Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: Effect of inhaled glucocorticoid

FASEB Journal

Volumn 12, Issue 11, 1998, Pages 929-937

  Saleh, Dina ^a,b   Ernst, Pierre ^a,b   Lim, Sam ^c   Barnes, Peter J ^c   Giaid, Adel ^a  

^a MONTREAL GENERAL HOSPITAL   (Canada)

^b GenPath Laboratories   (Canada)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Asthma; Human; Nitrotyrosine; Steroids

Indexed keywords

BUDESONIDE; GLUCOCORTICOID; NITRIC OXIDE SYNTHASE; OXIDIZING AGENT; PEROXYNITRITE; PLACEBO;

ADULT; ARTICLE; ASTHMA; BRONCHUS BIOPSY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; INHALATIONAL DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY EPITHELIUM;

BRONCHUS;

EID: 0031857283     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.12.11.929     Document Type: Article

References (44)

1. Wright, D. T., Cohn, L. A., Li, H., Fischer, B., Li, C. M., and Adler, K. B. (1994) Interactions of oxygen radicals with airway epithelium. Environ. Health Perspect. 102, 85-90
2. Pendino, K. J., Laskin, J. D., Shuler, R. L., Punjabi, C. L., and Laskin, D. L. (1993) Enhanced production of nitric oxide by rat alveolar macrophages after inhalation of a pulmonary irritant is associated with increased expression of nitric oxide synthase. J. Immunol. 151, 7196-7205
3. Kooy, N. W., Royall, J. A., Ye, Y. Z., Kelly, D. R., and Beckman, J.S. (1995) Evidence for in vivo peroxynitrite production in human acute lung injury. Am. J. Respir. Crit. Care Med. 151, 1250-1254
4. Conner, E. M., and Grisham, M. B. (1996) Inflammation, free radicals and antioxidants. Nutrition 12, 274-277
5. Takahashi, T., Miura, M., Katsumata, U., Ichinose, M., Kimura, K., Inoue, H., Takishima, T., and Shirato, K. (1993) Involvement of Superoxide in ozone-induced airway hyperresponsiveness in anesthetized cats. Am. Rev. Respir. Dis. 148, 103-106
6. Torres, A., Voter, K. Z., Utell, M. J., Whitin, J. C., Morrow, P. E., and Frampton, M.W. (1996) Production of reactive oxygen intermediates following exposure to ozone. Relative contribution of alveolar macrophages. Cheat 109 (Suppl.), 8S
7. Hulsmann, A. R., Raatgeep, H. R., Denhollander, J. C., Bakker, W. H., Sacena, P. R., and Dejongste, J. C. (1996) Permeability of human isolated airways increases after hydrogen peroxide and poly-L-arginine. Am. J. Respir. Crit. Care. Med. 153, 841-846
8. Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., and Freeman, B. A. (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and Superoxide. Proc. Natl. Acad. Sci. USA 87, 1620-1624
9. Ischiropoulos, H., Zhu, L., and Beckman, J. S. (1992) Peroxynitrite formation from macrophage-derived nitric oxide. Arch. Biochem. Biophys. 298, 446-451
10. Lipton, S. A., Choi, Y. B., Pan, Z. H., Lei, S. Z., Chen, H. S., Sucher, N.J., Loscalzo, J., Singel, D. J., and Stamler, J. S. (1993) A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature (London) 364, 626-632
11. Radi, R., Beckman, J. S., Bush, K. M., and Freeman, B. A. (1991) Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of Superoxide and nitric oxide. J. Biol. Chem. 266, 4244-4250
12. Ischiropoulos, H., Zhu, L., Chen, J., Tsai, M., Martin, J. C., Smith, C. D., and Beckman, J. S. (1992) Peroxynitrite-mediauxl tyrosine nitration catalyzed by Superoxide dismutase. Arch. Biochem. Biophys. 298, 431-437
13. Beckman, J. S., Ischiropoulos, H., Zhu, L., Woerd, van der M., Smith, C., Chen, J., Harrison, J., Martin, J. C., and Tsai, M. (1992) Kinetics of Superoxide dismutase-and iron-catalyzed nitration of phenolics by peroxynitrite. Arch. Biochem. Biophys. 298, 438-445
14. Sadeghi-Hashjin, G., Folkerts, G., Henricks, P. A. J., Verheyen, A. K. C. P., Linde, H. J., Ark, I., Coene, A., and Nijkamp, F. P. (1996) Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo. Am. J. Respir. Crit. Care Med. 153, 1697-1701
15. Haddad, I. Y., Ischiropoulos, H., Holm, B. A., Beckman, J. S., and Baker, J. R., Matalon, S. (1993) Mechanisms of peroxynitrite induced injury to pulmonary surfactants. Am. J. Physiol. 265, L555-L564
16. Matalon, S., Hu, P., Ischiropoulos, H., and Beckman, J. S. (1994) Peroxynitrite inhibition of oxygen consumption and ion transport in alveolar type II pneumocytes. Chest 105, 74S
17. Calhoun, W. J., Reed, H. E., Moest, D. R., and Stevens, C. A. (1992) Enhanced Superoxide production by alveolar macrophages and airspace cells, airway inflammation and alveolar macrophage density changes after segmentai antigen bronchoprovocation in allergic subjects. Am. Rev. Respir. Dis. 145, 317-325
18. Barnes, P. J. (1996) Pathophysiology of asthma. Br. J. Clin. Pharmacol. 42, 3-10
19. Teramoto, S., Shu, C. Y., Ouchi, Y., and Fukuchi, Y. (1906) Increased spontaneous production and generation of superoxide anion by blood neutrophils in patients with asthma. J. Asthma 33, 149-155
