메뉴 건너뛰기




Volumn 6, Issue 4, 2006, Pages 295-307

Regulatory T cells, tumour immunity and immunotherapy

Author keywords

[No Author keywords available]

Indexed keywords

BASILIXIMAB; CALCINEURIN INHIBITOR; CHEMOKINE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ASSOCIATED ANTIGEN 4 ANTIBODY; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR ANTIBODY; GRANZYME A; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 7; PERFORIN; TSUKUBAENOLIDE; TUMOR ANTIGEN; TUMOR VACCINE; UNCLASSIFIED DRUG;

EID: 33645286546     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri1806     Document Type: Review
Times cited : (1777)

References (145)
  • 1
    • 4644224624 scopus 로고    scopus 로고
    • Fatal attraction: Tumours beckon regulatory T cells
    • Shevach, E. M. Fatal attraction: tumours beckon regulatory T cells. Nature Med. 10, 900-901 (2004).
    • (2004) Nature Med. , vol.10 , pp. 900-901
    • Shevach, E.M.1
  • 2
    • 0015172562 scopus 로고
    • Infectious immunological tolerance
    • Gershon, R. K. & Kondo, K. Infectious immunological tolerance. Immunology 21, 903-914 (1971).
    • (1971) Immunology , vol.21 , pp. 903-914
    • Gershon, R.K.1    Kondo, K.2
  • 3
    • 0014792798 scopus 로고
    • Cell interactions in the induction of tolerance: The role of thymic lymphocytes
    • Gershon, R. K. & Kondo, K. Cell interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology 18, 723-737 (1970).
    • (1970) Immunology , vol.18 , pp. 723-737
    • Gershon, R.K.1    Kondo, K.2
  • 4
    • 84907107964 scopus 로고
    • Immunosuppressor T cells in tumour bearing host
    • Fujimoto, S., Creene, M. & Sehon, A. H. Immunosuppressor T cells in tumour bearing host. Immunol. Commun. 4, 201-217 (1975).
    • (1975) Immunol. Commun. , vol.4 , pp. 201-217
    • Fujimoto, S.1    Creene, M.2    Sehon, A.H.3
  • 5
    • 0018906201 scopus 로고
    • T-cell-mediated suppression of anti-tumour immunity. An explanation for progressive growth of an immunogenic tumour
    • Berendt, M. J. & North, R. J. T-cell-mediated suppression of anti-tumour immunity. An explanation for progressive growth of an immunogenic tumour. J. Exp. Med. 151, 69-80 (1980).
    • (1980) J. Exp. Med. , vol.151 , pp. 69-80
    • Berendt, M.J.1    North, R.J.2
  • 6
    • 0021275482 scopus 로고
    • Generation and decay of the immune response to a progressive fibrosarcoma. II. Failure to demonstrate postexcision immunity after the onset of T cell-mediated suppression of immunity
    • Bursuker, I. & North, R. J. Generation and decay of the immune response to a progressive fibrosarcoma. II. Failure to demonstrate postexcision immunity after the onset of T cell-mediated suppression of immunity. J. Exp. Med. 159, 1312-1321 (1984).
    • (1984) J. Exp. Med. , vol.159 , pp. 1312-1321
    • Bursuker, I.1    North, R.J.2
  • 8
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • + regulatory T cells.
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 9
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori, S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061 (2003).
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 12
    • 0030704726 scopus 로고    scopus 로고
    • + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389, 737-742 (1997). The first study showing that functional regulatory T cells can be induced.
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1
  • 13
    • 0035186416 scopus 로고    scopus 로고
    • Induction and mechanism of action of transforming growth factor-β-secreting Th3 regulatory cells
    • Weiner, H. L. Induction and mechanism of action of transforming growth factor-β-secreting Th3 regulatory cells. Immunol. Rev. 182, 207-214 (2001).
    • (2001) Immunol. Rev. , vol.182 , pp. 207-214
    • Weiner, H.L.1
  • 14
    • 10744226674 scopus 로고    scopus 로고
    • + regulatory thymocytes
    • + regulatory thymocytes. Blood 102, 4107-4114 (2003).
    • (2003) Blood , vol.102 , pp. 4107-4114
    • Cosmi, L.1
  • 15
    • 0036122891 scopus 로고    scopus 로고
    • S cells: The crucial role of inhibitory receptors ILT3 and ILT4
    • S cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nature Immunol. 3, 237-243 (2002).
    • (2002) Nature Immunol. , vol.3 , pp. 237-243
    • Chang, C.C.1
  • 17
    • 0035658072 scopus 로고    scopus 로고
    • Stromal-derived factor-1 in human tumours recruits and alters the function of plasmacytoid precursor dendritic cells
    • Zou, W. et al. Stromal-derived factor-1 in human tumours recruits and alters the function of plasmacytoid precursor dendritic cells. Nature Med. 7, 1339-1346 (2001).
    • (2001) Nature Med. , vol.7 , pp. 1339-1346
    • Zou, W.1
  • 18
    • 20444485236 scopus 로고    scopus 로고
    • + regulatory T cells in human ovarian carcinoma
    • + regulatory T cells in human ovarian carcinoma. Cancer Res. 65, 5020-5026 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 5020-5026
    • Wei, S.1
  • 19
    • 0037128654 scopus 로고    scopus 로고
    • Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells
    • + regulatory T cells.
