CCR8 is not essential for the development of inflammation in a mouse model of allergic airway disease

Journal of Immunology

Volumn 170, Issue 1, 2003, Pages 581-587

  Chung, Chan D ^a   Kuo, Frederick ^a   Kumer, Jeffrey ^a   Motani, Alykhan S ^a   Lawrence, Christopher E ^a   Henderson Jr , William R ^b   Venkataraman, Chandrasekar ^a  

^a AMGEN INC   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR8; CYTOKINE; GENOMIC DNA; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; LIGAND; NEUTRALIZING ANTIBODY; OVALBUMIN; RNA;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CELL MIGRATION; CONTROLLED STUDY; ENZYME ASSAY; HISTOLOGY; INFLAMMATION; LUNG LAVAGE; LYMPHOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0037222228     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.1.581     Document Type: Article

References (25)

1. Romagnani, S. 2002. Cytokines and chemoattractants in allergic inflammation. Mol. Immunol. 38:881.
2. Salusto, F., C. R. Mackay, and A. Lanzavecchia. 1997. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 277:2005.
3. Zingoni, A., H. Soto, J. A. Hedrick, A. Stoppacciaro, C. T. Storlazzi, F. Sinigaglia, D. D'Ambrosio, A. O'Garra, D. Robinson, M. Rocchi, et al. 1998. The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. J. Immunol. 161:547.
4. D'Ambrosio, D., A. Iellem, R. Bonecchi, D. Mazzeo, S. Sozzani, A. Mantovani, and F. Sinigaglia. 1998. Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J. Immunol. 161:5111.
5. Nagata, K., K. Tanaka, K. Ogawa, K. Kemmotsu, T. Imai, O. Yoshie, H. Abe, K. Tada, M. Nakamura, K. Sugamura, and S. Takano. 1999. Selective expression of a novel surface molecule by human Th2 cells in vivo. J. Immunol. 162:1278.
6. Heath, H. S., Qin, P. Rao, L. Wu, G. LaRosa, N. Kassam, P. D. Ponath, and C. R. Mackay. 1997. Chemokine receptor usage by human eosinophils: The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J. Clin. Invest. 99:178.
7. Ma, W., P. J. Bryce, A. A. Humbles, D. Laouini, A. Yalcindag, H. Alenius, D. S. Friend, H. C. Oettgen, C. Gerard, and R. S. Geha. 2002. CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J. Clin. Invest. 109:621.
8. Kawasaki, S., H. Takizawa, H. Yoneyama, T. Nakayama, R. Fujisawa, M. Izumizaki, T. Imai, O. Yoshie, I. Homma, K. Yamamoto, and K. Matsushima. 2001. Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice. J. Immunol. 166:2055.
9. Gonzalo, J. A., Y. Pan, C. M. Lloyd, G. Q. Jia, G. Yu, B. Dussault, C. A. Powers, A. E. Proudfoot, A. J. Coyle, D. Gearing, and J. C. Gutierrez-Ramos. 1999. Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation. J. Immunol. 163:403.
10. Roos, R. S., M. Loetscher, D. F. Legler, I. Clark-Lewis, M. Baggiolini, and B. Moser. 1997. Identification of CCR8, the receptor for the human CC chemokine I-309. J. Biol. Chem. 272:17251.
11. Tiffany, H. L., L. L. Lautens, J. L. Gao, J. Pease, M. Locati, C. Combadiere, W. Modi, T. I. Bonner, and P. M. Murphy. 1997. Identification of CCR8: A human monocyte and thymus receptor for the CC chemokine 1-309. J. Exp. Med. 186:165.
12. Goya, I., J. Gutierrez, R. Varona, L. Kremer, A. Zaballos, and G. Marquez. 1998. Identification of CCR8 as the specific receptor for the human β-chemokine I-309: Cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. J. Immunol. 160:1975.
13. Mathew, A., J. A. MacLean, E. DeHaan, A. M. Tager, F. H. Green, and A. D. Luster. 2001. Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation. J. Exp. Med. 193:1087.
14. Oliveira, S. H., S. Lira, A. C. Martinez, M. Wiekowski, L. Sullivan, and N. W. Lukacs. 2002. Increased responsiveness of murine eosinophils to MIP-1β (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. J. Leukocyte Biol. 71:1019.
15. Panina-Bordignon, P., A. Papi, M. Mariani, P. Di Lucia, G. Casoni, C. Bellettato, C. Buonsanti, D. Miotto, C. Mapp, A. Villa, et al. 2001. The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J. Clin. Invest. 107:1357.
16. Haque, N. S., J. T. Fallon, M. B. Taubman, and P. C. Harpel. 2001. The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by 1-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium. Blood 97:39.
17. Haque, N. S., X. Zhang, D. L. French, J. Li, M. Poon, J. T. Fallon, B. R. Gabel, M. B. Taubman, M. Koschinsky, and P. C. Harpel. 2000. CC chemokine I-309 is the principal monocyte chemoattractant induced by apolipoprotein(a) in human vascular endothelial cells. Circulation 102:786.
18. - regulatory T cells. J. Exp. Med. 194:847.
19. Inngjerdingen, M., B. Damaj, and A. A. Maghazachi. 2000. Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. J. Immunol. 164:4048.
20. + T lymphocytes with regulatory activity. J. Immunol. 166:996.
21. Chensue, S. W., N. W. Lukacs, T. Y. Yang, X. Shan, K. A. Frait, S. L. Kunkel, T. Kung, M. T. Wiekowski, J. A. Hedrick, D. N. Cook, et al. 2001. Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. J. Exp. Med. 193:573.
22. 4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. J. Clin. Invest. 100:3083.
23. Kung, T. T., H. Jones, G. K. Adams III, S. P. Umland, W. Kreutner, R. W. Egan, R. W. Chapman, and A. S. Watnick. 1994. Characterization of a murine model of allergic pulmonary inflammation. Int. Arch. Allergy Immunol. 105:83.
24. Kobayashi, T., T. Miura, T. Haba, M. Sato, I. Serizawa, H. Nagai, and K. Ishizaka. 2000. An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model. J. Immunol. 164:3855.
25. Oh, S. W., C. I. Pae, D. K. Lee, F. Jones, G. K. Chiang, H. O. Kim, S. H. Moon, B. Cao, C. Ogbu, K. W. Jeong, et al. 2002. Tryptase inhibition blocks airway inflammation in a mouse asthma model. J. Immunol. 168:1992.