The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR

Journal of Immunology

Volumn 167, Issue 11, 2001, Pages 6609-6614

  Liang, T S ^a   Gao, J L ^a   Fatemi, O ^a   Lavigne, M ^a   Leto, T L ^a   Murphy, P M ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR; FORMYLMETHIONYLLEUCYLPHENYLALANINE; FORMYLPEPTIDE; HEMORPHIN 4; HEPTAPEPTIDE; OPIATE; RECEPTOR SUBTYPE; SPINORPHIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; DRUG RECEPTOR BINDING; ENZYME DEGRADATION; EXOCYTOSIS; HUMAN; HUMAN CELL; LUNG LAVAGE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN FAMILY; RECEPTOR BLOCKING;

EID: 0035575780     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.11.6609     Document Type: Article

References (49)

1. Milk protein-derived opioid receptor ligands
2. Hemorphins, cytochrophins, and human β-casomorphins bind to antiopiate (TYR-MIE-1) as well as opiate binding sites in rat brain
3. Novel opioid peptides derived from mitochondrial cytochrome b: Cytochrophins
4. Isolation of the opioid peptide leu-val-val-hemorphin-7 from bronchoalveolar lavage fluid of a patient with non-small cell lung cancer
5. Isolation of endogenous hemorphin-related hemoglobin fragments from bovine brain
6. Concomitant increase in blood plasma levels of immunoreactive hemorphin-7 and β-endorphin following long distance running
7. Protein isolation and characterization of a hemoglobin-derived opioid peptide from the human pituitary gland
8. Mass spectrometric identification and quantification of hemorphins extracted from human adrenal and pheochromocytoma tissue
9. Isolation of a hemoglobin-derived opioid peptide from cerebrospinal fluid of patients with cerebrovascular bleedings
10. Reversed-phase high-performance liquid chromatography for the determination of haemorphin-like immunoreactivity in human cerebrospinal fluid
11. Generation of VV-hemorphin-7 from globin by peritoneal macrophages
12. High molecular weight aspartic endopeptidase generates a coronaro-constrictory peptide from the β-chain of hemoglobin
13. Cathepsin D is a good candidate for the specific release of a stable hemorphin from hemoglobin in vivo: VV-hemorphin-7
14. The globin fragment LLV-hemorphin-7 is an endogenous ligand for the AT4 receptor in the brain
15. Haemorphin peptides may be endogenous ligands for brain angiotensin AT4 receptors
16. Investigation of inhibition angiotensin-converting enzyme (ACE) activity and opioid activity of two hemorphins, LVV-hemorphin-5 and VV-hemorphin-5, isolated from a defined peptic hydrolysate of bovine hemoglobin
17. Hemorphins derived from hemoglobin have an inhibitory action on angiotensin converting enzyme activity
18. Protein isolation and identification of an endogenous inhibitor of enkephalin-degrading enzymes from bovine spinal cord
19. Complete inhibition of purinoceptor agonist-induced nociception by spinorphin, but not by morphine
20. Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N
21. Increased expression of neutral endopeptidase (NEP) and aminopeptidase N (APN) on peripheral blood mononuclear cells in patients with multiple sclerosis
22. Peptidases in human bronchoalveolar lining fluid, macrophages, and epithelial cells: Dipeptidyl (amino)peptidase IV, aminopeptidase N, and dipeptidyl (carboxy)peptidase (angiotensin-converting enzyme)
23. p161. A murine membrane protein expressed on mast cells and some macrophages, is mouse CD13/aminopeptidase N
24. Distribution of neutral endopeptidase activity in human blood leukocytes
25. Function of neutral endopeptidase on the cell membrane of human neutrophils
26. - generation, and exocytosis by N-formylmethionyl-leucyl-phenylalanine (FMLP)-stimulated neutrophils
27. Inhibitory action of spinorphin, an endogenous regulator of enkephalin-degrading enzymes, on carrageenan-induced polymorphonuclear neutrophil accumulation in mouse air-pouches
28. The human N-formylpeptide receptor: Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors
29. Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor
30. A structural homologue of the N-formyl peptide receptor: Characterization and chromosomal mapping of a peptide chemoattractant receptor gene family
31. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1.FPRH2) to chromosome 19
32. Differential expression of the members of the N-formylpeptide receptor gene cluster in human phagocytes
33. Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor
34. A seven-transmembrane, G protein-coupled receptor, FPRL1R, mediates the chemotactic activity of serum amyloid A for human phagocytic cells
35. Species and subtype variants of the N-formyl peptide chemoattractant receptor reveal multiple important functional domains
36. Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse
37. Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: Evidence for anti-inflammatory receptors
38. N-formylpeptides induce two distinct concentration optima for mouse neutrophil chemotaxis by differential interaction with two N-formylpeptide receptor (FPR) subtypes: Molecular characterization of FPR2, a second mouse neutrophil FPR
39. Serum Amyloid A is a chemotactic agonist at FPR2, a low-affinity N-formylpeptide receptor on mouse neutrophils
40. Impaired anti-bacterial host defense in mice lacking the N-formylpeptide receptor
41. The molecular biology of leukocyte chemoattractant receptors
42. The N-formylpeptide chemotactic receptor
43. Tethered ligand library for discovery of peptide agonists
44. T20/DP178, an ectodomain peptide of human immunodeficiency virus type 1 gp41, is an activator of human phagocyte N-formyl peptide receptor
45. Red blood cells are a sink for interleukin 8, a leukocyte chemotaxin
46. Neutrophil attractant protein-1-immunoglobulin G immune complexes and free anti-NAP-1 antibody in normal human serum
47. Processing by CD26/dipeptidyl-peptidase IV reduces the chemotactic and anti-HIV-1 activity of stromal-cell-derived factor-1Eα
48. Chemoattractant receptor cross-desensitization
49. Binding and functional properties of recombinant and endogenous CXCR3 chemokinereceptors