Peripheral expansion of thymus-derived regulatory cells in anti-myelin basic protein T cell receptor transgenic mice

European Journal of Immunology

Volumn 32, Issue 12, 2002, Pages 3729-3735

  Hori, Shohei ^a,c   Haury, Matthias ^a   Lafaille, Juan J ^b   Demengeot, Jocelyne ^a   Coutinho, António ^a  

^a INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DONOR; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECIPIENT; T LYMPHOCYTE SUBPOPULATION; THYMUS; TISSUE SPECIFICITY; TRANSGENIC MOUSE; WILD TYPE;

EID: 0036919854     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200212)32:12<3729::AID-IMMU3729>3.0.CO;2-2     Document Type: Article

References (30)

1. Belo, M., Corbel, C., Martin, C. and Le Douarin, N. M., Thymic epithelium tolerizes chickens to embryonic graft of quail bursa of Fabricius. Int. Immunol. 1989.1: 105-112.
2. Modigliani, Y., Bandeira, A. and Coutinho, A., A model for developmentally acquired thymus-dependent tolerance to central and peripheral antigens. Immunol. Rev. 1996. 149: 155-220.
3. + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 2001. 182:18-32.
4. Seddon, B. and Mason, D., The third function of the thymus. Immunol. Today 2000. 21: 95-99.
5. + suppressor T cells. Immunol. Rev. 2001. 182:58-67.
6. Sakaguchi, S., Takahashi, T. and Nishizuka, Y., Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J. Exp. Med. i982. 156:1577-1586.
7. Seddon, B. and Mason, D., Peripheral autoantigen induces regulatory T cells that prevent autoirnmunity. J. Exp. Med. 1999.189: 877-882.
8. Modigliani, Y., Thomas-Vaslin, V., Bandeira, A., Coltey, M., Le Douarin, N. M., Coutinho, A. and Salaun, J., Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype. Proc. Natl.. Acad. Sci. USA 1995. 92: 7555-7559.
9. Saoudi, A., Seddon, B., Fowell, D. and Mason, D., The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients. J. Exp. Med. 1996. 184:2393-2398.
10. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 1999. 162: 5317-5326.
11. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2001. 2: 301-306.
12. Bensinger, S. J., Bandeira, A., Jordan, M. S., Caton, A. J. and Laufer, T. M., Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J. Exp. Med. 2001. 194: 427-438.
13. Qin, S., Cobbold, S. P., Pope, H., Elliott, J., Kioussis, D., Davies, J. and Waldmann, H., "Infectious" transplantation tolerance. Science 1993. 259: 974-977.
14. Cobbold, S. and Waldmann, H., Infectious tolerance. Curr Opin. Immunol. 1998.10:518-524.
15. Lafaille, J. J., Nagashima, K., Katsuki, M. and Tonegawa, S., High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell 1994. 78: 399-408.
16. + T cells that prevent spontaneous autoimmune encephalomyelitis. J. Immunol. 2000. 164: 5499-5507.
17. Van de Keere, F. and Tonegawa, S., CD4(+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J. Exp. Med. 1998. 188:1875-1882.
18. + regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA 2002. 99: 8213-8218.
19. Tough, D. F. and Sprent, J., Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 1994. 179: 1127-1135.
20. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 1998. 188: 287-296.
21. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 1998. 10: 1969-1980.
22. Modigliani, Y., Coutinho, A., Pereira, P., Le Douarin, N., Thomas-Vaslin, V., Burien-Defranoux, O., Salaun, J. and Bandeira, A., Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium. Eur J. Immunol. 1996.26:1807-1815.
23. Sakaguchi, S., Animal models of autoimmunity and their relevance to human diseases. Curr. Opin. Immunol. 2000. 12: 684-690.
24. North, R. J., Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells. J. Exp. Med. 1982. 155:1063-1074.
25. North, R. J., Radiation-induced, immunologically mediated regression of an established tumor as an example of successful therapeutic immunomanipulation. Preferential elimination of suppressor T cells allows sustained production of effector T cells. J. Exp. Med. 1986.164:1652-1666.
26. Howard, J. G., Hale, C. and Liew, F. Y., Immunological regulation of experimental cutaneous leishmaniasis. IV. Prophylactic effect of sublethal irradiation as a result of abrogation of suppressor T cell generation in mice genetically susceptible to Leishmania tropica. J. Exp. Med. 1981. 153: 557-568.
27. Papiernik, M., de Moraes, M. L., Pontoux, C., Vasseur, F and Penit, C., Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int. Immunol. 1998. 10: 371-378.
28. Willerford, D. M., Chen, J., Ferry, J. A., Davidson, L., Ma, A. and Alt, F. W., Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995. 3: 521-530.
29. Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A. C. and Horak, I., Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993. 75: 253-261.
30. Bernstein, I. D., Tam, M. R. and Nowinski, R. C., Mouse leukemia: therapy with monoclonal antibodies against a thymus differentiation antigen. Science 1980. 207: 68-71.