The two neutrophil members of the formylpeptide receptor family activate the NADPH-oxidase through signals that differ in sensitivity to a gelsolin derived phosphoinositide-binding peptide

BMC Cell Biology

Volumn 5, Issue , 2004, Pages

  Fu, Huamei ^a   Björkman, Lena ^a   Janmey, Paul ^b   Karlsson, Anna ^a   Karlsson, Jennie ^a   Movitz, Charlotta ^a   Dahlgren, Claes ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CALCIUM; FORMYLPEPTIDE RECEPTOR; FORMYLPEPTIDE RECEPTOR LIKE 1; G PROTEIN COUPLED RECEPTOR; GELSOLIN; OXYGEN RADICAL; PEPTIDE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPID BINDING PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ADULT; ARTICLE; CALCIUM CELL LEVEL; CELL MEMBRANE PERMEABILITY; CELL SECRETION; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NEUTROPHIL; NORMAL HUMAN; PROTEIN FAMILY; SIGNAL TRANSDUCTION;

EID: 24744438566     PISSN: 14712121     EISSN: 14712121     Source Type: Journal    
DOI: 10.1186/1471-2121-5-50     Document Type: Article

References (46)

1. Liu H, Pope RM: Phagocytes: mechanisms of inflammation and tissue destruction. Rheum Dis Clin North Am 2004, 30:19-39.
2. Rashid AJ, BF OD, George SR: Minireview: Diversity and Complexity of Signaling through Peptidergic G Protein-Coupled Receptors. Endocrinology 2004, 145:2645-2652.
3. Kenakin T: Principles: receptor theory in pharmacology. Trends Pharmacol Sci 2004, 25:186-192.
4. Heit B, Tavener S, Raharjo E, Kubes P: An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients. J Cell Biol 2002, 159:91-102.
5. Le Y, Murphy PM, Wang JM: Formyl-peptide receptors revisited. Trends Immunol 2002, 23:541-548.
6. Bylund J, Samuelsson M, Collins LV, Karlsson A: NADPH-oxidase activation in murine neutrophils via formyl peptide receptors. Exp Cell Res 2003, 282:70-77.
7. Ye RD, Boulay F: Structure and function of leukocyte chemoattractant receptors. Adv Pharmacol 1997, 39:221-289.
8. Le Y, Yang Y, Cui Y, Yazawa H, Gong W, Qiu C, Wang JM: Receptors for chemotactic formyl peptides as pharmacological targets. Int Immunopharmacol 2002, 2:1-13.
9. Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, Sozzani S, Mantovani A, Altruda F, Wymann MP: Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 2000, 287:1049-1053.
10. Christophe T, Karlsson A, Dugave C, Rabiet MJ, Boulay F, Dahlgren C: The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyteexpressed chemoattractant receptor FPRL2. J Biol Chem 2001, 276:21585-21593.
11. Christophe T, Karlsson A, Rabiet MJ, Boulay F, Dahlgren C: Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. Scand J Immunol 2002, 56:470-476.
12. Bylund J, Karlsson A, Boulay F, Dahlgren C: Lipopolysaccharide-induced granule mobilization and priming of the neutrophil response to Helicobacter pylori peptide Hp(2-20), which activates formyl peptide receptor-like 1. Infect Immun 2002, 70:2908-2914.
13. Bylund J, Bjorstad A, Granfeldt D, Karlsson A, Woschnagg C, Dahlgren C: Reactivation of formyl peptide receptors triggers the neutrophil NADPH-oxidase but not a transient rise in intracellular calcium. J Biol Chem 2003, 278:30578-30586.
14. Betten A, Dahlgren C, Hermodsson S, Hellstrand K: Histamine inhibits neutrophil NADPH oxidase activity triggered by the lipoxin A4 receptor-specific peptide agonist Trp-Lys-Tyr-Met-Val-Met. Scand J Immunol 2003, 58:321-326.
15. Fu H, Bylund J, Karlsson A, Pellme S, Dahlgren C: The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8. Immunology 2004, 112:201-210.
16. Cunningham CC, Vegners R, Bucki R, Funaki M, Korde N, Hartwig JH, Stossel TP, Janmey PA: Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J Biol Chem 2001, 276:43390-43399.
17. Bae YS, Lee HY, Jo EJ, Kim JI, Kang HK, Ye RD, Kwak JY, Ryu SH: Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling. J Immunol 2004, 173:607-614.
18. Pan ZK, Chen LY, Cochrane CG, Zuraw BL: fMet-Leu-Phe stimulates proinflammatory cytokine gene expression in human peripheral blood monocytes: the role of phosphatidylinositol 3-kinase. J Immunol 2000, 164:404-411.
19. Su SB, Gong W, Gao JL, Shen W, Murphy PM, Oppenheim JJ, Wang JM: A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells. J Exp Med 1999, 189:395-402.
20. Pieretti S, Di Giannuario A, De Felice M, Perretti M, Cirino G: Stimulus-dependent specificity for annexin 1 inhibition of the inflammatory nociceptive response: the involvement of the receptor for formylated peptides. Pain 2004, 109:52-63.
21. Bucki R, Janmey PA, Vegners R, Giraud F, Sulpice JC: Involvement of phosphatidylinositol 4,5-bisphosphate in phosphatidylserine exposure in platelets: use of a permeant phosphoinositide-binding peptide. Biochemistry 2001, 40:15752-15761.
