Synthesis of potent and highly selective inhibitors of human tryptase

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 21, 2002, Pages 3235-3238

  Slusarchyk, William A ^a   Bolton, Scott A ^a   Hartl, Karen S ^a   Huang, Ming Hsing ^a   Jacobs, Glenn ^a   Meng, Wei ^a   Ogletree, Martin L ^a   Pi, Zulan ^a   Schumacher, William A ^a   Seiler, Steven M ^a   Sutton, James C ^a   Treuner, Uwe ^a   Zahler, Robert ^a   Zhao, Guohua ^a   Bisacchi, Gregory S ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZETIDINONE DERIVATIVE; BMS 262084; BMS 363130; BMS 363131; SERINE PROTEINASE; TRYPSIN; TRYPTASE; TRYPTASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIASTEREOISOMER; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; NONHUMAN; PNEUMONIA; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; AZETIDINES; AZIRIDINES; DRUG STABILITY; GUINEA PIGS; HUMANS; OVALBUMIN; PIPERAZINES; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTASES;

EID: 18644381739     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00689-3     Document Type: Article

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