20. Barnes, P. J., and Kharitonov, S. A. (1996) Exhaled nitric oxide -a new lung function test. Thorax 51, 233-237
21. Massaro, A. F., Mehta, S., Lilly, C. M., Kobzik, L., Reilly, J. J., and Drazen, J. M. (1996) Elevated nitric oxide concentrations in isolated lower airway gas of asthmatic subjects. Am. J. Respir. Crit. Care Med. 153, 1510-1514
22. Jarjour, N. N., and Calhoun W. J. (1994) Enhanced productio nof oxygen radicals in asthma. J. Lab. Clin. Med. 123, 131-136
23. Joseph, B. Z., Routes, J. M., and Borish, L. (1993) Activities of Superoxide dismutases and NADPH oxidase in neutrophils obtained from asthmatic and normal donors. Inflammation 17, 361-370
24. Juniper, E. F., Frith, P. A., Dunnett, C., Cockcroft, D. W., and Hargreave, F. E. (1978) Reproductibility and comparison of responses to inhaled histamine and methacholine. Thorax 33, 705-710
25. Bleecker, E. R., McFaddun, E. R., Jr., Hurd, S. S., Goldstein, R. A., and Ram, J. S. 1992. Investigative bronchoscopy in subjects with asthma and other obstructive pulmonary diseases-whether and when. Chest 101, 297-298
26. Beckman, J. S., Ye, Y. Z., and Anderson, P. (1994) Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. Biol. Chem. Hoppe-Seyler 375, 81-88
27. Giaid, A., and Saleli, D. (1995) Reduced expression of endothelial nitric oxide synthase in lungs of patients with pulmonary hypertension. N. Engl. J. Med. 333, 214-221
28. Furukawa, K., Harrison, D. G., Shennib, H., Chagnon, F. P., Giaid, A. (1996) Expression of nitric oxide synthase in the human nasal mucosa. Am. J. Respir. Crit. Care Med. 328, 1732-1739
29. Giaid, A., Yanagisawa, M., Langleben, D., Michel, R. P., Levy, R., Shennib, H., Kimura, S., Masaki, T., Duguid, W. P., Steward, D. J. (1993) Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N. Engl. J. Med. 328, 1732-1739
30. Levey, A. I., Bolam, J. P., Rye, D. B., Hallanger, A. E., Demuth, R. M., Mesulam, M. M., and Wainer, B. H. (1986) A light and electron microscopic procedure for sequential double antigen localization using diaminobenzidine and benzidine dihydrochloride. J. Histochem. Cytochem. 34, 1449-1457
31. Haddad, I. Y., Pataki, G., Hu, P., Galliani, C., Beckman J. S., and Matalon, S. (1994) Quantification of nitrotyrosine levels in lung sections of patients and animals with acute lung injury. J. Clin. Invest. 94, 2407-2413
32. Barnes, P. J., and Liew, F. Y. (1995) Nitric oxide and asthmatic inflammation. Immunol. Today 16, 128-130
33. Dugas, B., Debre, P., and Moncada, S. (1995) Nitric oxide, a vital poison inside the immune and inflammatory network. Res. Immunol. 146, 664-670
34. Hamid, Q., Springall, D. R., Riveros Moreno, V., Chanez, P., Howarth, P., Redington, A., Bousquet, J., Godard, P., Holgate, S., and Polak, J. M. (1993) Induction of nitric oxide synthase in asthma. Lancet 342, 1510-1513
35. Guo, F. H., Raeve, H. R. D., Rice, T. W., Stuehr, D. J., Thunnissen, F. B. J. M., and Erzurum, S. C. (1995) Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Pror. Natl. Acad. Sci. USA 92, 7809-7813
36. Li, Y., Ito, N., Suzuki, T., Stechschulte, D. J., Dileepan, and K. N. (1995) Dexamethasone inhibits nitric oxide-mediated cytotoxicity via effects on both macrophages and target cells. Immunopharmacology 30, 177-186
37. Yates, D. H., Kharatinov, S. A., Robbins, R. A., Thomas, P. S., and Barnes, P. J. (1995) Effect of nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide. Am. J. Respir. Crit. Care Med. 152, 892-896
38. Kharitonov, S. A., Yates, D. H., and Barnes, P. J. (1996) Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients. Am. J. Respir. Crit. Care Med. 153, 454-457
39. Oswald, I. P., Eltoum, I., Wynn, T. A., Shwartz, B., Caspar, P., Paulin, D., Sher, A., and James, S. L. (1994) Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistoma mansoni, through the production of nitric oxide. Proc. Natl. Acad. Sci. USA 91, 999-1003
40. Wileman, S. M., Mann, G. E., and Baydoun, A. R. (1995) Induction of L-arginine transport and nitric oxide synthase in vascular smooth muscle cells - synergistic actions of pro-inflammatory cytokines and bacterial lipopolysaccharide. Br. J. Pharmacol 116, 3243-3250
41. Szabo, C., Zingarelli, B., and Salzman, A. L. (1996) Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Circ. Res. 78, 1051-1063
42. Jones, O. T. (1993) The mechanism of the production for superoxide by phagocytes. Mol. Chem. Neuropathol. 19, 177-184
43. Imaizumi, S., Kondo, T., Deli, M.A., Gobbel, G., Joo, F., Epstein, C. J., Yoshimoto, T., and Chan, P. H. (1996) The influence of oxygen free radicals on the permeability of the monolayer of cultured brain endothelial cells. Neurochem. Int. 29, 205-211
44. Halliwell, B. (1997) What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo? FEBS Lett. 411, 157-159