Proinflammatory proteases liberate a discrete high-affinity functional FPRL1 (CCR12) ligand from CCL23

Journal of Immunology

Volumn 178, Issue 11, 2007, Pages 7395-7404

  Miao, Zhenhua ^a   Premack, Brett A ^b   Wei, Zheng ^a   Wang, Yu ^a   Gerard, Craig ^b   Showell, Henry ^c   Howard, Maureen ^a   Schall, Thomas J ^a   Berahovich, Robert ^a  

^a ChemoCentryx Inc   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CCL23 CHEMOKINE; CHEMOKINE; CHEMOKINE RECEPTOR CCR1; FORMYLPEPTIDE RECEPTOR LIKE 1; GENE PRODUCT; LIGAND; PATTERN RECOGNITION RECEPTOR; PEPTIDE; PROTEINASE; SERYLHISTIDYLALANYLALANYLGLYCINE; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INFLAMMATION; INNATE IMMUNITY; MONOCYTE; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION;

EID: 34249823951     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.11.7395     Document Type: Article

References (58)

1. Matzinger, P. 1998. An innate sense of danger. Semin. Immunol. 10: 399-415.
2. Kirnbrell, D. A., and B. Beutler. 2001. The evolution and genetics of innate immunity. Nat. Rev. Genet. 2: 256-267.
3. Medzhitov, R., and C. Janeway, Jr. 2000. Innate immune recognition: mechanisms and pathways. Immunol. Rev. 173: 89-97.
4. Stahl, P. D., and R. A. Ezekowitz. 1998. The mannose receptor is a pattern recognition receptor involved in host defense. Curr. Opin. Immunol. 10: 50-55.
5. Bendelac, A., and R. Medzhitov. 2002. Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J. Exp. Med. 195: F19-F23.
6. Sallusto, F., and A. Lanzavecchia. 2002. The instructive role of dendritic cells on T cell responses. Arthritis. Res. 4(Suppl. 3): S127-S132.
7. Moingeon, P. 2002. Strategies for designing vaccines eliciting Th1 responses in humans. J. Biotechnol. 98: 189-198.
8. Vogel, F. R. 1998. Adjuvants in perspective. Dev. Biol. Stand. 92: 241-248.
9. Schijns, V. E. 2001. Induction and direction of immune responses by vaccine adjuvants. Crit. Rev. Immunol. 21: 75-85.
10. Yip, H. C., A. Y. Karulin, M. Tary-Lehmann, M. D. Hesse, H. Radeke, P. S. Heeger, R. P. Trezza, F. P. Heinzel, T. Forsthuber, and P. V. Lehmann. 1999. Adjuvant-guided type-1 and type-2 immunity: infectious/noninfectious dichotomy defines the class of response. J. Immunol. 162: 3942-3949.
11. Lillard, J. W., Jr., P. N. Boyaka, J. A. Hedrick, A. Zlotnik, and J. R. McGhee. 1999. Lymphotactin acts as an innate mucosal adjuvant. J. Immunol. 162: 1959-1965.
12. Lillard, J. W., Jr., P. N. Boyaka, D. D. Taub, and J. R. McGhee. 2001. RANTES potentiates antigen-specific mucosal immune responses. J. Immunol. 166: 162-169.
13. Luster, A. D. 2002. The role of chemokines in linking innate and adaptive immunity. Curr. Opin. Immunol. 14: 129-135.
14. Schall, T. J., and K. B. Bacon. 1994: Chemokines, leukocyte trafficking, and inflammation. Curr. Opin. Immunol. 6: 865-873.
15. Premack, B. A., and T. J. Schall. 1996. Chemokine receptors: gateways to inflammation and infection. Nat. Med. 2: 1174-1178.
16. Mackay, C. R. 2001. Chemokines: immunology's high impact factors. Nat. Immunol. 2: 95-101.
17. Murphy, P. M., M. Baggiolini, I. F. Charo, C. A. Hebert, R. Horuk, K. Matsushima, L. H. Miller, J. J. Oppenheim, and C. A. Power. 2000. International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol. Rev. 52: 145-176.
18. Sallusto, F., and A. Lanzavecchia. 2000. Understanding dendritic cell and T lymphocyte traffic through the analysis of chemokine receptor expression. Immunol. Rev. 177: 134-140.
19. Nestle, F. O., J. Banchereau, and D. Hart. 2001. Dendritic cells: on the move from bench to bedside. Nat. Med. 7: 761-765.
20. Bao, L., N. P. Gerard. R. L. Eddy, Jr., T. B. Shows, and C. Gerard. 1992. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. Genomics 13: 437-440.