    • (2002) J. Exp. Med. , vol.195 , pp. 695-704
    • Gilliet, M.1    Liu, Y.J.2
  • 20
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • + suppressor T cells: more questions than answers. Nature Rev. Immunol. 2, 389-400 (2002). An outstanding Review that summarizes recent findings in the field of regulatory T cells and gives an outlook for future direction.
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 21
    • 4143141823 scopus 로고    scopus 로고
    • The immunobiology of cancer immunosurveillance and immunoediting
    • Dunn, G. P., Old, L. J. & Schreiber, R. D. The immunobiology of cancer immunosurveillance and immunoediting. Immunity 21, 137-148 (2004). This paper summarizes the most important experimental information to refine and revisit the concept of tumour immune surveillance.
    • (2004) Immunity , vol.21 , pp. 137-148
    • Dunn, G.P.1    Old, L.J.2    Schreiber, R.D.3
  • 22
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • Zou, W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nature Rev. Cancer 5, 263-274 (2005).
    • (2005) Nature Rev. Cancer , vol.5 , pp. 263-274
    • Zou, W.1
  • 23
    • 16844365788 scopus 로고    scopus 로고
    • + regulatory T cells in immunological tolerance to self and non-self
    • + regulatory T cells in immunological tolerance to self and non-self. Nature Immunol. 6, 345-352 (2005).
    • (2005) Nature Immunol. , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 24
    • 0033168037 scopus 로고    scopus 로고
    • Tumour rejection by in vivo administration of anti-CD25 (interleukin-2 receptor α) monoclonal antibody
    • Onizuka, S. et al. Tumour rejection by in vivo administration of anti-CD25 (interleukin-2 receptor α) monoclonal antibody. Cancer Res. 59, 3128-3133 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 3128-3133
    • Onizuka, S.1
  • 26
    • 17944364189 scopus 로고    scopus 로고
    • Elucidating the autoimmune and antitumour effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: Comparison of prophylaxis and therapy
    • van Elsas, A. et al. Elucidating the autoimmune and antitumour effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy. J. Exp. Med. 194, 481-489 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 481-489
    • Van Elsas, A.1
  • 27
    • 0035903324 scopus 로고    scopus 로고
    • + regulatory T cells in antitumour therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
    • + regulatory T cells in antitumour therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J. Exp. Med. 194, 823-832 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 823-832
    • Sutmuller, R.P.1
  • 28
    • 15444377017 scopus 로고    scopus 로고
    • + cells unmasks tumour immunogenicity leading to the rejection of late-stage tumours
    • + cells unmasks tumour immunogenicity leading to the rejection of late-stage tumours. J. Exp. Med. 201, 779-791 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 779-791
    • Yu, P.1
  • 30
    • 3242736641 scopus 로고    scopus 로고
    • + regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice
    • + regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. Cancer Immun. 2, 1 (2002).
    • (2002) Cancer Immun. , vol.2 , pp. 1
    • Jones, E.1
  • 31
    • 0036093489 scopus 로고    scopus 로고
    • + regulatory cells augments the generation of specific immune T cells in tumour-draining lymph nodes
    • + regulatory cells augments the generation of specific immune T cells in tumour-draining lymph nodes. J. Immunother. 25, 207-217 (2002).
    • (2002) J. Immunother. , vol.25 , pp. 207-217
    • Tanaka, H.1    Tanaka, J.2    Kjaergaard, J.3    Shu, S.4
  • 32
    • 5144228905 scopus 로고    scopus 로고
    • + regulatory T cells leads to tumour rejection of B16F10 melanoma, when combined with interleukin-12 gene transfer
    • + regulatory T cells leads to tumour rejection of B16F10 melanoma, when combined with interleukin-12 gene transfer. Exp. Dermatol. 13, 613-620 (2004).
    • (2004) Exp. Dermatol. , vol.13 , pp. 613-620
    • Nagai, H.1
  • 33
    • 10844269645 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. J. Immunol. 174, 90-98 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 90-98
    • Prasad, S.J.1
  • 34
    • 25844517914 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. J. Exp. Med. 202, 885-891 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 885-891
    • Ko, K.1
  • 36
    • 0344153890 scopus 로고    scopus 로고
    • + T cells with IFN-γ-dependent antiangiogenic activity, as well as long-lasting tumour immunity elicited by peptide vaccination
    • + T cells with IFN-γ-dependent antiangiogenic activity, as well as long-lasting tumour immunity elicited by peptide vaccination. J. Immunol. 171, 5931-5939 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 5931-5939
    • Casares, N.1
  • 37
    • 28644447974 scopus 로고    scopus 로고
    • Regulatory T cells in ovarian cancer: Biology and therapeutic potential
    • Barnett, B., Kryczek, I., Cheng, P., Zou, W. & Curiel, T. J. Regulatory T cells in ovarian cancer: biology and therapeutic potential. Am. J. Reprod. Immunol. 54, 369-377 (2005).
