Variable responses of formyl peptide receptor haplotypes toward bacterial peptides

Immunogenetics

Volumn 60, Issue 2, 2008, Pages 83-93

  Gripentrog, Jeannie M ^a   Mills, John S ^a   Saari, George J ^a   Miettinen, Heini M ^a  

^a MONTANA STATE UNIVERSITY   (United States)

Author keywords

Cell signaling; Chemoattractant receptor; Chemotaxis; Haplotype; Inflammation

Indexed keywords

BACTERIAL PROTEIN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; FORMYLPEPTIDE RECEPTOR; PROTEIN FMFEDAVAWF; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANIMAL CELL; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ESCHERICHIA COLI; FEMALE; GENE SEQUENCE; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MALE; MYCOBACTERIUM AVIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MYCOBACTERIUM AVIUM;

EID: 40149093843     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00251-008-0277-3     Document Type: Article

References (48)

1. FC Arnett SM Edworthy DA Bloch DJ McShane JF Fries NS Cooper LA Healey SR Kaplan MH Liang HS Luthra TA Medsger Jr DM Mitchell DH Neustadt RS Pinals JG Schaller JT Sharp RL Wilder GG Hunder 1988 The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis Arthritis Rheum 31 315 324 3358796 10.1002/art.1780310302 1:STN:280:DyaL1c7pt1Ohsg%3D%3D Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA Jr, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324
2. F Autschbach S Eisold U Hinz S Zinser M Linnebacher T Giese T Loffler MW Buchler J Schmidt 2005 High prevalence of Mycobacterium avium subspecies paratuberculosis IS900 DNA in gut tissues from individuals with Crohn’s disease Gut 54 944 949 15951539 10.1136/gut.2004.045526 1:CAS:528:DC%2BD2MXmsFKqsbk%3D Autschbach F, Eisold S, Hinz U, Zinser S, Linnebacher M, Giese T, Loffler T, Buchler MW, Schmidt J (2005) High prevalence of Mycobacterium avium subspecies paratuberculosis IS900 DNA in gut tissues from individuals with Crohn’s disease. Gut 54:944–949
3. TJ Borody S Leis EF Warren R Surace 2002 Treatment of severe Crohn’s disease using antimycobacterial triple therapy—approaching a cure? Dig Liver Dis 34 29 38 11926571 10.1016/S1590-8658(02)80056-1 1:CAS:528:DC%2BD38XjtFGmu70%3D Borody TJ, Leis S, Warren EF, Surace R (2002) Treatment of severe Crohn’s disease using antimycobacterial triple therapy—approaching a cure? Dig Liver Dis 34:29–38
4. F Boulay M Tardif L Brouchon P Vignais 1990 The human N-formyl peptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors Biochemistry 29 11123 11133 2176894 10.1021/bi00502a016 1:CAS:528:DyaK3cXmt12nurg%3D Boulay F, Tardif M, Brouchon L, Vignais P (1990) The human N-formyl peptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G protein-coupled receptors. Biochemistry 29:11123–11133
5. G Bouma W Strober 2003 The immunological and genetic basis of inflammatory bowel disease Nat Rev Immunol 3 521 533 12876555 10.1038/nri1132 1:CAS:528:DC%2BD3sXls1Smtr4%3D Bouma G, Strober W (2003) The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 3:521–533
6. F Brunello A Pera S Martini L Marino M Astegiano C Barletti P Gastaldi G Verme G Emanuelli 1991 Antibodies to Mycobacterium paratuberculosis in patients with Crohn’s disease Dig Dis Sci 36 1741 1745 1748044 10.1007/BF01296619 1:STN:280:DyaK38%2FotlOrtg%3D%3D Brunello F, Pera A, Martini S, Marino L, Astegiano M, Barletti C, Gastaldi P, Verme G, Emanuelli G (1991) Antibodies to Mycobacterium paratuberculosis in patients with Crohn’s disease. Dig Dis Sci 36:1741–1745
7. H Carp 1982 Mitochondrial N-formyl methionyl proteins as chemoattractants for neutrophils J Exp Med 155 264 275 6274994 10.1084/jem.155.1.264 1:CAS:528:DyaL38Xotl2ksg%3D%3D Carp H (1982) Mitochondrial N-formyl methionyl proteins as chemoattractants for neutrophils. J Exp Med 155:264–275
8. DW Cleveland SG Fischer MW Kirschner UK Laemmli 1977 Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis J Biol Chem 252 1102 1106 320200 1:CAS:528:DyaE2sXhtValtLc%3D Cleveland DW, Fischer SG, Kirschner MW, Laemmli UK (1977) Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. J Biol Chem 252:1102–1106
9. PJP Croucher S Mascheretti J Hampe K Huse H Frenzel M Stoll T Lu S Nikolaus S-K Yang M Krawczak WH Kim S Schreiber 2003 Haplotype structure and association to Crohn’s disease of CARD15 mutations in two ethnically divergent populations Eur J Hum Genet 11 6 16 12529700 10.1038/sj.ejhg.5200897 1:CAS:528:DC%2BD3sXht12hurs%3D Croucher PJP, Mascheretti S, Hampe J, Huse K, Frenzel H, Stoll M, Lu T, Nikolaus S, Yang S-K, Krawczak M, Kim WH, Schreiber S (2003) Haplotype structure and association to Crohn’s disease of CARD15 mutations in two ethnically divergent populations. Eur J Hum Genet 11:6–16
10. CK Derian HF Solomon JDI Higgins MJ Beblavy RJ Santulli GJ Bridger MC Pike DJ Kroon AJ Fischman 1996 Selective inhibition of N-formyl peptide-induced neutrophil activation by carbamate-modified peptide analogues Biochemistry 35 1256 1269 10.1021/bi952087k Derian CK, Solomon HF, Higgins JDI, Beblavy MJ, Santulli RJ, Bridger GJ, Pike MC, Kroon DJ, Fischman AJ (1996) Selective inhibition of N-formyl peptide-induced neutrophil activation by carbamate-modified peptide analogues. Biochemistry 35:1256–1269
11. RH Duerr KD Taylor SR Brant JD Rioux MS Silverberg MJ Daly AH Steinhart C Abraham M Regueiro A Griffiths T Dassopoulos A Bitton H Yang S Targan LW Datta EO Kistner LP Schumm AT Lee PK Gregersen MM Barmada JI Rotter DL Nicolae JH Cho 2006 A genome-wide association study identifies IL23R as an inflammatory bowel disease gene Science 314 1461 1463 17068223 10.1126/science.1135245 1:CAS:528:DC%2BD28Xht1CntrjF Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314:1461–1463
12. D Franchimont S Vermeire H Housni El M Pierik K Steen Van T Gustot E Quertinmont M Abramowicz A Gossum Van J Deviere P Rutgeerts 2004 Deficient host–bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn’s disease and ulcerative colitis Gut 53 987 992 15194649 10.1136/gut.2003.030205 1:CAS:528:DC%2BD2cXlvFemtrY%3D Franchimont D, Vermeire S, El Housni H, Pierik M, Van Steen K, Gustot T, Quertinmont E, Abramowicz M, Van Gossum A, Deviere J, Rutgeerts P (2004) Deficient host–bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn’s disease and ulcerative colitis. Gut 53:987–992
13. AT Gewirtz M Vijay-Kumar SR Brant RH Duerr DL Nicolae JH Cho 2006 Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn’s disease Am J Physiol Gastrointest Liver Physiol 290 G1157 G1163 16439468 10.1152/ajpgi.00544.2005 1:CAS:528:DC%2BD28XlvVeisL4%3D Gewirtz AT, Vijay-Kumar M, Brant SR, Duerr RH, Nicolae DL, Cho JH (2006) Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn’s disease. Am J Physiol Gastrointest Liver Physiol 290:G1157–G1163
14. JM Gripentrog HM Miettinen 2005 Activation and nuclear translocation of ERK1/2 by the formyl peptide receptor is regulated by G protein and is not dependent on β-arrestin translocation or receptor endocytosis Cell Signal 17 1300 1311 16038804 10.1016/j.cellsig.2005.01.006 1:CAS:528:DC%2BD2MXmsVOnsLo%3D Gripentrog JM, Miettinen HM (2005) Activation and nuclear translocation of ERK1/2 by the formyl peptide receptor is regulated by G protein and is not dependent on β-arrestin translocation or receptor endocytosis. Cell Signal 17:1300–1311
