Pattern recognition receptors and control of adaptive immunity

Immunological Reviews

Volumn 227, Issue 1, 2009, Pages 221-233

  Palm, Noah W ^a   Medzhitov, Ruslan ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell activation; Inflammation; T cells; Toll like receptors pattern recognition receptors

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CRYOPYRIN; DEAD BOX PROTEIN; DECTIN 1; PATTERN RECOGNITION RECEPTOR; PROTEIN MDA5; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANTIBODY RESPONSE; CYTOSOL; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; LONG TERM MEMORY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODY FORMATION; EPITOPES; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, INNATE; IMMUNOLOGIC MEMORY; MEMBRANE PROTEINS; NOD SIGNALING ADAPTOR PROTEINS; RECEPTOR CROSS-TALK; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SELF TOLERANCE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 58049220365     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2008.00731.x     Document Type: Review

References (89)

1. Hoffmann JA, Kafatos FC, Janeway CA, Ezekowitz RA. Phylogenetic perspectives in innate immunity. Science 1999 284 : 1313 1318.
2. Medzhitov R, Janeway CA Jr. Innate immunity: the virtues of a nonclonal system of recognition. Cell 1997 91 : 295 298.
3. Cooper MD, Alder MN. The evolution of adaptive immune systems. Cell 2006 124 : 815 822.
4. Janeway CA Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 1989 54 : 1 13.
5. Gallegos AM, Bevan MJ. Central tolerance: good but imperfect. Immunol Rev 2006 209 : 290 296.
6. Macian F, Im SH, Garcia-Cozar FJ, Rao A. T-cell anergy. Curr Opin Immunol 2004 16 : 209 216.
7. Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell 2008 133 : 775 787.
8. Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004 5 : 987 995.
9. Carroll MC. The complement system in regulation of adaptive immunity. Nat Immunol 2004 5 : 981 986.
10. Blander JM, Medzhitov R. Regulation of phagosome maturation by signals from toll-like receptors. Science 2004 304 : 1014 1018.
11. Blander JM, Medzhitov R. On regulation of phagosome maturation and antigen presentation. Nat Immunol 2006 7 : 1029 1035.
12. Blander JM, Medzhitov R. Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 2006 440 : 808 812.
13. Pasare C, Medzhitov R. Toll-dependent control mechanisms of CD4 T-cell activation. Immunity 2004 21 : 733 741.
14. Sporri R, Reis e Sousa C. Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T-cell populations lacking helper function. Nat Immunol 2005 6 : 163 170.
15. Reiner SL. Development in motion: helper T cells at work. Cell 2007 129 : 33 36.
16. Badovinac VP, Porter BB, Harty JT. Programmed contraction of CD8(+) T cells after infection. Nat Immunol 2002 3 : 619 626.
17. Bernasconi NL, Traggiai E, Lanzavecchia A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 2002 298 : 2199 2202.
18. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006 124 : 783 801.
19. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998 392 : 245 252.
20. Pasare C, Medzhitov R. Toll-like receptors: linking innate and adaptive immunity. Adv Exp Med Biol 2005 560 : 11 18.
21. Pasare C, Medzhitov R. Control of B-cell responses by Toll-like receptors. Nature 2005 438 : 364 368.
22. Schnare M, Barton GM, Holt AC, Takeda K, Akira S, Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2001 2 : 947 950.
23. Yarovinsky F, Kanzler H, Hieny S, Coffman RL, Sher A. Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T-cell response. Immunity 2006 25 : 655 664.
24. West MA, et al. Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling. Science 2004 305 : 1153 1157.
25. Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4+ CD25+ T cell-mediated suppression by dendritic cells. Science 2003 299 : 1033 1036.
26. Vella AT, Dow S, Potter TA, Kappler J, Marrack P. Cytokine-induced survival of activated T cells in vitro and in vivo. Proc Natl Acad Sci USA 1998 95 : 3810 3815.
27. Ruprecht CR, Lanzavecchia A. Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur J Immunol 2006 36 : 810 816.
28. Nagai Y, et al. The radioprotective 105/ MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes. J Immunol 2005 174 : 7043 7049.
29. Herlands RA, Christensen SR, Sweet RA, Hershberg U, Shlomchik MJ. T cell-independent and Toll-like receptor-dependent antigen-driven activation of autoreactive B cells. Immunity 2008 29 : 249 260.
30. Brown GD, Gordon S. Immune recognition. A new receptor for beta-glucans. Nature 2001 413 : 36 37.
31. LeibundGut-Landmann S, et al. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 2007 8 : 630 638.
32. Acosta-Rodriguez EV, et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol 2007 8 : 639 646.
33. Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 2007 25 : 821 852.
34. Mangan PR, et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006 441 : 231 234.
35. Gross O, et al. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 2006 442 : 651 656.
36. Taylor PR, et al. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol 2007 8 : 31 38.
37. Rogers NC, et al. Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 2005 22 : 507 517.
38. Herre J, et al. Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages. Blood 2004 104 : 4038 4045.
39. Dennehy KM, Brown GD. The role of the beta-glucan receptor Dectin-1 in control of fungal infection. J Leukoc Biol 2007 82 : 253 258.
40. Meylan E, Tschopp J, Karin M. Intracellular pattern recognition receptors in the host response. Nature 2006 442 : 39 44.
41. Takeuchi O, Akira S. Recognition of viruses by innate immunity. Immunol Rev 2007 220 : 214 224.
42. Martinon F, Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004 117 : 561 574.
43. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE. Nod-like proteins in immunity, inflammation and disease. Nat Immunol 2006 7 : 1250 1257.
44. Girardin SE, et al. Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 2003 300 : 1584 1587.
45. Cho JH. The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol 2008 8 : 458 466.
46. Girardin SE, et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 2003 278 : 8869 8872.
47. Kobayashi KS, et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 2005 307 : 731 734.
48. Fritz JH, et al. Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity 2007 26 : 445 459.
49. Kaparakis M, Philpott DJ, Ferrero RL. Mammalian NLR proteins; discriminating foe from friend. Immunol Cell Biol 2007 85 : 495 502.
50. van Beelen AJ, et al. Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 2007 27 : 660 669.
51. Mariathasan S, et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006 440 : 228 232.
52. Ye Z, Ting JP. NLR, the nucleotide-binding domain leucine-rich repeat containing gene family. Curr Opin Immunol 2008 20 : 3 9.
53. Sutterwala FS, et al. Critical role for NALP3/CIAS1/cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 2006 24 : 317 327.
54. Watanabe H, et al. Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol 2007 127 : 1956 1963.
55. Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 2008 453 : 1122 1126.
56. Kool M, et al. Cutting Edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J Immunol 2008 181 : 3755 3759.
57. Franchi L, Nunez G. The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity. Eur J Immunol 2008 38 : 2085 2089.
58. Li H, Willingham SB, Ting JP, Re F. Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J Immunol 2008 181 : 17 21.
59. Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006 440 : 237 241.
60. Keller M, Ruegg A, Werner S, Beer HD. Active caspase-1 is a regulator of unconventional protein secretion. Cell 2008 132 : 818 831.
61. Stetson DB, Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 2006 24 : 93 103.
62. Ishii KJ, et al. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol 2006 7 : 40 48.
63. Gurunathan S, Klinman DM, Seder RA. DNA vaccines: immunology, application, and optimization*. Annu Rev Immunol 2000 18 : 927 974.
64. Ishii KJ, et al. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 2008 451 : 725 729.
65. Ishii KJ, Akira S. Innate immune recognition of, and regulation by, DNA. Trends Immunol 2006 27 : 525 532.
66. Spies B, et al. Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice. J Immunol 2003 171 : 5908 5912.
67. Takeuchi O, Akira S. MDA5/RIG-I and virus recognition. Curr Opin Immunol 2008 20 : 17 22.
68. Jung A, et al. Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88. J Virol 2008 82 : 196 206.
69. Koyama S, et al. Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination. J Immunol 2007 179 : 4711 4720.
70. Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature 2007 449 : 819 826.
71. Sato A, Iwasaki A. Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments. Proc Natl Acad Sci USA 2004 101 : 16274 16279.
72. Fritz JH, Le Bourhis L, Magalhaes JG, Philpott DJ. Innate immune recognition at the epithelial barrier drives adaptive immunity: APCs take the back seat. Trends Immunol 2008 29 : 41 49.
73. Groom JR, et al. BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J Exp Med 2007 204 : 1959 1971.
74. Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 2002 416 : 603 607.
75. Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol 2006 6 : 823 835.
76. Guay HM, Andreyeva TA, Garcea RL, Welsh RM, Szomolanyi-Tsuda E. MyD88 is required for the formation of long-term humoral immunity to virus infection. J Immunol 2007 178 : 5124 5131.
77. Heer AK, et al. TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T-cell responses. J Immunol 2007 178 : 2182 2191.
78. Jegerlehner A, Maurer P, Bessa J, Hinton HJ, Kopf M, Bachmann MF. TLR9 signaling in B cells determines class switch recombination to IgG2a. J Immunol 2007 178 : 2415 2420.
79. Meyer-Bahlburg A, Khim S, Rawlings DJ. B cell intrinsic TLR signals amplify but are not required for humoral immunity. J Exp Med 2007 204 : 3095 3101.
80. Hinton HJ, Jegerlehner A, Bachmann MF. Pattern recognition by B cells: the role of antigen repetitiveness versus Toll-like receptors. Curr Top Microbiol Immunol 2008 319 : 1 15.
81. Gavin AL, et al. Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science 2006 314 : 1936 1938.
82. Nemazee D, Gavin A, Hoebe K, Beutler B. Immunology: Toll-like receptors and antibody responses. Nature 2006 441 : E4.
83. Billiau A, Matthys P. Modes of action of Freund's adjuvants in experimental models of autoimmune diseases. J Leukoc Biol 2001 70 : 849 860.
84. Lindblad EB. Aluminium compounds for use in vaccines. Immunol Cell Biol 2004 82 : 497 505.
85. Kaisho T, Akira S. Toll-like receptors as adjuvant receptors. Biochim Biophys Acta 2002 1589 : 1 13.
86. Klinman DM. Adjuvant activity of CpG oligodeoxynucleotides. Int Rev Immunol 2006 25 : 135 154.
87. Guy B. The perfect mix: recent progress in adjuvant research. Nat Rev Microbiol 2007 5 : 505 517.
88. Pulendran B, Ahmed R. Translating innate immunity into immunological memory: implications for vaccine development. Cell 2006 124 : 849 863.
89. Cuadros C, Lopez-Hernandez FJ, Dominguez AL, McClelland M, Lustgarten J. Flagellin fusion proteins as adjuvants or vaccines induce specific immune responses. Infect Immun 2004 72 : 2810 2816.