Mitigation of experimental allergic encephalomyelitis by TGF-β induced Foxp3+ regulatory T lymphocytes through the induction of anergy and infectious tolerance

Journal of Immunology

Volumn 180, Issue 5, 2008, Pages 2830-2838

  Selvaraj, Ramesh K ^a   Geiger, Terrence L ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; EPITOPE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35 55); MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); NERVE PROTEIN; PEPTIDE FRAGMENT;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CLONAL ANERGY; FLOW CYTOMETRY; IMMUNOMODULATION; LYMPH NODE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ALLERGIC ENCEPHALOMYELITIS; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOLECULAR GENETICS; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE; TRANSPLANTATION;

ADOPTIVE TRANSFER; AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CLONAL ANERGY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPITOPES, T-LYMPHOCYTE; FORKHEAD TRANSCRIPTION FACTORS; GLYCOPROTEINS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 48249143387     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.5.2830     Document Type: Article

References (56)

1. McFarland, H. F., and R. Martin. 2007. Multiple sclerosis: a complicated picture of autoimmunity. Nat. Immunol. 8: 913-919.
2. Kuchroo, V. K., A. C. Anderson, H. Waldner, M. Munder, E. Bettelli, and L. B. Nicholson. 2002. T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu. Rev. Immunol. 20: 101-123.
3. Mendel, I., N. Kerlero de Rosbo, and A. Ben-Nun. 1995. A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V β expression of encephalitogenic T cells. Eur. J. Immunol. 25: 1951-1959.
4. Korn, T., J. Reddy, W. Gao, E. Bettelli, A. Awasthi, T. R. Petersen, B. T. Backstrom, R. A. Sobel, K. W. Wucherpfennig, T. B. Strom, et al. 2007. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat. Med. 13: 423-431.
5. + regulatory T cells. J. Immunol. 179: 958-966.
6. + regulatory cells within the central nervous system. J. Immunol. 175: 3025-3032.
7. + regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J. Immunol. 169: 4712-4716.
8. + regulatory T cells. Int. Immunol. 16: 249-256.
9. + T lymphocytes. Blood 105: 2090-2092.
10. + T cells: analysis using depleting antibodies. J. Autoimmun. 23: 1-7.
11. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2: 389-400.
12. Fontenot, J. D., and A. Y. Rudensky. 2005. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 6: 331-337.
13. Hsieh, C. S., Y. Zheng, Y. Liang, J. D. Fontenot, and A. Y. Rudensky. 2006. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 7: 401-410.
14. Tang, Q., and J. A. Bluestone. 2006. Regulatory T cell physiology and application to treat autoimmunity. Immunol. Rev. 212: 217-237.
15. + regulatory T cells: current controversies and future perspectives. Eur. J. Immunol. 36: 2832-2836.
16. Bluestone, J. A., A. W. Thomson, E. M. Shevach, and H. L. Weiner. 2007. What does the future hold for cell-based tolerogenic therapy? Nat. Rev. Immunol. 7: 650-654.
17. Selvaraj, R. K., and T. L. Geiger. 2007. A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-β. J. Immunol. 178: 7667-7677.
18. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198: 1875-1886.
19. - precursors. J. Immunol. 169: 4183-4189.
20. +. J. Immunol. 178: 2018-2027.
21. + T regulatory cells. J. Immunol. 178: 4022-4026.
22. + cells in the recipient. Int. Immunol. 18: 279-289.
23. + regulatory T cells suppress Th1 mediated experimental colitis. Gut 55: 671-680.
24. Weber, S. E., J. Harbertson, E. Godebu, G. A. Mros, R. C. Padrick, B. D. Carson, S. F. Ziegler, and L. M. Bradley. 2006. Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo. J. Immunol. 176: 4730-4739.
25. + regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells. J. Immunol. 179: 4685-4693.
26. Fontenot, J. D., J. P. Rasmussen, L. M. Williams, J. L. Dooley, A. G. Farr, and A. Y. Rudensky. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22: 329-341.
27. Inaba, H., and T. L. Geiger. 2006. Defective cell cycle induction by IL-2 in naive T cells antigen stimulated in the presence of refractory T lymphocytes. Int. Immunol. 18: 1043-1054.