    • (2005) Am. J. Reprod. Immunol. , vol.54 , pp. 369-377
    • Barnett, B.1    Kryczek, I.2    Cheng, P.3    Zou, W.4    Curiel, T.J.5
  • 38
    • 30144444279 scopus 로고    scopus 로고
    • Enhancement of vaccine-mediated antitumour immunity in cancer patients after depletion of regulatory T cells
    • Dannull, J. et al. Enhancement of vaccine-mediated antitumour immunity in cancer patients after depletion of regulatory T cells. J. Clin. Invest. 115, 3623-3633 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 3623-3633
    • Dannull, J.1
  • 39
    • 27444435581 scopus 로고    scopus 로고
    • Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma
    • Attia, P., Maker, A. V., Haworth, L. R., Rogers-Freezer, L. & Rosenberg, S. A. Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma. J. Immunother. 28, 582-592 (2005).
    • (2005) J. Immunother. , vol.28 , pp. 582-592
    • Attia, P.1    Maker, A.V.2    Haworth, L.R.3    Rogers-Freezer, L.4    Rosenberg, S.A.5
  • 40
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel, T. J. et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nature Med. 10, 942-949 (2004).
    • (2004) Nature Med. , vol.10 , pp. 942-949
    • Curiel, T.J.1
  • 41
    • 4644342928 scopus 로고    scopus 로고
    • Concomitant tumour immunity to a poorly immunogenic melanoma is prevented by regulatory T cells
    • Turk, M. J., Guevara-Patino, J. A., Rizzuto, G. A., Engelhorn, M. E. & Houghton, A. N. Concomitant tumour immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. J. Exp. Med. 200, 771-782 (2004).
    • (2004) J. Exp. Med. , vol.200 , pp. 771-782
    • Turk, M.J.1    Guevara-Patino, J.A.2    Rizzuto, G.A.3    Engelhorn, M.E.4    Houghton, A.N.5
  • 42
    • 20044363610 scopus 로고    scopus 로고
    • + T helper cells and hindered by naturally occurring T regulatory cells
    • + T cells and tumour immunopathogenesis in tumour patients and in tumour-bearing mice, respectively.
    • (2005) J. Immunol. , vol.174 , pp. 2591-2601
    • Antony, P.A.1
  • 44
    • 0034679567 scopus 로고    scopus 로고
    • + regulatory cells that control intestinal inflammation
    • + regulatory cells that control intestinal inflammation. J. Exp. Med. 192, 295-302 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 45
    • 0034679560 scopus 로고    scopus 로고
    • + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192, 303-310 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 303-310
    • Takahashi, T.1
  • 46
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumour immunity by CTLA-4 blockade
    • Leach, D. R., Krummel, M. F. & Allison, J. P. Enhancement of antitumour immunity by CTLA-4 blockade. Science 271, 1734-1736 (1996).
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 47
    • 0030743846 scopus 로고    scopus 로고
    • Manipulation of T cell co-stimulatory and inhibitory signals for immunotherapy of prostate cancer
    • Kwon, E. D. et al. Manipulation of T cell co-stimulatory and inhibitory signals for immunotherapy of prostate cancer. Proc. Natl Acad. Sci. USA 94, 8099-8103 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 8099-8103
    • Kwon, E.D.1
  • 48
    • 0033592924 scopus 로고    scopus 로고
    • Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy
    • Kwon, E. D. et al. Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy. Proc. Natl Acad. Sci. USA 96, 15074-15079 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 15074-15079
    • Kwon, E.D.1
  • 49
    • 0034194329 scopus 로고    scopus 로고
    • Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade
    • Hurwitz, A. A. et al. Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade. Cancer Res. 60, 2444-2448 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 2444-2448
    • Hurwitz, A.A.1
  • 50
    • 0032544067 scopus 로고    scopus 로고
    • CTLA-4 blockade synergizes with tumour-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
    • Hurwitz, A. A., Yu, T. F., Leach, D. R. & Allison, J. P. CTLA-4 blockade synergizes with tumour-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma. Proc. Natl Acad. Sci. USA 95, 10067-10071 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 10067-10071
    • Hurwitz, A.A.1    Yu, T.F.2    Leach, D.R.3    Allison, J.P.4
  • 51
    • 0033517152 scopus 로고    scopus 로고
    • Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumours accompanied by autoimmune depigmentation
    • van Elsas, A., Hurwitz, A. A. & Allison, J. P. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumours accompanied by autoimmune depigmentation. J. Exp. Med. 190, 355-366 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 355-366
    • Van Elsas, A.1    Hurwitz, A.A.2    Allison, J.P.3
  • 52
    • 0037443573 scopus 로고    scopus 로고
    • CTLA-4 blockade enhances the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumour model
    • Espenschied, J. et al. CTLA-4 blockade enhances the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumour model. J. Immunol. 170, 3401-3407 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 3401-3407
    • Espenschied, J.1
  • 53
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    • Phan, G. Q. et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc. Natl Acad. Sci. USA 100, 8372-8377 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 8372-8377
    • Phan, G.Q.1
  • 54
    • 0344341626 scopus 로고    scopus 로고
    • Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
    • Hodi, F. S. et al. Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc. Natl Acad. Sci. USA 100, 4712-4717 (2003). References 53 and 54 report clinical trials that show that CTLA4 blockade can induce tumour regression as well as severe, but manageable, autoimmune diseases in patients with tumours.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 4712-4717
    • Hodi, F.S.1
  • 55
    • 28244492012 scopus 로고    scopus 로고
    • Analysis of the cellular mechanism of antitumour responses and autoimmunity in patients treated with CTLA-4 blockade
    • Maker, A. V., Attia, P. & Rosenberg, S. A. Analysis of the cellular mechanism of antitumour responses and autoimmunity in patients treated with CTLA-4 blockade. J. Immunol. 175, 7746-7754 (2005).
