2. J Immunol 175:685-692. (Pubitemid 41094948)
166. Karlsson J, Fu H, Boulay F, Bylund J, and Dahlgren C (2006) The peptide Trp-Lys-Tyr-Met-Val-D-Met activates neutrophils through the formyl peptide receptor only when signaling through the formylpeptide receptor like 1 is blocked. A receptor switch with implications for signal transduction studies with inhibitors and receptor antagonists. Biochem Pharmacol 71:1488-1496.
167. Karlsson J, Fu H, Boulay F, Dahlgren C, Hellstrand K, and Movitz C (2005) Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J Leukoc Biol 78:762-771. (Pubitemid 41292099)
168. Karnad AB, Hartshorn KL, Wright J, Myers JB, Schwartz JH, and Tauber AI (1989) Priming of human neutrophils with N-formyl-methionyl-leucyl-phenylalanine by a calcium-independent, pertussis toxin-insensitive pathway. Blood 74:2519-2526. (Pubitemid 19286474)
169. Kettritz R, Falk RJ, Jennette JC, and Gaido ML (1997) Neutrophil superoxide release is required for spontaneous and FMLP-mediated but not for TNF alpha-mediated apoptosis. J Am Soc Nephrol 8:1091-1100. (Pubitemid 27427216)
170. Key TA, Foutz TD, Gurevich VV, Sklar LA, and Prossnitz ER (2003) N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity. J Biol Chem 278:4041-4047. (Pubitemid 36801138)
171. Key TA, Vines CM, Wagener BM, Gurevich VV, Sklar LA, and Prossnitz ER (2005) Inhibition of chemoattractant N-formyl peptide receptor trafficking by active arrestins. Traffic 6:87-99.
172. Khan AI, Heit B, Andonegui G, Colarusso P, and Kubes P (2005) Lipopolysaccharide: a p38 MAPK-dependent disrupter of neutrophil chemotaxis. Microcirculation 12:421-432. (Pubitemid 41122466)
173. Kim C, Marchal CC, Penninger J, and Dinauer MC (2003) The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl- leucylphenylalanine-activated neutrophil functions. J Immunol 171:4425-4430. (Pubitemid 37238722)
174. Kim JW and Cunningham JM (1993) N-linked glycosylation of the receptor for murine ecotropic retroviruses is altered in virus-infected cells. J Biol Chem 268:16316-16320. (Pubitemid 223001573)
175. Kim Y, Lee BD, Kim O, Bae YS, Lee T, Suh PG, and Ryu SH (2006) Pituitary adenylate cyclase-activating polypeptide 27 is a functional ligand for formyl peptide receptor-like 1. J Immunol 176:2969-2975. (Pubitemid 43306958)
176. Klein C, Paul JI, Sauvé K, Schmidt MM, Arcangeli L, Ransom J, Trueheart J, Manfredi JP, Broach JR, and Murphy AJ (1998) Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Nat Biotechnol 16:1334-1337. (Pubitemid 28547443)
177. Knaus UG, Heyworth PG, Evans T, Curnutte JT, and Bokoch GM (1991) Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science 254:1512-1515. (Pubitemid 21917492)
178. Kobilka BK, Matsui H, Kobilka TS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ, and Regan JW (1987) Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. Science 238:650-656. (Pubitemid 17158295)
179. Koczulla R, von Degenfeld G, Kupatt C, Krötz F, Zahler S, Gloe T, Issbrü cker K, Unterberger P, Zaiou M, Lebherz C, et al. (2003) An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest 111:1665-1672.
180. Kodama T, Hazeki K, Hazeki O, Okada T, and Ui M (1999) Enhancement of chemotactic peptide-induced activation of phosphoinositide 3-kinase by granulocyte-macrophage colony-stimulating factor and its relation to the cytokine-mediated priming of neutrophil superoxide-anion production. Biochem J 337:201-209. (Pubitemid 29052012)
181. Kohout TA, Lin FS, Perry SJ, Conner DA, and Lefkowitz RJ (2001) beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc Natl Acad Sci U S A 98:1601-1606. (Pubitemid 32165545)
182. König B, Arendt A, McDowell JH, Kahlert M, Hargrave PA, and Hofmann KP (1989) Three cytoplasmic loops of rhodopsin interact with transducin. Proc Natl Acad Sci U S A 86:6878-6882. (Pubitemid 19240835)
183. Koo C, Lefkowitz RJ, and Snyderman R (1982) The oligopeptide chemotactic factor receptor on human polymorphonuclear leukocyte membranes exists in two affinity states. Biochem Biophys Res Commun 106:442-449. (Pubitemid 13214635)
184. Koo C, Lefkowitz RJ, and Snyderman R (1983) Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes. J Clin Invest 72:748-753. (Pubitemid 14211384)
185. Korchak HM, Wilkenfeld C, Rich AM, Radin AR, Vienne K, and Rutherford LE (1984) Stimulus response coupling in the human neutrophil. Differential requirements for receptor occupancy in neutrophil responses to a chemoattractant. J Biol Chem 259:7439-7445. (Pubitemid 14081146)
186. Kozasa T, Hepler JR, Smrcka AV, Simon MI, Rhee SG, Sternweis PC, and Gilman AG (1993) Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits. Proc Natl Acad Sci U S A 90:9176-9180. (Pubitemid 23306475)
187. Kubo T, Fukuda K, Mikami A, Maeda A, Takahashi H, Mishina M, Haga T, Haga K, Ichiyama A, and Kangawa K (1986) Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor. Nature 323:411-416. (Pubitemid 16026268)
188. Kucharzik T, Gewirtz AT, Merlin D, Madara JL, and Williams IR (2003) Lateral membrane LXA4 receptors mediate LXA4's anti-inflammatory actions on intestinal epithelium. Am J Physiol Cell Physiol 284:C888-896. (Pubitemid 36336945)
189. Kurosaka K, Chen Q, Yarovinsky F, Oppenheim JJ, and Yang D (2005) Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant. J Immunol 174:6257-6265. (Pubitemid 40663818)
190. Kushner I and Rzewnicki D (1999) Acute phase response, in Inflammation: Basic Principles and Clinical Correlates (Gallin JI and Snyderman R eds) pp 317-329, Lippincott Willams & Wilkins, Philadelphia.
191. Lacy M, Jones J, Whittemore SR, Haviland DL, Wetsel RA, and Barnum SR (1995) Expression of the receptors for the C5a anaphylatoxin, interleukin-8 and FMLP by human astrocytes and microglia. J Neuroimmunol 61:71-78.
