Normal cell surface expression and selective loss of functions resulting from Phe110 to Ser and Cys126 to Trp substitutions in the formyl peptide receptor

Immunological Investigations

Volumn 33, Issue 2, 2004, Pages 193-212

  Nanamori, Masakatsu ^a   He, Rong ^a   Sang, Hairong ^a   Ye, Richard D ^a,b  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Cellular activation; Chemotaxis; Inflammation; Neutrophils

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE; CHEMOATTRACTANT; CYSTEINE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; FORMYLPEPTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHENYLALANINE; RECEPTOR PROTEIN; SERINE; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BACTERIUM; CALCIUM MOBILIZATION; CELL ACTIVATION; CELL STIMULATION; CELL STRAIN; CELL STRAIN RBL 2H3; CELL SURFACE; CELLULAR IMMUNITY; CONTROLLED STUDY; ENDOCYTOSIS; IMMUNOSTIMULATION; INFLAMMATION; LEUKOCYTE FUNCTION; MUTATION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

EID: 2542467020     PISSN: 08820139     EISSN: None     Source Type: Journal    
DOI: 10.1081/IMM-120034234     Document Type: Article

References (35)

1. Barlic, J., Andrews, J. D., Kelvin, A. A., Bosinger, S. E., DeVries, M. E., Xu, L., Dobransky, T., Feldman, R. D., Ferguson, S. S., Kelvin, D. J. (2000). Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI. Nat. Immunol. 1:227-233.
2. Berridge, M. J., Downes, C. P., Hanley, M. R. (1982). Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem. J. 206:587-595.
3. Bokoch, G. M., Gilman, A. G. (1984). Inhibition of receptor mediated release of arachidonic acid by pertussis toxin. Cell 39:301-303.
4. Bommakanti, R. K., Dratz, E. A., Siemsen, D. W., Jesaitis, A. J. (1995). Extensive contact between Gi2 and N-formyl peptide receptor of human neutrophils: mapping of binding sites using receptor-mimetic peptides. Biochemistry 34:6720-6728.
5. Cianciola, L. J., Genco, R. J., Patters, M. R., McKenna, J., van Oss, C. J. (1977). Defective polymorphonuclear leukocyte function in a human periodontal disease. Nature 265:445-447.
6. Clark, R. A., Page, R. C., Wilde, G. (1977). Defective neutrophil chemotaxis in juvenile periodontitis. Infect. Immun. 18:694-700.
7. Daniel, M. A., McDonald, G., Offenbacher, S., Van Dyke, T. E. (1993). Defective chemotaxis and calcium response in localized juvenile periodontitis neutrophils. J. Periodontol. 64:617-621.
8. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:3440-3450.
9. Gwinn, M. R., Sharma, A., De Nardin, E. (1999). Single nucleotide polymorphisms of the N-formyl peptide receptor in localized juvenile periodontitis. J. Periodontol. 70:1194-1201.
10. He, R., Tan, L., Browning, D. D., Wang, J. M., Ye, R. D. (2000). The synthetic peptide trp-lys-tyr-met-val-D-Met is a potent chemotactic agonist for mouse formyl peptide receptor. J. Immunol. 165:4598-4605.
11. Jones, B. E., Miettinen, H. M., Jesaitis, A. J., Mills, J. S. (2003). Mutations of F110 and C126 of the formyl peptide receptor interfere with G-protein coupling and chemotaxis. J. Periodontol. 74:475-484.
12. Knall, C., Young, S., Nick, J. A., Buhl, A. M., Worthen, G. S., Johnson, G. L. (1996). Interleukin-8 regulation of the Ras/Raf/Mitogen-activated protein kinase pathway in human neutrophils. J. Biol. Chem. 271:2832-2838.
13. Kulczycki, A. Jr., Isersky, C., Metzger, H. (1974). The interaction of IgE with rat basophilic leukemia cells. I. Evidence for specific binding of IgE. J. Exp. Med. 139:600-616.
14. Le, Y., Murphy, P. M., Wang, J. M. (2002). Formyl-peptide receptors revisited. Trends Immunol. 23:541-548.
15. Leino, L., Hurttia, H. M., Sorvajarvi, K., Sewon, L. A. (1994). Increased respiratory burst activity is associated with normal expression of IgG-Fc-receptors and complement receptors in peripheral neutrophils from patients with juvenile periodontitis. J. Periodontal. Res. 29:179-184.
16. Miettinen, H. M., Gripentrog, J. M., Mason, M. M., Jesaitis, A. J. (1999). Identification of putative sites of interaction between the human formyl peptide receptor and G protein. J. Biol. Chem. 274:27934-27942.