    • (2005) J. Immunol. , vol.175 , pp. 7746-7754
    • Maker, A.V.1    Attia, P.2    Rosenberg, S.A.3
  • 56
    • 9244261022 scopus 로고    scopus 로고
    • + regulatory T cell function
    • + regulatory T cell function. Eur. J. Immunol. 34, 2996-3005 (2004).
    • (2004) Eur. J. Immunol. , vol.34 , pp. 2996-3005
    • Tang, Q.1
  • 57
    • 0017345190 scopus 로고
    • Cyclophosphamide-sensitive T lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T lymphocytes
    • Rollinghoff, M., Starzinski-Powitz, A., Pfizenmaier, K. & Wagner, H. Cyclophosphamide-sensitive T lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T lymphocytes. J. Exp. Med. 145, 455-459 (1977).
    • (1977) J. Exp. Med. , vol.145 , pp. 455-459
    • Rollinghoff, M.1    Starzinski-Powitz, A.2    Pfizenmaier, K.3    Wagner, H.4
  • 58
    • 0018694155 scopus 로고
    • Augmentation of specific immune response against a syngeneic SV40-induced sarcoma in mice by depletion of suppressor T cells with cyclophosphamide
    • Glaser, M. Augmentation of specific immune response against a syngeneic SV40-induced sarcoma in mice by depletion of suppressor T cells with cyclophosphamide. Cell Immunol. 48, 339-345 (1979).
    • (1979) Cell Immunol. , vol.48 , pp. 339-345
    • Glaser, M.1
  • 59
    • 0018597670 scopus 로고
    • Immune response to syngeneic or autologous testicular cells in mice. I. Augmented delayed footpad reaction in cyclophosphamide-treated mice
    • Yoshida, S., Nomoto, K., Himeno, K. & Takeya, K. Immune response to syngeneic or autologous testicular cells in mice. I. Augmented delayed footpad reaction in cyclophosphamide-treated mice. Clin. Exp. Immunol. 38, 211-217 (1979).
    • (1979) Clin. Exp. Immunol. , vol.38 , pp. 211-217
    • Yoshida, S.1    Nomoto, K.2    Himeno, K.3    Takeya, K.4
  • 62
    • 0023682494 scopus 로고
    • Cyclophosphamide (Cy)-facilitated adoptive immunotherapy of a Cy-resistant tumour. Evidence that Cy permits the expression of adoptive T-cell mediated immunity by removing suppressor T cells rather than by reducing tumour burden
    • Awwad, M. & North, R. J. Cyclophosphamide (Cy)-facilitated adoptive immunotherapy of a Cy-resistant tumour. Evidence that Cy permits the expression of adoptive T-cell mediated immunity by removing suppressor T cells rather than by reducing tumour burden. Immunology 65, 87-92 (1988).
    • (1988) Immunology , vol.65 , pp. 87-92
    • Awwad, M.1    North, R.J.2
  • 63
    • 15944410592 scopus 로고    scopus 로고
    • + T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
    • + T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 105, 2862-2868 (2005).
    • (2005) Blood , vol.105 , pp. 2862-2868
    • Lutsiak, M.E.1
  • 64
    • 21144454780 scopus 로고    scopus 로고
    • +T cells to the antitumour immune response
    • +T cells to the antitumour immune response. J. Exp. Med. 201, 1591-1602 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 1591-1602
    • Ercolini, A.M.1
  • 65
    • 1642378018 scopus 로고    scopus 로고
    • + regulatory T cells suppress tumour immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumours to be curative
    • + regulatory T cells suppress tumour immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumours to be curative. Eur. J. Immunol. 34, 336-344 (2004).
    • (2004) Eur. J. Immunol. , vol.34 , pp. 336-344
    • Ghiringhelli, F.1
  • 66
    • 30744458573 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. Nature Med. 11, 1238-1243 (2005).
    • (2005) Nature Med. , vol.11 , pp. 1238-1243
    • Zhang, H.1
  • 67
    • 0037361819 scopus 로고    scopus 로고
    • Regulatory Lymphocytes: Antigen-induced regulatory T cells in autoimmunity
    • Von Herrath, M. G. & Harrison, L. C. Regulatory Lymphocytes: antigen-induced regulatory T cells in autoimmunity. Nature Rev. Immunol. 3, 223-232 (2003).
    • (2003) Nature Rev. Immunol. , vol.3 , pp. 223-232
    • Von Herrath, M.G.1    Harrison, L.C.2
  • 68
    • 0036852191 scopus 로고    scopus 로고
    • Natural selection of tumour variants in the generation of 'tumour escape' phenotypes
    • Khong, H. T. & Restifo, N. P. Natural selection of tumour variants in the generation of 'tumour escape' phenotypes. Nature Immunol. 3, 999-1005 (2002). An outstanding review of tumour immune-evasion mechanisms.
    • (2002) Nature Immunol. , vol.3 , pp. 999-1005
    • Khong, H.T.1    Restifo, N.P.2
  • 69
    • 0035874949 scopus 로고    scopus 로고
    • + T cells in tumours from patients with early- stage non-small cell lung cancer and late-stage ovarian cancer
    • + T cells are increased in patients with tumours and can suppress T-cell activation in vitro.