192. Lad PM, Olson CV, and Smiley PA (1985) Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils with a GTP-binding protein sensitive to pertussis toxin. Proc Natl Acad Sci U S A 82:869-873. (Pubitemid 15142778)
193. Lad PM, Welton AF, and Rodbell M (1977) Evidence for distinct guanine nucleotide sites in the regulation of the glucagon receptor and of adenylate cyclase activity. J Biol Chem 252:5942-5946. (Pubitemid 8192539)
194. Laporte SA, Miller WE, Kim KM, and Caron MG (2002) β-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a β-arrestin binging site in β2-adaptin. J Biol Chem 277:9247-9254. (Pubitemid 34953006)
195. Lavigne MC, Murphy PM, Leto TL, and Gao JL (2002) The N-formylpeptide receptor (FPR) and a second G(i) -coupled receptor mediate fMet-Leu-Phe- stimulated activation of NADPH oxidase in murine neutrophils. Cell Immunol 218:7-12. (Pubitemid 36027086)
196. Le Y, Gong W, Li B, Dunlop NM, Shen W, Su SB, Ye RD, and Wang JM (1999) Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and formyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation. J Immunol 163:6777-6784.
197. Le Y, Gong W, Tiffany HL, Tumanov A, Nedospasov S, Shen W, Dunlop NM, Gao JL, Murphy PM, Oppenheim JJ, et al. (2001a) Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1. J Neurosci 21:RC123.
198. Le Y, Hu J, Gong W, Shen W, Li B, Dunlop NM, Halverson DO, Blair DG, and Wang JM (2000a) Expression of functional formyl peptide receptors by human astrocytoma cell lines. J Neuroimmunol 111:102-108. (Pubitemid 30792066)
199. Le Y, Jiang S, Hu J, Gong W, Su S, Dunlop NM, Shen W, Li B, and Ming Wang J (2000b) N36, a synthetic N-terminal heptad repeat domain of the HIV-1 envelope protein gp41, is an activator of human phagocytes. Clin Immunol 96:236-242. (Pubitemid 30677772)
200. Le Y, Murphy PM, and Wang JM (2002) Formyl-peptide receptors revisited. Trends Immunol 23:541-548. (Pubitemid 35223553)
201. Le Y, Oppenheim JJ, and Wang JM (2001b) Pleiotropic roles of formyl peptide receptors. Cytokine Growth Factor Rev 12:91-105. (Pubitemid 32294589)
202. Le Y, Yazawa H, Gong W, Yu Z, Ferrans VJ, Murphy PM, and Wang JM (2001c) The neurotoxic prion peptide fragment PrP(106-126) is a chemotactic agonist for the G protein-coupled receptor formyl peptide receptor-like 1. J Immunol 166:1448-1451.
203. Le Y, Ye RD, Gong W, Li J, Iribarren P, and Wang JM (2005) Identification of functional domains in the formyl peptide receptor-like 1 for agonist-induced cell chemotaxis. FEBS J 272:769-778. (Pubitemid 40208879)
204. Lee HY, Kim MK, Park KS, Bae YH, Yun J, Park JI, Kwak JY, and Bae YS (2005) Serum amyloid A stimulates matrix-metalloproteinase-9 upregulation via formyl peptide receptor like-1-mediated signaling in human monocytic cells. Biochem Biophys Res Commun 330:989-998. (Pubitemid 40462183)
205. Lee HY, Kim MK, Park KS, Shin EH, Jo SH, Kim SD, Jo EJ, Lee YN, Lee C, Baek SH, et al. (2006a) Serum amyloid A induces contrary immune responses via formyl peptide receptor-like 1 in human monocytes. Mol Pharmacol 70:241-248. (Pubitemid 43920813)
206. Lee MS, Yoo SA, Cho CS, Suh PG, Kim WU, and Ryu SH (2006b) Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis. J Immunol 177:5585-5594. (Pubitemid 44527633)
207. Lefkowitz RJ and Whalen EJ (2004) beta-arrestins: traffic cops of cell signaling. Curr Opin Cell Biol 16:162-168. (Pubitemid 38757292)
208. Lehmeyer JE, Snyderman R, and Johnston RB Jr (1979) Stimulation of neutrophil oxidative metabolism by chemotactic peptides: influence of calcium ion concentration and cytochalasin B and comparison with stimulation by phorbol myristate acetate. Blood 54:35-45. (Pubitemid 9228084)
209. Li Z, Jiang H, Xie W, Zhang Z, Smrcka AV, and Wu D (2000) Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science 287:1046-1049. (Pubitemid 30094361)
210. Liang TS, Gao JL, Fatemi O, Lavigne M, Leto TL, and Murphy PM (2001) The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR. J Immunol 167:6609-6614. (Pubitemid 33081598)
211. Liang TS, Wang JM, Murphy PM, and Gao JL (2000) Serum amyloid A is a chemotactic agonist at FPR2, a low-affinity N-formylpeptide receptor on mouse neutrophils. Biochem Biophys Res Commun 270:331-335. (Pubitemid 30446837)
212. Liles WC, Dale DC, and Klebanoff SJ (1995) Glucocorticoids inhibit apoptosis of human neutrophils. Blood 86:3181-3188.
213. Linnekin D, Bowles CA, Murano G, and MacVittie TJ (1990) Migration of dog polymorphonuclear neutrophilic leukocytes to formylated peptides. Inflammation 14:691-703.
214. Lloyd AR and Oppenheim JJ (1992) Poly's lament: the neglected role of the polymorphonuclear neutrophil in the afferent limb of the immune response. Immunol Today 13:169-172.
215. Loor F, Tiberghien F, Wenandy T, Didier A, and Traber R (2002) Cyclosporins: structure-activity relationships for the inhibition of the human FPR1 formylpeptide receptor. J Med Chem 45:4613-4628.
216. Machado FS, Esper L, Dias A, Madan R, Gu Y, Hildeman D, Serhan CN, Karp CL, and Aliberti J (2008) Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. J Exp Med 205:1077-1086. (Pubitemid 351679683)
217. Machado FS, Johndrow JE, Esper L, Dias A, Bafica A, Serhan CN, and Aliberti J (2006) Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. Nat Med 12:330-334. (Pubitemid 43355082)
218. Maddox JF, Hachicha M, Takano T, Petasis NA, Fokin VV, and Serhan CN (1997) Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. J Biol Chem 272:6972-6978. (Pubitemid 27166397)
219. Maddox JF and Serhan CN (1996) Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction. J Exp Med 183:137-146. (Pubitemid 3023584)
220. Maderna P, Cottell DC, Berlasconi G, Petasis NA, Brady HR, and Godson C (2002) Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils: differential involvement of rho GTPases. Am J Pathol 160:2275-2283. (Pubitemid 34663418)
221. Maestes DC, Potter RM, and Prossnitz ER (1999) Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor. J Biol Chem 274:29791-29795. (Pubitemid 29483353)
222. Malech HL, Gardner JP, Heiman DF, and Rosenzweig SA (1985) Asparagine-linked oligosaccharides on formyl peptide chemotactic receptors of human phagocytic cells. J Biol Chem 260:2509-2514. (Pubitemid 15104860)
223. Marasco WA, Phan SH, Krutzsch H, Showell HJ, Feltner DE, Nairn R, Becker EL, and Ward PA (1984) Purification and identification of formyl-methionyl- leucylphenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli. J Biol Chem 259:5430-5439. (Pubitemid 14144994)
224. Marchese A, Chen C, Kim YM, and Benovic JL (2003) The ins and outs of G protein-coupled receptor trafficking. Trends Biochem Sci 28:369-376. (Pubitemid 36851618)
225. McCoy R, Haviland DL, Molmenti EP, Ziambaras T, Wetsel RA, and Perlmutter DH (1995) N-formylpeptide and complement C5a receptors are expressed in liver cells and mediate hepatic acute phase gene regulation. J Exp Med 182:207-217.
