A dose-dependent effect of the novel inhaled corticosteroid ciclesonide on airway responsiveness to adenosine-5'-monophosphate in asthmatic patients

American Journal of Respiratory and Critical Care Medicine

Volumn 160, Issue 1, 1999, Pages 237-243

  Taylor, David A ^a   Jensen, Marianne W ^b   Kanabar, Varsha ^b   Engelstätter, Renate ^b   Steinijans, Volker W ^b   Barnes, Peter J ^b   O'Connor, Brian J ^b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; BUDESONIDE; CICLESONIDE; CORTICOSTEROID; METHACHOLINE; SODIUM METABISULFITE; UNCLASSIFIED DRUG;

ADULT; ALLERGIC ASTHMA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRONCHUS REACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SAFETY; DRUG TOLERABILITY; DRY POWDER; EOSINOPHIL; HUMAN; HYDROCORTISONE BLOOD LEVEL; INHALATIONAL DRUG ADMINISTRATION; MAST CELL; PRIORITY JOURNAL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; SPUTUM ANALYSIS; TREATMENT OUTCOME;

EID: 0032794908     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.160.1.9809046     Document Type: Article

References (23)

1. Barnes, P. J., and S. Pederson. 1993. Efficacy and safety of inhaled corticosteroids in asthma. Am. Rev. Respir. Dis. 148:S1-S26.
2. Jatakanon, A., S. Lim, K. F. Chung, and P. J. Barnes. 1998. An inhaled steroid improves markers of airway inflammation in patients with mild asthma. Eur. Respir. J. 12:1084-1088.
3. Kamada, A. K., J. S. Stanley, R. J. Martin, H. A. Boushey, V. M. Chinchilli, J. M. Drazen, J. E. Fish, E. Israel, S. C. Lazarus, and R. F. Lemanske. 1996. Issues in the use of inhaled glucocorticoids. Am. J. Respir. Crit. Care Med. 153:1739-1748.
4. O'Connor, B. J., S. M. Ridge, P. J. Barnes, and R. W. Fuller. 1992. Greater effect of inhaled budesonide on adenosine 5-monophosphate-induced bronchoconstriction in asthma. Am. Rev. Respir. Dis. 146: 560-564.
5. Barnes, P. J. 1996. Pathophysiology of asthma. Br. J. Clin. Pharmacol. 42:3-10.
6. Ryan, G., K. M. Latimer, E. F. Juniper, R. S. Roberts, and F. E. Hargreave. 1985. Effect of beclomethasone dipropionate on bronchial responsiveness to histamine in controlled nonsteroid-dependent asthma. J. Allergy Clin. Immunol. 75:25-30.
7. Henriksen, J. M., and R. Dahl. 1983. Effects of inhaled budesonide alone and in combination with low-dose terbutaline in children with exercise-induced asthma. Am. Rev. Respir. Dis. 128:993-997.
8. Vathenen, A. S., A. J. Knox, A. Wisniewski, and A. E. Tattersfield. 1991. Effect of inhaled budesonide on bronchial reactivity to histamine, exercise, and eucapnic dry air ventilation in patients with asthma. Thorax 46:811-816.
9. Polosa, R., and S. T. Holgate. 1997. Adenosine bronchoprovocation: a promising marker of allergic inflammation in asthma? Thorax 52:919-923.
10. Hollander, M., and D. A. Wolfe. 1973. Nonparametric Statistical Methods. John Wiley and Sons, New York, 120-123.
11. Juniper, E. F., P. A. Kline, M. A. Vanzieleghem, E. H. Ramsdale, P. M. O'Byrne, and F. E. Hargreave. 1990. Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in nonsteroid-dependent asthmatics. Am. Rev. Respir. Dis. 142:832-836.
12. Weersink, E. J. M., R. R. Douma, D. S. Postma, and G. H. Koeter. 1997. Fluticasone propionate, salmeterol xinafoate, and their combination in the treatment of nocturnal asthma. Am. J. Respir. Crit. Care Med. 155:1241-1246.
13. Gaddie, J., I. W. Reid, C. Skinner, G. R. Petrie, D. J. M. Sinclair, and K. N. V. Palmer. 1973. Aerosol beclomethasone dipropionate: a dose-response study in chronic bronchial asthma. Lancet ii:280-281.
14. Toogood, J. H., N. M. Lefcoe, D. S. M. Haines, B. Jennings, N. Errington, L. Baksh, and L. Chuang. 1977. A graded dose assessment of the efficacy of beclomethasone dipropionate aerosol for severe chronic asthma. J. Allergy Clin. Immunol. 59:298-308.
15. Hughes, P. J., S. T. Holgate, and M. K. Church. 1984. Adenosine inhibits and potentiates IgE-dependent histamine release from lung mast cells by an A2-purinoceptor mediated mechanism. Biochem. Pharmacol. 33:3847-3852.
16. Peachell, P. T., M. Columbo, A. Kagey-Sobotka, L. M. Lichtenstein, and G. Marone. 1988. Adenosine potentiates mediator release from human lung mast cells. Am. Rev. Respir. Dis. 138:1143-1151.
17. Mann, J. S., M. J. Cushley, and S. T. Holgate. 1985. Adenosine-induced bronchoconstriction in asthma: role of parasympathetic stimulation and adrenergic inhibition. Am. Rev. Respir. Dis. 132:1-6.
18. Oosterhoff, Y., J. W. de Jong, M. A. M. Janson, G. H. Koeler, and D. S. Postma. 1993. Airway responsiveness to AMP in chronic obstructive pulmonary disease is determined by smoking. Am. Rev. Respir. Dis. 147:553-558.
19. van Velzen, E., J. van den Bos, J. A. W. Benckhuijsen, T. van Essel, R. de Bruijn, and R. Aalbers. 1996. Effect of allergen avoidance at high altitude on direct and indirect bronchial hyperresponsiveness and markers of inflammation in children with allergic asthma. Thorax 51: 582-584.
20. Burke, C. M., S. Sreenan, S. Pathmakanthan, J. Patterson, B. Schmekel, and L. W. Poulter. 1996. Relative effects of inhaled corticosteroids on immunopathology and physiology in asthma: a case controlled study. Thorax 51:993-999.
21. Trigg, C. J., N. D. Manolitsas, J. Wang, M. A. Calderon, A. McAuley, S. E. Jordan, M. J. Herdman, N. Jhalli, and S. A. Hamilton. 1994. Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma. Am. J. Respir. Crit. Care Med. 150:17-22.
22. Dahl, R., and S. Johansson. 1982. Importance of duration of treatment with inhaled budesonide on the immediate and late bronchial reaction. Eur. Respir. Dis. Suppl. 122:167-175.
23. Jatakanon, A., S. A. Kharitonov, S. Lim, and P. J. Barnes. 1999. Effect of differing doses of inhaled budesonide on markers of airway inflammation in patients with mild asthma. Thorax 54:108-114.