A Potent and Selective Histamine H4 Receptor Antagonist with Anti-Inflammatory Properties

Journal of Pharmacology and Experimental Therapeutics

Volumn 309, Issue 1, 2004, Pages 404-413

  Thurmond, Robin L ^a   Desai, Pragnya J ^a   Dunford, Paul J ^a   Fung Leung, Wai Ping ^a   Hofstra, Claudia L ^a,b   Jiang, Wen ^a   Nguyen, Steven ^a   Riley, Jason P ^a   Sun, Siquan ^a   Williams, Kacy N ^a   Edwards, James P ^a   Karlsson, Lars ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b NV ORGANON   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(5 CHLORO 1H INDOL 2 YL)CARBONYL] 4 METHYLPIPERAZINE; ANTIHISTAMINIC AGENT; HISTAMINE H4 RECEPTOR; JNJ 777120; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE MARROW CELL; CALCIUM TRANSPORT; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; CROSS REACTION; DOG; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG POTENCY; DRUG RECEPTOR BINDING; FEMALE; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; MALE; MAST CELL; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RAT; RECEPTOR BLOCKING; RECEPTOR INTRINSIC ACTIVITY; SPECIES DIFFERENCE; TRACHEA;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL MOVEMENT; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; HISTAMINE ANTAGONISTS; HUMANS; INDOLES; INFLAMMATION; MALE; MAST CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PAIN; PIPERAZINES; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE;

EID: 12144288036     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.061754     Document Type: Article

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