226. McDonald PP, Bald A, and Cassatella MA (1997) Activation of the NF-kappaB pathway by inflammatory stimuli in human neutrophils. Blood 89:3421-3433. (Pubitemid 27229830)
227. Medzhitov R and Janeway C Jr (2000) Innate immune recognition: mechanisms and pathways. Immunol Rev 173:89-97. (Pubitemid 30095213)
228. 2-terminal region of C5aR but not that of FPR is critical for both protein transport and ligand binding. J Biol Chem 269:3457-3463.
229. Miao Z, Premack BA, Wei Z, Wang Y, Gerard C, Showell H, Howard M, Schall TJ, and Berahovich R (2007) Proinflammatory proteases liberate a discrete high-affinity functional FPRL1 (CCR12) ligand from CCL23. J Immunol 178:7395-7404. (Pubitemid 46847467)
230. Miettinen HM, Gripentrog JM, Mason MM, and Jesaitis AJ (1999) Identification of putative sites of interaction between the human formyl peptide receptor and G protein. J Biol Chem 274:27934-27942. (Pubitemid 129527850)
231. Miettinen HM, Mills JS, Gripentrog JM, Dratz EA, Granger BL, and Jesaitis AJ (1997) The ligand binding site of the formyl peptide receptor maps in the transmembrane region. J Immunol 159:4045-4054. (Pubitemid 127469662)
232. Migeotte I, Communi D, and Parmentier M (2006) Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses. Cytokine Growth Factor Rev 17:501-519. (Pubitemid 44793122)
233. Migeotte I, Riboldi E, Franssen JD, Grégoire F, Loison C, Wittamer V, Detheux M, Robberecht P, Costagliola S, Vassart G, et al. (2005) Identification and characterization of an endogenous chemotactic ligand specific for FPRL2. J Exp Med 201:83-93. (Pubitemid 40130086)
234. Milano SK, Pace HC, Kim YM, Brenner C, and Benovic JL (2002) Scaffolding functions of arrestin-2 revealed by crystal structure and mutagenesis. Biochemistry 41:3321-3328. (Pubitemid 34214030)
235. Mills JS (2006) Peptides derived from HIV-1, HIV-2, Ebola virus, SARS coronavirus and coronavirus 229E exhibit high affinity binding to the formyl peptide receptor. Biochim Biophys Acta 1762:693-703. (Pubitemid 44175826)
236. Mills JS (2007) Differential activation of polymorphisms of the formyl peptide receptor by formyl peptides. Biochim Biophys Acta 1772:1085-1092. (Pubitemid 47314233)
237. Mills JS, Miettinen HM, Barnidge D, Vlases MJ, Wimer-Mackin S, Dratz EA, Sunner J, and Jesaitis AJ (1998) Identification of a ligand binding site in the human neutrophil formyl peptide receptor using a site-specific fluorescent photoaffinity label and mass spectrometry. J Biol Chem 273:10428-10435. (Pubitemid 28227652)
238. Mills JS, Miettinen HM, Cummings D, and Jesaitis AJ (2000) Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu. J Biol Chem 275:39012-39017. (Pubitemid 32058913)
239. Mills JS, Miettinen HM, Vlases MJ, and Jesaitis AJ (1999) The N-formyl peptide receptor, in Molecular and Cellular Basis of Inflammation (Serhan CN and Ward PA eds) pp 215-245, Humana, Totowa, NJ.
240. Mócsai A, Jakus Z, Vántus T, Berton G, Lowell CA, and Ligeti E (2000) Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases. J Immunol 164:4321-4331. (Pubitemid 30215095)
241. Mócsai A, Ligeti E, Lowell CA, and Berton G (1999) Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck. J Immunol 162:1120-1126. (Pubitemid 29035443)
242. Mü nch G, Dees C, Hekman M, and Palm D (1991) Multisite contacts involved in coupling of the beta-adrenergic receptor with the stimulatory guanine-nucleotide-binding regulatory protein. Structural and functional studies by beta-receptorsite-specific synthetic peptides. Eur J Biochem 198:357-364.
243. Murphy PM (1993) Molecular mimicry and the generation of host defense protein diversity. Cell 72:823-826. (Pubitemid 23110224)
244. Murphy PM, Gallin EK, Tiffany HL, and Malech HL (1990) The formyl peptide chemoattractant receptor is encoded by a 2 kilobase messenger RNA. Expression in Xenopus oocytes. FEBS Lett 261:353-357. (Pubitemid 20074992)
245. Murphy PM and McDermott D (1991) Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor. J Biol Chem 266:12560-12567. (Pubitemid 21907131)
246. Murphy PM, Ozçelik T, Kenney RT, Tiffany HL, McDermott D, and Francke U (1992) A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family. J Biol Chem 267:7637-7643.
247. Nanamori M, Chen J, Du X, and Ye RD (2007) Regulation of leukocyte degranulation by cGMP-dependent protein kinase and phosphoinositide 3-kinase: potential roles in phosphorylation of target membrane SNARE complex proteins in rat mast cells. J Immunol 178:416-427. (Pubitemid 46033625)
248. Nanamori M, Cheng X, Mei J, Sang H, Xuan Y, Zhou C, Wang MW, and Ye RD (2004a) A novel nonpeptide ligand for formyl peptide receptor-like 1. Mol Pharmacol 66:1213-1222. (Pubitemid 39411061)
249. Nanamori M, He R, Sang H, and Ye RD (2004b) Normal cell surface expression and selective loss of functions resulting from Phe110 to Ser and Cys126 to Trp substitutions in the formyl peptide receptor. Immunol Invest 33:193-212. (Pubitemid 38685931)
250. Nascimento-Silva V, Arruda MA, Barja-Fidalgo C, Villela CG, and Fierro IM (2005) Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells. Am J Physiol Cell Physiol 289:C557-563. (Pubitemid 41192664)
251. Nauseef WM (2007) How human neutrophils kill and degrade microbes: an integrated view. Immunol Rev 219:88-102. (Pubitemid 47390004)
252. Nelson RD, Quie PG, and Simmons RL (1975) Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes. J Immunol 115:1650-1656.
253. Neptune ER and Bourne HR (1997) Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs. Proc Natl Acad Sci U S A 94:14489-14494. (Pubitemid 28041401)
254. Neptune ER, Iiri T, and Bourne HR (1999) Gαi is not required for chemotaxis mediated by Gi-coupled receptors. J Biol Chem 274:2824-2828. (Pubitemid 29075365)
255. Niedel J, Davis J, and Cuatrecasas P (1980a) Covalent affinity labeling of the formyl peptide chemotactic receptor. J Biol Chem 255:7063-7066.
256. Niedel J, Kahane I, Lachman L, and Cuatrecasas P (1980b) A subpopulation of cultured human promyelocytic leukemia cells (HL-60) displays the formyl peptide chemotactic receptor. Proc Natl Acad Sci U S A 77:1000-1004. (Pubitemid 10105045)
257. Niedel J, Wilkinson S, and Cuatrecasas P (1979a) Receptor-mediated uptake and degradation of 125-I-chemotactic peptide by human neutrophils. J Biol Chem 254:10700-10706. (Pubitemid 10159363)
258. Niedel JE, Kahane I, and Cuatrecasas P (1979b) Receptor-mediated internalization of fluorescent chemotactic peptide by human neutrophils. Science 205:1412-1414. (Pubitemid 10226658)
259. Nigam S, Fiore S, Luscinskas FW, and Serhan CN (1990) Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion. J Cell Physiol 143:512-523. (Pubitemid 20201668)
260. Niggli V and Keller H (1997) The phosphatidylinositol 3-kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human neutrophils. Eur J Pharmacol 335:43-52. (Pubitemid 27450468)
261. Nomura H, Nielsen BW, and Matsushima K (1993) Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. Int Immunol 5:1239-1249. (Pubitemid 23308083)
262. Offermanns S and Simon MI (1995) G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C. J Biol Chem 270:15175-15180.
263. O'Hara R, Murphy EP, Whitehead AS, FitzGerald O, and Bresnihan B (2004) Local expression of the serum amyloid A and formyl peptide receptor-like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis. Arthritis Rheum 50:1788-1799. (Pubitemid 38725091)
264. Olofsson S, Khanna B, and Lycke E (1980) Altered kinetic properties of sialyl and galactosyl transferases associated with herpes simplex virus infection of GMK and BHK cells. J Gen Virol 47:1-9. (Pubitemid 10105182)
265. O'Meara SJ, Rodgers K, and Godson C (2008) Lipoxins: update and impact of endogenous pro-resolution lipid mediators. Rev Physiol Biochem Pharmacol 160:47-70.
266. Onnheim K, Bylund J, Boulay F, Dahlgren C, and Forsman H (2008) Tumour necrosis factor (TNF)-alpha primes murine neutrophils when triggered via formyl peptide receptor-related sequence 2, the murine orthologue of human formyl peptide receptor-like 1, through a process involving the type I TNF receptor and subcellular granule mobilization. Immunology 125:591-600.
267. Onorato JJ, Palczewski K, Regan JW, Caron MG, Lefkowitz RJ, and Benovic JL (1991) Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. Biochemistry 30:5118-5125.
268. Oseas RS, Boxer LA, Butterick C, and Baehner RL (1980) Differences in polymorphonuclear leukocyte aggregating responses among several species in response to chemotactic stimulation. J Lab Clin Med 96:213-221.
269. Pamer EG, Wang CR, Flaherty L, Lindahl KF, and Bevan MJ (1992) H-2M3 presents a Listeria monocytogenes peptide to cytotoxic T lymphocytes. Cell 70:215-223.
270. Partida-Sánchez S, Iribarren P, Moreno-García ME, Gao JL, Murphy PM, Oppenheimer N, Wang JM, and Lund FE (2004) Chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic ADP ribose. J Immunol 172:1896-1906. (Pubitemid 38116840)
271. Paul-Clark MJ, Van Cao T, Moradi-Bidhendi N, Cooper D, and Gilroy DW
272. Perez HD, Holmes R, Kelly E, McClary J, and Andrews WH (1992) Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils. Gene 118:303-304.
273. Perez HD, Holmes R, Vilander LR, Adams RR, Manzana W, Jolley D, and Andrews WH (1993) Formyl peptide receptor chimeras define domains involved in ligand binding. J Biol Chem 268:2292-2295. (Pubitemid 23057839)
274. Perez HD, Kelly E, Elfman F, Armitage G, and Winkler J (1991) Defective polymorphonuclear leukocyte formyl peptide receptor(s) in juvenile periodontitis. J Clin Invest 87:971-976.
275. Perretti M (2003) The annexin 1 receptor(s): is the plot unravelling? Trends Pharmacol Sci 24:574-579. (Pubitemid 37357141)
276. Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ, Solito E, and Serhan CN (2002) Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat Med 8:1296-1302. (Pubitemid 35373563)
277. Perretti M, Getting SJ, Solito E, Murphy PM, and Gao JL (2001) Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol 158:1969-1973. (Pubitemid 32545181)
278. Pitcher JA, Freedman NJ, and Lefkowitz RJ (1998) G protein-coupled receptor kinases. Annu Rev Biochem 67:653-692. (Pubitemid 28411141)
279. Posner RG, Fay SP, Domalewski MD, and Sklar LA (1994) Continuous spectrofluorometric analysis of formyl peptide receptor ternary complex interactions. Mol Pharmacol 45:65-73.
280. Potter RM, Maestas DC, Cimino DF, and Prossnitz ER (2006) Regulation of N-formyl peptide receptor signaling and trafficking by individual carboxyl-terminal serine and threonine residues. J Immunol 176:5418-5425.
281. Prat C, Bestebroer J, de Haas CJ, van Strijp JA, and van Kessel KP (2006) A new staphylococcal anti-inflammatory protein that antagonizes the formyl peptide receptor-like 1. J Immunol 177:8017-8026. (Pubitemid 44846319)
282. Price MO, McPhail LC, Lambeth JD, Han CH, Knaus UG, and Dinauer MC (2002) Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system. Blood 99:2653-2661. (Pubitemid 34525349)
283. Prossnitz ER, Kim CM, Benovic JL, and Ye RD (1995a) Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2. J Biol Chem 270:1130-1137.
284. Prossnitz ER, Quehenberger O, Cochrane CG, and Ye RD (1991) Transmembrane signalling by the N-formyl peptide receptor in stably transfected fibroblasts. Biochem Biophys Res Commun 179:471-476.
285. Prossnitz ER, Quehenberger O, Cochrane CG, and Ye RD (1993) Signal transducing properties of the N-formyl peptide receptor expressed in undifferentiated HL60 cells. J Immunol 151:5704-5715. (Pubitemid 23332380)
286. Prossnitz ER, Schreiber RE, Bokoch GM, and Ye RD (1995b) Binding of low affinity N-formyl peptide receptors to G protein. Characteriztion of a novel inactive receptor intermediate. J Biol Chem 270:10686-10694.
287. Qiu FH, Devchand PR, Wada K, and Serhan CN (2001) Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils. Faseb J 15:2736-2738.
288. Quehenberger O, Pan ZK, Prossnitz ER, Cavanagh SL, Cochrane CG, and Ye RD (1997) Identification of an N-formyl peptide receptor ligand binding domain by a gain-of-function approach. Biochem Biophys Res Commun 238:377-381. (Pubitemid 27464392)
289. Quehenberger O, Prossnitz ER, Cavanagh SL, Cochrane CG, and Ye RD (1993) Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors. J Biol Chem 268:18167-18175. (Pubitemid 23260338)
290. Rabiet MJ, Huet E, and Boulay F (2005) Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR. Eur J Immunol 35:2486-2495. (Pubitemid 41179770)
291. Rabiet MJ, Huet E, and Boulay F (2007) The N-formyl peptide receptors and the anaphylatoxin C5a receptors: an overview. Biochimie 89:1089-1106. (Pubitemid 47260646)
292. Redl H, Flynn PJ, Lamche H, Schiesser A, Schlag G, and Hammerschmidt DE (1983) Aggregation, chemotaxis, and chemiluminescence of canine granulocytes. Studies utilizing improved cell preparation techniques. Inflammation 7:67-80.
293. Resnati M, Pallavicini I, Wang JM, Oppenheim J, Serhan CN, Romano M, and Blasi F (2002) The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R. Proc Natl Acad Sci U S A 99:1359-1364. (Pubitemid 34136498)
294. Richardson RM, Ali H, Tomhave ED, Haribabu B, and Snyderman R (1995) Cross-desensitization of chemoattractant receptors occurs at multiple levels. Evidence for a role for inhibition of phospholipase C activity. J Biol Chem 270:27829-27833.
295. Roberts AW, Kim C, Zhen L, Lowe JB, Kapur R, Petryniak B, Spaetti A, Pollock JD, Borneo JB, Bradford GB, et al. (1999) Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity 10:183-196. (Pubitemid 29115624)
296. Rodgers K, McMahon B, Mitchell D, Sadlier D, and Godson C (2005) Lipoxin A4 modifies platelet-derived growth factor-induced pro-fibrotic gene expression in human renal mesangial cells. Am J Pathol 167:683-694. (Pubitemid 41216354)
297. 2+ mobilization. J Immunol 157:2149-2154.
298. Rot A, Henderson LE, Copeland TD, and Leonard EJ (1987) A series of six ligands for the human formyl peptide receptor: tetrapeptides with high chemotactic potency and efficacy. Proc Natl Acad Sci U S A 84:7967-7971. (Pubitemid 17162814)
299. Rot A, Henderson LE, Sowder R, and Leonard EJ (1989) Staphylococcus aureus tetrapeptide with high chemotactic potency and efficacy for human leukocytes. J Leukoc Biol 45:114-120. (Pubitemid 19077297)
300. Rotrosen D, Malech HL, and Gallin JI (1987) Formyl peptide leukocyte chemoattractant uptake and release by cultured human umbilical vein endothelial cells. J Immunol 139:3034-3040. (Pubitemid 17157476)
301. Rovati GE, Capra V, and Neubig RR (2007) The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state. Mol Pharmacol 71:959-964. (Pubitemid 46456999)
302. Sahagun-Ruiz A, Colla JS, Juhn J, Gao JL, Murphy PM, and McDermott DH (2001) Contrasting evolution of the human leukocyte N-formylpeptide receptor subtypes FPR and FPRL1R. Genes Immun 2:335-342. (Pubitemid 33674246)
303. Sandri S, Rodriguez D, Gomes E, Monteiro HP, Russo M, and Campa A (2008) Is serum amyloid A an endogenous TLR4 agonist? J Leukoc Biol 83:1174-1180. (Pubitemid 351960349)
304. Sasaki T, Irie-Sasaki J, Jones RG, Oliveira-dos-Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, et al. (2000) Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science 287:1040-1046. (Pubitemid 30094360)
305. Savarese TM and Fraser CM (1992) In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors. Biochem J 283:1-19.
306. Savill J (1997) Apoptosis in resolution of inflammation. J Leukoc Biol 61:375-380. (Pubitemid 27219829)
307. Schaldach CM, Riby J, and Bjeldanes LF (1999) Lipoxin A4: a new class of ligand for the Ah receptor. Biochemistry 38:7594-7600. (Pubitemid 129516135)
308. Schepetkin IA, Kirpotina LN, Khlebnikov AI, and Quinn MT (2007) High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists. Mol Pharmacol 71:1061-1074. (Pubitemid 46457010)
309. Schepetkin IA, Kirpotina LN, Tian J, Khlebnikov AI, Ye RD, and Quinn MT (2008) Identification of novel formyl peptide receptor-like 1 agonists that induce macrophage tumor necrosis factor-α production. Mol Pharmacol 74:392-402.
310. Schiffmann E, Corcoran BA, and Wahl SM (1975a) N-formylmethionyl peptides as chemoattractants for leucocytes. Proc Natl Acad Sci U S A 72:1059-1062.
311. Schiffmann E, Showell HV, Corcoran BA, Ward PA, Smith E, and Becker EL (1975b) The isolation and partial characterization of neutrophil chemotactic factors from Escherichia coli. J Immunol 114:1831-1837.
312. Schreiber RE, Prossnitz ER, Ye RD, Cochrane CG, and Bokoch GM (1994) Domains of the human neutrophil N-formyl peptide receptor involved in G protein coupling. Mapping with receptor-derived peptides. J Biol Chem 269:326-331. (Pubitemid 24026662)
313. Schreiber RE, Prossnitz ER, Ye RD, Cochrane CG, Jesaitis AJ, and Bokoch GM (1993) Reconstitution of recombinant N-formyl chemotactic peptide receptor with G protein. J Leukocyte Biol 53:470-474. (Pubitemid 23159890)
314. Schultz P, Stannek P, Voigt M, Jakobs KH, and Gierschik P (1992) Complementation of formyl peptide receptor-mediated signal transduction in Xenopus laevis oocytes. Biochem J 284:207-212.
