Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses

Journal of Medicinal Chemistry

Volumn 42, Issue 5, 1999, Pages 920-934

  Lin, Ko Chung ^a   Ateeq, Humayun S ^a   Hsiung, Sherry H ^a   Chong, Lillian T ^a   Zimmerman, Craig N ^a   Castro, Alfredo ^a   Lee, Wen Cherng ^a   Hammond, Charles E ^a   Kalkunte, Sandhya ^a   Chen, Ling Ling ^a   Pepinsky, R Blake ^a   Leone, Diane R ^a   Sprague, Andrew G ^a   Abraham, William M ^b   Gill, Alan ^a   Lobb, Roy R ^a   Adams, Steven P ^a  

^a BIOGEN   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIO 1211; CARBACHOL; INTEGRIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ALLERGIC REACTION; ARTICLE; ASTHMA; CELL ADHESION; DRUG BINDING; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; DRUG SPECIFICITY; HUMAN CELL; NONHUMAN; PATHOGENESIS; RESPIRATORY TRACT ALLERGY; SHEEP;

ANIMALS; ANTI-ALLERGIC AGENTS; BINDING SITES; BRONCHIAL HYPERREACTIVITY; CARBACHOL; CELL ADHESION; CELL LINE; DRUG DESIGN; EPITOPES; FIBRONECTINS; HUMANS; INTEGRIN ALPHA4BETA1; INTEGRINS; JURKAT CELLS; KINETICS; LIGANDS; OLIGOPEPTIDES; RECEPTORS, LYMPHOCYTE HOMING; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0033545639     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980673g     Document Type: Article

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