    • (2001) Cancer Res. , vol.61 , pp. 4766-4772
    • Woo, E.Y.1
  • 70
    • 0036721629 scopus 로고    scopus 로고
    • Prevalence of regulatory T cells is increased in peripheral blood and tumour microenvironment of patients with pancreas or breast adenocarcinoma
    • Liyanage, U. K. et al. Prevalence of regulatory T cells is increased in peripheral blood and tumour microenvironment of patients with pancreas or breast adenocarcinoma. J. Immunol. 169, 2756-2761 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 2756-2761
    • Liyanage, U.K.1
  • 71
    • 0037105759 scopus 로고    scopus 로고
    • + regulatory T cells in a colorectal carcinoma patient is mediated by transforming growth factor-β
    • + regulatory T cells in a colorectal carcinoma patient is mediated by transforming growth factor-β. Cancer Res. 62, 5267-5272 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 5267-5272
    • Somasundaram, R.1
  • 72
    • 0037312480 scopus 로고    scopus 로고
    • Increase of regulatory T cells in the peripheral blood of cancer patients
    • Wolf, A. M. et al. Increase of regulatory T cells in the peripheral blood of cancer patients. Clin. Cancer Res. 9, 606-612 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 606-612
    • Wolf, A.M.1
  • 73
    • 0141891466 scopus 로고    scopus 로고
    • Increased populations of regulatory T cells in peripheral blood and tumour-infiltrating lymphocytes in patients with gastric and esophageal cancers
    • Ichihara, F. et al. Increased populations of regulatory T cells in peripheral blood and tumour-infiltrating lymphocytes in patients with gastric and esophageal cancers. Clin. Cancer Res. 9, 4404-4408 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 4404-4408
    • Ichihara, F.1
  • 74
    • 0041386189 scopus 로고    scopus 로고
    • + regulatory T cells in patients with gastrointestinal malignancies: Possible involvement of regulatory T cells in disease progression
    • + regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression. Cancer 98, 1089-1099 (2003).
    • (2003) Cancer , vol.98 , pp. 1089-1099
    • Sasada, T.1    Kimura, M.2    Yoshida, Y.3    Kanai, M.4    Takabayashi, A.5
  • 75
    • 16844378685 scopus 로고    scopus 로고
    • Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma
    • Ormandy, L. A. et al. Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res. 65, 2457-2464 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 2457-2464
    • Ormandy, L.A.1
  • 76
    • 3042838753 scopus 로고    scopus 로고
    • Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells
    • Karube, K. et al. Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells. Br. J. Haematol. 126, 81-84 (2004).
    • (2004) Br. J. Haematol. , vol.126 , pp. 81-84
    • Karube, K.1
  • 77
    • 1442283424 scopus 로고    scopus 로고
    • Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma
    • Marshall, N. A. et al. Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma. Blood 103, 1755-1762 (2004).
    • (2004) Blood , vol.103 , pp. 1755-1762
    • Marshall, N.A.1
  • 78
    • 3142737258 scopus 로고    scopus 로고
    • high regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells
    • high regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells. J. Immunol. 173, 1444-1453 (2004).
    • (2004) J. Immunol. , vol.173 , pp. 1444-1453
    • Viguier, M.1
  • 79
  • 81
    • 2442628376 scopus 로고    scopus 로고
    • + regulatory T cells in autoimmune polyglandular syndrome type II
    • + regulatory T cells in autoimmune polyglandular syndrome type II. J. Exp. Med. 199, 1285-1291 (2004).
    • (2004) J. Exp. Med. , vol.199 , pp. 1285-1291
    • Kriegel, M.A.1
  • 82
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy
    • Ehrenstein, M. R. et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy. J. Exp. Med. 200, 277-285 (2004).
    • (2004) J. Exp. Med. , vol.200 , pp. 277-285
    • Ehrenstein, M.R.1
  • 83
    • 15244354286 scopus 로고    scopus 로고
    • Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    • Fontenot, J. D. et al. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22, 329-341 (2005).
    • (2005) Immunity , vol.22 , pp. 329-341
    • Fontenot, J.D.1
  • 84
    • 8544281696 scopus 로고    scopus 로고
    • + regulatory T cells that traffic through CXCL12/CXCR4 signals
    • + regulatory T cells that traffic through CXCL12/CXCR4 signals. Cancer Res. 64, 8451-8455 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 8451-8455
    • Zou, L.1
  • 85
    • 10244279184 scopus 로고    scopus 로고
    • Mechanisms and functional significance of tumour-induced dendritic-cell defects
    • Gabrilovich, D. Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nature Rev. Immunol. 4, 941-952 (2004).
    • (2004) Nature Rev. Immunol. , vol.4 , pp. 941-952
    • Gabrilovich, D.1
  • 86
    • 0034613767 scopus 로고    scopus 로고
    • + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
    • + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 192, 1213-1222 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 1213-1222
    • Jonuleit, H.1    Schmitt, E.2    Schuler, G.3    Knop, J.4    Enk, A.H.5
  • 87
    • 0035862333 scopus 로고    scopus 로고
    • Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
    • Dhodapkar, M. V., Steinman, R. M., Krasovsky, J., Munz, C. & Bhardwaj, N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J. Exp. Med. 193, 233-238 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 233-238
    • Dhodapkar, M.V.1    Steinman, R.M.2    Krasovsky, J.3    Munz, C.4    Bhardwaj, N.5
  • 88
    • 4444279152 scopus 로고    scopus 로고
    • Regulatory T-cell response and tumour vaccine-induced cytotoxic T lymphocytes in human melanoma
    • Chakraborty, N. G., Chattopadhyay, S., Mehrotra, S., Chhabra, A. & Mukherji, B. Regulatory T-cell response and tumour vaccine-induced cytotoxic T lymphocytes in human melanoma. Hum. Immunol. 65, 794-802 (2004). References 86-88 and 143 provide evidence that APCs can induce regulatory T cells in humans.