315. Seifert R and Wenzel-Seifert K (2001) Defective Gi protein coupling in two formyl peptide receptor mutants associated with localized juvenile periodontitis. J Biol Chem 276:42043-42049. (Pubitemid 37371108)
316. Selleri C, Montuori N, Ricci P, Visconte V, Carriero MV, Sidenius N, Serio B, Blasi F, Rotoli B, Rossi G, et al. (2005) Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilization. Blood 105:2198-2205. (Pubitemid 40731813)
317. Sengeløv H, Boulay F, Kjeldsen L, and Borregaard N (1994) Subcellular localization and translocation of the receptor for N-formylmethionyl-leucyl-phenylalanine in human neutrophils. Biochem J 299:473-479. (Pubitemid 24114142)
318. Sengeløv H, Kjeldsen L, and Borregaard N (1993) Control of exocytosis in early neutrophil activation. J Immunol 150:1535-1543. (Pubitemid 23127445)
319. Serhan CN (2005) Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. Prostaglandins Leukot Essent Fatty Acids 73:141-162. (Pubitemid 41253472)
320. Serhan CN (2007) Resolution phase of inflammation: novel endogenous antiinflammatory and proresolving lipid mediators and pathways. Annu Rev Immunol 25:101-137. (Pubitemid 46697904)
321. Serhan CN, Fiore S, Brezinski DA, and Lynch S (1993) Lipoxin A4 metabolism by differentiated HL-60 cells and human monocytes: conversion to novel 15-oxo and dihydro products. Biochemistry 32:6313-6319. (Pubitemid 23208812)
322. Serhan CN, Maddox JF, Petasis NA, Akritopoulou-Zanze I, Papayianni A, Brady HR, Colgan SP, and Madara JL (1995) Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils. Biochemistry 34:14609-14615. (Pubitemid 3000720)
323. Servant G, Weiner OD, Neptune ER, Sedat JW, and Bourne HR (1999) Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell 10:1163-1178. (Pubitemid 29193738)
324. Sha'afi RI, and Molski TF (1988) Activation of the neutrophil. Prog Allergy 42:1-64. (Pubitemid 18166898)
325. Shen W, Proost P, Li B, Gong W, Le Y, Sargeant R, Murphy PM, Van Damme J, and Wang JM (2000) Activation of the chemotactic peptide receptor FPRL1 in monocytes phosphorylates the chemokine receptor CCR5 and attenuates cell responses to selected chemokines. Biochem Biophys Res Commun 272:276-283. (Pubitemid 30444934)
326. Shenoy SK and Lefkowitz RJ (2003) Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. Biochem J 375:503-515. (Pubitemid 37433499)
327. q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes. J Exp Med 204:2705-2718.
328. Showell HJ, Freer RJ, Zigmond SH, Schiffmann E, Aswanikumar S, Corcoran B, and Becker EL (1976) The structure-activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal secretion for neutrophils. J Exp Med 143:1154-1169.
329. Simon MI, Strathmann MP, and Gautam N (1991) Diversity of G proteins in signal transduction. Science 252:802-808. (Pubitemid 121000516)
330. Sklar LA, Bokoch GM, Button D, and Smolen JE (1987) Regulation of ligand-receptor dynamics by guanine nucleotides. Real-time analysis of interconverting states for the neutrophil formyl peptide receptor. J Biol Chem 262:135-139. (Pubitemid 17235643)
331. Sklar LA, Fay SP, Seligmann BE, Freer RJ, Muthukumaraswamy N, and Mueller H (1990) Fluorescence analysis of the size of a binding pocket of a peptide receptor at natural abundance. Biochemistry 29:313-316. (Pubitemid 20037634)
332. Sklar LA and Finney DA (1982) Analysis of ligand-receptor interactions with the fluorescence activated cell sorter. Cytometry 3:161-165. (Pubitemid 13171822)
333. Sklar LA, Finney DA, Oades ZG, Jesaitis AJ, Painter RG, and Cochrane CG (1984) The dynamics of ligand-receptor interactions. Real-time analyses of association, dissociation, and internalization of an N-formyl peptide and its receptors on the human neutrophil. J Biol Chem 259:5661-5669. (Pubitemid 14145029)
334. Sklar LA, Oades ZG, Jesaitis AJ, Painter RG, and Cochrane CG (1981) Fluoresceinated chemotactic peptide and high-affinity antifluorescein antibody as a probe of the temporal characteristics of neutrophil stimulation. Proc Natl Acad Sci U S A 78:7540-7544. (Pubitemid 12186178)
335. Smith RJ, Sam LM, and Justen JM (1988) Diacylglycerols modulate human polymorphonuclear neutrophil responsiveness: effects on intracellular calcium mobilization, granule exocytosis, and superoxide anion production. J Leukoc Biol 43:411-419. (Pubitemid 18136104)
336. Snyderman R and Pike MC (1980) N-Formylmethionyl peptide receptors on equine leukocytes initiate secretion but not chemotaxis. Science 209:493-495. (Pubitemid 10022753)
337. Snyderman R and Uhing RJ (1992) Phagocytic cells: stimulus-response coupling mechanisms, in Inflammation: Basic Principles and Clinical Correlates (Gallin JI, Goldstein IM, and Snyderman R eds) pp 421-439, Raven Press, New York.
338. Sodin-Semrl S, Spagnolo A, Mikus R, Barbaro B, Varga J, and Fiore S (2004) Opposing regulation of interleukin-8 and NF-kappaB responses by lipoxin A4 and serum amyloid A via the common lipoxin A receptor. Int J Immunopathol Pharmacol 17:145-156. (Pubitemid 39572170)
339. Sodin-Semrl S, Taddeo B, Tseng D, Varga J, and Fiore S (2000) Lipoxin A4 inhibits IL-1 beta-induced IL-6, IL-8, and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases. J Immunol 164:2660-2666. (Pubitemid 30115498)
340. Solito E, Kamal A, Russo-Marie F, Buckingham JC, Marullo S, and Perretti M (2003) A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils. Faseb J 17:1544-1546.
341. Solito E, Romero IA, Marullo S, Russo-Marie F, and Weksler BB (2000) Annexin 1 binds to U937 monocytic cells and inhibits their adhesion to microvascular endothelium: involvement of the alpha 4 beta 1 integrin. J Immunol 165:1573-1581. (Pubitemid 30604594)
342. Southgate EL, He RL, Gao JL, Murphy PM, Nanamori M, and Ye RD (2008) Identification of formyl peptides from Listeria monocytogenes and Staphylococcus aureus as potent chemoattractants for mouse neutrophils. J Immunol 181:1429-1437.
343. Souza DG, Fagundes CT, Amaral FA, Cisalpino D, Sousa LP, Vieira AT, Pinho V, Nicoli JR, Vieira LQ, Fierro IM, et al. (2007) The required role of endogenously produced lipoxin A4 and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in mice. J Immunol 179:8533-8543.