22. Hallett MB, Hodges R, Cadman M, Blanchfield H, Dewitt S, Pettit EJ, Laffafian I, Davies EV: Techniques for measuring and manipulating free Ca2+ in the cytosol and organelles of neutrophils. J Immunol Methods 1999, 232:77-88.
23. Foyouzi-Youssefi R, Petersson F, Lew DP, Krause KH, Nusse O: Chemoattractant-induced respiratory burst: increases in cytosolic Ca2+ concentrations are essential and synergize with a kinetically distinct second signal. Biochem J 1997, 322(Pt 3):709-718.
24. Pozzan T, Lew DP, Wollheim CB, Tsien RY: Is cytosolic ionized calcium regulating neutrophil activation? Science 1983, 221:1413-1415.
25. Borregaard N, Cowland JB: Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 1997, 89:3503-3521.
26. Nusse O, Serrander L, Lew DP, Krause KH: Ca2+-induced exocytosis in individual human neutrophils: high-and low-affinity granule populations and submaximal responses. Embo J 1998, 17:1279-1288.
27. Sengelov H, Kjeldsen L, Borregaard N: Control of exocytosis in early neutrophil activation. J Immunol 1993, 150:1535-1543.
28. Jesaitis AJ, Klotz KN: Cytoskeletal regulation of chemotactic receptors: molecular complexation of N-formyl peptide receptors with G proteins and actin. Eur J Haematol 1993, 51:288-293.
29. Gwinn MR, Sharma A, De Nardin E: Single nucleotide polymorphisms of the N-formyl peptide receptor in localized juvenile periodontitis. J Periodontol 1999, 70:1194-1201.
30. Seifert R, Wenzel-Seifert K: Defective Gi protein coupling in two formyl peptide receptor mutants associated with localized juvenile periodontitis. J Biol Chem 2001, 276:42043-42049.
31. Miettinen HM, Gripentrog JM, Mason MM, Jesaitis AJ: Identification of putative sites of interaction between the human formyl peptide receptor and G protein. J Biol Chem 1999, 274:27934-27942.
32. He R, Browning DD, Ye RD: Differential roles of the NPXXY motif in formyl peptide receptor signaling. J Immunol 2001, 166:4099-4105.
33. Wymann MP, Zvelebil M, Laffargue M: Phosphoinositide 3-kinase signalling - which way to target? Trends Pharmacol Sci 2003, 24:366-376.
34. Bucki R, Pastore JJ, Randhawa P, Vegners R, Weiner DJ, Janmey PA: Antibacterial activities of rhodamine B-conjugated gelsolinderived peptides compared to those of the antimicrobial peptides cathelicidin LL37, magainin II, and melittin. Antimicrob Agents Chemother 2004, 48:1526-1533.
35. Lundqvist H, Gustafsson M, Johansson A, Sarndahl E, Dahlgren C: Neutrophil control of formylmethionyl-leucyl-phenylalanine induced mobilization of secretory vesicles and NADPH-oxidase activation: effect of an association of the ligand-receptor complex to the cytoskeleton. Biochim Biophys Acta 1994, 1224:43-50.
36. Bylund J, Pellme S, Mellqvist UH, Hellstrand K, Fu H, Karlsson A, Dahlgren C: Cytochalasin B triggers a novel pertussis toxin sensitive activation pathway in TNF-alpha primed neutrophils. BMC Cell Biol 2004, 5:21.
37. Sahagun-Ruiz A, Colla JS, Juhn J, Gao JL, Murphy PM, McDermott DH: Contrasting evolution of the human leukocyte N-formylpeptide receptor subtypes FPR and FPRL1R. Genes Immun 2001, 2:335-342.
38. Bennett TA, Foutz TD, Gurevich VV, Sklar LA, Prossnitz ER: Partial phosphorylation of the N-formyl peptide receptor inhibits G protein association independent of arrestin binding. J Biol Chem 2001, 276:49195-49203.
39. Murphy PM, Eide B, Goldsmith P, Brann M, Gierschik P, Spiegel A, Malech HL: Detection of multiple forms of Gi alpha in HL60 cells. FEBS Lett 1987, 221:81-86.
40. Seifert R, Wenzel-Seifert K: The human formyl peptide receptor as model system for constitutively active G-protein-coupled receptors. Life Sci 2003, 73:2263-2280.
41. Janmey PA, Lamb J, Allen PG, Matsudaira PT: Phosphoinositide-binding peptides derived from the sequences of gelsolin and villin. J Biol Chem 1992, 267:11818-11823.
42. Goetzl EJ, Lee H, Azuma T, Stossel TP, Turck CW, Karliner JS: Gelsolin binding and cellular presentation of lysophosphatidic acid. J Biol Chem 2000, 275:14573-14578.
43. Boyum A, Lovhaug D, Tresland L, Nordlie EM: Separation of leucocytes: improved cell purity by fine adjustments of gradient medium density and osmolality. Scand J Immunol 1991, 34:697-712.
44. Lundqvist H, Dahlgren C: Isoluminol-enhanced chemiluminescence: a sensitive method to study the release of superoxide anion from human neutrophils. Free Radic Biol Med 1996, 20:785-792.
45. Dahlgren C, Karlsson A: Respiratory burst in human neutrophils. J Immunol Methods 1999, 232:3-14.
46. Dahlgren C, Christophe T, Boulay F, Madianos PN, Rabiet MJ, Karlsson A: The synthetic chemoattractant Trp-Lys-Tyr-Met-Val-DMet activates neutrophils preferentially through the lipoxin A(4) receptor. Blood 2000, 95:1810-1818.