17. Murphy, P. M. (1994). The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol. 12:593-633.
18. Okajima, F., Katada, T., Ui, M. (1985). Coupling of the guanine nucleotide regulatory protein to chemotactic peptide receptors in neutrophil membranes and its uncoupling by islet-activating protein, pertussis toxin. J. Biol. Chem. 260:6761-6768.
19. Payne, D. M., Rossomando, A. J., Martino, P., Erickson, A. K., Her, J. H., Shabanowitz, J., Hunt, D. F., Weber, M. J., Sturgill, T. W. (1991). Identification of the regulatory phosphorylation sites in pp42/ mitogen-activated protein kinase (MAP kinase). Embo. J. 10:885-892.
20. Perez, H. D., Kelly, E., Elfman, F., Armitage, G., Winkler, J. (1991). Defective polymorphonuclear leukocyte formyl peptide receptor(s) in juvenile periodontitis. J. Clin. Invest. 87:971-976.
21. Prossnitz, E. R., Ye, R. D. (1997). The N-formyl peptide receptor: a model for the study of chemoattractant receptor structure and function. Pharmacol. Ther. 74:73-102.
22. Prossnitz, E. R., Schrieber, R. E., Bokoch, G. M., Ye, R. D. (1995). Binding of low affinity N-formyl peptide receptors to G protein. Characterization of a novel inactive receptor intermediate. J. Biol. Chem. 270:10686-10694.
23. Prossnitz, E. R., Gilbert, T. L., Chiang, S., Campbell, J. J., Qin, S., Newman, W., Sklar, L. A., Ye, R. D. (1999). Multiple activation steps of the N-formyl peptide receptor. Biochemistry 38:2240-2247.
24. Quehenberger, O., Prossnitz, E. R., Cochrane, C. G., Ye, R. D. (1992). Absence of Gi proteins in the Sf9 insect cell. Characterization of the uncoupled recombinant N-formyl peptide receptor. J. Biol. Chem. 267:19757-19760.
25. Richardson, R. M., DuBose, R. A., Ali, H., Tomhave, E. D., Haribabu, B., Snyderman, R. (1995). Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions. Biochemistry 34:14193-14201.
26. Schreiber, R. E., Prossnitz, E. R., Ye, R. D., Cochrane, C. G., Bokoch, G. M. (1994). Domains of the human neutrophil N-formyl peptide receptor involved in G protein coupling. Mapping with receptor-derived peptides. J. Biol. Chem. 269:326-331.
27. Seifert, R., Wenzel-Seifert, K. (2001). Defective Gi protein coupling in two formyl peptide receptor mutants associated with localized juvenile periodontitis. J. Biol. Chem. 276:42043-42049.
28. Snyderman, R., Uhing, R. J. (1992). Phagocytic cells: stimulus-response coupling mechanisms. In: Gallin, J. I., Goldstein, I. M., Snyderman, R., eds. Inflammation: Basic Principles and Clinical Correlates. New York: Raven Press, pp. 421-439.
29. Torres, M., Hall, F. L., O'Neill, K. (1993). Stimulation of human neutrophils with formyl-methionyl-leucyl-phenylalanine induces tyrosine phosphorylation and activation of two distinct mitogen-activated protein-kinases. J. Immunol. 150:1563-1578.
30. Van Dyke, T. E., Zinney, W., Winkel, K., Taufiq, A., Offenbacher, S., Arnold, R. R. (1986). Neutrophil function in localized juvenile periodontitis. Phagocytosis, superoxide production and specific granule release. J. Periodontol. 57:703-708.
31. Vines, C. M., Revankar, C. M., Maestas, D. C., LaRusch, L. L., Cimino, D. F., Kohout, T. A., Lefkowitz, R. J., Prossnitz, E. R. (2003). N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. J. Biol. Chem. 278:41581-41584.
32. von Zastrow, M. (2003). Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathway. Life Sci. 74:217-224.
33. Wu, D., LaRosa, G. J., Simon, M. I. (1993). G protein-coupled signal transduction pathways for interleukin-8. Science 261:101-103.
34. Zhang, Y., Syed, R., Uygar, C., Pallos, D., Gorry, M. C., Firatli, E., Cortelli, J. R., VanDyke, T. E., Hart, P. S., Feingold, E., Hart, T. C. (2003). Evaluation of human leukocyte N-formylpeptide receptor (FPR1) SNPs in aggressive periodontitis patients. Genes Immun. 4:22-29.
35. 2+-dependent exocytosis and arachidonic acid release in cultured mast cells (RBL-2H3) by a GTPase-deficient mutant of G alpha i3. Eur. J. Biochem. 258:144-149.