    • (2004) Hum. Immunol. , vol.65 , pp. 794-802
    • Chakraborty, N.G.1    Chattopadhyay, S.2    Mehrotra, S.3    Chhabra, A.4    Mukherji, B.5
  • 89
    • 25844504654 scopus 로고    scopus 로고
    • + regulatory T cell proliferation
    • + regulatory T cell proliferation. J. Exp. Med. 202, 919-929 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 919-929
    • Ghiringhelli, F.1
  • 90
    • 0042512461 scopus 로고    scopus 로고
    • + regulatory T cells by antigen-processing dendritic cells
    • + regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198, 235-247 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 235-247
    • Yamazaki, S.1
  • 91
    • 2942692039 scopus 로고    scopus 로고
    • + T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
    • + T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J. Exp. Med. 199, 1467-1477 (2004).
    • (2004) J. Exp. Med. , vol.199 , pp. 1467-1477
    • Tarbell, K.V.1    Yamazaki, S.2    Olson, K.3    Toy, P.4    Steinman, R.M.5
  • 92
    • 0348223787 scopus 로고    scopus 로고
    • + regulatory T cells by TGF-β induction of transcription factor Foxp3
    • + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1
  • 94
    • 2142645808 scopus 로고    scopus 로고
    • -T cells through Foxp3 induction and downregulation of Smad7
    • -T cells through Foxp3 induction and downregulation of Smad7. J. Immunol. 172, 5149-5153 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 5149-5153
    • Fantini, M.C.1
  • 95
    • 12344307563 scopus 로고    scopus 로고
    • + regulatory T cells in vivo requires B7 co-stimulation, but not the thymus
    • + regulatory T cells in vivo requires B7 co-stimulation, but not the thymus. J. Exp. Med. 201, 127-137 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 127-137
    • Liang, S.1
  • 96
    • 17044430217 scopus 로고    scopus 로고
    • Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter
    • Wan, Y. Y. & Flavell, R. A. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc. Natl Acad. Sci. USA 102, 5126-5131 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 5126-5131
    • Wan, Y.Y.1    Flavell, R.A.2
  • 97
    • 0034880059 scopus 로고    scopus 로고
    • +T-regulatory cells and systemic collapse of antitumour immunity
    • +T-regulatory cells and systemic collapse of antitumour immunity. Immunology 103, 449-457 (2001).
    • (2001) Immunology , vol.103 , pp. 449-457
    • Seo, N.1    Hayakawa, S.2    Takigawa, M.3    Tokura, Y.4
  • 98
    • 0023858264 scopus 로고
    • Do suppressor T cells exist?
    • Moller, G. Do suppressor T cells exist? Scand J. Immunol. 27, 247-250 (1988).
    • (1988) Scand J. Immunol. , vol.27 , pp. 247-250
    • Moller, G.1
  • 99
    • 1642497640 scopus 로고    scopus 로고
    • + regulatory T cells and their ligands: Implications for immunotherapy
    • + T cells in human cancer.
    • (2004) Immunity , vol.20 , pp. 107-118
    • Wang, H.Y.1
  • 100
    • 17144405680 scopus 로고    scopus 로고
    • Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma
    • Hawrylowicz, C. M. & O'Garra, A. Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma. Nature Rev. Immunol. 5, 271-283 (2005).
    • (2005) Nature Rev. Immunol. , vol.5 , pp. 271-283
    • Hawrylowicz, C.M.1    O'Garra, A.2
  • 101
    • 4143066714 scopus 로고    scopus 로고
    • + T cell receptors
    • + T cell receptors. Immunity 21, 267-277 (2004).
    • (2004) Immunity , vol.21 , pp. 267-277
    • Hsieh, C.S.1
  • 102
    • 11844302141 scopus 로고    scopus 로고
    • Reciprocal changes in tumour antigenicity and antigen-specific T cell function during tumour progression
    • Zhou, G., Lu, Z., McCadden, J. D., Levitsky, H. I. & Marson, A. L. Reciprocal changes in tumour antigenicity and antigen-specific T cell function during tumour progression. J. Exp. Med. 200, 1581-1592 (2004).
    • (2004) J. Exp. Med. , vol.200 , pp. 1581-1592
    • Zhou, G.1    Lu, Z.2    McCadden, J.D.3    Levitsky, H.I.4    Marson, A.L.5
  • 103
    • 26844464792 scopus 로고    scopus 로고
    • + regulatory T cells inhibit natural killer cell functions in a transforming growth factor-β-dependent manner
    • + T cells in blunting the NK-cell arm of the innate immune system in tumour immunity.
