Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor

Journal of Experimental Medicine

Volumn 189, Issue 4, 1999, Pages 657-662

  Gao, Ji Liang ^a   Lee, Eric J ^b   Murphy, Philip M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Chemoattractant; Chemotaxis; Inflammation; Listeria; Neutrophil

Indexed keywords

DNA; FORMYLMETHIONYLLEUCYLPHENYLALANINE; FORMYLPEPTIDE; MESSENGER RNA; RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNE SYSTEM; INFLAMMATION; LISTERIA MONOCYTOGENES; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHAGOCYTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ANIMALS; CHEMOTAXIS, LEUKOCYTE; GENETIC PREDISPOSITION TO DISEASE; IMMUNITY, NATURAL; IMMUNOLOGIC DEFICIENCY SYNDROMES; LEUKOCYTE COUNT; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; LIVER; MICE; MICE, KNOCKOUT; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PEPTIDE; SPLEEN;

EID: 0033557172     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.4.657     Document Type: Article

References (35)

1. Murphy, P.M. 1996. The N-formylpeptide chemotactic receptor. In Chemoattractant Ligands and Their Receptors. R. Horuk, editor. CRC Press, Inc., Boca Raton, FL. 269-299.
2. Schiffmann, E., B.A. Corcoran, and S.M. Wahl. 1975. N-formylmethionyl peptides as chemoattractants for leukocytes. Proc. Natl. Acad. Sci. USA. 72:1059-1063.
3. Schiffmann, E., H.V. Showell, B.A. Corcoran, P.A. Ward, E. Smith, and E.L. Becker. 1975. The isolation and partial characterization of neutrophil chemotactic factors from Escherichia coli. J. Immunol. 114:1831-1837.
4. Marasco, W.A., S.H. Phan, H. Krutzsch, H.J. Showell, D.C. Feltner, R. Nairn, E.L. Becker, and P.A. Ward. 1984. Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli. J. Biol. Chem. 259:5430-5439.
5. Boulay, F., M. Tardif, L. Brouchon, and P. Vignais. 1990. Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA. Biochem. Biophys. Res. Commun. 168:1103-1109.
6. Murphy, P.M., and D. McDermott. 1991. Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor. J. Biol. Chem. 266:12560-12567.
7. Murphy, P.M., T. Ozcelik, R.T. Kenney, H.L. Tiffany, D. McDermott, and U. Francke. 1992. A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family. J. Biol. Chem. 267:7637-7643.
8. Ye, R.D., S.L. Cavanagh, O. Quehenberger, E.R. Prossnitz, and C.G. Cochrane. 1992. Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor. Biochem. Biophys. Res. Commun. 184:582-589.
9. Bao, L., N.P. Gerard, R.L. Eddy, Jr., T.B. Shows, and C. Gerard. 1992. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. Genomics. 13:437-440.
10. Murphy, P.M. 1994. The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol. 12:593-633.
11. Durstin, M., J.-L. Gao, H.L. Tiffany, D. McDermott, and P.M. Murphy. 1994. Differential expression of the members of the N-formylpeptide receptor gene cluster in human phagocytes. Biochem. Biophys. Res. Commun. 201:174-179.
12. Laudanna, C., J.J. Campbell, and E.C. Butcher. 1996. Role of Rho in chemoattractant-activated leukocyte adhesion through integrins. Science. 271:981-983.
13. Fiore, S., J.F. Maddox, H.D. Perez, and C.N. Serhan. 1994. Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. J. Exp. Med. 180:253-260.
14. Gerard, N.P., L. Bao, X.-P. He, R.L. Eddy, Jr., T.B. Shows, and C. Gerard. 1993. Human chemotactic receptor genes cluster at 19q13.3/13.4. Characterization of the human C5a receptor gene. Biochemistry. 32:1243-1250.
15. Gao, J.-L., and P.M. Murphy. 1993. Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains. J. Biol. Chem. 268: 25395-25401.
