Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1α, granulocyte-macrophage colony-stimulating factor, and interferon-γ release from alveolar macrophages in asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 157, Issue 1, 1998, Pages 256-262

  John, Matthias ^a   Lim, Sam ^a   Seybold, Joachim ^a   Jose, Peter ^a   Robichaud, Annette ^a   O'Connor, Brian ^a   Barnes, Peter J ^a   Chung, K Fan ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA;

ADULT; ARTICLE; ASTHMA; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL TRIAL; COMPLEX FORMATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; IMMUNOSTIMULATION; INHALATIONAL DRUG ADMINISTRATION; INSPIRATORY CAPACITY; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; MALE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; T LYMPHOCYTE ACTIVATION;

EID: 0031943945     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.157.1.9703079     Document Type: Article

References (31)

1. Nathan, C. F. 1987. Secretory products of macrophages. J. Clin. Invest. 79:319-326.
2. Holt, P. G. 1985. Downregulation of immune responses in the lower respiratory tract: role of alveolar macrophages. Clin. Exp. Immunol. 63: 261-270.
3. Spiteri, M., R. A. Knight, J. Y. Jeremy, P. J. Barnes, and K. F. Chung. 1994. Alveolar macrophage-induced suppression of T-cell hyperresponsiveness in bronchial asthma is reversed by allergen exposure. Eur. Respir. J. 7:1431-1438.
4. Bilyk, N., and P. G. Holt. 1993. Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 177:1773-1777.
5. Spiteri, M. A., C. Prior, M. Herold, R. A. Knight, S. W. Clarke, and K. F. Chung. 1992. Spontaneous release of IL-1, IL-6, TNF-α and GMCSF by alveolar macrophages (AM) in bronchial asthma (abstract). Am. Rev. Respir. Dis. 145:A239.
6. Hallsworth, M. P., C. P. C. Soh, S. J. Lane, J. P. Arm, and T. H. Lee. 1994. Selective enhancement of GM-CSF, TNF-α, IL-1β and IL-8 production by monocytes and macrophages of asthmatic subjects. Eur. Respir. J. 7:1096-1102.
7. Cembrzynska-Norvak, M., E. Szklarz, A. D. Inglot, and J. A. Teodorczyk-Injeyan. 1993. Elevated release of TNF-α and interferon-gamma by bronchoalveolar leukocytes from patients with bronchial asthma. Am. Rev. Respir. Dis. 147:291-295.
8. Djukanovic, R., J. W. Wilson, K. M. Britten, S. J. Wilson, A. F. Walls, W. R. Roche, P. H. Howarth, and S. T. Holgate. 1992. The effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am. Rev. Respir. Dis. 145:669-674.
9. Robinson, D. S., Q. Hamid, S. Ying, A. M. Bentley, B. Assoufi, J. North, M. Qui, S. R. Durham, and A. B. Kay. 1993. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell IL-4, IL-5, and IFN-γ cytokine gene expression. Am. Rev. Respir. Dis. 148:401-406.
10. Wang, J. H., C. J. Trigg, L. L. Devalia, S. Jordan, and R. J. Davies. 1994. Effect of inhaled beclomethasone dipropionate on expression of proinflammatory cytokines and activated eosinophils in the bronchial epithelium of patients with mild asthma. J. Allergy Clin. Immunol. 94: 1025-1034.
11. Davies, R. J., J. H. Wang, C. J. Trigg, and J. L. Devalia. 1995. Expression of granulocyte/macrophage-colony-stimulating factor, interleukin-8 and RANTES in the bronchial epithelium of mild asthmatics is down-regulated by inhaled beclomethasone dipropionate. Int. Arch. Allergy Immunol. 107:428-429.
12. Berkman, N., P. Jose, T. Williams, P. J. Barnes, and K. F. Chung. 1995. Corticosteroid inhibition of macrophage inflammatory protein-1α expression in human monocytes and alveolar macrophages. Am. J. Physiol. 269:L443-L452.
13. Linden, M., and R. Brattsand. 1994. Effects of a corticosteroid, budesonide, on alveolar macrophage and blood monocyte secretion of cytokines: differential sensitivity of GM-CSF, IL-1β, and IL-6. Pulm. Pharmacol. 7:43-47.
14. de Waal Malefyt, R., J. Abrams, B. Bennett, C. G. Figdor, and J. E. De Vries. 1991. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an auto regulatory role of IL-10 produced by monocytes. J. Exp. Med. 179:1209-1220.
15. Fiorentino, D. F., M. W. Bond, and T. R. Mosmann. 1989. Two types of mouse helper T cells: IV. Th 2 clones secrete a factor that inhibits cytokine production by Th 1 clones. J. Exp. Med. 170:2081-2095.
16. Berkman, N., M. John, G. Roesems, P. J. Jose, P. J. Barnes, and K. F. Chung. 1995. Inhibition of macrophage inflammatory protein-1α by interleukin-10: differential sensitivities in human blood monocytes and alveolar macrophages. J Immunol. 155:4412-4418.
17. Bogdan, C., Y. Vodovotz, and C. Nathan. 1991. Macrophage deactivation by interleukin 10. J. Exp. Med. 174:1549-1555.
18. Fiorentino, D. F., A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147:3815-3822.
19. de Waal Malefyt, R., H. Yssel, and J. E. DeVries. 1993. Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. J. Immunol. 150:4754-4765.
20. Del Prete, G., M. DeCarli, F. Almerigogna, M. G. Giudizi, R. Biagiotti, and S. Romagnani. 1993. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J. Immunol. 150:353-360.
21. Chomczynski, P., and N. Sacchi. 1987. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-160.
22. Collins, P. D., P. J. Jose, and T. J. Williams. 1991. The sequential generation of neutrophil chemoattractant protein in acute inflammation in the rabbit in vivo: relationship between C5a and proteins with the characteristics of L-8/neutrophil activating protein. J. Immunol. 146: 677-684.
23. Jose, P. J., I. K. Moss, R. N. Maini, and T. J. Williams. 1990. Measurement of the chemotactic complement fragment C5a in rheumatoid synovial fluids by radioimmunoassay: role of C5a in the acute inflammatory phase. Ann. Rheum. Dis. 49:747-752.
24. Borish, L., A. Aarons, J. Rumbyrt, P. Cvietusa, J. Negri, and S. Wenzel. 1996. Interleukin-10 regulation in normal subjects and patients with asthma. J. Allergy Clin. Immunol. 97:1288-1296.
25. Bach, M. K., and J. R. Brashler. 1995. Evidence that granulocyte/macrophage-colony-stimulating factor and interferon-gamma maintain the viability of human peripheral blood monocytes in part by their suppression of IL-10 production. Int. Arch. Allergy Immunol. 107:90-92.
26. Chomarat, P., M. C. Rissoan, J. Banchereau, and P. Miossec. 1993. Interferon gamma inhibits interleukin 10 production by monocytes. J. Exp. Med. 177:523-527.
27. Donnelly, R. P., S. L. Freeman, and M. P. Hayes. 1995. Inhibition of IL-10 expression by IFN-gamma up-regulates transcription of TNF-alpha in human monocytes. J. Immunol. 155:1420-1427.
28. Platzer, C., C. Meisel, K. Vogt, M. Platzer, and H. D. Volk. 1995. Upregulation of monocytic IL-10 by tumor necrosis factor-α and cAMP elevating drugs. Int. Immunol. 7:517-523.
29. Oswald, I. P., T. A. Wynn, A. Sher, and S. L. James. 1992. Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation. Proc. Natl. Acad. Sci. U.S.A. 89:8676-8680.
30. Wang, P., P. Wu, M. I. Siegel, R. W. Egan, and M. M. Billah. 1994. IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells. J. Immunol. 153:811-816.
31. Moore, K. W., A. O'Garra, R. de Waal Malefyt, P. Vieira, and T. R. Mosmann. 1993. Interleukin-10. Annu. Rev. Immunol. 11:165-190.