    • (2005) J. Exp. Med. , vol.202 , pp. 1075-1085
    • Ghiringhelli, F.1
  • 104
    • 12244285937 scopus 로고    scopus 로고
    • Regulatory T cells suppress tumour-specific CD8 T cell cytotoxicity through TGF-β signals in vivo
    • Chen, M. L. et al. Regulatory T cells suppress tumour-specific CD8 T cell cytotoxicity through TGF-β signals in vivo. Proc. Natl Acad. Sci. USA 102, 419-424 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 419-424
    • Chen, M.L.1
  • 107
    • 33645853780 scopus 로고    scopus 로고
    • B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
    • in the press
    • Kryczek, I. et al. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J. Exp. Med. (in the press).
    • J. Exp. Med.
    • Kryczek, I.1
  • 108
    • 33645872233 scopus 로고    scopus 로고
    • Induction of B7-H4 on antigen presenting cells through interleukin 10: Novel suppressive mode for regulatory T cells
    • in the press
    • Kryczek, I. et al. Induction of B7-H4 on antigen presenting cells through interleukin 10: novel suppressive mode for regulatory T cells. J. Immunol. (in the press).
    • J. Immunol.
    • Kryczek, I.1
  • 109
    • 16844362608 scopus 로고    scopus 로고
    • Mechanisms of suppression by suppressor T cells
    • von Boehmer, H. Mechanisms of suppression by suppressor T cells. Nature Immunol. 6, 338-344 (2005).
    • (2005) Nature Immunol. , vol.6 , pp. 338-344
    • Von Boehmer, H.1
  • 111
    • 5644302161 scopus 로고    scopus 로고
    • Human T regulatory cells can use the perforin pathway to cause autologous target cell death
    • Grossman, W. J. et al. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 21, 589-601 (2004).
    • (2004) Immunity , vol.21 , pp. 589-601
    • Grossman, W.J.1
  • 113
    • 5044220930 scopus 로고    scopus 로고
    • IDO expression by dendritic cells: Tolerance and tryptophan catabolism
    • Mellor, A. L. & Munn, D. H. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nature Rev. Immunol. 4, 762-774 (2004).
    • (2004) Nature Rev. Immunol. , vol.4 , pp. 762-774
    • Mellor, A.L.1    Munn, D.H.2
  • 114
    • 0346119234 scopus 로고    scopus 로고
    • Modulation of tryptophan catabolism by regulatory T cells
    • Fallarino, F. et al. Modulation of tryptophan catabolism by regulatory T cells. Nature Immunol. 4, 1206-1212 (2003).
    • (2003) Nature Immunol. , vol.4 , pp. 1206-1212
    • Fallarino, F.1
  • 115
    • 0038094524 scopus 로고    scopus 로고
    • B7-H4, a molecule of the B7 family, negatively regulates T cell immunity
    • Sica, G. L. et al. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 18, 849-861 (2003).
    • (2003) Immunity , vol.18 , pp. 849-861
    • Sica, G.L.1
  • 116
    • 0042337394 scopus 로고    scopus 로고
    • B7x: A widely expressed B7 family member that inhibits T cell activation
    • Zang, X. et al. B7x: a widely expressed B7 family member that inhibits T cell activation. Proc. Natl Acad. Sci. USA 100, 10388-10392 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 10388-10392
    • Zang, X.1
  • 117
    • 0038433329 scopus 로고    scopus 로고
    • B7S1, a novel B7 family member that negatively regulates T cell activation
    • Prasad, D. V., Richards, S., Mai, X. M. & Dong, C. B7S1, a novel B7 family member that negatively regulates T cell activation. Immunity 18, 863-873 (2003).
    • (2003) Immunity , vol.18 , pp. 863-873
    • Prasad, D.V.1    Richards, S.2    Mai, X.M.3    Dong, C.4
  • 118
    • 20144381908 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. J. Exp. Med. 201, 681-686 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 681-686
    • Nishikawa, H.1
  • 120
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou, I., Sarukhan, A., Klein, L. & von Boehmer, H. Origin of regulatory T cells with known specificity for antigen. Nature Immunol. 3, 756-763 (2002).
    • (2002) Nature Immunol. , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    Von Boehmer, H.4
  • 121
    • 30444443314 scopus 로고    scopus 로고
    • Amplification of tumour-specific regulatory T cells following therapeutic cancer vaccines
    • Zhou, G., Drake, C. G. & Levitsky, H. I. Amplification of tumour-specific regulatory T cells following therapeutic cancer vaccines. Blood 107, 628-636 (2006).
    • (2006) Blood , vol.107 , pp. 628-636
    • Zhou, G.1    Drake, C.G.2    Levitsky, H.I.3
  • 122
    • 0033985780 scopus 로고    scopus 로고
    • + immunoregulatory T cells is antigen nonspecific
    • + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164, 183-190 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 183-190
    • Thornton, A.M.1    Shevach, E.M.2
  • 123
    • 0034280315 scopus 로고    scopus 로고
    • 389 IL-2 (ONTAK): A novel fusion toxin therapy for lymphoma
    • 389 IL-2 (ONTAK): a novel fusion toxin therapy for lymphoma. Clin. Lymphoma 1, 110-116 (2000).
    • (2000) Clin. Lymphoma , vol.1 , pp. 110-116
    • Foss, F.M.1
  • 124
    • 20944446276 scopus 로고    scopus 로고
    • Effects of immunosuppressants on induction of regulatory cells after intratracheal delivery of alloantigen
    • Shibutani, S. et al. Effects of immunosuppressants on induction of regulatory cells after intratracheal delivery of alloantigen. Transplantation 79, 904-913 (2005).
