N-formylpeptides induce two distinct concentration optima for mouse neutrophil chemotaxis by differential interaction with two N-formylpeptide receptor (FPR) subtypes: Molecular characterization of FPR2, a second mouse neutrophil FPR

Journal of Experimental Medicine

Volumn 190, Issue 5, 1999, Pages 741-747

  Hartt, Jennifer K ^a,c   Barish, Grant ^a,b   Murphy, Philip M ^a   Gao, Ji Liang ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Chemoattractant; G protein coupled receptor; Inflammation; Neutrophil; Phagocyte

Indexed keywords

CALCIUM; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GUANINE NUCLEOTIDE BINDING PROTEIN; RECEPTOR SUBTYPE;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; HUMAN; HUMAN CELL; KIDNEY CELL; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; CALCIUM; CELL LINE; CHEMOTAXIS, LEUKOCYTE; DNA PRIMERS; GTP-BINDING PROTEINS; HUMANS; ION TRANSPORT; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PEPTIDE; RNA, MESSENGER; TRANSFECTION;

EID: 0032841624     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.5.741     Document Type: Article

References (29)

1. Schiffinann, E., B.A. Corcoran, and S.M. Wahl. 1975. N-formyl-methionyl peptides as chemoattractants for leukocytes. Proc. Natl. Acad. Sci. USA. 72:1059-1063.
2. Marasco, W.A., S.H. Phan, H. Krutzsch, H.J. Showell, D.C. Feltner, R. Nairn, E.L. Becker, and P.A. Ward. 1984. Purification and identification of formyl-methionyl-leucyl-phenyl-alanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli. J. Biol. Chem. 259:5430-5439.
3. Carp, H. 1982. Mitochondrial N-formylmethionyl proteins as chemoattractants for neutrophils. J. Exp. Med. 155:264-275.
4. Murphy, P.M. 1996. The N-formylpeptide chemotactic receptor. In Chemoattractant Ligands and Their Receptors. R. Horuk, editor. CRC Press, Inc., Boca Raton, FL. 269-299.
5. Murphy, P.M. 1994. The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol. 12:593-633.
6. Boulay, F., M. Tardif, L. Brouchon, and P. Vignais. 1990. Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA. Biochem. Biophys. Res. Commun. 168:1103-1109.
7. Boulay, F., M. Tardif, L. Brouchon, and P. Vignais. 1990. The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors. Biochemistry. 29:11123-11133.
8. Murphy, P.M., and D. McDermott. 1991. Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor. J. Biol. Chem. 266:12560-12567.
9. Murphy, P.M., T. Ozcelik, R.T. Kenney, H.L. Tiffany, D. McDermott, and U. Francke. 1992. A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family. J. Biol. Chem. 267:7637-7643.
10. Ye, R.D., S.L. Cavanagh, O. Quehenberger, E.R. Prossnitz, and C.G. Cochrane. 1992. Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor. Biochem. Biophys. Res. Commun. 184:582-589.
11. Bao, L., N.P. Gerard, R.L. Eddy, Jr., T.B. Shows, and C. Gerard. 1992. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. Genomics. 13:437-440.
12. Quehenberger, O., E.R. Prossnitz, S.L. Cavanagh, C.G. Cochrane, and R.D. Ye. 1993. Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors, J. Biol. Chem. 268:18167-18175.
13. Durstin, M., J.-L. Gao, H.L. Tiffany, D. McDermott, and P.M. Murphy. 1994. Differential expression of the members of the N-formylpeptide receptor gene cluster in human phagocytes. Biochem. Biophys. Res. Commun. 201:174-179.
14. Laudanna, C., J.J. Campbell, and E.C. Butcher. 1996. Role of Rho in chemoattractant-activated leukocyte adhesion through integrins. Science. 271:981-983.
15. Fiore, S., J.F. Maddox, H.D. Perez, and C.N. Serhan. 1994. Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. J. Exp. Med. 180:253-260.
16. Su, S.B., W. Gong, J.-L. Gao, W. Shen, P.M. Murphy, J.J. Oppenheim, and J.M. Wang. 1999. A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells. J. Exp. Med. 189:395-402.
17. Su, S.B., J.-L. Gao, W. Gong, N.M. Dunlop, P.M. Murphy, J.J. Oppenheim, and J.M. Wang. 1999. T21/DP107, a synthetic leucine zipper-like domain of the HIV-1 envelope gp41, attracts and activates human phagocytes by using G protein-coupled formyl peptide receptors. J. Immunol. 162: 5924-5930.
18. Su, S.B., W. Gong, J.-L. Gao, W. Shen, M.C. Grimm, X. Deng, P.M. Murphy, J.J. Oppenheim, and J.M. Wang. 1999. T20/DP178, an ectodoniain peptide of human immunodeficiency virus type 1 gp41, is an activator of human phagocyte N-formyl peptide receptor. Blood. 93:3885-3892.
19. Kilby J.M., S. Hopkins, T.M. Venetta, B. DiMassimo, G.A. Cloud, J.Y. Lee, L. Alldredge, E. Hunter, D. Lambert, D. Bolognesi, et al. 1998. Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry. Nat. Med. 4:1302-1307.
20. Gao, J.-L., and P.M. Murphy. 1993. Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains. J. Biol, Chem. 268: 25395-25401.
21. Gao, J.-L., E.J. Lee, and P.M. Murphy. 1999. Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor. J. Exp. Med. 189:657-662.
22. Gao, J.-L., H. Chen, J.D. Filie, C.A. Kozak, and P.M. Murphy. 1998. Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse. Genomics. 51:270-276.
23. 4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. J. Exp. Med. 185:1693-1704.
24. Davis, L.G., M.D. Dibner, and J.F. Battey. 1986. Basic Methods in Molecular Biology. Elsevier Science B.V., Amsterdam. 143-146.
25. Ali, H., R.M. Richardson, B. Haribabu, and R. Snyderman. 1999. Chemoattractant receptor cross-desensitization. J. Biol. Chem. 274:6027-6030.
26. Foxman, E.F., J.J. Campbell, and E.C. Butcher. 1997. Multistep navigation and the combinatorial control of leukocyte chemotaxis. J. Cell Biol. 139:1349-1360.
27. Abuja, S.K., and P.M. Murphy. 1996. The CXC chemokines growth-related oncogene (GRO)α, GROβ, GROγ, neutrophil-activating peptide-2 and epithelial cell-derived neutrophil-activating peptide-78 (ENA-78) are potent agonists for the type B, but not the type A, human interleukin-8 receptor. J. Biol. Chem. 271:20545-20550.
28. Neote, K., D. DiGregorio, J.Y. Mak, R. Horuk, and T.J. Schall. 1993. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell. 72:415-425.
29. Ludwig, A., F. Petersen, S. Zahn, O. Gotze, J.M. Schroder, H.D. Flad, and E. Brandt. 1997. The CXC-chemokine neutrophil-activating peptide-2 induces two distinct optima of neutrophil chemotaxis by differential interaction with interleukin-8 receptors CXCR-1 and CXCR-2. Blood. 90:4588-4597.