15. JM Gripentrog AJ Jesaitis HM Miettinen 2000 A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activation and chemotaxis Biochem J 352 399 407 11085933 10.1042/0264-6021:3520399 1:CAS:528:DC%2BD3MXhtFahsQ%3D%3D Gripentrog JM, Jesaitis AJ, Miettinen HM (2000) A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activation and chemotaxis. Biochem J 352:399–407
16. JM Gripentrog KP Kantele AJ Jesaitis HM Miettinen 2003 Experimental evidence for lack of homodimerization of the G protein-coupled human N-formyl peptide receptor J Immunol 171 3187 3193 12960347 1:CAS:528:DC%2BD3sXmvFGqu74%3D Gripentrog JM, Kantele KP, Jesaitis AJ, Miettinen HM (2003) Experimental evidence for lack of homodimerization of the G protein-coupled human N-formyl peptide receptor. J Immunol 171:3187–3193
17. J Haier M Nasralla AR Franco GL Nicolson 1999 Detection of mycoplasmal infections in blood of patients with rheumatoid arthritis Rheumatology (Oxford) 38 504 509 10.1093/rheumatology/38.6.504 1:STN:280:DyaK1MzivVGiuw%3D%3D Haier J, Nasralla M, Franco AR, Nicolson GL (1999) Detection of mycoplasmal infections in blood of patients with rheumatoid arthritis. Rheumatology (Oxford) 38:504–509
18. JK Hartt T Liang A Sahagun-Ruiz JM Wang JL Gao PM Murphy 2000 The HIV-1 cell entry inhibitor T-20 potently chemoattracts neutrophils by specifically activating the N-formyl peptide receptor Biochem Biophys Res Commun 272 699 704 10860818 10.1006/bbrc.2000.2846 1:CAS:528:DC%2BD3cXktVKkt7g%3D Hartt JK, Liang T, Sahagun-Ruiz A, Wang JM, Gao JL, Murphy PM (2000) The HIV-1 cell entry inhibitor T-20 potently chemoattracts neutrophils by specifically activating the N-formyl peptide receptor. Biochem Biophys Res Commun 272:699–704
19. B Henderson SP Nair JM Ward M Wilson 2003 Molecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans Annu Rev Microbiol 57 29 55 14527274 10.1146/annurev.micro.57.030502.090908 1:CAS:528:DC%2BD3sXptFWmurk%3D Henderson B, Nair SP, Ward JM, Wilson M (2003) Molecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans. Annu Rev Microbiol 57:29–55
20. JDI Higgins GJ Bridger CK Derian MJ Beblavy PE Hernandez FE Gaul MJ Abrams MC Pike HF Solomon 1996 N-terminus urea-substituted chemotactic peptides: new potent agonists and antagonists toward the neutrophil fMLF receptor J Med Chem 39 1013 1017 8676333 10.1021/jm950908d 1:CAS:528:DyaK28XpsFKguw%3D%3D Higgins JDI, Bridger GJ, Derian CK, Beblavy MJ, Hernandez PE, Gaul FE, Abrams MJ, Pike MC, Solomon HF (1996) N-terminus urea-substituted chemotactic peptides: new potent agonists and antagonists toward the neutrophil fMLF receptor. J Med Chem 39:1013–1017
21. S Horowitz B Evinson A Borer J Horowitz 2000 Mycoplasma fermentans in rheumatoid arthritis and other inflammatory arthritides J Rheumatol 27 2747 2753 11128659 1:STN:280:DC%2BD3M7gsVKlsQ%3D%3D Horowitz S, Evinson B, Borer A, Horowitz J (2000) Mycoplasma fermentans in rheumatoid arthritis and other inflammatory arthritides. J Rheumatol 27:2747–2753
22. JP Hugot M Chamaillard H Zouali S Lesage JP Cezard J Belaiche S Almer C Tysk CA O’Morain M Gassull V Binder Y Finkel A Cortot R Modigliani P Laurent-Puig C Gower-Rousseau J Macry JF Colombel M Sahbatou G Thomas 2001 Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease Nature 411 599 603 11385576 10.1038/35079107 1:CAS:528:DC%2BD3MXksVShtLY%3D Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O’Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature 411:599–603
23. N Inohara Y Ogura A Fontalba O Gutierrez F Pons J Crespo K Fukase S Inamura S Kusumoto M Hashimoto SJ Foster AP Moran JL Fernandez-Luna G Nunez 2003 Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn’s disease J Biol Chem 278 5509 5512 12514169 10.1074/jbc.C200673200 1:CAS:528:DC%2BD3sXht1aqsro%3D Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, Fukase K, Inamura S, Kusumoto S, Hashimoto M, Foster SJ, Moran AP, Fernandez-Luna JL, Nunez G (2003) Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn’s disease. J Biol Chem 278:5509–5512