21. Murphy, P. M., T. Ozcelik, R. T. Kenney, H. L. Tiffany, D. McDermott, and U. Francke. 1992. A structural homologue of the N-formyl peptide receptor: characterization and chromosome mapping of a peptide chemoattractant receptor family. J. Biol. Chem. 267: 7637-7643.
22. Durstin, M., J. L. Gao, H. L. Tiffany, D. McDermott, and P. M. Murphy. 1994. Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes. Biochem. Biophys. Res. Commun. 201: 174-179.
23. Yang, D., Q. Chen, Y. Le, J. M. Wang, and J. J. Oppenheim. 2001. Differential regulation of formyl peptide receptor-like 1 expression during the differentiation of monocytes to dendritic cells and macrophages. J. Immunol. 166: 4092-4098.
24. Le, Y., P. M. Murphy, and J. M. Wang. 2002. Formyl-peptide receptors revisited. Trends Immunol. 23: 541-548.
25. Le, Y., W. Gong, H. L. Tiffany, A. Tumanov, S. Nedospasov, W. Shen, N. M. Dunlop, J. L. Gao, P. M. Murphy, J. J. Oppenheim, and J. M. Wang. 2001. Amyloid (β)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1. J. Neurosci. 21: 123.
26. Le, Y., J. J. Oppenheim, and J. M. Wang. 2001. Pleiotropic roles of formyl peptide receptors. Cytokine Growth Factor Rev. 12: 91-105.
27. Fiore, S., J. F. Maddox, H. D. Perez, and C. N. Serhan. 1994. Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. J. Exp. Med. 180: 253-260.
28. Fiore, S., and C. N. Serhan. 1995. Lipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: inhibition of CD11/18 expression by lipoxin A4-lipoxin A4 receptor interaction. Biochemistry 34: 16678-16686.
29. Macphee, C. H., E. R. Appelbaum, K. Johanson, K. E. Moores, C. S. Imburgia, J. Forawald, T. Berkhout, M. Brawner, P. H. Groot, K. O'Donnell, et al. 1998. Identification of a truncated form of the CC chemokine CKβ-8 demonstrating greatly enhanced biological activity. J. Immunol. 161: 6273-6279.
30. 4. Nat. Med. 8: 1018-1023.
31. Christophe, T., A. Karlsson, C. Dugave, M. J. Rabiet, F. Boulay, and C. Dahlgren. 2001. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J. Biol. Chem. 276: 21585-21593.
32. Christophe, T., A. Karlsson, M. J. Rabiet, F. Boulay, and C. Dahlgren. 2002. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. Scand. J. Immunol. 56: 470-476.
33. Le, Y., W. Gong, B. Li, N. M. Dunlop, W. Shen, S. B. Su, R. D. Ye, and J. M. Wang. 1999. Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and formyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation. J. Immunol. 163: 6777-6784.
34. Le, Y., M. A. Wetzel, W. Shen, W. Gong, T. J. Rogers, E. E. Henderson, and J. M. Wang. 2001. Desensitization of chemokine receptor CCR5 in dendritic cells at the early stage of differentiation by activation of formyl peptide receptors. Clin. Immunol. 99: 365-372.
35. Chen, Q., D. Wade, K. Kurosaka, Z. Y. Wang, J. J. Oppenheim, and D. Yang. 2004. Temporin A and related frog antimicrobial peptides use formyl peptide receptor-like 1 as a receptor to chemoattract phagocytes. J. Immunol. 173: 2652-2659.
36. Ernst, S., C. Lange, A. Wilbers, V. Goebeler, V. Gerke, and U. Rescher. 2004. An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family. J. Immunol. 172: 7669-7676.
37. Harada, M., Y. Habata, M. Hosoya, K. Nishi, R. Fujii, M. Kobayashi, and S. Hinuma. 2004. N-Formylated humanin activates both formyl peptide receptor-like 1 and 2. Biochem. Biophys. Res. Commun. 324: 255-261.
38. Nanamori, M., X. Cheng, J. Mei, H. Sang, Y. Xuan, C. Zhou, M. W. Wang, and R. D. Ye. 2004. A novel nonpeptide ligand for formyl peptide receptor-like 1. Mol. Pharmacol. 66: 1213-1222.
39. Ying, G., P. Iribarren, Y. Zhou, W. Gong, N. Zhang, Z. X. Yu, Y. Le, Y. Cui, and J. M. Wang. 2004. Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor. J. Immunol. 172: 7078-7085.
40. Patel, V. P., B. L. Kreider, Y. Li, H. Li, K. Leung, T. Salcedo, B. Nardelli, V. Pippalla, S. Gentz, R. Thotakura, et al. 1997. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. J. Exp. Med. 185: 1163-1172.
