Differential roles of the NPXXY motif in formyl peptide receptor signaling

Journal of Immunology

Volumn 166, Issue 6, 2001, Pages 4099-4105

  He, R ^a   Browning, D D ^a   Ye, R D ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; ASPARAGINE; FORMYLPEPTIDE; G PROTEIN COUPLED RECEPTOR; LIGAND; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHENYLALANINE; PHOSPHOLIPASE C; TYROSINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL SURFACE; CHEMOTAXIS; ENZYME ACTIVATION; GENETIC TRANSFECTION; HYDROGEN BOND; INTERNALIZATION; LEUKEMIA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; RAT; SIGNAL TRANSDUCTION;

EID: 0035869440     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.6.4099     Document Type: Article

References (52)

1. The molecular biology of leukocyte chemoattractant receptors
2. Structure and function of leukocyte chemoattractant receptors
3. Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor
4. Sequence alignment of the G-protein coupled receptor superfamily
5. NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor
6. Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor β-subunit
7. The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development
8. Signal-dependent membrane protein trafficking in the endocytic pathway
9. Clathrin, adaptors, and sorting
10. The role of clathrin, adaptors and dynamin in endocytosis
11. A small region of the β-adrenergic receptor is selectively involved in its rapid regulation
12. 2-adrenergic receptor sequestration
13. Identification of potential tyrosine-containing encotytic motifs in the carboxyl-tail and seventh transmembrane domain of the neurokinin 1 receptor
14. A conserved NPLFY sequence contributes to agonist binding and signal transduction but is not an internalization signal for the type I angiotensin II receptor
15. The conserved NPXnY motif present in the gastrin-releasing peptide receptor is not a general sequestration sequence
16. 125I-chemotactic peptide by human neutrophils
17. Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2
18. Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence
19. The human N-formylpeptide receptor: Characterization of two eDNA isolates and evidence for a new subfamily of G-protein-coupled receptors
20. A general method of in vitro preparation and specific mutagenesis of DNA fragments: Study of protein and DNA interactions
21. Expression of membrane interleukin 1 by fibroblasts transfected with routine pro-interleukin la DNA
22. The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met is a potent chemotactic agonist for mouse formyl pepfide receptor
23. Multiple activation steps of the N-formyl peptide receptor
24. The rabbit neutrophil N-formyl peptide receptor, cDNA cloning, expression, and structure/function implications
25. Relationship of ligand-receptor dynamics to actin polymerization in RBL-2H3 cells transfected with the human formyl peptide receptor
26. Signal transducing properties of the N-formyl peptide receptor expressed in undifferentiated HL60 cells
27. Chemoattractant-induced tyrosine phosphorylation and activation of microtubule-associated protein kinase in human neutrophils
28. Stimulation of human neutrophils with formyl-methionyl-leucyl-phenylalanine induces tyrosine phosphorylation and activation of two distinct mitogen-activated protein-kinases
29. Activation of the mitogen-activated protein kinase pathway by fMet-Leu-Phe in the absence of Lyn and tyrosine phosphorylation of SHC in transfected cells
30. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
31. 1 integrin
32. Phosphorylation of the N-formyl peptide receptor is required for receptor internalization but not chemotaxis
33. Utilization of two seven-transmembrane. G-protein coupled receptors, formyl peptide receptor-like I and formyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation
34. In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors
35. The evolution and structure of aminergic G protein-coupled receptors
36. 2-adrenergic receptor
37. Interactions between conserved residues in transmembrane helices 1, 2, and 7 of the thyrotropin-releasing hormone receptor
38. Related contribution of specific helix 2 and 7 residues to conformational activation of the serotonin 5-HT2A receptor
39. Identification of transmembrane domain residues determinant in the structure function relationship of the human platelet-activating factor receptor by site directed mutagenesis
40. Rhodopsin-family receptors associate with small G proteins to activate phospholipase D
41. q protein activation without affecting its association with the receptor
42. A proposed structure for transmembrane segment 7 of G protein-coupled receptors incorporating an Ash-Pro/Asp-Pro motif
43. Identification of putative sites of interaction between the human formyl peptide receptor and G protein
44. Endocytosis and signals for internalization
45. Tyrosine phosphorylation of G protein α subunits by pp60c-src
46. Dissociation of chemotaxis from agonist-induced receptor internalization in a lymphocyte cell line transfected with CCR2B: Evidence that directed migration does not require rapid modulation of signaling at the receptor level
47. Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase
48. 2 adrenergic receptor-Src protein kinase complexes
49. 2-adrenergic receptors does not require agonist-elicited endocytosis
50. Opioid receptor endocytosis and activation of MAP kinase pathway
51. Synergistic role of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase cascade in the regulation of insulin receptor trafficking