A Model for Developmentally Acquired Thymus-Dependent Tolerance to Central and Peripheral Antigens

Immunological Reviews

Volumn , Issue 149, 1996, Pages 155-174

  Modigliani, Y ^a   Bandeira, A ^a   Coutinho, A ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HISTOCOMPATIBILITY ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; AUTOANTIGEN;

ANIMAL; ANTIGEN PRESENTATION; AUTOIMMUNITY; BIOLOGICAL MODEL; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; REVIEW; T LYMPHOCYTE; THYMECTOMY; THYMUS; VIRUS INFECTION; ANTIGEN PRESENTING CELL; CELL FUNCTION; CELL SELECTION; EMBRYO DEVELOPMENT; HEMATOPOIESIS; IMMUNOCOMPETENT CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; ANTIGEN PRESENTATION; AUTOIMMUNITY; HISTOCOMPATIBILITY ANTIGENS; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; MICE; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; THYMECTOMY; THYMUS GLAND; VIRUS DISEASES;

EID: 0030073402     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065x.1996.tb00903.x     Document Type: Article

References (58)

1. Adams, T.E., Alpert, S. & Hanahan, D. (1987) Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells. Nature 325, 223.
2. Ashton-Rickardt, P. G., Bandeira, A., Delaney, J.R., van Kaer, L., Pircher, H.-P., Zinkernagel, R.M. & Tonegawa, S. (1994) Evidence for a differential-avidity model for T-cell election in the thymus. Cell 76, 651.
3. Bandeira, A., Larsson, E.-L., Forni, L., Pereira, P. & Coutinho, A. (1987) "In vivo" activated splenic T cells are refractory to interleukin 2 growth "in vitro". Eur. J. Immunol. 17, 901-908.
4. a antigens. Eur. J. Immunol. 22, 1397-1404.
5. Barrett, S. P., Toh, B.-H., Alderuccio, F., van Driel, I. R. & Gleeson, P. A. (1995) Organ-specific autoimmunity induced by adult thymectomy and cyclophosphamide-induced lymphopenia. Eur. J. Immunol. 25, 238-244.
6. Belo, M., Corbel, C., Martin, C. & Le Douarin, N. M. (1989) Thymic epithelium tolerizes chickens to embryonic grafts of quail bursa of Fabricius. Int. Immunol. 1, 105-112.
7. Bevan, M. J. (1977) In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature 269, 417-418.
8. Billingham, R. E., Brent, L. & Medawar, P. B. (1953) Actively acquired tolerance of foreign cells. Nature 172, 603.
9. Billingham, R. E. & Silvers, W. K. (1960) Studies on tolerance of the Y chromosome antigen in mice. J. Immunol. 85, 14-26
10. Bix, M. & Raulet, D. (1992) Inefficient positive selection of T cells directed by haematopoietic cells. Nature 172, 603.
11. Brunner, M.C., Mitchison, N.A. & Schneider S.C. (1994) The integrative activity of the immune system. Scand. J. Immunol. 40, 579.
12. Carlow, D.A., Teh, S.J. & Teh, H.S. (1992) Altered thymocyte development resulting from expressing a deleting ligand on selecting thymic epithelium. J. Immunol. 148, 2988.
13. + T lymphocyte populations. Int. Immunol. 7, 1265-1277.
14. Cohen, I. R. (1986) Regulation of autoimmune disease: physiological and therapeutic. Immunol. Rev. 94, 5.
15. Coutinho, A. & Bandeira, A. (1989) Tolerize one, tolerize them all: tolerance is self-assertion. Immunol. Today 10, 264-266.
16. Coutinho, A. (1989) Beyond clonal selection and network. Immunol. Rev. 110, 63-87.
17. Coutinho, A., Coutinho, G., Grandien, A., Marcos, M. A. R. & Bandeira, A. (1992) Some reasons why deletion and anergy do not satisfactorily account for natural tolerance. Res. Immunol. 143, 345-354.
18. Coutinho, A., Salaün, J., Corbel, C., Bandeira, A. & Le Douarin, N. (1993) The role of thymic epithelium in the establishment of transplantation tolerance. Immunol. Rev. 133, 225-240.
19. Elliott, J. I. (1993) The identity of the cells that positively select thymocytes Immunol. Rev. 135, 215.
20. Forni, L., Heusser, C. & Coutinho, A. (1988) Natural lymphocyte activation in postnatal development of germ-free and conventional mice. Ann . Inst. Pasteur Immunol. 139, 245-256.
21. Hoffmann, M. W., Allison, J. & Miller, J. A. P. (1992) Tolerance induction by thymic medullary epithelium. Proc. Natl. Acad. Sci. USA 89, 2526-2530.
22. + T cells. Immunity 3, 79.
23. Houssaint, E., Torano, A. & Ivanyi, J. (1986) Split tolerance induced by chick embryo thymic epithelium allografted to embryonic recipients. J. Immunol. 136, 3155.
24. Huetz, F., Jacquemart, F., Pena-Rossi, C., Varela, F. & Coutinho, A. (1988) Autoimmunity: The moving boundaries between physiology and pathology. J. Autoimmunity 1, 507-518.
25. Jameson S.C., Hogquist, K. A. & Bevan, M.J. (1995) Positive selection of thymocytes. Ann. Rev. Immunol. 13, 93.
26. Jones, L. A., Chin, L. T., Merriam, G. R., Nelson, L. M. & Kruisbeck, A. M. (1990) Failure of clonal deletion in neonatally thymectomized mice: tolerance is preserved through clonal anergy. J. Exp. Med. 172, 1277-1285.
27. Kappler, J. W., Roehm, N. & Marrack, P. (1987) T cell tolerance by clonal elimination in the thymus. Cell. 49, 273-280.