344. Stenfeldt AL, Karlsson J, Wennerås C, Bylund J, Fu H, and Dahlgren C (2007) Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation 30:224-229. (Pubitemid 350284401)
345. Su SB, Gao J, Gong W, Dunlop NM, Murphy PM, Oppenheim JJ, and Wang JM (1999a) T21/DP107, A synthetic leucine zipper-like domain of the HIV-1 envelope gp41, attracts and activates human phagocytes by using G-protein-coupled formyl peptide receptors. J Immunol 162:5924-5930. (Pubitemid 29314947)
346. Su SB, Gong W, Gao JL, Shen W, Murphy PM, Oppenheim JJ, and Wang JM (1999b) A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells. J Exp Med 189:395-402. (Pubitemid 29063260)
347. Su SB, Gong WH, Gao JL, Shen WP, Grimm MC, Deng X, Murphy PM, Oppenheim JJ, and Wang JM (1999c) T20/DP178, an ectodomain peptide of human immunodeficiency virus type 1 gp41, is an activator of human phagocyte N-formyl peptide receptor. Blood 93:3885-3892. (Pubitemid 29249837)
348. Sun R, Iribarren P, Zhang N, Zhou Y, Gong W, Cho EH, Lockett S, Chertov O, Bednar F, Rogers TJ, et al. (2004) Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor. J Immunol 173:428-436. (Pubitemid 38797369)
349. Svensson CI, Zattoni M, and Serhan CN (2007) Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing. J Exp Med 204:245-252. (Pubitemid 46294540)
350. Takano T, Clish CB, Gronert K, Petasis N, and Serhan CN (1998) Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues. J Clin Invest 101:819-826. (Pubitemid 28096079)
351. Takano T, Fiore S, Maddox JF, Brady HR, Petasis NA, and Serhan CN (1997) Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. J Exp Med 185:1693-1704. (Pubitemid 27203265)
352. Tardif M, Mery L, Brouchon L, and Boulay F (1993) Agonist-dependent phosphorylation of N-Formylpeptide and activation peptie from the fifth component of C (C5a) chemoattractant receptors in differentiated HL60 cells. J Immunol 150:3534-3545. (Pubitemid 23129734)
353. Tardif M, Rabiet MJ, Christophe T, Milcent MD, and Boulay F (1998) Isolation and characterization of a variant HL60 cell line defective in the activation of the NADPH oxidase by phorbol myristate acetate. J Immunol 161:6885-6895. (Pubitemid 28562234)
354. Thelen M, Peveri P, Kernen P, von Tscharner V, Walz A, and Baggiolini M (1988) Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist. Faseb J 2:2702-2706. (Pubitemid 18196198)
355. Thelen M, Wymann MP, and Langen H (1994) Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes. Proc Natl Acad Sci U S A 91:4960-4964. (Pubitemid 24177770)
356. Thomas KM, Pyun HY, and Navarro J (1990) Molecular cloning of the fMet-Leu-Phe receptor from neutrophils. J Biol Chem 265:20061-20064. (Pubitemid 120013971)
357. Thomas KM, Taylor L, and Navarro J (1991) The interleukin-8 receptor is encoded by a neutrophil-specific cDNA clone, F3R. J Biol Chem 266:14839-14841. (Pubitemid 21907579)
358. Tiffany HL, Lavigne MC, Cui YH, Wang JM, Leto TL, Gao JL, and Murphy PM (2001) Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain. J Biol Chem 276:23645-23652. (Pubitemid 37410756)
359. Toniolo C, Crisma M, Moretto V, Freer RJ, and Becker EL (1990) N alpha-formylated and tert-butyloxycarbonylated Phe-(Leu-Phe)n and (Leu-Phe)n peptides as agonists and antagonists of the chemotactic formylpeptide receptor of the rabbit peritoneal neutrophil. Biochim Biophys Acta 1034:67-72. (Pubitemid 20114801)
360. Tuluc F, Meshki J, and Kunapuli SP (2003) Membrane lipid microdomains differentially regulate intracellular signaling events in human neutrophils. Int Immunopharmacol 3:1775-1790. (Pubitemid 37421263)
361. Van Dyke TE, Zinney W, Winkel K, Taufiq A, Offenbacher S, and Arnold RR (1986) Neutrophil function in localized juvenile periodontitis. Phagocytosis, superoxide production and specific granule release. J Periodontol 57:703-708.
362. Vaughn MW, Proske RJ, and Haviland DL (2002) Identification, cloning, and functional characterization of a murine lipoxin A4 receptor homologue gene. J Immunol 169:3363-3369. (Pubitemid 35013186)
363. Verghese MW, Charles L, Jakoi L, Dillon SB, and Snyderman R (1987) Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants. J Immunol 138:4374-4380. (Pubitemid 17090414)
364. Villanueva MS, Beckers CJ, and Pamer EG (1994) Infection with Listeria monocytogenes impairs sialic acid addition to host cell glycoproteins. J Exp Med 180:2137-2145. (Pubitemid 24351594)
365. Vines CM, Revankar CM, Maestas DC, LaRusch LL, Cimino DF, Kohout TA, Lefkowitz RJ, and Prossnitz ER (2003) N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. J Biol Chem 278:41581-41584. (Pubitemid 37310411)
366. Vitkauskas G, Showell HJ, and Becker EL (1980) Specific binding of synthetic chemotactic peptides to rabbit peritoneal neutrophils: effects on dissociability of bound peptide, receptor activity and subsequent biologic responsiveness (deactivation). Mol Immunol 17:171-180. (Pubitemid 10164304)
367. von der Weid PY, Hollenberg MD, Fiorucci S, and Wallace JL (2004) Aspirin-triggered, cyclooxygenase-2-dependent lipoxin synthesis modulates vascular tone. Circulation 110:1320-1325. (Pubitemid 39202352)
368. von Wartburg A and Traber R (1986) Chemistry of the natural cyclosporin metabolites. Prog Allergy 38:28-45. (Pubitemid 16043247)
369. Walther A, Riehemann K, and Gerke V (2000) A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol Cell 5:831-840.
370. Wang F, Herzmark P, Weiner OD, Srinivasan S, Servant G, and Bourne HR (2002) Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat Cell Biol 4:513-518. (Pubitemid 34752437)
371. Wang ZG and Ye RD (2002) Characterization of two new members of the formyl peptide receptor gene family from 129S6 mice. Gene 299:57-63. (Pubitemid 35379827)
372. Ward PA, Lepow IH, and Newman LJ (1968) Bacterial factors chemotactic for polymorphonuclear leukocytes. Am J Pathol 52:725-736.
