Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues

Journal of Clinical Investigation

Volumn 101, Issue 4, 1998, Pages 819-826

  Takano, Tomoko ^a,c   Clish, Clary B ^a   Gronert, Karsten ^a   Petasis, Nicos ^b   Serhan, Charles N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

Antiinflammatory receptors; Aspirin; Leukocytes; Lipid mediators; Vascular permeability

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONATE 5 LIPOXYGENASE; COMPLEMENT COMPONENT C5A; FORMYLMETHIONYLLEUCYLPHENYLALANINE; INTERLEUKIN 8; LEUKOTRIENE B4 RECEPTOR ANTAGONIST; LEUKOTRIENE D4; LIPOXIN; LIPOXIN A; LIPOXIN B; MYELOPEROXIDASE; PROSTAGLANDIN E2; THROMBOCYTE ACTIVATING FACTOR;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; BLOOD VESSEL PERMEABILITY; CELL INFILTRATION; CONTROLLED STUDY; INFLAMMATION; LEUKOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

EID: 0032519406     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1578     Document Type: Article

References (16)

1. Varani, J., and P.A. Ward. 1994. Mechanism of neutrophil-dependent and neutrophil-independent endolbelial cell injury. Biol. Signals. 3:1-14.
2. 4. Clin. Biochem. 23:459-468.
3. Serhan, C.N. 1997. Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity? Prostaglandins. 53:107-137.
4. 4 and N-formyl-L-methionyl-L-leucyl-L-phenylalanine. Clin. Sci. 77:195-203.
5. 4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. J. Immunol. 156:2264-2272.
6. 4 modulates transmigration of human neutrophils across intestinal epithelial monolayers. J. Clin. Invest. 92:75-82.
7. 4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. J. Exp. Med. 185:1693-1704.
8. 4 inhibits cholinergic neurotransmission through nitric oxide generation in the rabbit trachea. Eur. J. Pharmacol. 287:233-238.
9. 4 stable analogues that block transmigration and adhesion of human neutrophils. Biochemistry. 34:14609-14615.
10. 4 analogs with increased biologic activity. FASEB (Fed. Am. Sac. Exp. Biol.) J. In press.
11. 4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents. J. Phurtnacol. Exp. Ther. 255:565-571.
12. Collgan, J.E., A.M. Krulsbeek, D.H. Margulies, E.M. Shevach, and W. Strober. 1996. Current Protocols in Immunology. Vol. 3.1. John Wiley & Sons Inc., New York. 3.1.1-3.1.5.
13. Gronert, K., S.P. Colgan, and C.N. Serhan. 1997. Hypoxia enhances lipoxin inhibition of neutrophil transendothelial migration: characterization of ligand operated proton efflux. FASEB (Fed. Am. Soc. Exp. Biol.) J. 11:A331. (Abstr.)
14. 4 with human neutrophils. J. Biol. Chem. 267:16168-16176.
15. McConnell, H.M., J.C. Owicki, J.W. Parce, D.L. Miller, GT. Baxter, H.G. Wada, and S. Pitchford. 1992. The Cytosensor microphysiometer: biological applications of silicon technology. Science. 257:1906-1912.
16. Hedqvist, P., L. Lindbom, U. Palmertz, and J. Raud. 1994. Microvascular mechanisms in inflammation. Adv: Prostglandin Thromboxiane Leukotriene Res. 22:91-99.