28. + thymocytes. Nature 333, 742.
29. Kisielow, P., Teh, H. S., Blüthmann, H. & Von Boehmer, H. (1988) Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 335, 730-733.
30. Kourilsky, P. & Claverie J. M. (1989) MHC restriction, alloreactivity and thymic education: a common link. Cell 56, 327.
31. Lafaille, J. J., Nagashima, K., Katsuki, M. & Tonegawa, S. (1994) High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell 78, 399-408.
32. Marrack, P. & Kappler, J. (1987) The T cell receptor. Science 238, 1073.
33. Marrack, P., Ignatowicz, L., Kappler, J. W., Boymel, J. & Freed, J. H. (1993) Comparison of peptides bound to spleen and thymus class II. J. Exp. Med. 178, 2173-2183.
34. Martin, C., Belo, M., Le Douarin, N.M. & Corbel, C. (1994) A study of peripheral tolerance through embryonic grafts of the bursal epithelial rudiment between MHC-distinct chick embryos . Int. Immunol. 6, 795.
35. Medawar, P. B. & Woodruff, M. F. A. (1958) The induction of tolerance by skin homografts on newborn rats. Immunology 1, 27-35.
36. Modigliani, Y., Coutinho, G., Burlen-Defranoux, O., Coutinho, A. & Bandeira, A. (1994) Differential contribution of thymic outputs and peripheral expansion in the development of peripheral T cell pools. Eur. J. Immunol. 24, 1223-1227.
37. Modigliani, Y., Thomas-Vaslin, V., Bandeira, A., Coltey, M., Le Douarin, N., Coutinho, A. & Salaün, J. (1995a) Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype. Proc. Natl. Acad. Sci. USA 92, 7555-7559.
38. Modigliani, Y., Pereira, P., Thomas-Vaslin, V., Salaün, J., Burlen-Defranoux, O., Coutinho, A., Le Douarin, N. & Bandeira, A. (1995b) Regulatory T cells in thymic epithelium-induced tolerance. I. Suppression of mature peripheral non-tolerant T cells. Eur. J. Immunol. 25, 2563-2571.
39. Modigliani, Y., Coutinho, A., Pereira, P., Salaün, J., Thomas-Vaslin, V., Burlen-Defranoux, O., Le Douarin, N. & Bandeira, A. (1996) Establisment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium. Eur. J. Immunol. (in press).
40. Mosmann, T.R. & Coffman, R.L. (1989) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol. 7, 145.
41. Ohki, H., Martin, C., Coltey, M. & Le Douarin, N. M. (1988) Implants of quail thymic epithelium generate permanent tolerance in embryonically constructed quail/chick chimeras. Development 104, 619.
42. Ohki, H., Martin, C., Corbel, C., Coltey, M. & Le Douarin, N. M. (1987) Tolerance induced by thymic epithelial grafts in birds. Science 237, 1032-1035.
43. Oldstone, M.B.A., Nerenberg, M., Southern, P., Price, J. & Lewicki, H. (1991) Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 65, 319.
44. Pereira, P., Larsson, E.-L., Forni, L., Bandeira, A. & Coutinho, A. (1985) Natural effector T lymphocytes in normal mice. Proc. Natl. Acad. Sci. USA 82, 7691-7695.
45. low subset. J. Exp. Med. 172, 1701.
46. + T cells. Immunity 1, 553-562.
47. Roser, B. J. (1989) Cellular mechanisms in neonatal and adult tolerance. Immunol. Rev. 107, 179.
48. Sakaguchi, S., Takahashi, T. & Nishizuka, Y. (1982) Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt- 1 cells in normal female mice for the prevention of oophoritis. J. Exp. Med. 156, 1577-1586.
49. Salaün, J., Bandeira, A., Khazaal, I., Calman, F., Coltey, M., Coutinho, A. & Le Douarin, N. (1990) Thymic epithelium tolerizes for histocompatibilily antigens. Science 247, 1471-1474.
50. a mice. Implications for T cell development and autoimmunity. J. Exp. Med. 169, 2149-2158.
51. Sebzda, E. Wallace, V.A., Mayer, J., Yeung, R.S.M., Mark, T.W. & Ohashi, P.S. (1994) Positive and negative thymocyte selection induced by different concentrations of a single peptide Science 263, 1615.
52. Sete, A., Alexander, J., Ruppert, J., Snoke, K., Franco, A., Ishioka, G. & Grey, H. M. (1994) Antigen analogues/MHC complexes as specific T cell receptor antagonists. Ann. Rev. Immunol. 12, 413.
53. Smith, H., Chen, I.-M. Kubo, R. & Tung, K.S.K. (1989) Neonatal thymectomy results in a repertoire enriched in T cells deleted in adult thymus. Science 245, 749.
54. Sprent, J., Lo, D., Gao, E. K. & Ron, Y. (1988) T cell selection in the thymus. Immunol. Rev. 101, 173-189.
55. Thomas-Vaslin, V., Salaün, J., Gajdos, B., Le Douarin, N., Coutinho, A. & Bandeira, A. (1995) Thymic epithelium induces full tolerance to skin and heart but not to B lymphocyte grafts. Eur. J. Immunol. 25, 438-445.
56. Valitutti, S., Müller, S., Cella, M., Padovan, E. & Lanzavecchia, A. (1995) Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375, 148-151.
57. von Boehmer H. (1990) Self-nonself discrimination by T cells. Science 248, 1369.
58. Zamoyska, R., Waldmann, H. & Matzinger, P. (1989) Peripheral Tolerance mechanisms prevent the development of autoreactive T cells in chimeras grafted with two minor incompatible thymuses. Eur. J. Immunol. 19, 111.