Aspirin-triggered, cyclooxygenase-2-dependent lipoxin synthesis modulates vascular tone

Circulation

Volumn 110, Issue 10, 2004, Pages 1320-1325

  Von Der Weid, Pierre Yves ^a   Hollenberg, Morley D ^a   Fiorucci, Stefano ^b   Wallace, John L ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Endothelium; Inflammation; Muscle, smooth; Nitric oxide; Vasodilation

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; ARACHIDONATE 5 LIPOXYGENASE; BOC2 PROTEIN; CELECOXIB; CYCLOOXYGENASE 2; EPILIPOXIN A4; LIPOXIN; LIPOXIN A; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; UNCLASSIFIED DRUG; ZILEUTON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD FLOW; BLOOD PRESSURE; BLOOD VESSEL TONE; CONTROLLED STUDY; DRUG MECHANISM; INFLAMMATION; MALE; MESENTERIC ARTERY; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; VASODILATATION;

ACETYLCHOLINE; ANIMALS; AORTA; ARACHIDONATE 5-LIPOXYGENASE; ASPIRIN; BLOOD PRESSURE; CYCLOOXYGENASE 2 INHIBITORS; ENDOTHELIUM, VASCULAR; HYDROXYUREA; LIPOXINS; MALE; MESENTERIC ARTERIES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROARGININE; OLIGOPEPTIDES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, LIPOXIN; SULFONAMIDES; VASCULAR RESISTANCE; VASODILATION; VASODILATOR AGENTS;

EID: 4444274015     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000140985.89766.CB     Document Type: Article

References (28)

1. 2 inhibitors. Nat Rev Drug Discov. 2003;2:179-191.
2. Claria J, Serhan CN. Aspirin triggers previously unrecognized bioactive eicosanoids in human endothelial cell-leukocyte interactions. Proc Natl Acad Sci U S A. 1995;92:9475-9479.
3. 4 modulates transmigration of human neutrophils across intestinal epithelial monolayers. J Clin Invest. 1993;92:75-82.
4. Wallace JL. Nitric oxide, aspirin-triggered lipoxins and NO-aspirin in gastric protection. Curr Drug Targets Inflamm Allergy. In press.
5. 4 in the conscious rat. FEBS Lett. 1988;232:51-55.
6. Katoh T, Takahashi K, DeBoer DK, et al. Renal hemodynamic actions of lipoxins in rats: a comparative physiological study. Am J Physiol. 1992;263:F436-F442.
7. Singh G, Miller JD, Huse DM, et al. Consequences of increased systolic blood pressure in patients with osteoarthritis and rheumatoid arthritis. J Rheumatol. 2003;30:714-719.
8. Muscara MN, Lovren F, McKnight W, et al. Vasorelaxant effects of a nitric oxide-releasing aspirin derivative in normotensive and hypertensive rats. Br J Pharmacol. 2001;133:1314-1322.
9. Perretti M, Getting SJ, Solito E, et al. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol. 2001;158:1969-1973.
10. Wallace JL, Chapman K, McKnight W. Limited anti-inflammatory efficacy of cyclo-oxygenase-2 inhibition in carrageenan-airpouch inflammation. Br J Pharmacol. 1999;126:1200-1204.
11. Vaananen PM, Keenan CM, Grisham MB, et al. Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy. Inflammation. 1992;16:227-240.
12. Wallace JL, McKnight W, Asfaha S, et al. Reduction of acute and reactivated colitis in rats by an inhibitor of neutrophil activation. Am J Physiol. 1998;274:G802-G808.
13. Wallace JL, McKnight W, Reuter BK, et al. NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology. 2000;119:706-714.
14. 4 ELISA. J Pharmacol Exp Ther. 1998;287:779-790.
15. 4 increases gastric resistance to aspirin-induced damage. Gastroenterology. 2002;123:1598-1606.
16. Furchgott RF, Carvalho MH, Khan MT, et al. Evidence for endothelium-dependent vasodilation of resistance vessels by acetylcholine. Blood Vessels. 1987;24:145-149.
17. Hollenberg MD, Saifeddine M, Al-Ani B, et al. Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity and receptor selectivity of receptor-activating peptides. Can J Physiol Pharmacol. 1997;75:832-841.
18. Serhan CN. Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity? Prostaglandins. 1997;53:107-137.
19. 4 are potent inhibitors of acute inflammation: receptors and pathways. Adv Exp Med Biol. 1999;447:133-149.
20. Souza MH, de Lima OM Jr, Zamuner SR, et al. Gastritis increases resistance to aspirin-induced mucosal injury via COX-2-mediated lipoxin synthesis. Am J Physiol. 2003;285:G54-G61.
21. Wallace JL, Fiorucci S. A magic bullet for mucosal protection and aspirin is the trigger! Trends Pharmacol Sci. 2003;24:323-326.
22. 4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. J Exp Med. 1997;185:1693-1704.
23. 4 receptor that is conserved in structure and function. Br J Pharmacol. 2003;139:89-98.
24. Garland CJ, McPherson GA. Evidence that nitric oxide does not mediate the hyperpolarization and relaxation to acetylcholine in the rat small mesenteric artery. Br J Pharmacol. 1992;105:429-435.
25. Parkington HC, Chow JA, Evans RG, et al. Role for endothelium-derived hyperpolarizing factor in vascular tone in rat mesenteric and hindlimb circulations in vivo. J Physiol. 2002;542:929-937.
26. McGuire JJ, Ding H, Triggle CR. Endothelium-derived relaxing factors: a focus on endothelium-derived hyperpolarizing factor(s). Can J Physiol Pharmacol. 2001;79:443-470.
27. Randall MD, Hiley CR. Detergent and methylene blue affect endothelium-dependent vasorelaxation and pressure/flow relations in rat blood perfused mesenteric arterial bed. Br J Pharmacol. 1988;95:1081-1088.
28. McCulloch AI, Bottrill FE, Randall MD, et al. Characterization and modulation of EDHF-mediated relaxations in the rat isolated superior mesenteric arterial bed. Br J Pharmacol. 1997;120:1431-1438.