28. + T lymphocytes. Proc. Natl. Acad. Sci. USA 102: 11817-11822.
29. Samoilova, E. B., J. L. Horton, and Y. Chen. 1998. Acceleration of experimental autoimmune encephalomyelitis in interleukin-10-deficient mice: roles of interleukin-10 in disease progression and recovery. Cell. Immunol. 188: 118-124.
30. Schwartz, R. H. 2003. T cell anergy. Annu. Rev. Immunol. 21: 305-334.
31. Furuzawa-Carballeda, J., M. I. Vargas-Rojas, and A. R. Cabral. 2007. Autoimmune inflammation from the Th17 perspective. Autoimmun. Rev. 6: 169-175.
32. Petersen, T. R., R. Lata, E. Spittle, and B. T. Backstrom. 2007. A chimeric TCR-β chain confers increased susceptibility to EAE. Mol. Immunol. 44: 3473-3481.
33. Bennett, C. L., J. Christie, F. Ramsdell, M. E. Brunkow, P. J. Ferguson, L. Whitesell, T. E. Kelly, F. T. Saulsbury, P. F. Chance, and H. D. Ochs. 2001. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27: 20-21.
34. + regulatory T cells. Nat. Immunol. 4: 330-336.
35. + regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis. J. Immunol. 175: 5591-5595.
36. + regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 101: 15434-15439.
37. Griffiths, R. W., E. Elkord, D. E. Gilham, V. Ramani, N. Clarke, P. L. Stern, and R. E. Hawkins. 2007. Frequency of regulatory T cells in renal cell carcinoma patients and investigation of correlation with survival. Cancer Immunol. Immunother. 56: 1743-1753.
38. Ling, K. L., S. E. Pratap, G. J. Bates, B. Singh, N. J. Mortensen, B. D. George, B. F. Warren, J. Piris, G. Roncador, S. B. Fox, et al. 2007. Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients. Cancer Immun. 7: 7.
39. + regulatory T cells in patients with multiple sclerosis. J. Exp. Med. 199: 971-979.
40. Gregori, S., R. Bacchetta, L. Passerini, M. K. Levings, and M. G. Roncarolo. 2007. Isolation, expansion, and characterization of human natural and adaptive regulatory T cells. Methods Mol. Biol. 380: 83-106.
41. Matsumura, Y., T. Kobayashi, K. Ichiyama, R. Yoshida, M. Hashimoto, T. Takimoto, K. Tanaka, T. Chinen, T. Shichita, T. Wyss-Coray, et al. 2007. Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells. J. Immunol. 179: 2170-2179.
42. + regulatory T cells from peripheral Foxp3 precursors. Blood 110: 4293-4302.
43. + regulatory T cells via a TGF-β and retinoic acid-dependent mechanism. J. Exp. Med. 204: 1757-1764.
44. Bettelli, E., M. P. Das, E. D. Howard, H. L. Weiner, R. A. Sobel, and V. K. Kuchroo. 1998. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J. Immunol. 161: 3299-3306.
45. Mekala, D. J., R. S. Alli, and T. L. Geiger. 2005. IL-10-dependent suppression of experimental allergic encephalomyelitis by Th2-differentiated, anti-TCR redirected T lymphocytes. J. Immunol. 174: 3789-3797.
46. Kennedy, M. K., D. S. Torrance, K. S. Picha, and K. M. Mohler. 1992. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149: 2496-2505.
47. Kremlev, S. G., and C. Palmer. 2005. Interleukin-10 inhibits endotoxin-induced proinflammatory cytokines in microglial cell cultures. J. Neuroimmunol. 162: 71-80.
48. Murray, P. J. 2005. The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription. Proc. Natl. Acad. Sci. USA 102: 8686-8691.
49. + [corrected] regulatory T cells render naive CD4. Immunology 120: 447-455.
50. + T cells facilitate the induction of T cell anergy. J. Immunol. 167: 4271-4275.
51. Burkly, L. C., D. Lo, O. Kanagawa, R. L. Brinster, and R. A. Flavell. 1989. T cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I-E. Nature 342: 564-566.
52. Lohr, J., B. Knoechel, V. Nagabhushanam, and A. K. Abbas. 2005. T cell tolerance and autoimmunity to systemic and tissue-restricted self-antigens. Immunol. Rev. 204: 116-127.
53. - cells to develop suppressive activity: the role of IL-2, TGF-β, and IL-10. J. Immunol. 172: 5213-5221.
54. + regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected]. J. Exp. Med. 196: 247-253.
55. + T helper cells. J. Exp. Med. 196: 255-260.
56. Kim, J. M., J. P. Rasmussen, and A. Y. Rudensky. 2007. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8: 191-197.