24. G Jarnerot P Rolny G Wickbom G Alemayehu 1989 Antimycobacterial therapy ineffective in Crohn’s disease after a year Lancet 1 164 165 2563084 10.1016/S0140-6736(89)91184-7 1:STN:280:DyaL1M%2Fps1WksA%3D%3D Jarnerot G, Rolny P, Wickbom G, Alemayehu G (1989) Antimycobacterial therapy ineffective in Crohn’s disease after a year. Lancet 1:164–165
25. RWL Leong A Armuzzi T Ahmad ML Wong P Tse DP Jewell JJY Sung 2003 NOD2/CARD15 gene polymorphisms and Crohn’s disease in the Chinese population Aliment Pharmacol Ther 17 1465 1470 12823148 10.1046/j.1365-2036.2003.01607.x 1:CAS:528:DC%2BD3sXmt1Ogtbo%3D Leong RWL, Armuzzi A, Ahmad T, Wong ML, Tse P, Jewell DP, Sung JJY (2003) NOD2/CARD15 gene polymorphisms and Crohn’s disease in the Chinese population. Aliment Pharmacol Ther 17:1465–1470
26. WA Marasco SH Phan H Krutzsch HJ Showell DE Feltner R Nairn EL Becker PA Ward 1984 Purification and identification of formyl–methionyl–leucyl–phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli J Biol Chem 259 5430 5436 6371005 1:CAS:528:DyaL2cXktVelsb0%3D Marasco WA, Phan SH, Krutzsch H, Showell HJ, Feltner DE, Nairn R, Becker EL, Ward PA (1984) Purification and identification of formyl–methionyl–leucyl–phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli. J Biol Chem 259:5430–5436
27. HM Miettinen JS Mills JM Gripentrog EA Dratz BL Granger AJ Jesaitis 1997 The ligand binding site of the formyl peptide receptor maps in the transmembrane region J Immunol 159 4045 4054 9378994 1:CAS:528:DyaK2sXmvVSku7k%3D Miettinen HM, Mills JS, Gripentrog JM, Dratz EA, Granger BL, Jesaitis AJ (1997) The ligand binding site of the formyl peptide receptor maps in the transmembrane region. J Immunol 159:4045–4054
28. HM Miettinen JM Gripentrog AJ Jesaitis 1998 Chemotaxis of Chinese hamster ovary cells expressing the human neutrophil formyl peptide receptor: role of signal transduction molecules and α5β1 integrin J Cell Sci 111 1921 1928 9645940 1:CAS:528:DyaK1cXltlCltbs%3D Miettinen HM, Gripentrog JM, Jesaitis AJ (1998) Chemotaxis of Chinese hamster ovary cells expressing the human neutrophil formyl peptide receptor: role of signal transduction molecules and α5β1 integrin. J Cell Sci 111:1921–1928
29. JS Mills 2006 Peptides derived from HIV-1, HIV-2, Ebola virus, SARS coronavirus and coronavirus 229E exhibit high affinity binding to the formyl peptide receptor Biochim Biophys Acta 1762 693 703 16842982 1:CAS:528:DC%2BD28XotVyrsLs%3D Mills JS (2006) Peptides derived from HIV-1, HIV-2, Ebola virus, SARS coronavirus and coronavirus 229E exhibit high affinity binding to the formyl peptide receptor. Biochim Biophys Acta 1762:693–703
30. JS Mills 2007 Differential activation of polymorphisms of the formyl peptide receptor by formyl peptides Biochim Biophys Acta 1772 1085 1092 17644322 1:CAS:528:DC%2BD2sXpvFWntb8%3D Mills JS (2007) Differential activation of polymorphisms of the formyl peptide receptor by formyl peptides. Biochim Biophys Acta 1772:1085–1092
31. JS Mills HM Miettinen RD Cummings AJ Jesaitis 2000 Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met–Leu–Phe and Met–Met–Trp–Leu–Leu J Biol Chem 275 39012 39017 10960471 10.1074/jbc.M003081200 1:CAS:528:DC%2BD3cXptFSkurg%3D Mills JS, Miettinen HM, Cummings RD, Jesaitis AJ (2000) Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met–Leu–Phe and Met–Met–Trp–Leu–Leu. J Biol Chem 275:39012–39017