373. Ward PA, Sulavik MC, and Johnson KJ (1984) Rat neutrophil activation and effects of lipoxygenase and cyclooxygenase inhibitors. Am J Pathol 116:223-233. (Pubitemid 14053913)
374. Weingarten R, Ransnäs L, Mueller H, Sklar LA, and Bokoch GM (1990) Mastoparan interacts with the carboxyl terminus of the alpha subunit of Gi. J Biol Chem 265:11044-11049. (Pubitemid 20200101)
375. Welch HC, Coadwell WJ, Ellson CD, Ferguson GJ, Andrews SR, Erdjument-Bromage H, Tempst P, Hawkins PT, and Stephens LR (2002) P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell 108:809-821. (Pubitemid 34327532)
376. Welch HC, Condliffe AM, Milne LJ, Ferguson GJ, Hill K, Webb LM, Okkenhaug K, Coadwell WJ, Andrews SR, Thelen M, et al. (2005) P-Rex1 regulates neutrophil function. Curr Biol 15:1867-1873. (Pubitemid 41501523)
377. 3. J Biol Chem 274:33259-33266.
378. Wenzel-Seifert K, Grünbaum L, and Seifert R (1991) Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation. J Immunol 147:1940-1946.
379. Wenzel-Seifert K, Hurt CM, and Seifert R (1998) High constitutive activity of the human formyl peptide receptor. J Biol Chem 273:24181-24189. (Pubitemid 28435765)
380. Wenzel-Seifert K and Seifert R (1993) Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-leucyl-L- phenylalanine and cyclosporins A, B, C, D, and E. J Immunol 150:4591-4599. (Pubitemid 23133736)
381. Wilkinson PC (1979) Synthetic peptide chemotactic factors for neutrophils: the range of active peptides, their efficacy and inhibitory activity, and susceptibility of the cellular response to enzymes and bacterial toxins. Immunology 36:579-588. (Pubitemid 9249542)
382. Williams LT, Snyderman R, Pike MC, and Lefkowitz RJ (1977) Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A 74:1204-1208. (Pubitemid 8065634)
383. Wu D, Jiang H, and Simon MI (1995) Different alpha 1-adrenergic receptor sequences required for activating different G alpha subunits of Gq class of G proteins. J Biol Chem 270:9828-9832.
384. Wu SH, Liao PY, Dong L, and Chen ZQ (2008) Signal pathway involved in inhibition by lipoxin A(4) of production of interleukins induced in endothelial cells by lipopolysaccharide. Inflamm Res 57:430-437.
385. Wu SH, Lu C, Dong L, Zhou GP, He ZG, and Chen ZQ (2005) Lipoxin A4 inhibits TNF-alpha-induced production of interleukins and proliferation of rat mesangial cells. Kidney Int 68:35-46. (Pubitemid 43181362)
386. Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, Kelly K, Takuwa Y, Sugimoto N, Mitchison T, and Bourne HR (2003) Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 114:201-214. (Pubitemid 36936914)
387. Xue M, Hsieh G, Raymond-Stintz MA, Pfeiffer J, Roberts D, Steinberg SL, Oliver JM, Prossnitz ER, Lidke DS, and Wilson BS (2007) Activated N-formyl peptide receptor and high-affinity IgE receptor occupy common domains for signaling and internalization. Mol Biol Cell 18:1410-1420. (Pubitemid 46626635)
388. Yamamoto Y, Kanazawa T, Shimamura M, Ueki M, and Hazato T (1997) Inhibitory effects of spinorphin, a novel endogenous regulator, on chemotaxis, O2- generation, and exocytosis by N-formylmethionyl-leucyl-phenylalanine (FMLP)-stimulated neutrophils. Biochem Pharmacol 54:695-701. (Pubitemid 27404629)
389. Yan P, Nanamori M, Sun M, Zhou C, Cheng N, Li N, Zheng W, Xiao L, Xie X, Ye RD, et al. (2006) The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding. J Immunol 177:7050-7058. (Pubitemid 44715072)
390. Yang D, Chen Q, Gertz B, He R, Phulsuksombati M, Ye RD, and Oppenheim JJ (2002) Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation. J Leukoc Biol 72:598-607.
391. Yang D, Chen Q, Le Y, Wang JM, and Oppenheim JJ (2001a) Differential regulation of formyl peptide receptor-like 1 expression during the differentiation of monocytes to dendritic cells and macrophages. J Immunol 166:4092-4098. (Pubitemid 32224940)
392. Yang D, Chen Q, Schmidt AP, Anderson GM, Wang JM, Wooters J, Oppenheim JJ, and Chertov O (2000) LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med 192:1069-1074. (Pubitemid 30765699)
393. Yang M, Sang H, Rahman A, Wu D, Malik AB, and Ye RD (2001b) G alpha 16 couples chemoattractant receptors to NF-kappa B activation. J Immunol 166:6885-6892. (Pubitemid 32467235)
394. Yazawa H, Yu ZX, Takeda, Le Y, Gong W, Ferrans VJ, Oppenheim JJ, Li CC, and Wang JM (2001) Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages. Faseb J 15:2454-2462. (Pubitemid 33063173)
395. Ye RD (2001) Regulation of nuclear factor kappaB activation by G-protein-coupled receptors. J Leukoc Biol 70:839-848. (Pubitemid 33151122)
396. Ye RD, Cavanagh SL, Quehenberger O, Prossnitz ER, and Cochrane CG (1992) Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor. Biochem Biophys Res Commun 184:582-589.
397. Ye RD, Quehenberger O, Thomas KM, Navarro J, Cavanagh SL, Prossnitz ER, and Cochrane CG (1993) The rabbit neutrophil N-formyl peptide receptor. cDNA cloning, expression, and structure/function implications. J Immunol 150:1383-1394. (Pubitemid 23127428)
398. Ying G, Iribarren P, Zhou Y, Gong W, Zhang N, Yu ZX, Le Y, Cui Y, and Wang JM (2004) Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor. J Immunol 172:7078-7085. (Pubitemid 38669150)
399. Zhang Y, Syed R, Uygar C, Pallos D, Gorry MC, Firatli E, Cortelli JR, VanDyke TE, Hart PS, Feingold E, et al. (2003) Evaluation of human leukocyte N-formylpeptide receptor (FPR1) SNPs in aggressive periodontitis patients. Genes Immun 4:22-29. (Pubitemid 38967571)
400. Zhou C, Zhang S, Nanamori M, Zhang Y, Liu Q, Li N, Sun M, Tian J, Ye PP, Cheng N, et al. (2007) Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol Pharmacol 72:976-983. (Pubitemid 47481420)
401. Zigmond SH (1977) Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors. J Cell Biol 75:606-616. (Pubitemid 8205010)