A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activation and chemotaxis

Biochemical Journal

Volumn 352, Issue 2, 2000, Pages 399-407

  Gripentrog, J M ^a   Jesaitis, A J ^a   Miettinen, H M ^a  

^a MONTANA STATE UNIVERSITY   (United States)

Author keywords

G protein coupled receptor; MAPK; Migration; Signal transduction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CALCIUM; FORMYLMETHIONYLLEUCYLPHENYLALANINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MUTANT PROTEIN; MUTANT PROTEIN N297A; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CHEMOTAXIS; DESENSITIZATION; DOSE RESPONSE; ENDOCYTOSIS; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECEPTOR BINDING; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

AMINO ACID SUBSTITUTION; ANIMALS; CHEMOTAXIS; CHO CELLS; CRICETINAE; ENDOCYTOSIS; ENZYME ACTIVATION; HUMANS; LIGANDS; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PEPTIDE;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0034535608     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3520399     Document Type: Article

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