Treatment of established asthma in a murine model using CpG oligodeoxynucleotides

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 283, Issue 1 27-1, 2002, Pages

  Kline, Joel N ^a,b   Kitagaki, Kunihiko ^a,b   Businga, Thomas R ^a,b   Jain, Vipul V ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Allergy; Cytokines; Immunomodulators; Lung; Th1 Th2

Indexed keywords

CHEMOKINE; EOTAXIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; OLIGODEOXYNUCLEOTIDE; OVALBUMIN; RANTES;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; CPG ISLAND; CYTOKINE RELEASE; EOSINOPHILIA; FEMALE; IMMUNOMODULATION; IMMUNOTHERAPY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; TH1 CELL;

EID: 0036315258     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00402.2001     Document Type: Article

References (43)

1. Is there a role for immunotherapy in the treatment of asthma? No
2. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice
3. Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response
4. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
5. Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma
6. Long-term clinical efficacy of grass-pollen immunotherapy
7. CXCL10 (IFN-gamma-inducible protein-10) control of encephalitogenic CD4+ T cell accumulation in the central nervous system during experimental autoimmune encephalomyelitis
8. Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract
9. Human IP-10 selectively promotes dominance of polyclonally activated and environmental antigen-driven IFN-gamma over IL-4 responses
10. The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness
11. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation
12. CpG oligodeoxynucleotides do not require Th1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma
13. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
14. From bugs to drugs: Therapeutic immunomodulation with oligodeoxynucleotides containing CpG sequences from bacterial DNA
15. Causing a commotion in the blood: Immunotherapy progresses from bacteria to bacterial DNA
16. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12
17. Fatalities from immunotherapy (IT) and skin testing (ST)
18. C-C chemokine-induced eosinophil chemotaxis during allergic airway inflammation
19. Expression of IFN-gamma-inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in TH1- and TH2-mediated lung diseases
20. Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins
21. Prophylactic inoculation against hay fever
22. Is there a role for immunotherapy in the treatment of asthma?
23. Treatment of cat allergy with T-cell reactive peptides
24. Inducible lung-specific expression of RANTES: Preferential recruitment of neutrophils
25. CpG oligodeoxynucleotide vaccination suppresses IgE induction but may fail to down-regulate ongoing IgE responses in mice
26. IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism
27. Survey of fatalities from skin testing and immunotherapy 1985-1989
28. CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract
29. Local treatment with IL-12 is an effective inhibitor of airway hyperresponsiveness and lung eosinophilia after airway challenge in sensitized mice
30. CpG oligodeoxynucleotides can reverse Th2-associated allergic airway responses and alter the B7.1/B72 expression in a murine model of asthma
31. Elevated serum IP-10 levels observed in type 1 diabetes
32. Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigenspecific immunomodulator
33. Fel d 1 peptides: Effect on skin tests and cytokine synthesis in cat-allergic human subjects
34. T helper 1 and T helper 2 cells respond differentially to chemokines
35. Eosinophils retain their granule major basic protein in a murine model of allergic pulmonary inflammation
36. Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides
37. CpG oligodeoxynucleotides induce murine macrophages to up-regulate chemokine mRNA expression
38. Temporal association between airway hyperresponsiveness and airway eosinophilia in ovalbumin-sensitized mice
39. A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness
40. Serum sickness triggered by anaphylaxis: A complication of immunotherapy
41. Expression of the Th1 chemokine IFN-gamma-inducible protein 10 in the airway alters mucosal allergic sensitization in mice
42. Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid: pDNA complexes