32. Y Ogura DK Bonen N Inohara DL Nicolae FF Chen R Ramos H Britton T Moran R Karaliuskas RH Duerr JP Achkar SR Brant TM Bayless BS Kirschner SB Hanauer G Nunez JH Cho 2001 A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease Nature 411 603 606 11385577 10.1038/35079114 1:CAS:528:DC%2BD3MXksVShur8%3D Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nunez G, Cho JH (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature 411:603–606
33. M Pierik S Joossens K Steen Van N Schuerbeek Van R Vlietinck P Rutgeerts S Vermeire 2006 Toll-like receptor-1,-2, and-6 polymorphisms influence disease extension in inflammatory bowel diseases Inflamm Bowel Dis 12 1 8 16374251 10.1097/01.MIB.0000195389.11645.ab Pierik M, Joossens S, Van Steen K, Van Schuerbeek N, Vlietinck R, Rutgeerts P, Vermeire S (2006) Toll-like receptor-1,-2, and-6 polymorphisms influence disease extension in inflammatory bowel diseases. Inflamm Bowel Dis 12:1–8
34. MJ Rabiet E Huet F Boulay 2005 Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR Eur J Immunol 35 2486 2495 16025565 10.1002/eji.200526338 1:CAS:528:DC%2BD2MXps1Gmur0%3D Rabiet MJ, Huet E, Boulay F (2005) Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR. Eur J Immunol 35:2486–2495
35. AS Ramirez A Rosas JA Hernandez-Beriain JC Orengo P Saavedra FC la de A Fernandez JB Poveda 2005 Relationship between rheumatoid arthritis and Mycoplasma pneumoniae: a case-control study Rheumatology (Oxford) 44 912 914 10.1093/rheumatology/keh630 1:STN:280:DC%2BD2MzjslGgsQ%3D%3D Ramirez AS, Rosas A, Hernandez-Beriain JA, Orengo JC, Saavedra P, de la FC, Fernandez A, Poveda JB (2005) Relationship between rheumatoid arthritis and Mycoplasma pneumoniae: a case-control study. Rheumatology (Oxford) 44:912–914
36. C Romero A Hamdi JF Valentine SA Naser 2005 Evaluation of surgical tissue from patients with Crohn’s disease for the presence of Mycobacterium avium subspecies paratuberculosis DNA by in situ hybridization and nested polymerase chain reaction Inflamm Bowel Dis 11 116 125 15677904 10.1097/00054725-200502000-00004 Romero C, Hamdi A, Valentine JF, Naser SA (2005) Evaluation of surgical tissue from patients with Crohn’s disease for the presence of Mycobacterium avium subspecies paratuberculosis DNA by in situ hybridization and nested polymerase chain reaction. Inflamm Bowel Dis 11:116–125
37. A Sahagun-Ruiz JS Colla J Juhn J-L Gao PM Murphy DH McDermott 2001 Contrasting evolution of the human leukocyte N-formyl peptide receptor subtypes FPR and FPRL1 Genes Immun 2 335 342 11607790 10.1038/sj.gene.6363787 1:CAS:528:DC%2BD3MXnvVGjtr8%3D Sahagun-Ruiz A, Colla JS, Juhn J, Gao J-L, Murphy PM, McDermott DH (2001) Contrasting evolution of the human leukocyte N-formyl peptide receptor subtypes FPR and FPRL1. Genes Immun 2:335–342
38. RB Sartor 2006 Mechanisms of disease: pathogenesis of Crohn’s disease and ulcerative colitis Nat Clin Pract Gastroenterol Hepatol 3 390 407 16819502 10.1038/ncpgasthep0528 1:CAS:528:DC%2BD28XnslKjs7o%3D Sartor RB (2006) Mechanisms of disease: pathogenesis of Crohn’s disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 3:390–407
39. E Schiffmann HV Showell BA Corcoran PA Ward E Smith EL Becker 1975 The isolation and partial characterization of neutrophil chemotactic factors from Escherichia coli J Immunol 114 1831 1837 165239 1:STN:280:DyaE2M7lt1aqsw%3D%3D Schiffmann E, Showell HV, Corcoran BA, Ward PA, Smith E, Becker EL (1975) The isolation and partial characterization of neutrophil chemotactic factors from Escherichia coli. J Immunol 114:1831–1837
40. MG Schultz HL Rieder T Hersh S Riepe 1987 Remission of Crohn’s disease with antimycobacterial chemotherapy Lancet 2 1391 1392 2890968 10.1016/S0140-6736(87)91276-1 1:STN:280:DyaL1c%2FmsVOlsA%3D%3D Schultz MG, Rieder HL, Hersh T, Riepe S (1987) Remission of Crohn’s disease with antimycobacterial chemotherapy. Lancet 2:1391–1392
41. SB Su WH Gong JL Gao WP Shen MC Grimm XY Deng PM Murphy JJ Oppenheim JM Wang 1999 T20/DP178, an ectodomain peptide of human immunodeficiency virus type 1 gp41, is an activator of human phagocyte N-formyl peptide receptor Blood 93 3885 3892 10339497 1:CAS:528:DyaK1MXjsVOnt78%3D Su SB, Gong WH, Gao JL, Shen WP, Grimm MC, Deng XY, Murphy PM, Oppenheim JJ, Wang JM (1999) T20/DP178, an ectodomain peptide of human immunodeficiency virus type 1 gp41, is an activator of human phagocyte N-formyl peptide receptor. Blood 93:3885–3892
42. S Subramanian BJ Campbell JM Rhodes 2006 Bacteria in the pathogenesis of inflammatory bowel disease Curr Opin Inf Dis 19 475 484 10.1097/01.qco.0000244054.69253.f3 Subramanian S, Campbell BJ, Rhodes JM (2006) Bacteria in the pathogenesis of inflammatory bowel disease. Curr Opin Inf Dis 19:475–484
43. K Suenaga Y Yokoyama I Nishimori S Sano M Morita K Okazaki S Onishi 1999 Serum antibodies to Mycobacterium paratuberculosis in patients with Crohn’s disease Dig Dis Sci 44 1202 1207 10389697 10.1023/A:1026692627460 1:STN:280:DyaK1Mzhs1Gmuw%3D%3D Suenaga K, Yokoyama Y, Nishimori I, Sano S, Morita M, Okazaki K, Onishi S (1999) Serum antibodies to Mycobacterium paratuberculosis in patients with Crohn’s disease. Dig Dis Sci 44:1202–1207
44. RH Sun P Iribarren N Zhang Y Zhou WH Gong EH Cho S Lockett O Chertov F Bednar TJ Rogers JJ Oppenheim JM Wang 2004 Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor J Immunol 173 428 436 15210802 1:CAS:528:DC%2BD2cXltVaisbs%3D Sun RH, Iribarren P, Zhang N, Zhou Y, Gong WH, Cho EH, Lockett S, Chertov O, Bednar F, Rogers TJ, Oppenheim JJ, Wang JM (2004) Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor. J Immunol 173:428–436
45. M Tosa K Negoro Y Kinouchi H Abe E Nomura S Takagi H Aihara S Oomori M Sugimura K Takahashi N Hiwatashi S Takahashi T Shimosegawa 2006 Lack of association between IBD5 and Crohn’s disease in Japanese patients demonstrates population-specific differences in inflammatory bowel disease Scand J Gastroenterol 41 48 53 16373276 10.1080/00365520510023864 1:CAS:528:DC%2BD2MXhtlCnurjN Tosa M, Negoro K, Kinouchi Y, Abe H, Nomura E, Takagi S, Aihara H, Oomori S, Sugimura M, Takahashi K, Hiwatashi N, Takahashi S, Shimosegawa T (2006) Lack of association between IBD5 and Crohn’s disease in Japanese patients demonstrates population-specific differences in inflammatory bowel disease. Scand J Gastroenterol 41:48–53
46. S Uthayakumar BL Granger 1995 Cell surface accumulation of overexpressed hamster lysosomal membrane glycoproteins Cell Mol Biol Res 41 405 420 8867788 1:CAS:528:DyaK28XhvFSlsb8%3D Uthayakumar S, Granger BL (1995) Cell surface accumulation of overexpressed hamster lysosomal membrane glycoproteins. Cell Mol Biol Res 41:405–420
47. A Walther K Riehemann V Gerke 2000 A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR Mol Cell 5 831 840 10882119 10.1016/S1097-2765(00)80323-8 1:CAS:528:DC%2BD3cXjsl2ku7w%3D Walther A, Riehemann K, Gerke V (2000) A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol Cell 5:831–840
48. Y Zhang R Syed C Uygar D Pallos MC Gorry E Firatli JR Cortelli TE VanDyke PS Hart E Feingold TC Hart 2003 Evaluation of human leukocyte N-formyl peptide receptor (FPR1) SNPs in aggressive periodontitis patients Genes Immun 4 22 29 12595898 10.1038/sj.gene.6363900 1:CAS:528:DC%2BD3sXhsVCmtbo%3D Zhang Y, Syed R, Uygar C, Pallos D, Gorry MC, Firatli E, Cortelli JR, VanDyke TE, Hart PS, Feingold E, Hart TC (2003) Evaluation of human leukocyte N-formyl peptide receptor (FPR1) SNPs in aggressive periodontitis patients. Genes Immun 4:22–29