Inhibitory cytokines in asthma

Molecular Medicine Today

Volumn 4, Issue 10, 1998, Pages 452-458

  Barnes, Peter J ^a   Lim, Sam ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2C INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12;

ANTIINFLAMMATORY ACTIVITY; ASTHMA; GENE TARGETING; GENE THERAPY; HUMAN; INTERFERON PRODUCTION; PROTEIN SYNTHESIS REGULATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ASTHMA; CYTOKINES; FORECASTING; HUMANS;

EID: 0031718925     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-4310(98)01335-5     Document Type: Review

References (53)

1. Barnes, P.J., Chung, K.F. and Page, C.P. Inflammatory mediators of asthma - an update, Pharmacol. Rev. (in press).
2. Barnes P.J., Karin M. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. New Engl. J. Med. 336:1997;1066-1071.
3. Ho A.S., Moore K.W. Interleukin-10 and its receptor. Ther. Immunol. 1:1994;173-185.
4. Pretolani M., Goldman M. IL-10: a potential therapy for allergic inflammation? Immunol. Today. 18:1997;277-280.
5. Jeannin P.et al. IgE versus IgG4 production can be differentially regulated by IL-10. J. Immunol. 160:1998;3555-3561.
6. Kline J.N., Fisher P.A., Monick M.M., Hunninghake G.W. Regulation of interleukin-1 receptor antagonist by Th1 and Th2 cytokines. Am. J. Physiol. 269:1995;L92-L98.
7. Arock M.et al. Interleukin-10 inhibits cytokine generation from mast cells. Eur. J. Immunol. 26:1996;166-170.
8. John M.et al. Human airway smooth muscle cells express and release RANTES in response to Th1 cytokines: regulation by Th2 cytokines. J. Immunol. 158:1997;1841-1847.
9. Spencer S.D.et al. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J. Exp. Med. 187:1998;571-578.
10. Wang P.et al. Interleukin (IL)-10 inhibits nuclear factor κB activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J. Biol. Chem. 270:1995;9558-9563.
11. Zuany-Amorim C.et al. Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice. J. Clin. Invest. 95:1995;2644-2651.
12. Borish L.et al. Interleukin-10 regulation in normal subjects and patients with asthma. J. Allergy Clin. Immunol. 97:1996;1288-1296.
13. John M.et al. Inhaled corticosteroids increase IL-10 but reduce MIP-1α, GM-CSF and IFN-γ release from alveolar macrophages in asthma. Am. J. Respir. Crit. Care Med. 157:1998;256-262.
14. Spiteri M.A.et al. Alveolar macrophage-induced suppression of peripheral blood mononuclear cell responsiveness is reversed by in vitro allergen exposure in bronchial asthma. Eur. Respir. J. 7:1994;1431-1438.
15. Turner D.M.et al. An investigation of polymorphism in the interleukin-10 gene promoter. Eur. J. Immunogenet. 24:1997;1-8.
16. Lim S., Crawley E., Woo P., Barnes P.J. A haplotype associated with low IL-10 production in patients with severe asthma. Lancet. 352:1998;113.
17. Huhn R.D.et al. Pharmacodynamics of subcutaneous recombinant human interleukin-10 in healthy volunteers. Clin. Pharmacol. Ther. 62:1997;171-180.
18. van Deventer S.J., Elson C.O., Fedorak R.N. Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease, Crohn's Disease Study Group. Gastroenterology. 113:1997;383-389.
19. Xing Z.et al. Adenoviral vector-mediated interleukin-10 expression in vivo: intramuscular gene transfer inhibits cytokine responses in endotoxemia. Gene Ther. 4:1997;140-149.
20. Mascali J.J., Cvietusa P., Negri J., Borish L. Anti-inflammatory effects of theophylline: modulation of cytokine production. Ann. Allergy Asthma Immunol. 77:1996;34-38.
21. Eigler A.et al. Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production. J. Leukocyte Biol. 63:1998;101-107.
22. Akdis C.A.et al. Role of interleukin 10 in specific immunotherapy. J. Clin. Invest. 102:1998;98-106.
23. Arend W.P. Interleukin 1 receptor antagonist. A new member of the interleukin 1 family. J. Clin. Invest. 88:1991;1445-1451.
24. Sim T.C.et al. Interleukin-1 receptor antagonist protein inhibits the synthesis of IgE and proinflammatory cytokines by allergen-stimulated mononuclear cells. Am. J. Respir. Cell. Mol. Biol. 11:1994;473-479.
25. Sousa A.R.et al. Expression of interleukin-1 beta (IL-1β) and interleukin-1 receptor antagonist (IL-1ra) on asthmatic bronchial epithelium. Am. J. Respir. Crit. Care Med. 154:1996;1061-1066.