16. Gao, J.-L., H. Chen, J.D. Filie, C.A. Kozak, and P.M. Murphy. 1998. Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse. Genomics. 51: 270-276.
17. 4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. J. Exp. Med. 185:1693-1704.
18. Wenzel-Seifert, K., and R. Seifert. 1993. Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-leucyl-L- phenylalanine and cyclosporins A, B, C, D, and E. J. Immunol. 150:4591-4599.
19. Tybulewicz, V.L.J., C.E. Crawford, P.K. Jackson, R.T. Bronson, and R.C. Mulligan. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell. 65:1153-1163.
20. Li, E., T.H. Bestor, and R. Jaenisch. 1992. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. 69:915-926.
21. Gao, J.-L., E. Becker, R.J. Freer, N. Muthukumaraswamy, and P.M. Murphy. 1994. A high potency non-formylated peptide agonist for the phagocyte N-formylpeptide chemotactic receptor. J. Exp. Med. 180:2191-2198.
22. Elkins, K.L., A.T. MacIntyre, and T.R. Rhinehart-Jones. 1998. Nonspecific early protective immunity in Francisella and Listeria infections can be dependent on lymphocytes. Infect. Immun. 66:3467-3469.
23. Gao, J.-L., T.A. Wynn, Y. Chang, E.J. Lee, H.E. Broxmeyer, S. Cooper, H.L. Tiffany, H. Westphal, J. Kwon-Chung, and P.M. Murphy. 1997. Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J. Exp. Med. 185:1959-1968.
24. Kurihara, T., G. Warr, J. Loy, and R. Bravo. 1997. Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor. J. Exp. Med. 186:1757-1762.
25. Zhou, Y., T. Kurihara, R.P. Ryseck, Y. Yang, C. Ryan, J. Loy, G. Warr, and R. Bravo. 1998. Impaired macrophage function and enhanced T cell-dependent immune response in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor. J. Immunol. 160:4018-4025.
26. Cacalano, G., J. Lee, K. Kikly, A.M. Ryan, S. Pitts-Meek, B. Hultgren, W.I. Wood, and M.W. Moore. 1994. Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science. 265:682-684. (See published erratum. 270:365.)
27. Kuziel, W.A., S.J. Morgan, T.C. Dawson, S. Griffin, O. Smithies, K. Ley, and N. Maeda. 1997. Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc. Natl. Acad. Sci. USA 94:12053-12058.
28. Boring, L., J. Gosling, S.W. Chensue, S.L. Kunkel, R.V. Farese, Jr., H.E. Broxmeyer, and I.F. Charo. 1997. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J. Clin. Invest. 100:2552-2561.
29. Hopken, U.E., B. Lu, N.P. Gerard, and C. Gerard. 1996. The C5a chemoattractant receptor mediates mucosal defence to infection. Nature. 383:86-89.
30. Unanue, E.R. 1997. Studies in listeriosis show the strong symbiosis between the innate cellular system and the T-cell response. Immunol. Rev. 158:11-25.
31. Nataraj, C., G.R. Huffman, and R.J. Kurlander. 1998. H2M3 (wt)-restricted, Listeria monocytogenes-immune CD8 T cells respond to multiple formylated peptides and to a variety of Gram-positive and Gram-negative bacteria. Int. Immunol. 10:7-15.
32. Conlan, J.W., and R.J. North. 1991. Neutrophil-mediated dissolution of infected host cells as a defense strategy against a facultative intracellular bacterium. J. Exp. Med. 3:741-744.
33. Rogers, H.W., and E.R. Unanue. 1993. Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice. Infect. Immun. 12:5090-5096.
34. Dinauer, M.C., M.B. Deck, and E.R. Unanue. 1997. Mice lacking reduced nicotinamide adenine dinucleotide phosphate oxidase activity show increased susceptibility to early infection with Listeria monocytogenes. J. Immunol. 12:5581-5583.
35. Dai, W.J., W. Bartens, G. Kohler, M. Hufnagel, M. Kopf, and F. Brombacher. 1997. Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-gamma receptor-deficient mice. J. Immunol. 158:5297-5304.