41. Forssmann, U., M. B. Delgado, M. Uguccioni, P. Loetscher, G. Garotta, and M. Baggiolini. 1997. CKβ8, a novel CC chemokine that predominantly acts on monocytes. FEBS Lett. 408: 211-216.
42. Berahovich, R. D., Z. Miao, Y. Wang, B. Premack, M. C. Howard, and T. J. Schall. 2005. Proteolytic activation of alternative CCR1 ligands in inflammation. J. Immunol. 174: 7341-7351.
43. Youn, B. S., S. M. Zhang, H. E. Broxmeyer, S. Cooper, K. Antol, M. Fraser, Jr., and B. S. Kwon. 1998. Characterization of CKβ8 and CKβ8-1: two alternatively spliced forms of human β-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1. Blood 91: 3118-3126.
44. Berkhout, T. A., J. Gohil, P. Gonzalez, C. L. Nicols, K. E. Moores, C. H. Macphee, J. R. White, and P. H. Groot. 2000. Selective binding of the truncated form of the chemokine CKβ8 (25-99) to CC chemokine receptor 1(CCR1). Biochem. Pharmacol. 59: 591-596.
45. Elagoz, A., D. Henderson, P. S. Babu, S. Salter, C. Grahames, L. Bowers, M. O. Roy, P. Laplante, E. Grazzini, S. Ahmad, and P. M. Lembo. 2004. A truncated form of CKβ8-1 is a potent agonist for human formyl peptide-receptor-like 1 receptor. Br. J. Pharmacol. 141: 37-46.
46. Rottman, J. B., A. J. Slavin, R. Silva, H. L. Weiner, C. G. Gerard, and W. W. Hancock. 2000. Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent. Eur. J. Immunol. 30: 2372-2377.
47. Katschke, K. J., Jr., J. B. Rottman, J. H. Ruth, S. Qin, L. Wu, G. LaRosa, P. Ponath, C. C. Park, R. M. Pope, and A. E. Koch. 2001. Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis. Arthritis Rheum. 44: 1022-1032.
48. Sorensen, T. L., and F. Sellebjerg. 2001. Distinct chemokine receptor and cytokine expression profile in secondary progressive MS. Neurology 57: 1371-1376.
49. + mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis. Am. J. Pathol. 159: 1701-1710.
50. Deng, X., H. Ueda, S. B. Su, W. Gong, N. M. Dunlop, J. L. Gao, P. M. Murphy, and J. M. Wang. 1999. A synthetic peptide derived from human immunodeficiency virus type 1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G protein-coupled receptor FPRL1/LXA4R. Blood 94: 1165-1173.
51. De, Y., Q. Chen, A. P. Schmidt, G. M. Anderson, J. M. Wang, J. Wooters, J. J. Oppenheim, and O. Chertov. 2000. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J. Exp. Med. 192: 1069-1074.
52. Le, Y., H. Yazawa, W. Gong, Z. Yu, V. J. Ferrans, P. M. Murphy, and J. M. Wang. 2001. The neurotoxic prion peptide fragment PrP(106-126) is a chemotactic agonist for the G protein-coupled receptor formyl peptide receptor-like 1. J. Immunol. 166: 1448-1451.
53. Betten, A., J. Bylund, T. Cristophe, F. Boulay, A. Romero, K. Hellstrand, and C. Dahlgren. 2001. A proinflammatory peptide from Helicobacter pylori activates monocytes to induce lymphocyte dysfunction and apoptosis. J. Clin. Invest. 108: 1221-1228.
54. Yazawa, H., Z. X. Yu, Takeda, Y. Le, W. Gong, V. J. Ferrans, J. J. Oppenheim, C. C. Li, and J. M. Wang. 2001. Beta amyloid peptide (Aβ42) is internalized via the G protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages. FASEB J. 15: 2454-2462.
55. Niyonsaba, F., K. Iwabuchi, A. Someya, M. Hirata, H. Matsuda, H. Ogawa, and I. Nagaoka. 2002. A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis. Immunology 106: 20-26.
56. Perretti, M., N. Chiang, M. La, I. M. Fierro, S. Marullo, S. J. Getting, E. Solito, and C. N. Serhan. 2002. Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat. Med. 8: 1296-1302.
57. Resnati, M., I. Pallavicini, J. M. Wang, J. Oppenheim, C. N. Serhan, M. Romano, and F. Blasi. 2002. The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R. Proc. Natl. Acad. Sci. USA 99: 1359-1364.
58. He, R., H. Sang, and R. D. Ye. 2003. Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R. Blood 101: 1572-1581.