The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions

Journal of Immunology

Volumn 171, Issue 8, 2003, Pages 4425-4430

  Kim, Chaekyun ^a,b   Marchal, Christophe C ^a   Penninger, Josef ^c   Dinaue, Mary C ^a,d  

^a RILEY HOSPITAL FOR CHILDREN   (United States)

^b Inha University School of Medicine   (South Korea)

^c ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; FORMYLMETHIONYLLEUCYLPHENYLALANINE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV1; GUANOSINE TRIPHOSPHATASE; INTERLEUKIN 8; LEUKOTRIENE B4; MEMBRANE RECEPTOR; RAC PROTEIN; RHO FACTOR; SUPEROXIDE; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL FUNCTION; CELL MOTILITY; CELL STIMULATION; CONTROLLED STUDY; GRANULOCYTE; HEMATOPOIESIS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PERITONEUM EXUDATE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0141889083     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.8.4425     Document Type: Article

References (33)

1. Benard, V., G. M. Bokoch, and B. A. Diebold. 1999. Potential drug targets: small GTPases that regulate leukocyte function. Trends Pharmacol. Sci. 20:365.
2. Quinn, M. T. 1995. Low-molecular-weight GTP-binding proteins and leukocyte signal transduction. J. Leukocyte Biol. 58:263.
3. Dinauer, M. 2003. Regulation of neutrophil function by Rac GTPases. Curr. Opin. Hematol. 10:8.
4. Roberts, A., C. Kim, L. Zhen, J. Lowe, R. Kapur, B. Petryniak, A. Spaetti, J. Pollock, J. Borneo, G. Bradford, et al. 1999. Deficiency of the hematopoietic cell-specific Rho-family GTPase, Rac2, is characterized by abnormalities in neutrophil function and host defense. Immunity 10:183.
5. Kim, C., and M. Dinauer. 2001. Rac2 is an essential regulator of neutrophil NADPH oxidase activation in response to specific signaling pathways. J. Immunol. 166:1223.
6. Li, S., A. Yamauchi, C. Marchal, J. Molitoris, L. A. Quilliam, and M. Dinauer. 2002. Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions. J. Immunol. 169:5043.
7. Alblas, J., L. Ulfman, P. Hordijk, and L. Koenderman. 2001. Activation of RhoA and ROCK are essential for detachment of migrating leukocytes. Mol. Biol. Cell 12:2137.
8. Scita, G., P. Tenca, E. Frittoli, A. Tocchetti, M. Innocenti, G. Giardina, and P. P. Di Fiore. 2000, Signaling from Ras to Rac and beyond: not just a matter of GEFs. EMBO J. 19:2393.
9. 3- and Gβγ-regulated guanine-nucleotide exchange factor for Rac. Cell 108:809.
10. Akasaki, T., H. Koga, and H. Sumimoto. 1999. Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils. J. Biol. Chem. 274:18055.
11. Benard, V., B. P. Bohl, and G. M. Bokoch. 1999. Characterization of Rac and Cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases, J. Biol. Chem. 274:13198.
12. Bustelo, X. R. 2000. Regulatory and signaling properties of the Vav family. Mol. Cell. Biol 20:1461.
13. Turner, M., and D. D. Billadeau. 2002. Vav proteins as signal integrators for multi-subunit immune-recognition receptors. Nature 2:476.
14. Aghazadeh, B., W. E. Lowry, X. Y. Huang, and M. K. Rosen. 2000. Structural basis for relief of autoinhibition of the Db1 homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell 102:625.
15. Movilla, N., M. Dosil, Y. Zheng, and X. R. Bustelo. 2001. How Vav proteins discriminate the GTPases Rac1 and RhoA from Cdc42. Oncogene 20:8057.
16. Patel, J. C., A. Hall, and E. Caron. 2002. Vav regulates activation of Rac but not Cdc42 during FcγR-mediated phagocytosis. Mol. Biol. Cell 13:1215.
17. Manetz, T. S., C. Gonzalez-Espinosa, R. Arudchandran, S. Xirasagar, V. Tybulewicz, and J. Rivera. 2001. Vav1 regulates phospholipase Cγ activation and calcium responses in mast cells. Mol. Cell. Biol. 21:3763,
18. ras through tyrosine phosphorylation of the protooncogene product Vav. Proc. Natl. Acad. Sci. USA 93:8431.
19. Vilhardt, F., O. Plastre, M. Sawada, K. Suzuki, M. Wiznerowicz, E. Kiyokawa, D. Trono, and K. Krause. 2002. The HIV-1 Nef protein and phagocyte NADPH oxidase activation. J. Biol. Chem. 277:42136
20. Ma, A. D., A. Metijan, S. Bagrodia, S. Taylor, and C. S. Abrams. 1998, Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase γ, a Rac guanosine exchange factor, and Rac. Mol. Cell. Biol. 18:4744.
21. phox cells and level of superoxide production is exchange factor-dependent. J. Biol. Chem. 277:19220.
22. Fischer, K. D., Y. Y. Kong, H. Nishina, K. Tedford, L. E. Marengere, I. Kozieradzki, T. Sasaki, M. Starr, G. Chan, S. Gardener, M. P. Nghiem, D. Bouchard, M. Barbacid, A. Bernstein, and J. M. Penninger. 1998. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr. Biol 8:554.
23. Gao, J. L., E. J. Lee, and P. M. Murphy. 1999. Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor. J. Exp. Med. 189:657.
24. vav in platelets. J. Biol. Chem. 271:7544.
25. Ptasznik, A., E. Prossnitz, D. Yoshikawa, A. Smrcka, A. Traynor-Kaplan, and G. Bokoch. 1996. A tyrosine kinase signaling, pathway for the majority of phosphalidylinositol 3,4,5-trisphosphate formation in chemoattractant-stimulated human neutrophils. J. Biol. Chem. 271:25204.
26. Welch, H., and I. Maridonneau-Parini. 1997. Lyn and Fgr are activated in distinct membrane fractions of human granulocytic cells. Oncogene 15:2021.
27. Nijhuis, E., J. W. Lammers, L. Koenderman, and P. J. Coffer. 2002. Src kinases regulate PKB activation and modulate cytokine and chemoattractant-controlled neutrophil functioning. J. Leukocyte Biol. 71:115.
28. Barlic, J., J. D. Andrews, A. A. Kelvin, S. E. Bosinger, M. E. DeVries, L. Xu, T. Dobransky, R. D. Feldman, S. S. Ferguson, and D. J. Kelvin. 2000. Regulation of tyrosine kinase activation and granule release through β-arrestin by CXCRI. Nat. Imumnol. 1:227.
29. Jagels, M. A., and T. E. Hugli. 1994. Mechanism, and mediators of neutrophilic leukocytosis. Immunopharmacology 28:1.
30. Kubo, H., L. Graham, N. A. Doyle, W. M. Quinlan, J. C. Hogg, and C. M. Doerschuk. 1998. Complement fragment-induced release of neutrophils from bone marrow and sequestration within pulmonary capillaries in rabbits. Blood 92:283.
31. 1 integrins by chemoattractants regulates neutrophil migration through fibrin. J. Cell Biol. 144:1047.
32. i-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils. J. Leukocyte Biol. 71:798.
33. Vigorito, E., D. D. Billadeu, D. Savoy, S. McAdam, G. Doody, P. Fort, and M. Turner. 2003. RhoG regulates gene expression and the actin cytoskeleton in lymphocytes. Oncogene 22:330.