Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response

Lancet

Volumn 356, Issue 9248, 2000, Pages 2149-2153

  Bryan, Shannon A ^a   O’connor, Brian J ^b   Matti, Salah ^c   Leckie, Margaret ^a   Kanabar, Varsha ^b   Khan, Jamey ^a   Warrington, Steven J ^d   Renzetti, Louis ^e   Rames, Alexis ^f   Bock, Juergen A ^f   Boyce, Malcolm J ^d   Hansel, Trevor T ^a   Holgate, Stephen T ^c   Barnes, Peter J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

^c SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^d HMR London   (United Kingdom)

^e HOFFMANN LA ROCHE INC   (United States)

^f Abteilung fur Physische Geographie   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; PLACEBO; RECOMBINANT INTERLEUKIN 12;

ADULT; ALLERGIC ASTHMA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRONCHUS HYPERREACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EOSINOPHILIA; FEMALE; FLU LIKE SYNDROME; HEART ARRHYTHMIA; HUMAN; LIVER TOXICITY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPUTUM ANALYSIS;

EID: 6644223789     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(00)03497-8     Document Type: Article

References (27)

1. + cells in human allergic diseases
2. Interleukin-13: Central mediator of allergic asthma
3. Requirement for IL-13 independently of IL-4 in experimental asthma
4. The interleukin-12/interleukin-12-receptor system: Role in normal and pathological immune responses
5. IL-12 as a therapeutic target for pharmacological modualtion in immune-mediated and inflammatory diseases: Regulation of T helper/T helper responses
6. Interferon-γ production by cord-blood mononuclear cells is reduced in newborns with a family history of atopic disease and is independent from cord blood IgE-levels
7. Abnormalities in cord blood mononuclear cytokine production as a predictor of later atopic disease in childhood
8. Reduced production of Il-12 and Il-12-dependent IFN-γ release in patients with allergic asthma
9. Recombinant interkeukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes
10. Interleukin-12 inhibits production of interleukin-5 but not of granulocyte/macrophage colony stimulating factor by antigen-stimulated blood mononuclear cells in allergic bronchial asthmatics
11. Interleukin-12 inhibits antigen-induced airway hyper-responsiveness in mice
12. Local treatment with IL-12 is an effective inhibitor of airway hyper-responsiveness and lung eosinophilia after airway challenge in sensitized mice
13. Allergen-induced asthmatic responses: Relationship between increases in airway responsiveness and increases in circulating eosinophils, basophils, and their progenitors
14. Effects of inhaled budesonide on allergen-induced airway responses and airway inflammation
15. Allergen-induced early and late asthmatic responses are not affected by inhibition of endogenous nitric oxide
16. Indices of airway inflammation in induced sputum: Reproducibility and validity of cell and fluid-phase movements
17. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
18. The relationship between inflammation and hyperreactivity of the airways in asthma
19. Contribution of intercellular adhesion molecule-1 in allergen-induced airway hyper-responsiveness and inflammation in sensitised Brown-Norway rats
20. Effect of dexamethasone and cyclosporin A on allergen-induced airway hyper-responsiveness and inflammatory cell responses in sensitized Brown-Norway rats
21. Dissociation between airway inflammation and airway hyper-responsiveness in allergic asthma
22. Sputum analysis, bronchial hyper-responsiveness and airway function in asthma: Results of a factor analysis
23. Combined antagonism of leukotrienes and histamine produces predominant inhibition of allergen-induced early and late phase airway obstruction in asthmatics
24. Effect of cyclosporin A on the allergen-induced late asthmatic reaction
25. Effect of single-dose interleukin-12 exposure on interleukin-12 associated toxicity and interferon-γ production
26. Interleukin-12 as a target for modulation of the inflammatory response in asthma
27. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen