The role of co-stimulation in airway inflammation

Clinical and Experimental Allergy, Supplement

Volumn 30, Issue 1, 2000, Pages 46-50

  Djukanovic, R ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Antigen presenting cell; Asthma; B7; Co stimulation; CTLA 4; Immune response; T lymphocytes cytokines

Indexed keywords

B7 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ANTIGEN PRESENTING CELL; ASTHMA; CELL INTERACTION; CELL PROLIFERATION; COMPLEX FORMATION; CONFERENCE PAPER; CYTOKINE RELEASE; HUMAN; IMMUNE RESPONSE; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RESPIRATORY TRACT INFECTION; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; ASTHMA; HUMANS; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION;

EID: 0034120110     PISSN: 09602178     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (5)

1. Tsuyuki S, Tsuyuki J, Einsle K, Kopf M, Coyle AJ. Costimulation through B-7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (Th2) immune response and altered airway responsiveness. J Exp Med 1997; 185: 1671-9.
2. Sayegh MH. Finally, CTLA4Ig graduates to the clinic. J Clin Invest 1999; 103:1223-5.
3. Larche M, Till SJ, Haselden BM et al. Costimulation through CD86 is involved in airway antigen-presenting cell and T cell responses to allergen in atopic asthmatics. J Immunol 1998; 161:6375-82.
4. Jaffar Z, Roberts K, Pandit A, Linsley P, Djukanovic R, Holgate S. B7 costimulation is required for IL-5 and IL-13 secretion by bronchial biopsy tissue of atopic asthmatic subjects in response to allergen stimulation. Am J Respir Cell Mol Biol 1999; 20:153-62.
5. Hidi R, Riches V, Al-Ali M, Cruikshank WW, Center DM, Holgate ST, Djukanovic R. The role of B7-CD28/CTLA-4 costimulation and NF-κB in allergen-induced T cell chemotaxis by interleukin-16 and RANTES. J Immunol 2000; 164:412-418.