26. Okada S.et al. Potential role of interleukin-1 in allergen-induced late asthmatic reactions in guinea pigs: suppressive effect of interleukin-1 receptor antagonist on late asthmatic reaction. J. Allergy Clin. Immunol. 95:1995;1236-1245.
27. Coyle A.J.et al. Mice lacking the IFN-γ receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile. J. Immunol. 156:1996;2680-2685.
28. Leonard C., Tormey V., Burke C., Poulter L.W. Allergen-induced cytokine production in atopic disease and its relationship to disease severity. Am. J. Respir. Cell. Mol. Biol. 17:1997;368-375.
29. Koning H.et al. T cell subsets and cytokines in allergic and non-allergic children. I. Analysis of IL-4, IFN-γ and IL-13 mRNA expression and protein production. Cytokine. 9:1997;416-426.
30. Hayden C.et al. Mutation screening of interferon-gamma (IFNγ) as a candidate gene for asthma. Clin. Exp. Allergy. 27:1997;1412-1416.
31. Boguniewicz M.et al. The effects of nebulized recombinant interferon-γ in asthmatic airways. J. Allergy Clin. Immunol. 95:1995;133-135.
32. Lack G.et al. Rush immunotherapy results in allergen-specific alterations in lymphocyte function and interferon-γ production in CD4+ T cells. J. Allergy Clin. Immunol. 99:1997;530-538.
33. + cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy. J. Allergy Clin. Immunol. 99:1997;254-260.
34. Gately M.K.et al. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 16:1998;495-521.
35. Kips J.C.et al. Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice. Am. J. Respir. Crit. Care Med. 153:1996;535-539.
36. Wills-Karp M. Interleukin-12 as a target for modulation of the inflammatory response. Allergy. 53:1998;113-119.
37. Sur S.et al. Immunomodulatory effects of IL-12 on allergic lung inflammation depend on timing of doses. J. Immunol. 157:1996;4173-4180.
38. Bruselle G.G.et al. Role of IFN-γ in the inhibition of the allergic airway inflammation caused by IL-12. Am. J. Respir. Cell. Mol. Biol. 17:1997;767-771.
39. van der Pouw Kraan T.C.et al. Reduced production of IL-12 and IL-12-dependent IFN-γ release in patients with allergic asthma. J. Immunol. 158:1997;5560-5565.
40. Naseer T.et al. Expression of IL-12 and IL-13 mRNA in asthma and their modulation in reponse to steroids. Am. J. Respir. Crit. Care Med. 155:1997;845-851.
41. + lymphocytes. J. Immunol. 158:1997;5589-5595.
42. 2-agonists prevent Th1 development by selective inhibition of interleukin 12. J. Clin. Invest. 100:1997;1513-1519.
43. Leonard J.P.et al. Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-γ production. Blood. 90:1997;2541-2548.
44. Hogan S.P., Foster P.S., Tan X., Ramsay A.J. Mucosal IL-12 gene delivery inhibits allergic airways disease and restores local antiviral immunity. Eur. J. Immunol. 28:1998;413-423.
45. Kim T.S.et al. An ovalbumin-IL-12 fusion protein is more effective than ovalbumin plus free recombinant IL-12 in inducing a T helper cell type 1-dominated immune response and inhibiting antigen-specific IgE production. J. Immunol. 158:1997;4137-4144.
46. Kohno K., Kurimoto M. Interleukin 18, a cytokine which resembles IL-1 structurally and IL-12 functionally but exerts its effect independently of both. Clin. Immunol. Immunopathol. 86:1998;11-15.
47. Robinson D.et al. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFκB. Immunity. 7:1997;571-581.
48. Yoshimoto T.et al. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells. Proc. Natl. Acad. Sci. U. S. A. 94:1997;3948-3953.
49. + human blood mononuclear cells. J. Clin. Invest. 101:1998;711-721.
50. Berkman N.et al. Interleukin 13 inhibits macrophage inflammatory protein-1a production from human alveolar macrophages and monocytes. Am. J. Respir. Cell. Mol. Biol. 15:1996;382-389.
51. Berkman N.et al. Inhibition of inducible nitric oxide synthase in a human bronchial epithelial cell line by IL-4 and IL-13. Immunology. 89:1996;363-367.
52. Spahn J.D.et al. A novel action of IL-13: induction of diminished monocyte glucocorticoid receptor-binding affinity. J. Immunol. 157:1996;2654-2659.
53. Horwitz D.A.et al. The immunoregulatory effects of NK cells: the role of TGF-β and implications for autoimmunity. Immunol. Today. 18:1997;538-542.