    • (2005) Transplantation , vol.79 , pp. 904-913
    • Shibutani, S.1
  • 125
    • 18644381923 scopus 로고    scopus 로고
    • Inhibitory and stimulatory effects of cyclosporine A on the development of regulatory T cells in vivo
    • Kawai, M., Kitade, H., Mathieu, C., Waer, M. & Pirenne, J. Inhibitory and stimulatory effects of cyclosporine A on the development of regulatory T cells in vivo. Transplantation 79, 1073-1077 (2005).
    • (2005) Transplantation , vol.79 , pp. 1073-1077
    • Kawai, M.1    Kitade, H.2    Mathieu, C.3    Waer, M.4    Pirenne, J.5
  • 127
    • 4544241811 scopus 로고    scopus 로고
    • Tolerance, not immunity, crucially depends on IL-2
    • Malek, T. R. & Bayer, A. L. Tolerance, not immunity, crucially depends on IL-2. Nature Rev. Immunol. 4, 665-674 (2004).
    • (2004) Nature Rev. Immunol. , vol.4 , pp. 665-674
    • Malek, T.R.1    Bayer, A.L.2
  • 129
    • 15444374646 scopus 로고    scopus 로고
    • + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
    • + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 201, 723-735 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 723-735
    • Setoguchi, R.1    Hori, S.2    Takahashi, T.3    Sakaguchi, S.4
  • 131
    • 14744268262 scopus 로고    scopus 로고
    • + T regulatory cells, immunotherapy of cancer, and interleukin-2
    • + T regulatory cells, immunotherapy of cancer, and interleukin-2. J. Immunother. 28, 120-128 (2005).
    • (2005) J. Immunother. , vol.28 , pp. 120-128
    • Antony, P.A.1    Restifo, N.P.2
  • 132
    • 0141720783 scopus 로고    scopus 로고
    • Cancer vaccines: Between the idea and the reality
    • Finn, O. J. Cancer vaccines: between the idea and the reality. Nature Rev. Immunol. 3, 630-641 (2003). An outstanding and comprehensive review of the development of vaccination and immunotherapy for cancer. It proposes that cancer vaccines must overcome immune suppression.
    • (2003) Nature Rev. Immunol. , vol.3 , pp. 630-641
    • Finn, O.J.1
  • 133
    • 3242773778 scopus 로고    scopus 로고
    • + T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation
    • + T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation. Blood 104, 775-780 (2004).
    • (2004) Blood , vol.104 , pp. 775-780
    • Sereti, I.1
  • 134
    • 33644784733 scopus 로고    scopus 로고
    • + regulatory T cells in cancer patients
    • + regulatory T cells in cancer patients. Blood 107, 2409-2414 (2006).
    • (2006) Blood , vol.107 , pp. 2409-2414
    • Ahmadzadeh, M.1    Rosenberg, S.A.2
  • 135
    • 19944431949 scopus 로고    scopus 로고
    • CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers
    • Kryczek, I. et al. CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers. Cancer Res. 65, 465-472 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 465-472
    • Kryczek, I.1
  • 137
    • 19944434230 scopus 로고    scopus 로고
    • + T cell expansion and function
    • + T cell expansion and function. J. Exp. Med. 201, 139-148 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 139-148
    • Zeng, R.1
  • 138
  • 139
    • 22344432319 scopus 로고    scopus 로고
    • + regulatory T cells in inflamed synovia
    • + regulatory T cells in inflamed synovia. J. Exp. Med. 201, 1793-1803 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 1793-1803
    • Ruprecht, C.R.1
  • 141
    • 0037987977 scopus 로고    scopus 로고
    • Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo
    • Wakkach, A. et al. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 18, 605-617 (2003).
    • (2003) Immunity , vol.18 , pp. 605-617
    • Wakkach, A.1
  • 142
    • 0036715411 scopus 로고    scopus 로고
    • Immature, semi-mature and fully mature dendritic cells: Which signals induce tolerance or immunity?
    • Lutz, M. B. & Schuler, G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol. 23, 445-449 (2002).
    • (2002) Trends Immunol. , vol.23 , pp. 445-449
    • Lutz, M.B.1    Schuler, G.2
  • 143
    • 0036659913 scopus 로고    scopus 로고
    • + regulatory T cells in vivo in humans
    • + regulatory T cells in vivo in humans. Blood 100, 174-177 (2002).
    • (2002) Blood , vol.100 , pp. 174-177
    • Dhodapkar, M.V.1    Steinman, R.M.2
  • 144
    • 17844364183 scopus 로고    scopus 로고
    • Mature dendritic cells induce tumour-specific type 1 regulatory T cells
    • Lundqvist, A., Palmborg, A., Pavlenko, M., Levitskaya, J. & Pisa, P. Mature dendritic cells induce tumour-specific type 1 regulatory T cells. J. Immunother. 28, 229-235 (2005).
    • (2005) J. Immunother. , vol.28 , pp. 229-235
    • Lundqvist, A.1    Palmborg, A.2    Pavlenko, M.3    Levitskaya, J.4    Pisa, P.5
  • 145
    • 16544364635 scopus 로고    scopus 로고
    • Immunology. Policing the immune system
    • Wickelgren, I. Immunology. Policing the immune system. Science 306, 596-599 (2004).
    • (2004) Science , vol.306 , pp. 596-599
    • Wickelgren, I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.